IL-6 mobilizes bone marrow-derived cells to the vascular wall, resulting in neointima formation via inflammatory effects

Journal of Atherosclerosis and Thrombosis

Volumn 21, Issue 4, 2014, Pages 304-312

  Shoji, Makoto ^a   Furuyama, Fumiaki ^a   Yokota, Yuya ^a   Omori, Yasutoshi ^a   Sato, Takatoshi ^a   Tsunoda, Fumiyoshi ^a   Iso, Yoshitaka ^b   Koba, Shinji ^a   Geshi, Eiichi ^a   Katagiri, Takashi ^a   Suzuki, Hiroshi ^b   Kobayashi, Youichi ^a  

^a SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

Author keywords

Arterial remodeling; Bone marrow derived cells; IL 6

Indexed keywords

CD34 ANTIGEN; INTERLEUKIN 6; HGF PROTEIN, MOUSE; SCATTER FACTOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD VESSEL INJURY; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL INVASION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MOUSE; NEOINTIMA; NONHUMAN; VASCULAR ENDOTHELIUM; ANIMAL; BAGG ALBINO MOUSE; BONE MARROW CELL; CYTOLOGY; FLOW CYTOMETRY; GENETICS; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD34; APOPTOSIS; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; HEPATOCYTE GROWTH FACTOR; INFLAMMATION; INTERLEUKIN-6; MALE; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; NEOINTIMA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84899411229     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.19414     Document Type: Article

References (25)

1. Ross R: The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature, 1993; 362: 801-809
2. Saiura A, Sata M, Hirata Y, Nagai R, Makuuchi M: Cir-culating smooth muscle progenitor cells contribute to atherosclerosis. Nat Med, 2001; 7: 382-383
3. Sata M, Saiura A, Kunisato A, Tojo A, Okada S, Tokuhisa T, Hirai H, Makuuchi M, Hirata Y, Nagai R: Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med, 2002; 8: 403-409
4. Rectenwald JE, Moldawer LL, Huber TS, Seeger JM, Ozaki CK: Direct evidence for cytokine involvement in neointimal hyperplasia. Circulation, 2000; 102: 1697-1702
5. Schwartz RS, Henry TD: Pathophysiology of coronary artery restenosis. Rev Cardiovasc Med, 2002; Suppl 5: S4-9
6. van der Meer IM, de Maat MP, Bots ML, Breteler MM, Meijer J, Kiliaan AJ, Hofman A, Witteman JC: Inflammatory mediators and cell adhesion molecules as indicators of severity of atherosclerosis: the Rotterdam Study. Atheroscler Thromb Vasc Biol, 2002; 22: 838-842
7. Danesh J, Kaptoge S, Mann AG, Sarwar N, Wood A, Angleman SB, Wensley F, Higgins JP, Lennon L, Eiriksdottir G, Rumley A, Whincup PH, Lowe GD, Gudnason V: Long-term interleukin-6 levels and subsequent risk of coronary heart disease: two new prospective studies and a systematic review. PLos Med, 2008; 5: e78
8. Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, Zinkernagel R, Bluethmann H, Kohler G: Impaired immune and acute-phase responses in inter leukin-6-deficient mice. Nature, 1994; 368: 339-342
9. Shoji M, Sata M, Fukuda D, Tahaka K, Sato T, Iso Y, Shibata M, Suzuki H, Koba, S, Geshi E, Katagiri T: Temporal and spatial characterization of cellular constituents during neointimal hyperplasia after vascular injury: Potential contribution of bone-marrow-derived progenitors to arterial remodeling. Cardiovasc Pathol, 2004; 13: 306-312
10. Sata M, Maejima Y, Adachi F, Fukino K, Saiura A, Sugiura S, Aoyagi T, Imai Y, Kurihara H, Kimura K, Omata M, Makuuchi M, Hirata Y, Nagai R: A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia. J Mol Cell Cardiol, 2000; 32: 2097-2104
11. Okada S, Yoshida T, Hong Z, Ishii G, Hatano M, Kuro-o M, Nabeshima Y, Nabeshima Y, Tokuhisa T: Impairment of B lymphopoiesis in precocious aging (klotho) mice. Int Immunol, 2000; 12: 861-871
12. Tanaka K, Sata M, Hirata Y, Nagai R: Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries. Circ Res, 2003; 93: 783-790
13. Shoji M, Iso Y, Kusuyama T, Omori Y, Soda T, Tsunoda F, Sato T, Koba S, Geshi E, Kobayashi Y, Katagiri T, Suzuki H: High-dose granulocyte-colony stimulating factor promotes neointimal hyperplasia in the early phase and inhibits neointimal hyperplasia in the late phase after vascular injury. Circ J, 2008; 72: 1885-1893
14. Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM: Isolation of putative progenitor endothelial cells for angiogenesis. Science, 1997; 275: 964-967
15. Takaoka M, Suzuki H, Shioda S, Sekikawa K, Saito Y, Nagai R, Sata M: Endovascular injury induces rapid phenotypic changes in perivascular adipose tissue. Arteriorscler Thromb Vasc Biol, 2010; 30: 1576-1582
16. McKay R: Stem cells-hype and hope. Nature, 2000; 406: 361-364
17. Caplice NM, Bunch TJ, Stalboerger PG, Wang S, Simper D, Miller DV, Russell SJ, Litzow MR, Edwards WD: Smooth muscle cells in human coronary atherosclerosis can originate from cells administered at marrow trans plantation. Proc Natl Acad Sci U S A, 2003; 100: 4754-4759
18. Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA, Finkle T: Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med, 2003; 348: 593-600
19. Rafii S, Lyden D: Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med, 2003; 9: 702-712
20. Shoji M, Oskowitz A, malone CD, Prockop DJ, Pochampally R: Human mesenchymal stromal cells (MSCs) reduce neointimal hyperplasia in a mouse model of flowrestriction by transient suppression of anti-inflammatory cytokines. J Atheroscler Thromb, 2011; 18: 464-474
21. Iwata H, Manabe I, Fujiu K, Yamamoto T, Takeda N, Eguchi K, Furuya A, Kuro-o M, Sata M, Nagai R: Bone marrow-derived cells contribute to vascular inflammation but do not differentiate into smooth muscle cell lineages. Circulation, 2010; 122: 2048-2057
22. Oguro T, Takahashi Y, Ashino T, Takaki A, Shioda S, Horai R, Asano M, Sekikawa K, Iwakura Y, Yoshida T: Involvement of tumor necrosis factor α, rather than interleukin-1α/β or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver. FEBS Letters, 2002; 516: 63-66
23. Yang H, Li M, Chai H, Yan S, Zhang R, Yao Q, Chen C: Expression and Regulation of Neuropilins and VEGF Receptors by TNF-α in Human Endothelial Cells. J Surg Res, 2004; 122: 249-255
24. Shibata M, Sueki H, Suzuki H, Watanabe H, Ohtaki H, Shioda S, Nakanishi-Ueda T, Yasuhara H, Sekikawa K, Iijima M: Impaired Contact Hypersensitivity Reaction and Reduced Production of Vascular Endothelial Growth Factor in Tumor Necrosis Factor-α Gene-Deficient Mice. J Dermatol, 2005; 32: 523-533
25. Oh JY, Lee RH, Yu JM, Ko JH, Lee HJ, Ko AY, Roddy GW, Prockop DJ: Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response. Mol Ther, 2012; 20: 2143-2152