TGF-β1 suppression of microRNA-450b-5p expression: A novel mechanism for blocking myogenic differentiation of rhabdomyosarcoma

Oncogene

Volumn 33, Issue 16, 2014, Pages 2075-2086

  Sun, M M ^a   Li, J F ^b   Guo, L L ^a   Xiao, H T ^c   Dong, L ^a   Wang, F ^a   Huang, F B ^a   Cao, D ^a   Qin, T ^a   Yin, X H ^a   Li, J M ^a   Wang, S L ^a  

^a MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

differentiation; miR 450b 5p; rhabdomyosarcoma; TGF 1

Indexed keywords

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; MICRORNAS; MYOD PROTEIN; NADH, NADPH OXIDOREDUCTASES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PAX9 TRANSCRIPTION FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHABDOMYOSARCOMA; RNA INTERFERENCE; TRANSCRIPTOME; TRANSFORMING GROWTH FACTOR BETA1; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84899408031     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.165     Document Type: Article

References (35)

1. Sebire NJ, Malone M. Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas. J Clin Pathol 2003; 56: 412-416
2. Tapscott SJ, Thayer MJ, Weintraub H. Deficiency in rhabdomyosarcomas of a factor required for MyoD activity and myogenesis. Science 1993; 259: 1450-1453
3. Mishra PJ, Merlino G. MicroRNA reexpression as differentiation therapy in cancer. J Clin Invest 2009; 119: 2119-2123
4. Wurdinger T, Costa FF. Molecular therapy in the microRNA era. Pharmacogenomics J 2007; 7: 297-304
5. Wang V, Wu W. MicroRNA-based therapeutics for cancer. BioDrugs 2009; 23: 15-23
6. Li Y, Foster W, Deasy BM, Chan Y, Prisk V, Tang Y, et al. Transforming growth factor-beta1 induces the differentiation of myogenic cells into fibrotic cells in injured skeletal muscle: A key event in muscle fibrogenesis. Am J Pathol 2004; 164: 1007-1019
7. Sun Q, Zhang Y, Yang G, Chen X, Cao G, Wang J, et al. Transforming growth factorbeta-regulated miR-24 promotes skeletal muscle differentiation. Nucleic Acids Res 2008; 36: 2690-2699
8. Wang SL, Yao HH, Guo LL, Dong L, Li SG, Gu YP, et al. Selection of optimal sites for TGFB1 gene silencing by chitosan-TPP nanoparticle-mediated delivery of shRNA. Cancer Genet Cytogenet 2009; 190: 8-14
9. Wang S, Guo L, Dong L, Li S, Zhang J, Sun M. TGF-beta1 signal pathway may contribute to rhabdomyosarcoma development by inhibiting differentiation. Cancer Sci 2010; 101: 1108-1116
10. Ye L, Zhang HY, Wang H, Yang GH, Bu H, Zhang L, et al. Effects of transforming growth factor beta 1 on the growth of rhabdomyosarcoma cell line RD. Chin Med J (Engl) 2005; 118: 678-686
11. Davis BN, Hilyard AC, Lagna G, Hata A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 2008; 454: 56-61
12. Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, et al. MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol 2008; 28: 6773-6784
13. Wang B, Hsu SH, Majumder S, Kutay H, Huang W, Jacob ST, et al. TGFbetamediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3. Oncogene 2010; 29: 1787-1797
14. Shoji Y, Saegusa M, Takano Y, Ohbu M, Okayasu I. Correlation of apoptosis with tumour cell differentiation, progression, and HPV infection in cervical carcinoma. J Clin Pathol 1996; 49: 134-138
15. Liu D, Black BL, Derynck R. TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes Dev 2001; 15: 2950-2966
16. Massague J. TGFbeta in cancer. Cell 2008; 134: 215-230
17. Bouche M, Canipari R, Melchionna R, Willems D, Senni MI, Molinaro M. TGF-beta autocrine loop regulates cell growth and myogenic differentiation in human rhabdomyosarcoma cells. FASEB J 2000; 14: 1147-1158
18. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857-866
19. Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 2007; 39: 673-677
20. Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, et al. Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell 2009; 36: 340-347
21. Suzuki HI, Yamagata K, Sugimoto K, Iwamoto T, Kato S, Miyazono K. Modulation of microRNA processing by p53. Nature 2009; 460: 529-533
22. Suzuki HI, Miyazono K. Emerging complexity of microRNA generation cascades. J Biochem 2011; 149: 15-25
23. Bartel DP. MicroRNAs: Target recognition and regulatory functions. Cell 2009; 136: 215-233
24. Liu NC, Hsieh PF, Hsieh MK, Zeng ZM, Cheng HL, Liao JW, et al. Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo. J Agric Food Chem 2012; 60: 2758-2765
25. Rodrigo I, Hill RE, Balling R, Munsterberg A, Imai K. Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome. Development 2003; 130: 473-482
26. Zeng ZM, Chuang SM, Chang TC, Hong CW, Chou JC, Yang JJ, et al. Phosphorylation of serine-504 of tNOX (ENOX2) modulates cell proliferation and migration in cancer cells. Exp Cell Res 2012; 318: 1759-1766
27. Hatley ME, Tang W, Garcia MR, Finkelstein D, Millay DP, Liu N, et al. A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell 2012; 22: 536-546
28. Liu D, Kang JS, Derynck R. TGF-beta-Activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J 2004; 23: 1557-1566
29. Ge X, McFarlane C, Vajjala A, Lokireddy S, Ng ZH, Tan CK, et al. Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts. Cell Res 2011; 21: 1591-1604
30. Segev H, Fishman B, Ziskind A, Shulman M, Itskovitz-Eldor J. Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 2004; 22: 265-274
31. Yang Z, MacQuarrie KL, Analau E, Tyler AE, Dilworth FJ, Cao Y, et al. MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state. Genes Dev 2009; 23: 694-707
32. Guo H, Zhang HY, Wang SL, Ye L, Yang GH, Bu H. Smad4 and ERK2 stimulated by transforming growth factor beta1 in rhabdomyosarcoma. Chin Med J (Engl) 2007; 120: 515-521
33. Chen C, Ridzon DA, Broomer AJ, Zhou Z, Lee DH, Nguyen JT, et al. Real-Time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 2005; 33: E179
34. Schmittgen TD, Lee EJ, Jiang J, Sarkar A, Yang L, Elton TS, et al. Real-Time PCR quantification of precursor and mature microRNA. Methods 2008; 44: 31-38
35. Cheng AM, Byrom MW, Shelton J, Ford LP. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res 2005; 33: 1290-1297