Examining weak protein-protein interactions in start codon recognition via NMR spectroscopy

FEBS Journal

Volumn 281, Issue 8, 2014, Pages 1965-1973

  Luna, Rafael E ^a   Akabayov, Sabine R ^a   Ziarek, Joshua J ^a   Wagner, Gerhard ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

chemical shift perturbation; cross saturation; fragment based screening; initiation factors; nuclear magnetic resonance; paramagnetic relaxation enhancement; residual dipolar couplings; small angle X Ray scattering reconstitution assay; translation initiation; weak interactions

Indexed keywords

INITIATION FACTOR; INITIATION FACTOR 1; INITIATION FACTOR 2BETA; INITIATION FACTOR 5; MESSENGER RNA; UNCLASSIFIED DRUG;

BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; DRUG DESIGN; DRUG SCREENING; HETERONUCLEAR SINGLE QUANTUM COHERENCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; RIBOSOME; START CODON; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CHEMICAL SHIFT PERTURBATION; CROSS SATURATION; FRAGMENT BASED SCREENING; INITIATION FACTORS; NUCLEAR MAGNETIC RESONANCE; PARAMAGNETIC RELAXATION ENHANCEMENT; RESIDUAL DIPOLAR COUPLINGS; SMALL ANGLE X-RAY SCATTERING RECONSTITUTION ASSAY; TRANSLATION INITIATION; WEAK INTERACTIONS;

CODON, INITIATOR; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEINS;

EID: 84899410614     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12667     Document Type: Review

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