Predictors of two months culture conversion in multidrug-resistant tuberculosis: Findings from a retrospective cohort study

PLoS ONE

Volumn 9, Issue 4, 2014, Pages

  Basit, Anila ^a   Ahmad, Nafees ^b   Khan, Amer Hayat ^b   Javaid, Arshad ^c   Syed Sulaiman, Syed Azhar ^b   Afridi, Afsar Khan ^c   Adnan, Azreen Syazril ^d   Haq, Israr Ul ^e   Shah, Syed Saleem ^f   Ahadi, Ahmed ^g   Ahmad, Izaz ^h  

^a Postgraduate Medical Institute   (Pakistan)

^b SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

^c LADY READING HOSPITAL   (Pakistan)

^d SCHOOL OF MEDICAL SCIENCES   (Malaysia)

^e Saidu Medical College   (Pakistan)

^f KHYBER MEDICAL UNIVERSITY   (Pakistan)

^g UNIVERSITY OF BALOCHISTAN   (Pakistan)

^h QUAID I AZAM UNIVERSITY   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSERINE; ETHAMBUTOL; ETHIONAMIDE; KANAMYCIN; OFLOXACIN; PYRAZINAMIDE; STREPTOMYCIN; TUBERCULOSTATIC AGENT;

ADULT; ARTICLE; BACTERIUM CULTURE; CLINICAL EVALUATION; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIDRUG RESISTANT TUBERCULOSIS; NONHUMAN; OUTCOME ASSESSMENT; PAKISTAN; PREDICTIVE VALUE; RETROSPECTIVE STUDY; SPUTUM CULTURE; TREATMENT RESPONSE; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; MICROBIAL SENSITIVITY TEST; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; PROGNOSIS; TUBERCULOSIS, MULTIDRUG-RESISTANT;

ADULT; ANTITUBERCULAR AGENTS; FEMALE; HUMANS; MALE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; OFLOXACIN; PAKISTAN; PROGNOSIS; RETROSPECTIVE STUDIES; STREPTOMYCIN; TUBERCULOSIS, MULTIDRUG-RESISTANT;

EID: 84899416013     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0093206     Document Type: Article

References (23)

1. Chan ED, Laurel V, Strand MJ, Chan JF, Huynh MLN, et al. (2004) Treatment and outcome analysis of 205 patients with multidrug-resistant tuberculosis. Am J Respir Crit Care Med 169: 1103-1109. (Pubitemid 38624789)
2. Behr M, Warren S, Salamon H, Hopewell P, Ponce dLA, et al. (1999) Transmission of Mycobacterium tuberculosis from patients smear-negative for acid-fast bacilli. Lancet 353: 444-9. (Pubitemid 29067335)
3. Hernandez-Garduno E, Cook V, Kunimoto D, Elwood R, Black W, et al. (2004) Transmission of tuberculosis from smear negative patients: a molecular epidemiology study. Thorax 59: 286-90. (Pubitemid 38496744)
4. Qazi F, Khan U, Khowaja S, Javaid M, Ahmed A, et al. (2011) Predictors of delayed culture conversion in patients treated for multidrug-resistant tuberculosis in Pakistan. Int J Tuberc Lung Dis 15: 1556-60.
5. Diacon AH, Pym A, Grobusch M, Patientia R, Rustomjee R, et al. (2009) The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N Engl J Med 360: 2397-405.
6. Holtz TH, Sternberg M, Kammerer S, Laserson KF, Riekstina V, et al. (2006) Time to sputum culture conversion in multidrug-resistant tuberculosis: predictors and relationship to treatment outcome. Ann Intern Med 144: 650-659. (Pubitemid 46780649)
7. Yew WW, Chan CK, Chau CH, Tam CM, Leung CC, et al (2000). Outcomes of patients with multidrug-resistant pulmonary tuberculosis treated with ofloxacin/levofloxacin-containing regimens. Chest 117: 744-51. (Pubitemid 30152215)
8. Rodriguez M, Monedero I, Caminero J, Encarnación M, Dominguez Y, et al. (2013) Successful management of multidrug-resistant tuberculosis under programme conditions in the Dominican Republic. Int J Tuberc Lung Dis 17: 520-5.
9. Rieder H. (1996) Sputum smear conversion during directly observed treatment for tuberculosis. Tuber Lung Dis 77: 124-9.
10. Salaniponi F, Christensen J, Gausi F, Kwanjana J, Harries A. (1999) Sputum smear status at two months and subsequent treatment outcome in new patients with smear-positive pulmonary tuberculosis. Int J Tuberc Lung Dis 3: 1047-8.
11. Singla R, Osman M, Khan N, Al-Sharif N, Al-Sayegh M, et al. (2003) Factors predicting persistent sputum smear positivity among pulmonary tuberculosis patients 2 months after treatment. Int J Tuberc Lung Dis 7: 58-64. (Pubitemid 36427032)
12. Singla R, Sarin R, Khalid U, Mathuria K, Singla N, et al. (2009) Seven-year DOTS-Plus pilot experience in India: results, constraints and issues. Int J Tuberc Lung Dis 13: 976-81.
13. Joseph P, Desai VBR, Mohan NS, Fredrick JS, Ramachandran R, et al. (2012) Outcome of standardized treatment for patients with MDR-TB from Tamil Nadu, India. Indian J Med Res 133 (5): 529-34.
14. Dorman SE, Johnson JL, Goldberg S, Muzanye G, Padayatchi N, et al. (2009) Substitution of moxifloxacin for isoniazid during intensive phase treatment of pulmonary tuberculosis. Am J Respir Crit Care Med 180: 273-80.
15. Güler M, Ünsal E, Dursun B, AydIn Ö, Capan N. (2007) Factors influencing sputum smear and culture conversion time among patients with new case pulmonary tuberculosis. Int J Clin Prac 61: 231-5.
16. Telzak EE, Fazal BA, Pollard CL, Turett GS, Justman JE, et al. (1997) Factors influencing time to sputum conversion among patients with smear-positive pulmonary tuberculosis. Clin Infect Dis 25: 666-70. (Pubitemid 127774281)
17. Brust JC, Berman AR, Zalta B, Haramati LB, Ning Y, et al. (2013) Chest Radiograph Findings and Time to Culture Conversion in Patients with Multidrug-Resistant Tuberculosis and HIV in Tugela Ferry, South Africa. PLoS One 8 (9): e73975.
18. Leimane V, Riekstina V, Holtz TH, Zarovska E, Skripconoka V, et al. (2005) Clinical outcome of individualised treatment of multidrug-resistant tuberculosis in Latvia: a retrospective cohort study. Lancet 365: 318-26. (Pubitemid 40139109)
19. Kurbatova E, Gammino V, Bayona J, Becerra M, Danilovitz M, et al. (2012) Predictors of sputum culture conversion among patients treated for multidrug-resistant tuberculosis. Int J Tuberc Lung Dis 16: 1335-43.
20. Jabeen K, Shakoor S, Chishti S, Ayaz A, Hasan R. (2011) Fluoroquinolone-Resistant Mycobacterium tuberculosis, Pakistan, 2005-2009. Emerg Infect Dis 17: 564-6.
21. Wells WA, Ge CF, Patel N, Oh T, Gardiner E, et al. (2011) Size and usage patterns of private TB drug markets in the high burden countries. PloS One; 6: e18964.
22. Hwang S, Kim H, Kim H, Kim M, Lee S, et al. (2009) Impact of resistance to first-line and injectable drugs on treatment outcomes in MDR-TB. Eur Respir J 33: 581-5.
23. Kim DH, Kim HJ, Park SK, Kong SJ, Kim YS, et al. (2010) Treatment outcomes and survival based on drug resistance patterns in multidrug-resistant tuberculosis. Am J Respir Crit Care Med 182: 113-9.