메뉴 건너뛰기




Volumn 19, Issue 22, 2013, Pages 4094-4114

Drug combinations with proteasome inhibitors in antitumor therapy

Author keywords

Combination treatment; Cytotoxic agents; Proteasome; Target specific agents

Indexed keywords

ALKYLATING AGENT; ANTHRACYCLINE; ANTIMETABOLITE; ANTINEOPLASTIC AGENT; BORTEZOMIB; CARFILZOMIB; CYTOTOXIC AGENT; DASATINIB; DELANZOMIB; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; FLAVOPIRIDOL; HEAT SHOCK PROTEIN 90 INHIBITOR; HISTONE DEACETYLASE INHIBITOR; IXAZOMIB CITRATE; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MONOCLONAL ANTIBODY; OPROZOMIB; PLATINUM DERIVATIVE; PROTEASOME INHIBITOR; PROTEIN BCL 2 INHIBITOR; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN INHIBITOR; PROTEIN KINASE B INHIBITOR; SALINOSPORAMIDE A; SORAFENIB; SUNITINIB; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; DNA TOPOISOMERASE INHIBITOR; PROTEASOME;

EID: 84899158682     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612811319220015     Document Type: Article
Times cited : (19)

References (251)
  • 1
    • 0033801694 scopus 로고    scopus 로고
    • Basis for effective combination cancer chemotherapy with antimetabolites
    • Peters GJ, van der Wilt CL, van Moorsel CJ, et al. Basis for effective combination cancer chemotherapy with antimetabolites. Pharmacol Ther 2000; 87: 227-53.
    • (2000) Pharmacol Ther , vol.87 , pp. 227-253
    • Peters, G.J.1    van der Wilt, C.L.2    van Moorsel, C.J.3
  • 2
    • 84860214990 scopus 로고    scopus 로고
    • Intra-tumour heterogeneity: a looking glass for cancer?
    • Marusyk A, Almendro V, Polyak K. Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 2012; 12: 323-34.
    • (2012) Nat Rev Cancer , vol.12 , pp. 323-334
    • Marusyk, A.1    Almendro, V.2    Polyak, K.3
  • 3
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: a suitable antineoplastic target
    • Adams J., The proteasome: a suitable antineoplastic target. Nat Rev Cancer 2004; 4: 349-60.
    • (2004) Nat Rev Cancer , vol.4 , pp. 349-360
    • Adams, J.1
  • 4
    • 78651491709 scopus 로고    scopus 로고
    • Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast
    • Gatti L, Hoe KL, Hayles J, et al. Ubiquitin-proteasome genes as targets for modulation of cisplatin sensitivity in fission yeast. BMC Genomics 2011; 12: 44.
    • (2011) BMC Genomics , vol.12 , pp. 44
    • Gatti, L.1    Hoe, K.L.2    Hayles, J.3
  • 5
    • 44649103370 scopus 로고    scopus 로고
    • Defining targets of modulation of human tumor cell response to cisplatin
    • Beretta GL, Gatti L, Corna E, et al. Defining targets of modulation of human tumor cell response to cisplatin. J Inorg Biochem 2008; 102: 1406-15.
    • (2008) J Inorg Biochem , vol.102 , pp. 1406-1415
    • Beretta, G.L.1    Gatti, L.2    Corna, E.3
  • 6
    • 54049087405 scopus 로고    scopus 로고
    • A proteomic approach for evaluating the cell response to a novel histone deacetylase inhibitor in colon cancer cells
    • Milli A, Cecconi D, Campostrini N, et al. A proteomic approach for evaluating the cell response to a novel histone deacetylase inhibitor in colon cancer cells. Biochim Biophys Acta 2008; 1784: 1702-10.
    • (2008) Biochim Biophys Acta , vol.1784 , pp. 1702-1710
    • Milli, A.1    Cecconi, D.2    Campostrini, N.3
  • 7
    • 2642551603 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor Velcade (Bortezomib)
    • Adams J, Kauffman M. Development of the proteasome inhibitor Velcade (Bortezomib). Cancer Invest 2004; 22: 304-11.
    • (2004) Cancer Invest , vol.22 , pp. 304-311
    • Adams, J.1    Kauffman, M.2
  • 8
    • 41549133200 scopus 로고    scopus 로고
    • Proteasome inhibitors in cancer therapy: lessons from the first decade
    • Orlowski RZ, Kuhn DJ. Proteasome inhibitors in cancer therapy: lessons from the first decade. Clin Cancer Res 2008; 14: 1649-57.
    • (2008) Clin Cancer Res , vol.14 , pp. 1649-1657
    • Orlowski, R.Z.1    Kuhn, D.J.2
  • 9
    • 78650824534 scopus 로고    scopus 로고
    • Ubiquitinlike protein conjugation and the ubiquitin-proteasome system as drug targets
    • Bedford L, Lowe J, Dick LR, Mayer RJ, Brownell JE. Ubiquitinlike protein conjugation and the ubiquitin-proteasome system as drug targets. Nat Rev Drug Discov 2011; 10: 29-46.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 29-46
    • Bedford, L.1    Lowe, J.2    Dick, L.R.3    Mayer, R.J.4    Brownell, J.E.5
  • 10
    • 0037443551 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications
    • Mitsiades N, Mitsiades CS, Richardson PG, et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 2003; 101(6): 2377-80.
    • (2003) Blood , vol.101 , Issue.6 , pp. 2377-2380
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 11
    • 84862696482 scopus 로고    scopus 로고
    • Bortezomib combination therapy in multiple myeloma
    • Kapoor P, Ramakrishnan V, Rajkumar SV. Bortezomib combination therapy in multiple myeloma. Semin Hematol 2012; 49(3): 228-42.
    • (2012) Semin Hematol , vol.49 , Issue.3 , pp. 228-242
    • Kapoor, P.1    Ramakrishnan, V.2    Rajkumar, S.V.3
  • 12
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001; 61: 3071-6.
    • (2001) Cancer Res , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3
  • 13
    • 0037097595 scopus 로고    scopus 로고
    • Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Apoptotic signaling induced by immunomodulatory thalidomide analogs in human multiple myeloma cells: therapeutic implications. Blood 2002; 99: 4525-30.
    • (2002) Blood , vol.99 , pp. 4525-4530
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 14
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition
    • Cusack JC Jr, Liu R, Houston M, et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res 2001; 61: 3535-40.
    • (2001) Cancer Res , vol.61 , pp. 3535-3540
    • Cusack Jr., J.C.1    Liu, R.2    Houston, M.3
  • 15
    • 0037441760 scopus 로고    scopus 로고
    • Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS- 341
    • Hideshima T, Mitsiades C, Akiyama M, et al. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS- 341. Blood 2003; 101(4): 1530-4.
    • (2003) Blood , vol.101 , Issue.4 , pp. 1530-1534
    • Hideshima, T.1    Mitsiades, C.2    Akiyama, M.3
  • 16
    • 0037342894 scopus 로고    scopus 로고
    • The proteasome inhibitor PS- 341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
    • Ma MH, Yang HH, Parker K, et al. The proteasome inhibitor PS- 341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res 2003; 9: 1136-44.
    • (2003) Clin Cancer Res , vol.9 , pp. 1136-1144
    • Ma, M.H.1    Yang, H.H.2    Parker, K.3
  • 17
    • 38649122066 scopus 로고    scopus 로고
    • Proteasomal inhibition stabilizes topoisomerase IIalpha protein and reverses resistance to the topoisomerase II poison ethonafide (AMP-53, 6-ethoxyazonafide)
    • Congdon LM, Pourpak A, Escalante AM, Dorr RT, Landowski TH. Proteasomal inhibition stabilizes topoisomerase IIalpha protein and reverses resistance to the topoisomerase II poison ethonafide (AMP-53, 6-ethoxyazonafide). Biochem Pharmacol 2008; 75: 883- 90.
    • (2008) Biochem Pharmacol , vol.75 , pp. 883-890
    • Congdon, L.M.1    Pourpak, A.2    Escalante, A.M.3    Dorr, R.T.4    Landowski, T.H.5
  • 18
    • 41949099660 scopus 로고    scopus 로고
    • Alkylating agents induce activation of NFkappaB in multiple myeloma cells
    • Baumann P, Mandl-Weber S, Oduncu F, Schmidmaier R. Alkylating agents induce activation of NFkappaB in multiple myeloma cells. Leuk Res 2008; 32: 1144-7.
    • (2008) Leuk Res , vol.32 , pp. 1144-1147
    • Baumann, P.1    Mandl-Weber, S.2    Oduncu, F.3    Schmidmaier, R.4
  • 19
    • 33847297956 scopus 로고    scopus 로고
    • Sequence-dependent synergy of the proteasome inhibitor bortezomib and cytarabine in mantle cell lymphoma
    • Weigert O, Pastore A, Rieken M, Lang N, Hiddemann W, Dreyling M. Sequence-dependent synergy of the proteasome inhibitor bortezomib and cytarabine in mantle cell lymphoma. Leukemia 2007; 21(3): 524-8.
    • (2007) Leukemia , vol.21 , Issue.3 , pp. 524-528
    • Weigert, O.1    Pastore, A.2    Rieken, M.3    Lang, N.4    Hiddemann, W.5    Dreyling, M.6
  • 20
    • 84862701321 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib targets cell cycle and apoptosis and acts synergistically in a sequence-dependent way with chemotherapeutic agents in mantle cell lymphoma
    • Hutter G, Rieken M, Pastore A, et al. The proteasome inhibitor bortezomib targets cell cycle and apoptosis and acts synergistically in a sequence-dependent way with chemotherapeutic agents in mantle cell lymphoma. Ann Hematol 2012; 91: 847-56.
    • (2012) Ann Hematol , vol.91 , pp. 847-856
    • Hutter, G.1    Rieken, M.2    Pastore, A.3
  • 21
    • 10344222124 scopus 로고    scopus 로고
    • The role of the unfolded protein response in tumour development: friend or foe?
    • Ma Y, Hendershot LM. The role of the unfolded protein response in tumour development: friend or foe? Nat Rev Cancer 2004; 4: 966-77.
    • (2004) Nat Rev Cancer , vol.4 , pp. 966-977
    • Ma, Y.1    Hendershot, L.M.2
  • 22
    • 66849132245 scopus 로고    scopus 로고
    • Bortezomib induces schedule-dependent modulation of gemcitabine pharmacokinetics and pharmacodynamics in non-small cell lung cancer and blood mononuclear cells
    • Ceresa C, Giovannetti E, Voortman J, et al. Bortezomib induces schedule-dependent modulation of gemcitabine pharmacokinetics and pharmacodynamics in non-small cell lung cancer and blood mononuclear cells. Mol Cancer Ther 2009; 8: 1026-36.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1026-1036
    • Ceresa, C.1    Giovannetti, E.2    Voortman, J.3
  • 23
    • 29244454269 scopus 로고    scopus 로고
    • Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis
    • Nawrocki ST, Carew JS, Pino MS, et al. Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. Cancer Res 2005; 65: 11658-6.
    • (2005) Cancer Res , vol.65 , pp. 11658-11666
    • Nawrocki, S.T.1    Carew, J.S.2    Pino, M.S.3
  • 24
    • 49849104202 scopus 로고    scopus 로고
    • Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells
    • Li C, Li R, Grandis JR, Johnson DE. Bortezomib induces apoptosis via Bim and Bik up-regulation and synergizes with cisplatin in the killing of head and neck squamous cell carcinoma cells. Mol Cancer Ther 2008; 7: 1647-55.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1647-1655
    • Li, C.1    Li, R.2    Grandis, J.R.3    Johnson, D.E.4
  • 25
    • 38649116043 scopus 로고    scopus 로고
    • Antiproliferative activity of bortezomib alone and in combination with cisplatin or docetaxel in head and neck squamous cell carcinoma cell lines
    • Wagenblast J, Hambek M, Baghi M, et al. Antiproliferative activity of bortezomib alone and in combination with cisplatin or docetaxel in head and neck squamous cell carcinoma cell lines. J Cancer Res Clin Oncol 2008; 134: 323-30.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 323-330
    • Wagenblast, J.1    Hambek, M.2    Baghi, M.3
  • 26
    • 38049016884 scopus 로고    scopus 로고
    • Preclinical studies of the proteasome inhibitor bortezomib in malignant pleural mesothelioma
    • Gordon GJ, Mani M, Maulik G, et al. Preclinical studies of the proteasome inhibitor bortezomib in malignant pleural mesothelioma. Cancer Chemother Pharmacol 2008; 61: 549-58.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 549-558
    • Gordon, G.J.1    Mani, M.2    Maulik, G.3
  • 27
    • 77954678999 scopus 로고    scopus 로고
    • Targeted proteasome inhibition by Velcade induces apoptosis in human mesothelioma and breast cancer cell lines
    • Wang Y, Rishi AK, Puliyappadamba VT, et al. Targeted proteasome inhibition by Velcade induces apoptosis in human mesothelioma and breast cancer cell lines. Cancer Chemother Pharmacol 2010; 66: 455-66.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 455-466
    • Wang, Y.1    Rishi, A.K.2    Puliyappadamba, V.T.3
  • 28
    • 59449105383 scopus 로고    scopus 로고
    • Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1
    • Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, Howell SB. Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1. Clin Cancer Res 2009; 15: 553-60.
    • (2009) Clin Cancer Res , vol.15 , pp. 553-560
    • Jandial, D.D.1    Farshchi-Heydari, S.2    Larson, C.A.3    Elliott, G.I.4    Wrasidlo, W.J.5    Howell, S.B.6
  • 29
    • 80051653958 scopus 로고    scopus 로고
    • Modulation of cisplatin cytotoxicity due to its combination with bortezomib and the nature of its administration
    • Al-Eisawi Z, Beale P, Chan C, Yu JQ, Huq F. Modulation of cisplatin cytotoxicity due to its combination with bortezomib and the nature of its administration. Anticancer Res 2011; 31: 2757-62.
    • (2011) Anticancer Res , vol.31 , pp. 2757-2762
    • Al-Eisawi, Z.1    Beale, P.2    Chan, C.3    Yu, J.Q.4    Huq, F.5
  • 30
    • 0034333366 scopus 로고    scopus 로고
    • Prevention of cisplatin- DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors
    • Mimnaugh EG, Yunmbam MK, Li Q, et al. Prevention of cisplatin- DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors. Biochem Pharmacol 2000; 60: 1343-54.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1343-1354
    • Mimnaugh, E.G.1    Yunmbam, M.K.2    Li, Q.3
  • 31
    • 0035487184 scopus 로고    scopus 로고
    • Effect of the proteasome inhibitor ALLnL on cisplatin sensitivity in human ovarian tumor cells
    • Yunmbam MK, Li QQ, Mimnaugh EG, et al. Effect of the proteasome inhibitor ALLnL on cisplatin sensitivity in human ovarian tumor cells. Int J Oncol 2001; 19: 741-8.
    • (2001) Int J Oncol , vol.19 , pp. 741-748
    • Yunmbam, M.K.1    Li, Q.Q.2    Mimnaugh, E.G.3
  • 32
    • 0004920274 scopus 로고    scopus 로고
    • Lactacystin enhances cisplatin sensitivity in resistant human ovarian cancer cell lines via inhibition of DNA repair and ERCC-1 expression
    • Li QQ, Yunmbam MK, Zhong X, et al. Lactacystin enhances cisplatin sensitivity in resistant human ovarian cancer cell lines via inhibition of DNA repair and ERCC-1 expression. Cell Mol Biol (Noisy-le-grand) 2001; 47.
    • (2001) Cell Mol Biol (Noisy-le-grand) , pp. 47
    • Li, Q.Q.1    Yunmbam, M.K.2    Zhong, X.3
  • 33
    • 77952341427 scopus 로고    scopus 로고
    • Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs
    • Howell SB, Safaei R, Larson CA, Sailor MJ. Copper transporters and the cellular pharmacology of the platinum-containing cancer drugs. Mol Pharmacol 2010; 77: 887-94.
    • (2010) Mol Pharmacol , vol.77 , pp. 887-894
    • Howell, S.B.1    Safaei, R.2    Larson, C.A.3    Sailor, M.J.4
  • 34
    • 33846013251 scopus 로고    scopus 로고
    • Proteasome inhibitor PS- 341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa
    • Fribley AM, Evenchik B, Zeng Q, et al. Proteasome inhibitor PS- 341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. J Biol Chem 2006; 281: 31440-7.
    • (2006) J Biol Chem , vol.281 , pp. 31440-31447
    • Fribley, A.M.1    Evenchik, B.2    Zeng, Q.3
  • 35
    • 84862161278 scopus 로고    scopus 로고
    • Nonspecific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin
    • Jacquemont C, Simon JA, D'Andrea AD, Taniguchi T. Nonspecific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin. Mol Cancer 2012; 11: 26.
    • (2012) Mol Cancer , vol.11 , pp. 26
    • Jacquemont, C.1    Simon, J.A.2    D'Andrea, A.D.3    Taniguchi, T.4
  • 36
    • 84862290994 scopus 로고    scopus 로고
    • Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells
    • Gatti L, Benedetti V, De Cesare M, et al. Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells. J Inorg Biochem 2012; 113: 94-101.
    • (2012) J Inorg Biochem , vol.113 , pp. 94-101
    • Gatti, L.1    Benedetti, V.2    De Cesare, M.3
  • 37
    • 3042562304 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts
    • Nawrocki ST, Sweeney-Gotsch B, Takamori R, McConkey DJ. The proteasome inhibitor bortezomib enhances the activity of docetaxel in orthotopic human pancreatic tumor xenografts. Mol Cancer Ther 2004; 3: 59-70.
    • (2004) Mol Cancer Ther , vol.3 , pp. 59-70
    • Nawrocki, S.T.1    Sweeney-Gotsch, B.2    Takamori, R.3    McConkey, D.J.4
  • 38
    • 34548257719 scopus 로고    scopus 로고
    • Assessment of apoptosisinducing effects of docetaxel combined with the proteasome inhibitor PS-341 in human lung cancer cells
    • Jung CS, Zhou Z, Khuri FR, Sun SY. Assessment of apoptosisinducing effects of docetaxel combined with the proteasome inhibitor PS-341 in human lung cancer cells. Cancer Biol Ther 2007; 6: 749-54.
    • (2007) Cancer Biol Ther , vol.6 , pp. 749-754
    • Jung, C.S.1    Zhou, Z.2    Khuri, F.R.3    Sun, S.Y.4
  • 39
    • 53549129722 scopus 로고    scopus 로고
    • Docetaxel and bortezomib downregulate Bcl-2 and sensitize PC-3-Bcl-2 expressing prostate cancer cells to irradiation
    • Cao W, Shiverick KT, Namiki K, et al. Docetaxel and bortezomib downregulate Bcl-2 and sensitize PC-3-Bcl-2 expressing prostate cancer cells to irradiation. World J Urol 2008; 26: 509-16.
    • (2008) World J Urol , vol.26 , pp. 509-516
    • Cao, W.1    Shiverick, K.T.2    Namiki, K.3
  • 40
    • 43849086302 scopus 로고    scopus 로고
    • Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapeutic agents in gastric cancer cell lines
    • Bae SH, Ryoo HM, Kim MK, Lee KH, Sin JI, Hyun MS. Effects of the proteasome inhibitor bortezomib alone and in combination with chemotherapeutic agents in gastric cancer cell lines. Oncol Rep 2008; 19: 1027-32.
    • (2008) Oncol Rep , vol.19 , pp. 1027-1032
    • Bae, S.H.1    Ryoo, H.M.2    Kim, M.K.3    Lee, K.H.4    Sin, J.I.5    Hyun, M.S.6
  • 41
    • 33947230813 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib acts differently in combination with p53 gene transfer or cytotoxic chemotherapy on NSCLC cells
    • Neukirchen J, Meier A, Rohrbeck A, et al. The proteasome inhibitor bortezomib acts differently in combination with p53 gene transfer or cytotoxic chemotherapy on NSCLC cells. Cancer Gene Ther 2007; 14: 431-9.
    • (2007) Cancer Gene Ther , vol.14 , pp. 431-439
    • Neukirchen, J.1    Meier, A.2    Rohrbeck, A.3
  • 42
    • 34447299646 scopus 로고    scopus 로고
    • Antimyeloma effects of arsenic trioxide are enhanced by melphalan, bortezomib and ascorbic acid
    • Campbell RA, Sanchez E, Steinberg JA, et al. Antimyeloma effects of arsenic trioxide are enhanced by melphalan, bortezomib and ascorbic acid. Br J Haematol 2007; 138: 467-78.
    • (2007) Br J Haematol , vol.138 , pp. 467-478
    • Campbell, R.A.1    Sanchez, E.2    Steinberg, J.A.3
  • 43
    • 33646749892 scopus 로고    scopus 로고
    • The combination of the proteasome inhibitor bortezomib and the bcl-2 antisense molecule oblimersen sensitizes human B-cell lymphomas to cyclophosphamide
    • O'Connor OA, Smith EA, Toner LE, et al. The combination of the proteasome inhibitor bortezomib and the bcl-2 antisense molecule oblimersen sensitizes human B-cell lymphomas to cyclophosphamide. Clin Cancer Res 2006; 12: 2902-11.
    • (2006) Clin Cancer Res , vol.12 , pp. 2902-2911
    • O'Connor, O.A.1    Smith, E.A.2    Toner, L.E.3
  • 44
    • 84856430416 scopus 로고    scopus 로고
    • Indole-3- carbinol synergistically sensitises ovarian cancer cells to bortezomib treatment
    • Taylor-Harding B, Agadjanian H, Nassanian H, et al. Indole-3- carbinol synergistically sensitises ovarian cancer cells to bortezomib treatment. Br J Cancer 2012; 106: 333-43.
    • (2012) Br J Cancer , vol.106 , pp. 333-343
    • Taylor-Harding, B.1    Agadjanian, H.2    Nassanian, H.3
  • 45
    • 77952299094 scopus 로고    scopus 로고
    • New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer
    • Pandit B, Gartel AL. New potential anti-cancer agents synergize with bortezomib and ABT-737 against prostate cancer. Prostate 2010; 70(8): 825-33.
    • (2010) Prostate , vol.70 , Issue.8 , pp. 825-833
    • Pandit, B.1    Gartel, A.L.2
  • 46
  • 47
    • 84856744110 scopus 로고    scopus 로고
    • The 39th David A. Karnofsky Lecture: bench-tobedside translation of targeted therapies in multiple myeloma
    • Anderson KC. The 39th David A. Karnofsky Lecture: bench-tobedside translation of targeted therapies in multiple myeloma. J Clin Oncol 2012; 30(4): 445-52.
    • (2012) J Clin Oncol , vol.30 , Issue.4 , pp. 445-452
    • Anderson, K.C.1
  • 48
    • 84863637600 scopus 로고    scopus 로고
    • Novel agents derived from the currently approved treatments for MM: novel proteasome inhibitors and novel IMIDs
    • Ocio EM, Mateos MV, San-Miguel JF. Novel agents derived from the currently approved treatments for MM: novel proteasome inhibitors and novel IMIDs. Expert Opin Investig Drugs 2012; 21: 1075-87.
    • (2012) Expert Opin Investig Drugs , vol.21 , pp. 1075-1087
    • Ocio, E.M.1    Mateos, M.V.2    San-Miguel, J.F.3
  • 49
    • 84864568543 scopus 로고    scopus 로고
    • Proteasome inhibitors in multiple myeloma: 10 years later
    • Moreau P, Richardson PG, Cavo M, et al. Proteasome inhibitors in multiple myeloma: 10 years later. Blood 2012; 120: 947-59.
    • (2012) Blood , vol.120 , pp. 947-959
    • Moreau, P.1    Richardson, P.G.2    Cavo, M.3
  • 50
    • 84858321881 scopus 로고    scopus 로고
    • Next-generation proteasome blockers promise safer cancer therapy
    • Mullard A. Next-generation proteasome blockers promise safer cancer therapy. Nat Med 2012; 18: 7.
    • (2012) Nat Med , vol.18 , pp. 7
    • Mullard, A.1
  • 51
    • 33845288930 scopus 로고    scopus 로고
    • NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model
    • Cusack JC Jr, Liu R, Xia L, et al. NPI-0052 enhances tumoricidal response to conventional cancer therapy in a colon cancer model. Clin Cancer Res 2006; 12: 6758-64.
    • (2006) Clin Cancer Res , vol.12 , pp. 6758-6764
    • Cusack Jr., J.C.1    Liu, R.2    Xia, L.3
  • 52
    • 75149157969 scopus 로고    scopus 로고
    • The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan
    • Sanchez E, Li M, Steinberg JA, et al. The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan. Br J Haematol 2010; 148: 569-81.
    • (2010) Br J Haematol , vol.148 , pp. 569-581
    • Sanchez, E.1    Li, M.2    Steinberg, J.A.3
  • 53
    • 33748913900 scopus 로고    scopus 로고
    • Beyond single-agent bortezomib: combination regimens in relapsed multiple myeloma
    • Richardson PG, Mitsiades C, Ghobrial I, Anderson K. Beyond single-agent bortezomib: combination regimens in relapsed multiple myeloma. Curr Opin Oncol 2006; 18: 598-608.
    • (2006) Curr Opin Oncol , vol.18 , pp. 598-608
    • Richardson, P.G.1    Mitsiades, C.2    Ghobrial, I.3    Anderson, K.4
  • 54
    • 77956108780 scopus 로고    scopus 로고
    • Enhancing activity and overcoming chemoresistance in hematologic malignancies with bortezomib: preclinical mechanistic studies
    • Reddy N, Czuczman MS. Enhancing activity and overcoming chemoresistance in hematologic malignancies with bortezomib: preclinical mechanistic studies. Ann Oncol 2010; 21: 1756-64.
    • (2010) Ann Oncol , vol.21 , pp. 1756-1764
    • Reddy, N.1    Czuczman, M.S.2
  • 55
    • 20144387627 scopus 로고    scopus 로고
    • Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies
    • Orlowski RZ, Voorhees PM, Garcia RA, et al. Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood 2005; 105: 3058-65.
    • (2005) Blood , vol.105 , pp. 3058-3065
    • Orlowski, R.Z.1    Voorhees, P.M.2    Garcia, R.A.3
  • 56
    • 67650398258 scopus 로고    scopus 로고
    • Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma
    • Dunleavy K, Pittaluga S, Czuczman MS, et al. Differential efficacy of bortezomib plus chemotherapy within molecular subtypes of diffuse large B-cell lymphoma. Blood 2009; 113: 6069-76.
    • (2009) Blood , vol.113 , pp. 6069-6076
    • Dunleavy, K.1    Pittaluga, S.2    Czuczman, M.S.3
  • 57
    • 50449086728 scopus 로고    scopus 로고
    • VISTA Trial Investigators. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma
    • San Miguel JF, Schlag R, Khuageva NK, et al. VISTA Trial Investigators. Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma. N Engl J Med 2008; 359: 906-17.
    • (2008) N Engl J Med , vol.359 , pp. 906-917
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 58
    • 84858791957 scopus 로고    scopus 로고
    • Continued Overall Survival Benefit After 5 Years' Follow-up with Bortezomib- Melphalan-Prednisone (VMP) Versus Melphalan-Prednisone (MP) in Patients with Previously Untreated Multiple Myeloma, and No Increased Risk of Second Primary Malignancies: Final Results of the Phase 3 VISTA Trial
    • San Miguel JF, Schlag R, Khuageva NK, et al. Continued Overall Survival Benefit After 5 Years' Follow-up with Bortezomib- Melphalan-Prednisone (VMP) Versus Melphalan-Prednisone (MP) in Patients with Previously Untreated Multiple Myeloma, and No Increased Risk of Second Primary Malignancies: Final Results of the Phase 3 VISTA Trial. Blood (ASH Annual Meeting Abstracts), 2011; 118: 476.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , pp. 476
    • San Miguel, J.F.1    Schlag, R.2    Khuageva, N.K.3
  • 59
    • 84862696861 scopus 로고    scopus 로고
    • Efficacy and safety of three bortezomib-based combinations in elderly, newly diagnosed multiple myeloma patients: results from all randomized patients in the community-based, phase 3b UPFRONT study
    • Niesvizky R, Flinn IW, Rifkin R et al. Efficacy and safety of three bortezomib-based combinations in elderly, newly diagnosed multiple myeloma patients: results from all randomized patients in the community-based, phase 3b UPFRONT study. ASH Ann Meeting Abstr 2011; 118: 478.
    • (2011) ASH Ann Meeting Abstr , vol.118 , pp. 478
    • Niesvizky, R.1    Flinn, I.W.2    Rifkin, R.3
  • 60
    • 84859738459 scopus 로고    scopus 로고
    • Multiple myeloma: treatment evolution
    • San Miguel JF, Mateos MV, Ocio E, et al. Multiple myeloma: treatment evolution. Hematology 2012; 17 (Suppl 1): S3-6.
    • (2012) Hematology , vol.17 , Issue.SUPPL. 1
    • San Miguel, J.F.1    Mateos, M.V.2    Ocio, E.3
  • 61
    • 67650882695 scopus 로고    scopus 로고
    • Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial
    • Reeder CB, Reece DE, Kukreti V, et al. Cyclophosphamide, bortezomib and dexamethasone induction for newly diagnosed multiple myeloma: high response rates in a phase II clinical trial. Leukemia 2009; 23: 1337-41.
    • (2009) Leukemia , vol.23 , pp. 1337-1341
    • Reeder, C.B.1    Reece, D.E.2    Kukreti, V.3
  • 62
    • 79551623391 scopus 로고    scopus 로고
    • Novel therapeutic agents for B-cell lymphoma: developing rational combinations
    • Reeder CB, Ansell SM. Novel therapeutic agents for B-cell lymphoma: developing rational combinations. Blood 2011; 117: 1453- 62
    • (2011) Blood , vol.117 , pp. 1453-1462
    • Reeder, C.B.1    Ansell, S.M.2
  • 63
    • 33644785935 scopus 로고    scopus 로고
    • Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors
    • Messersmith WA, Baker SD, Lassiter L, et al. Phase I trial of bortezomib in combination with docetaxel in patients with advanced solid tumors. Clin Cancer Res 2006; 12: 1270-5.
    • (2006) Clin Cancer Res , vol.12 , pp. 1270-1275
    • Messersmith, W.A.1    Baker, S.D.2    Lassiter, L.3
  • 64
    • 33845363835 scopus 로고    scopus 로고
    • A phase I and pharmacologic study of sequences of the proteasome inhibitor, bortezomib (PS-341, Velcade), in combination with paclitaxel and carboplatin in patients with advanced malignancies
    • Ma C, Mandrekar SJ, Alberts SR, et al. A phase I and pharmacologic study of sequences of the proteasome inhibitor, bortezomib (PS-341, Velcade), in combination with paclitaxel and carboplatin in patients with advanced malignancies. Cancer Chemother Pharmacol 2007; 59: 207-15.
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 207-215
    • Ma, C.1    Mandrekar, S.J.2    Alberts, S.R.3
  • 65
    • 77951913630 scopus 로고    scopus 로고
    • A dose-finding and pharmacodynamic study of bortezomib in combination with weekly paclitaxel in patients with advanced solid tumors
    • Ramaswamy B, Bekaii-Saab T, Schaaf LJ, et al. A dose-finding and pharmacodynamic study of bortezomib in combination with weekly paclitaxel in patients with advanced solid tumors. Cancer Chemother Pharmacol 2010; 66: 151-8.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 151-158
    • Ramaswamy, B.1    Bekaii-Saab, T.2    Schaaf, L.J.3
  • 66
    • 79551527647 scopus 로고    scopus 로고
    • Randomized phase II trial of concurrent versus sequential bortezomib plus docetaxel in advanced non-small-cell lung cancer: a California cancer consortium trial
    • Lara PN Jr, Longmate J, Reckamp K, et al. Randomized phase II trial of concurrent versus sequential bortezomib plus docetaxel in advanced non-small-cell lung cancer: a California cancer consortium trial. Clin Lung Cancer 2011; 12: 33-7.
    • (2011) Clin Lung Cancer , vol.12 , pp. 33-37
    • Lara Jr., P.N.1    Longmate, J.2    Reckamp, K.3
  • 67
    • 62749089391 scopus 로고    scopus 로고
    • A phase I study of bortezomib, etoposide and carboplatin in patients with advanced solid tumors refractory to standard therapy
    • Lieu C, Chow L, Pierson AS, et al. A phase I study of bortezomib, etoposide and carboplatin in patients with advanced solid tumors refractory to standard therapy. Invest New Drugs 2009; 27: 53-62.
    • (2009) Invest New Drugs , vol.27 , pp. 53-62
    • Lieu, C.1    Chow, L.2    Pierson, A.S.3
  • 68
    • 84862640499 scopus 로고    scopus 로고
    • Phase I trial using the proteasome inhibitor bortezomib and concurrent chemoradiotherapy for head-and-neck malignancies
    • Kubicek GJ, Axelrod RS, Machtay M, et al. Phase I trial using the proteasome inhibitor bortezomib and concurrent chemoradiotherapy for head-and-neck malignancies. Int J Radiat Oncol Biol Phys 2012; 83: 1192-7.
    • (2012) Int J Radiat Oncol Biol Phys , vol.83 , pp. 1192-1197
    • Kubicek, G.J.1    Axelrod, R.S.2    Machtay, M.3
  • 69
    • 84864265152 scopus 로고    scopus 로고
    • Bortezomib in combination with rituximab, dexamethasone, ifosfamide, cisplatin and etoposide chemoimmunotherapy in patients with relapsed and primary refractory diffuse large B-cell lymphoma
    • Elstrom RL, Andemariam B, Martin P, et al. Bortezomib in combination with rituximab, dexamethasone, ifosfamide, cisplatin and etoposide chemoimmunotherapy in patients with relapsed and primary refractory diffuse large B-cell lymphoma. Leuk Lymphoma 2012; 53: 1469-73.
    • (2012) Leuk Lymphoma , vol.53 , pp. 1469-1473
    • Elstrom, R.L.1    Andemariam, B.2    Martin, P.3
  • 70
    • 68549133393 scopus 로고    scopus 로고
    • A novel regimen combining high dose cytarabine and bortezomib has activity in multiply relapsed and refractory mantle cell lymphoma - long-term results of a multicenter observation study
    • Weigert O, Weidmann E, Mueck R, et al. A novel regimen combining high dose cytarabine and bortezomib has activity in multiply relapsed and refractory mantle cell lymphoma - long-term results of a multicenter observation study. Leuk Lymphoma 2009; 50: 716-22.
    • (2009) Leuk Lymphoma , vol.50 , pp. 716-722
    • Weigert, O.1    Weidmann, E.2    Mueck, R.3
  • 71
    • 40949128188 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of bortezomib in combination with idarubicin and cytarabine in patients with acute mylogenous leukemia
    • Attar EC, DeAngelo DJ, Supko JG et al. Phase I and pharmacokinetic study of bortezomib in combination with idarubicin and cytarabine in patients with acute mylogenous leukemia. Clin Cancer Res 2008; 14: 1446-54.
    • (2008) Clin Cancer Res , vol.14 , pp. 1446-1454
    • Attar, E.C.1    DeAngelo, D.J.2    Supko, J.G.3
  • 72
    • 0030891198 scopus 로고    scopus 로고
    • LY231514, a pyrrolo[2,3- d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
    • Shih C, Chen VJ, Gossett LS, et al. LY231514, a pyrrolo[2,3- d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 1997; 57: 1116-23.
    • (1997) Cancer Res , vol.57 , pp. 1116-1123
    • Shih, C.1    Chen, V.J.2    Gossett, L.S.3
  • 73
    • 37349100108 scopus 로고    scopus 로고
    • Phase I study of two different schedules of bortezomib and pemetrexed in advanced solid tumors with emphasis on non-small cell lung cancer
    • Davies AM, Ho C, Metzger AS, et al. Phase I study of two different schedules of bortezomib and pemetrexed in advanced solid tumors with emphasis on non-small cell lung cancer. J Thorac Oncol 2007; 2: 1112-6.
    • (2007) J Thorac Oncol , vol.2 , pp. 1112-1116
    • Davies, A.M.1    Ho, C.2    Metzger, A.S.3
  • 74
    • 77952547062 scopus 로고    scopus 로고
    • Phase I/II trial of bortezomib and pemetrexed in patients with advanced non-small cell lung cancer
    • Abstract 18145
    • Natale RB, McKinley M, Hilger J, Myers T. Phase I/II trial of bortezomib and pemetrexed in patients with advanced non-small cell lung cancer. J Clin Oncol 2007; 25: Abstract 18145.
    • (2007) J Clin Oncol , vol.25
    • Natale, R.B.1    McKinley, M.2    Hilger, J.3    Myers, T.4
  • 75
    • 33748894875 scopus 로고    scopus 로고
    • A phase I/II study of arsenic trioxide, bortezomib, and ascorbic acid in relapsed or refractory multiple myeloma
    • (part I of II): 449s Abstract
    • Berenson JR, Matous J, Ferretti D, et al. A phase I/II study of arsenic trioxide, bortezomib, and ascorbic acid in relapsed or refractory multiple myeloma. J Clin Oncol 2006; 24(18S) (part I of II): 449s Abstract.
    • (2006) J Clin Oncol , vol.24 , Issue.18 S
    • Berenson, J.R.1    Matous, J.2    Ferretti, D.3
  • 76
    • 84862693704 scopus 로고    scopus 로고
    • The future of therapy for relapsed/refractory multiple myeloma: emerging agents and novel treatment strategies
    • Moreau P. The future of therapy for relapsed/refractory multiple myeloma: emerging agents and novel treatment strategies. Semin Hematol 2012; 49 (Suppl 1): S33-46.
    • (2012) Semin Hematol , vol.49 , Issue.SUPPL. 1
    • Moreau, P.1
  • 77
    • 34447116376 scopus 로고    scopus 로고
    • Antitumor activity of PR- 171, a novel irreversible inhibitor of the proteasome
    • Demo SD, Kirk CJ, Aujay MA, et al. Antitumor activity of PR- 171, a novel irreversible inhibitor of the proteasome. Cancer Res 2007; 67: 6383-91.
    • (2007) Cancer Res , vol.67 , pp. 6383-6391
    • Demo, S.D.1    Kirk, C.J.2    Aujay, M.A.3
  • 78
    • 79955498420 scopus 로고    scopus 로고
    • Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events
    • Arastu-Kapur S, Anderl JL, Kraus M, et al. Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events. Clin Cancer Res 2011; 17: 2734-43.
    • (2011) Clin Cancer Res , vol.17 , pp. 2734-2743
    • Arastu-Kapur, S.1    Anderl, J.L.2    Kraus, M.3
  • 79
    • 81155138545 scopus 로고    scopus 로고
    • A phase I, open-label, dose-escalation study of the novel oral proteasome inhibitor (PI) ONX 0912 in patients with advanced refractory or recurrent solid tumors
    • ASCO Meeting Abstr
    • Papadopoulos KP, Mendelson DS, Tolcher AW, et al. A phase I, open-label, dose-escalation study of the novel oral proteasome inhibitor (PI) ONX 0912 in patients with advanced refractory or recurrent solid tumors. Blood 2011; ASCO Meeting Abstr; 29(15 Suppl): 3075.
    • (2011) Blood , vol.29 , Issue.15 SUPPL. , pp. 3075
    • Papadopoulos, K.P.1    Mendelson, D.S.2    Tolcher, A.W.3
  • 80
    • 79951684725 scopus 로고    scopus 로고
    • Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials
    • Potts CB, Albitar XM, Anderson CK, et al. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets 2011; 11: 254-84.
    • (2011) Curr Cancer Drug Targets , vol.11 , pp. 254-284
    • Potts, C.B.1    Albitar, X.M.2    Anderson, C.K.3
  • 81
    • 84857919694 scopus 로고    scopus 로고
    • Phase 1 Clinical Evaluation of Twice-Weekly Marizomib (NPI-0052), a Novel Proteasome Inhibitor, in Patients with Relapsed/Refractory Multiple Myeloma (MM)
    • Richardson PG, Spencer A, Cannell P, et al. Phase 1 Clinical Evaluation of Twice-Weekly Marizomib (NPI-0052), a Novel Proteasome Inhibitor, in Patients with Relapsed/Refractory Multiple Myeloma (MM). Blood (ASH Annual Meeting Abstracts), 2011; 118: 302.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , pp. 302
    • Richardson, P.G.1    Spencer, A.2    Cannell, P.3
  • 82
    • 84863643928 scopus 로고    scopus 로고
    • Phase 1/2 Study of Oral MLN9708, A Novel, Investigational Proteasome Inhibitor, in Combination with Lenalidomide and Dexamethasone in Patients with Previously Untreated Multiple Myeloma (MM)
    • Berdeja JG, Richardson PG, Lonial S, et al. Phase 1/2 Study of Oral MLN9708, A Novel, Investigational Proteasome Inhibitor, in Combination with Lenalidomide and Dexamethasone in Patients with Previously Untreated Multiple Myeloma (MM). Blood (ASH Annual Meeting Abstracts), 2011; 118: 479.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , pp. 479
    • Berdeja, J.G.1    Richardson, P.G.2    Lonial, S.3
  • 83
    • 78049457409 scopus 로고    scopus 로고
    • Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements
    • Kummar S, Chen HX, Wright J, et al. Utilizing targeted cancer therapeutic agents in combination: novel approaches and urgent requirements. Nat Rev Drug Discov 2010; 9: 843-56.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 843-856
    • Kummar, S.1    Chen, H.X.2    Wright, J.3
  • 84
    • 77955729630 scopus 로고    scopus 로고
    • Combination therapy of bortezomib with novel targeted agents: an emerging treatment strategy
    • Wright JJ. Combination therapy of bortezomib with novel targeted agents: an emerging treatment strategy. Clin Cancer Res 2010; 16: 4094-104.
    • (2010) Clin Cancer Res , vol.16 , pp. 4094-4104
    • Wright, J.J.1
  • 85
    • 77956108780 scopus 로고    scopus 로고
    • Enhancing activity and overcoming chemoresistance in hematologic malignancies with bortezomib: preclinical mechanistic studies
    • Reddy N, Czuczman MS. Enhancing activity and overcoming chemoresistance in hematologic malignancies with bortezomib: preclinical mechanistic studies. Ann Oncol 2010; 21: 1756-64.
    • (2010) Ann Oncol , vol.21 , pp. 1756-1764
    • Reddy, N.1    Czuczman, M.S.2
  • 86
    • 13444306459 scopus 로고    scopus 로고
    • Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
    • Nebbioso A, Clarke N, Voltz E, et al. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nature Med 2005; 11: 77-83.
    • (2005) Nature Med , vol.11 , pp. 77-83
    • Nebbioso, A.1    Clarke, N.2    Voltz, E.3
  • 87
    • 30044434594 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide
    • Rosato RR, Maggio SC, Almenara JA, et al. The histone deacetylase inhibitor LAQ824 induces human leukemia cell death through a process involving XIAP down-regulation, oxidative injury, and the acid sphingomyelinase-dependent generation of ceramide. Mol Pharmacol 2006; 69(1): 216-25.
    • (2006) Mol Pharmacol , vol.69 , Issue.1 , pp. 216-225
    • Rosato, R.R.1    Maggio, S.C.2    Almenara, J.A.3
  • 88
    • 0035845541 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor and chemiotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell death pathway characterized by cleavage of bid and production of reactive oxygen species
    • Ruefli AA, Ausserlechner MJ, Bernhard D, et al. The histone deacetylase inhibitor and chemiotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell death pathway characterized by cleavage of bid and production of reactive oxygen species. Proc Natl Acad Sci USA 2001; 98: 10833-8.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10833-10888
    • Ruefli, A.A.1    Ausserlechner, M.J.2    Bernhard, D.3
  • 89
    • 0035072914 scopus 로고    scopus 로고
    • Histone-deacetylase: versatile players
    • Nakatani Y. Histone-deacetylase: versatile players. Genes cells 2001; 6: 79-86.
    • (2001) Genes cells , vol.6 , pp. 79-86
    • Nakatani, Y.1
  • 90
    • 28044471827 scopus 로고    scopus 로고
    • Acetylation and deacetylation of non-histone proteins
    • Glozak MA, Sengupta N, Zhang Z, et al. Acetylation and deacetylation of non-histone proteins. Gene 2005; 363: 15-23.
    • (2005) Gene , vol.363 , pp. 15-23
    • Glozak, M.A.1    Sengupta, N.2    Zhang, Z.3
  • 91
    • 0036527775 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: novel drugs for the treatment of cancer
    • Johnstone RW. Histone deacetylase inhibitors: novel drugs for the treatment of cancer. Nat. Rev. Drug Discov 2002; 1: 287-99.
    • (2002) Nat. Rev. Drug Discov , vol.1 , pp. 287-299
    • Johnstone, R.W.1
  • 92
    • 56049090769 scopus 로고    scopus 로고
    • Acetylation of nonhistone proteins modulates cellular signalling at multiple levels
    • Spange S, Wagner T, Heinzel T, Krämer OH. Acetylation of nonhistone proteins modulates cellular signalling at multiple levels. Int J Biochem Cell Biol 2009; 41: 185-98.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 185-198
    • Spange, S.1    Wagner, T.2    Heinzel, T.3    Krämer, O.H.4
  • 94
    • 33748451151 scopus 로고    scopus 로고
    • Anticancer activities of histone deacetylase inhibitors
    • Bolden JE, Peart M, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov 2006; 5: 769-84.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 769-784
    • Bolden, J.E.1    Peart, M.2    Johnstone, R.W.3
  • 95
    • 84856524861 scopus 로고    scopus 로고
    • Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy
    • Spiegel S, Milstien S, Grant S. Endogenous modulators and pharmacological inhibitors of histone deacetylases in cancer therapy. Oncogene 2012; 31: 537-51.
    • (2012) Oncogene , vol.31 , pp. 537-551
    • Spiegel, S.1    Milstien, S.2    Grant, S.3
  • 96
    • 0346020435 scopus 로고    scopus 로고
    • The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
    • Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 2003; 15: 727-38.
    • (2003) Cell , vol.15 , pp. 727-738
    • Kawaguchi, Y.1    Kovacs, J.J.2    McLaurin, A.3    Vance, J.M.4    Ito, A.5    Yao, T.P.6
  • 97
    • 69449102464 scopus 로고    scopus 로고
    • Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
    • Wang Z, Zang C, Cui K, et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 2009; 138(5): 1019-31.
    • (2009) Cell , vol.138 , Issue.5 , pp. 1019-1031
    • Wang, Z.1    Zang, C.2    Cui, K.3
  • 98
  • 99
    • 0037589018 scopus 로고    scopus 로고
    • Molecular sequelae of histone deacetylase inhibition in human malignant B cells
    • Mitsiades N, Mitsiades CS, Richardson PG, et al. Molecular sequelae of histone deacetylase inhibition in human malignant B cells. Blood 2003; 101: 4055-62.
    • (2003) Blood , vol.101 , pp. 4055-4062
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 100
    • 76249119531 scopus 로고    scopus 로고
    • Vorinostat enhances the antimyeloma effects of Melphalan and Bortezomib
    • Campbell RA, Sanchez E, Steinberg J, et al. Vorinostat enhances the antimyeloma effects of Melphalan and Bortezomib. Eur J Haematol 2010; 84: 201-11.
    • (2010) Eur J Haematol , vol.84 , pp. 201-211
    • Campbell, R.A.1    Sanchez, E.2    Steinberg, J.3
  • 101
    • 79952108058 scopus 로고    scopus 로고
    • The histone deactylase inhibitor LBH586 enhances the antymieloma effects of chemotherapy in vitro and in vivo
    • Sanchez E, Shen J, Steinerg J, et al. The histone deactylase inhibitor LBH586 enhances the antymieloma effects of chemotherapy in vitro and in vivo. Leuk Res 2011; 35: 373-9.
    • (2011) Leuk Res , vol.35 , pp. 373-379
    • Sanchez, E.1    Shen, J.2    Steinerg, J.3
  • 102
    • 50249175241 scopus 로고    scopus 로고
    • Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential?
    • Nolan L, Johnson PW, Ganesan A, Packham G, Crabb SJ. Will histone deacetylase inhibitors require combination with other agents to fulfil their therapeutic potential? Br J Cancer 2008; 99: 689-94.
    • (2008) Br J Cancer , vol.99 , pp. 689-694
    • Nolan, L.1    Johnson, P.W.2    Ganesan, A.3    Packham, G.4    Crabb, S.J.5
  • 103
    • 58149242889 scopus 로고    scopus 로고
    • A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study
    • Luu TH, Morgan RJ, Leong L, et al. A phase II trial of vorinostat (suberoylanilide hydroxamic acid) in metastatic breast cancer: a California Cancer Consortium study. Clin Cancer Res 2008; 14: 7138-42.
    • (2008) Clin Cancer Res , vol.14 , pp. 7138-7142
    • Luu, T.H.1    Morgan, R.J.2    Leong, L.3
  • 104
    • 33845996135 scopus 로고    scopus 로고
    • Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
    • Duvic M, Talpur R, Ni X, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood 2007; 109: 31-9.
    • (2007) Blood , vol.109 , pp. 31-39
    • Duvic, M.1    Talpur, R.2    Ni, X.3
  • 105
    • 52949083797 scopus 로고    scopus 로고
    • Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells
    • Yu C, Friday BB, Yang L, et al. Mitochondrial Bax translocation partially mediates synergistic cytotoxicity between histone deacetylase inhibitors and proteasome inhibitors in glioma cells. Neuro Oncol 2008; 10: 309-19.
    • (2008) Neuro Oncol , vol.10 , pp. 309-319
    • Yu, C.1    Friday, B.B.2    Yang, L.3
  • 106
    • 84863170102 scopus 로고    scopus 로고
    • KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells
    • Mannava S, Zhuang D, Nair JR, et al. KLF9 is a novel transcriptional regulator of bortezomib- and LBH589-induced apoptosis in multiple myeloma cells. Blood 2012; 119(6): 1450-8.
    • (2012) Blood , vol.119 , Issue.6 , pp. 1450-1458
    • Mannava, S.1    Zhuang, D.2    Nair, J.R.3
  • 107
    • 33751172982 scopus 로고    scopus 로고
    • Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells
    • Catley L, Weisberg E, Kiziltepe T, et al. Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells. Blood 2006; 108(10): 3441-9.
    • (2006) Blood , vol.108 , Issue.10 , pp. 3441-3449
    • Catley, L.1    Weisberg, E.2    Kiziltepe, T.3
  • 108
    • 20844435806 scopus 로고    scopus 로고
    • Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma
    • Hideshima T, Bradner JE, Wong J, et al. Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma. Proc Natl Acad Sci U S A 2005; 102: 8567-72.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 8567-8572
    • Hideshima, T.1    Bradner, J.E.2    Wong, J.3
  • 109
    • 84858640254 scopus 로고    scopus 로고
    • Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma
    • Santo L, Hideshima T, Kung AL, et al. Preclinical activity, pharmacodynamic, and pharmacokinetic properties of a selective HDAC6 inhibitor, ACY-1215, in combination with bortezomib in multiple myeloma. Blood 2012; 119: 2579-89.
    • (2012) Blood , vol.119 , pp. 2579-2589
    • Santo, L.1    Hideshima, T.2    Kung, A.L.3
  • 110
    • 2542523228 scopus 로고    scopus 로고
    • Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor Bortezomib and histone deacetylase inhibitors
    • Pei XY, Dai Y and Grant S. Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor Bortezomib and histone deacetylase inhibitors. Clin Canc Res 2004; 10: 3839-52.
    • (2004) Clin Canc Res , vol.10 , pp. 3839-3852
    • Pei, X.Y.1    Dai, Y.2    Grant, S.3
  • 111
    • 0035207110 scopus 로고    scopus 로고
    • The role of nuclear factorkappaB in the biology and treatment of multiple myeloma
    • Berenson JR, Ma HM, Veiscio R. The role of nuclear factorkappaB in the biology and treatment of multiple myeloma. Semin Oncol 2001; 28: 626-33.
    • (2001) Semin Oncol , vol.28 , pp. 626-633
    • Berenson, J.R.1    Ma, H.M.2    Veiscio, R.3
  • 112
    • 85031479846 scopus 로고    scopus 로고
    • Biological sequelae of nuclear factor-kappaB in the biology and treatment of multiple myeloma
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Biological sequelae of nuclear factor-kappaB in the biology and treatment of multiple myeloma. Sem Oncol 2001; 28: 626-33.
    • (2001) Sem Oncol , vol.28 , pp. 626-633
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 113
    • 20744449274 scopus 로고    scopus 로고
    • Blockade of histone deacetylase inhibitor-induced relA/p65 acetylation and NF-kB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, xiap downregulation and c-Jun N-terminal kinase 1 activation
    • Dai Y, Rahmani M, Dent P, Grant S. Blockade of histone deacetylase inhibitor-induced relA/p65 acetylation and NF-kB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, xiap downregulation and c-Jun N-terminal kinase 1 activation. Mol Cell Biol 2005; 25: 5429-44.
    • (2005) Mol Cell Biol , vol.25 , pp. 5429-5444
    • Dai, Y.1    Rahmani, M.2    Dent, P.3    Grant, S.4
  • 114
    • 0035979737 scopus 로고    scopus 로고
    • Duration of nuclear NF- B action regulated by reversible acetylation
    • Chen L, Fieschle W, Verdin E, et al. Duration of nuclear NF- B action regulated by reversible acetylation. Science 2001; 293: 1653-7.
    • (2001) Science , vol.293 , pp. 1653-1657
    • Chen, L.1    Fieschle, W.2    Verdin, E.3
  • 115
    • 0037011056 scopus 로고    scopus 로고
    • Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kB
    • Chen LF, Mu Y, Green WC. Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kB. EMBO J 2002; 21: 6539-48
    • (2002) EMBO J , vol.21 , pp. 6539-6548
    • Chen, L.F.1    Mu, Y.2    Green, W.C.3
  • 116
    • 33644873930 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphoma
    • Heider U, Kaiser M, Sterz J, et al. Histone deacetylase inhibitors reduce VEGF production and induce growth suppression and apoptosis in human mantle cell lymphoma. Eur J Haematol 2003; 76: 42-50.
    • (2003) Eur J Haematol , vol.76 , pp. 42-50
    • Heider, U.1    Kaiser, M.2    Sterz, J.3
  • 117
    • 1842413105 scopus 로고    scopus 로고
    • A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma
    • The Non-Hodgkin's Lymphoma Classification Project
    • The Non-Hodgkin's Lymphoma Classification Project. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin's lymphoma. Blood 1997; 89: 3909-18.
    • (1997) Blood , vol.89 , pp. 3909-3918
  • 118
    • 30144442233 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status
    • Perez-Galan P, Roue G, Villamor N, Montserrat E, Campo E, Colomer D. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood 2006; 107: 257-64.
    • (2006) Blood , vol.107 , pp. 257-264
    • Perez-Galan, P.1    Roue, G.2    Villamor, N.3    Montserrat, E.4    Campo, E.5    Colomer, D.6
  • 120
    • 33846530661 scopus 로고    scopus 로고
    • A phase II study of bortezomib in mantle cell lymphoma: the National Cancer Institute of Canada Clinical Trials Group trial IND.150
    • Belch A, Kouroukis CT, Crump M, et al. A phase II study of bortezomib in mantle cell lymphoma: the National Cancer Institute of Canada Clinical Trials Group trial IND.150. Ann Oncol 2007; 18: 116-21.
    • (2007) Ann Oncol , vol.18 , pp. 116-121
    • Belch, A.1    Kouroukis, C.T.2    Crump, M.3
  • 121
    • 38049126172 scopus 로고    scopus 로고
    • Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma
    • Heider U, von Metzler I, Kaiser M, et al. Synergistic interaction of the histone deacetylase inhibitor SAHA with the proteasome inhibitor bortezomib in mantle cell lymphoma. Eur J Haematol 2008; 80: 133-142.
    • (2008) Eur J Haematol , vol.80 , pp. 133-142
    • Heider, U.1    von Metzler, I.2    Kaiser, M.3
  • 122
    • 10744226486 scopus 로고    scopus 로고
    • The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival
    • Martinez N, Camacho FI, Algara P, et al. The molecular signature of mantle cell lymphoma reveals multiple signals favoring cell survival. Cancer Res 2003; 63: 8226-32.
    • (2003) Cancer Res , vol.63 , pp. 8226-8232
    • Martinez, N.1    Camacho, F.I.2    Algara, P.3
  • 123
    • 38949105902 scopus 로고    scopus 로고
    • Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells
    • Yun Dai, Shuang Chen, Lora B, et al. Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells. Clin Cancer Res 2008; 14: 549-558.
    • (2008) Clin Cancer Res , vol.14 , pp. 549-558
    • Yun, D.1    Chen, S.2    Lora, B.3
  • 124
    • 31144449861 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib
    • Sutheesophon K, Kobayashi Y, Takatoku MA, et al. Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib. Acta Haematol 2006; 115(1-2): 78-90.
    • (2006) Acta Haematol , vol.115 , Issue.1-2 , pp. 78-90
    • Sutheesophon, K.1    Kobayashi, Y.2    Takatoku, M.A.3
  • 125
    • 33744539521 scopus 로고    scopus 로고
    • Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
    • Obeng EA, Carlson LM, Gutman DM, Harrington WJ Jr, Lee KP, Boise LH. Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells. Blood 2006; 107: 4907- 16.
    • (2006) Blood , vol.107 , pp. 4907-4916
    • Obeng, E.A.1    Carlson, L.M.2    Gutman, D.M.3    Harrington Jr., W.J.4    Lee, K.P.5    Boise, L.H.6
  • 126
    • 53049110009 scopus 로고    scopus 로고
    • Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA
    • Nawrocki ST, Carew JS, Maclean KH, et al. Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA. Blood 2008; 112: 2917-26.
    • (2008) Blood , vol.112 , pp. 2917-2926
    • Nawrocki, S.T.1    Carew, J.S.2    Maclean, K.H.3
  • 127
    • 33645737411 scopus 로고    scopus 로고
    • Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells
    • Nawrocki ST, Carew JS, Pino MS, e al. Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. Cancer Res 2006; 66: 3773-81.
    • (2006) Cancer Res , vol.66 , pp. 3773-3781
    • Nawrocki, S.T.1    Carew, J.S.2    Pino, M.S.3
  • 128
    • 84859455667 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (SAHA) combined with bortezomib inhibits renal cancer growth by enhancing histone acetylation and protein ubiquitination synergistically
    • Sato A, Asano T, Ito K, Sumitomo M, Asano T. Suberoylanilide hydroxamic acid (SAHA) combined with bortezomib inhibits renal cancer growth by enhancing histone acetylation and protein ubiquitination synergistically. BJU Int 2012; 109: 1258-68.
    • (2012) BJU Int , vol.109 , pp. 1258-1268
    • Sato, A.1    Asano, T.2    Ito, K.3    Sumitomo, M.4    Asano, T.5
  • 129
    • 6344229760 scopus 로고    scopus 로고
    • Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitorinduce apoptosis through the generation of reactive oxygen species
    • Denlinger CE, Rundall BK, Jones DR. Proteasome inhibition sensitizes non-small cell lung cancer to histone deacetylase inhibitorinduce apoptosis through the generation of reactive oxygen species. J Thor Cardiovasc Surg 2004; 128: 740-8.
    • (2004) J Thor Cardiovasc Surg , vol.128 , pp. 740-748
    • Denlinger, C.E.1    Rundall, B.K.2    Jones, D.R.3
  • 130
    • 52949120373 scopus 로고    scopus 로고
    • Inactivation of NFkB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells
    • Domingo-Domenech, Pipa R, Tapia M, et al. Inactivation of NFkB by proteasome inhibition contributes to increased apoptosis induced by histone deacetylase inhibitors in human breast cancer cells. Breast Cancer Res Treat 2008; 112: 53-62.
    • (2008) Breast Cancer Res Treat , vol.112 , pp. 53-62
    • Domingo-Domenech1    Pipa, R.2    Tapia, M.3
  • 131
    • 33846850209 scopus 로고    scopus 로고
    • Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101
    • Duan J, Friedman J, Nottingham L, Chen Z, Ara G, Van Waes C. Nuclear factor-kappaB p65 small interfering RNA or proteasome inhibitor bortezomib sensitizes head and neck squamous cell carcinomas to classic histone deacetylase inhibitors and novel histone deacetylase inhibitor PXD101. Mol Cancer Ther 2007; 6: 37-50.
    • (2007) Mol Cancer Ther , vol.6 , pp. 37-50
    • Duan, J.1    Friedman, J.2    Nottingham, L.3    Chen, Z.4    Ara, G.5    Van Waes, C.6
  • 132
    • 0034902354 scopus 로고    scopus 로고
    • Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    • Sunwoo JB, Chen Z, Dong G, et al. Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res 2001; 7: 1419-28.
    • (2001) Clin Cancer Res , vol.7 , pp. 1419-1428
    • Sunwoo, J.B.1    Chen, Z.2    Dong, G.3
  • 133
    • 77954618581 scopus 로고    scopus 로고
    • PS-341 and histone deacetylase inhibitor synergistically induce apoptosis in head and neck squamous cell carcinoma cells
    • Kim J, Guan J, Chang I, Chen X, Han D, Wang CY. PS-341 and histone deacetylase inhibitor synergistically induce apoptosis in head and neck squamous cell carcinoma cells. Mol Cancer Ther 2010; 9: 1977-84.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1977-1984
    • Kim, J.1    Guan, J.2    Chang, I.3    Chen, X.4    Han, D.5    Wang, C.Y.6
  • 134
    • 59449084559 scopus 로고    scopus 로고
    • Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment
    • Lin Z, Bazzaro M, Wang MC. Combination of proteasome and HDAC inhibitors for uterine cervical cancer treatment. Clin Cancer Res 2009; 15: 570-7.
    • (2009) Clin Cancer Res , vol.15 , pp. 570-577
    • Lin, Z.1    Bazzaro, M.2    Wang, M.C.3
  • 135
    • 34848873093 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor, PXD101, potentiates bortezomib- induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage
    • Feng R, Oton A, Mapara MY, Anderson G, Belani C, Lentzsch S. The histone deacetylase inhibitor, PXD101, potentiates bortezomib- induced anti-multiple myeloma effect by induction of oxidative stress and DNA damage. Br J Haematol 2007; 139: 385-97.
    • (2007) Br J Haematol , vol.139 , pp. 385-397
    • Feng, R.1    Oton, A.2    Mapara, M.Y.3    Anderson, G.4    Belani, C.5    Lentzsch, S.6
  • 136
    • 33644874390 scopus 로고    scopus 로고
    • Advances in multiple myeloma and spine disease
    • Latif T, Hussein MA. Advances in multiple myeloma and spine disease. Clin Lymphoma Myeloma 2005; 6: 228-33.
    • (2005) Clin Lymphoma Myeloma , vol.6 , pp. 228-233
    • Latif, T.1    Hussein, M.A.2
  • 137
    • 84865603486 scopus 로고    scopus 로고
    • Soluble rank ligand produced by myeloma cells causes generalized bone loss in multiple myeloma
    • Buckle CH, De Leenheer E, Lawson MA et al. Soluble rank ligand produced by myeloma cells causes generalized bone loss in multiple myeloma. PLoS One 2012; 7: e41127
    • (2012) PLoS One , vol.7
    • Buckle, C.H.1    De Leenheer, E.2    Lawson, M.A.3
  • 138
    • 77958596106 scopus 로고    scopus 로고
    • The class-I HDAC inhibitor MGCD0103 induces apoptosis in Hodgkin lymphoma cell lines and synergizes with proteasome inhibitors by an HDAC6- independent mechanism
    • Buglio D, Mamidipudi V, Khaskhely NM, et al. The class-I HDAC inhibitor MGCD0103 induces apoptosis in Hodgkin lymphoma cell lines and synergizes with proteasome inhibitors by an HDAC6- independent mechanism. Br J Haematol 2010; 151: 387-96.
    • (2010) Br J Haematol , vol.151 , pp. 387-396
    • Buglio, D.1    Mamidipudi, V.2    Khaskhely, N.M.3
  • 139
    • 0842329639 scopus 로고    scopus 로고
    • Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases
    • Becker B, Multhoff G, Farkas B, et al. Induction of Hsp90 protein expression in malignant melanomas and melanoma metastases. Exp Dermatol 2004, 13: 27-32.
    • (2004) Exp Dermatol , vol.13 , pp. 27-32
    • Becker, B.1    Multhoff, G.2    Farkas, B.3
  • 140
    • 58749083904 scopus 로고    scopus 로고
    • Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin
    • Wu X, Wanders A, Wardega P, et al. Hsp90 is expressed and represents a therapeutic target in human oesophageal cancer using the inhibitor 17-allylamino-17-demethoxygeldanamycin. Br J Cancer 2009, 100: 334-343.
    • (2009) Br J Cancer , vol.100 , pp. 334-343
    • Wu, X.1    Wanders, A.2    Wardega, P.3
  • 141
    • 45849105629 scopus 로고    scopus 로고
    • Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target
    • Gallegos Ruiz MI, Floor K, Roepman P, et al. Integration of gene dosage and gene expression in non-small cell lung cancer, identification of HSP90 as potential target. PLoS One 2008, 3: e0001722.
    • (2008) PLoS One , vol.3
    • Gallegos Ruiz, M.I.1    Floor, K.2    Roepman, P.3
  • 142
    • 0034199865 scopus 로고    scopus 로고
    • Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma
    • Ogata M, Naito Z, Tanaka S, Moriyama Y, Asano G. Overexpression and localization of heat shock proteins mRNA in pancreatic carcinoma. J Nippon Med Sch 2000, 67: 177-85.
    • (2000) J Nippon Med Sch , vol.67 , pp. 177-185
    • Ogata, M.1    Naito, Z.2    Tanaka, S.3    Moriyama, Y.4    Asano, G.5
  • 144
    • 12144266330 scopus 로고    scopus 로고
    • Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation
    • Citri A, Gan J, Mosesson Y, et al. Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation. EMBO Rep 2004, 5: 1165-70.
    • (2004) EMBO Rep , vol.5 , pp. 1165-1170
    • Citri, A.1    Gan, J.2    Mosesson, Y.3
  • 146
    • 0032959590 scopus 로고    scopus 로고
    • Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin
    • Roe SM, Prodromou C, O'Brien R, Ladbury JE, Piper PW, Pearl LH. Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin. J Med Chem 1999; 42: 260-6.
    • (1999) J Med Chem , vol.42 , pp. 260-266
    • Roe, S.M.1    Prodromou, C.2    O'Brien, R.3    Ladbury, J.E.4    Piper, P.W.5    Pearl, L.H.6
  • 147
    • 33746379315 scopus 로고    scopus 로고
    • Using natural product inhibitors to validate Hsp90 as a molecular target in cancer
    • Neckers L. Using natural product inhibitors to validate Hsp90 as a molecular target in cancer. Curr Top Med Chem 2006; 6: 1163-71
    • (2006) Curr Top Med Chem , vol.6 , pp. 1163-1171
    • Neckers, L.1
  • 148
    • 4444311881 scopus 로고    scopus 로고
    • Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity
    • Mimnaugh EG, Xu W, Vos M, et al. Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity. Mol Cancer Ther 2004; 3: 551-66.
    • (2004) Mol Cancer Ther , vol.3 , pp. 551-566
    • Mimnaugh, E.G.1    Xu, W.2    Vos, M.3
  • 149
    • 31544436323 scopus 로고    scopus 로고
    • Antimyeloma activity of heat shock protein-90 inhibition
    • Mitsiades CS, Mitsiades NS, McMullan CJ, et al. Antimyeloma activity of heat shock protein-90 inhibition. Blood 2006; 107: 1092-100.
    • (2006) Blood , vol.107 , pp. 1092-1100
    • Mitsiades, C.S.1    Mitsiades, N.S.2    McMullan, C.J.3
  • 150
    • 0028170231 scopus 로고
    • Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum
    • Melnick J, Dul JL, Argon Y. Sequential interaction of the chaperones BiP and GRP94 with immunoglobulin chains in the endoplasmic reticulum. Nature 1994; 370: 373-5
    • (1994) Nature , vol.370 , pp. 373-375
    • Melnick, J.1    Dul, J.L.2    Argon, Y.3
  • 151
    • 3242777803 scopus 로고    scopus 로고
    • Advances in biology of multiple myeloma: clinical applications
    • Hideshima T, Bergsagel PL, Kuehl WM, Anderson KC. Advances in biology of multiple myeloma: clinical applications. Blood 2004; 104: 607-18.
    • (2004) Blood , vol.104 , pp. 607-618
    • Hideshima, T.1    Bergsagel, P.L.2    Kuehl, W.M.3    Anderson, K.C.4
  • 152
    • 33751258297 scopus 로고    scopus 로고
    • Development of 17- allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90
    • Sydor JR, Normant E, Pien CS, et al. Development of 17- allylamino-17-demethoxygeldanamycin hydroquinone hydrochloride (IPI-504), an anti-cancer agent directed against Hsp90. Proc Natl Acad Sci U S A 2006; 103: 17408-13.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17408-17413
    • Sydor, J.R.1    Normant, E.2    Pien, C.S.3
  • 153
    • 84864038902 scopus 로고    scopus 로고
    • Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib
    • Ishii T, Seike T, Nakashima T, et al. Anti-tumor activity against multiple myeloma by combination of KW-2478, an Hsp90 inhibitor, with bortezomib. Blood Cancer J 2012; 2: e68.
    • (2012) Blood Cancer J , vol.2
    • Ishii, T.1    Seike, T.2    Nakashima, T.3
  • 154
    • 0033890818 scopus 로고    scopus 로고
    • Induction of a heat shock factor 1-dependent stress response and cytotoxic activity of Hsp90-binding agents
    • Bagatell R, Paine-Murrieta, GD, Taylor CW, et al. Induction of a heat shock factor 1-dependent stress response and cytotoxic activity of Hsp90-binding agents. Clin Cancer Res 2000: 6: 3312-8.
    • (2000) Clin Cancer Res , vol.6 , pp. 3312-3318
    • Bagatell, R.1    Paine-Murrieta, G.D.2    Taylor, C.W.3
  • 155
    • 53049083867 scopus 로고    scopus 로고
    • Mechanisms of proteasome inhibitor action and resistance in cancer
    • McConkey DJ, Zhu K. Mechanisms of proteasome inhibitor action and resistance in cancer. Drug Resist Updat 2008; 11: 164-79.
    • (2008) Drug Resist Updat , vol.11 , pp. 164-179
    • McConkey, D.J.1    Zhu, K.2
  • 156
    • 78751530756 scopus 로고    scopus 로고
    • Bortezomib resistance in mantle cell lymphoma is associated with expression of a plasmacytoid differentiation
    • Galan PP, Jensen HM, Weniger MA, et al. Bortezomib resistance in mantle cell lymphoma is associated with expression of a plasmacytoid differentiation. Blood 2011; 117: 542-52.
    • (2011) Blood , vol.117 , pp. 542-552
    • Galan, P.P.1    Jensen, H.M.2    Weniger, M.A.3
  • 157
    • 44849083877 scopus 로고    scopus 로고
    • Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma
    • Yang DT, Young KH, Kahl BS, Markovina S, Miyamoto S. Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphoma. Mol Cancer 2008; 7: 40.
    • (2008) Mol Cancer , vol.7 , pp. 40
    • Yang, D.T.1    Young, K.H.2    Kahl, B.S.3    Markovina, S.4    Miyamoto, S.5
  • 158
    • 79251545172 scopus 로고    scopus 로고
    • The Hsp90 inhibitor IPI- 504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78
    • Roué G, Pérez-Galán P, Mozos A, et al. The Hsp90 inhibitor IPI- 504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78. Blood 2011; 117: 1270-9.
    • (2011) Blood , vol.117 , pp. 1270-1279
    • Roué, G.1    Pérez-Galán, P.2    Mozos, A.3
  • 159
    • 0036856008 scopus 로고    scopus 로고
    • Translational control in the endoplasmic reticulum stress response
    • Ron D. Translational control in the endoplasmic reticulum stress response. J Clin Invest 2002; 110: 1383-138.
    • (2002) J Clin Invest , vol.110 , pp. 1138-1383
    • Ron, D.1
  • 160
    • 84861981005 scopus 로고    scopus 로고
    • Effect of inhibition of the Ubiquitin- Proteasome System and Hsp90 on growth and survival of Rhabdomyosarcoma cells in vitro
    • Peron M, Bonvini P, Rosolen A. Effect of inhibition of the Ubiquitin- Proteasome System and Hsp90 on growth and survival of Rhabdomyosarcoma cells in vitro. BMC Cancer 2012; 12: 233.
    • (2012) BMC Cancer , vol.12 , pp. 233
    • Peron, M.1    Bonvini, P.2    Rosolen, A.3
  • 161
    • 35348822482 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
    • Stommel JM, Kimmelman AC, Ying H, et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 2007; 318: 287-90.
    • (2007) Science , vol.318 , pp. 287-290
    • Stommel, J.M.1    Kimmelman, A.C.2    Ying, H.3
  • 162
    • 84862215014 scopus 로고    scopus 로고
    • Proteasome inhibitors in mantle cell lymphoma
    • Holkova B, Grant S. Proteasome inhibitors in mantle cell lymphoma. Best Pract Res Clin Haematol 2012; 25: 133-41.
    • (2012) Best Pract Res Clin Haematol , vol.25 , pp. 133-141
    • Holkova, B.1    Grant, S.2
  • 163
    • 33644684217 scopus 로고    scopus 로고
    • Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment
    • Strumberg D. Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment. Drugs Today (Barc) 2005; 41: 773-84.
    • (2005) Drugs Today (Barc) , vol.41 , pp. 773-784
    • Strumberg, D.1
  • 164
    • 33749573178 scopus 로고    scopus 로고
    • Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2- terminal kinase pathways
    • Yu C, Friday BB, Lai JP, et al. Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2- terminal kinase pathways. Mol Cancer Ther 2006; 5: 2378-87.
    • (2006) Mol Cancer Ther , vol.5 , pp. 2378-2387
    • Yu, C.1    Friday, B.B.2    Lai, J.P.3
  • 165
    • 77649193345 scopus 로고    scopus 로고
    • Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs
    • Ramakrishnan V, Timm M, Haug JL, et al. Sorafenib, a dual Raf kinase/vascular endothelial growth factor receptor inhibitor has significant anti-myeloma activity and synergizes with common anti-myeloma drugs. Oncogene 2010; 29: 1190-202.
    • (2010) Oncogene , vol.29 , pp. 1190-1202
    • Ramakrishnan, V.1    Timm, M.2    Haug, J.L.3
  • 166
    • 84984585952 scopus 로고    scopus 로고
    • Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation
    • Chen KF, Yu HC, Liu TH, Lee SS, Chen PJ, Cheng AL. Synergistic interactions between sorafenib and bortezomib in hepatocellular carcinoma involve PP2A-dependent Akt inactivation. J Hepatol 2010; 52: 88-95.
    • (2010) J Hepatol , vol.52 , pp. 88-95
    • Chen, K.F.1    Yu, H.C.2    Liu, T.H.3    Lee, S.S.4    Chen, P.J.5    Cheng, A.L.6
  • 167
    • 79960189899 scopus 로고    scopus 로고
    • Proteasome inhibition in myelodysplastic syndromes and acute myelogenous leukemia cell lines
    • Liesveld JL, Rosell KE, Bechelli J, et al. Proteasome inhibition in myelodysplastic syndromes and acute myelogenous leukemia cell lines. Cancer Invest 2011; 29: 439-50.
    • (2011) Cancer Invest , vol.29 , pp. 439-450
    • Liesveld, J.L.1    Rosell, K.E.2    Bechelli, J.3
  • 168
    • 65949114300 scopus 로고    scopus 로고
    • Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway
    • Kurosu T, Ohki M, Wu N, Kagechika H, Miura O. Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Cancer Res 2009 1; 69: 3927-36.
    • (2009) Cancer Res , vol.1 , Issue.69 , pp. 927-936
    • Kurosu, T.1    Ohki, M.2    Wu, N.3    Kagechika, H.4    Miura, O.5
  • 169
    • 80053196640 scopus 로고    scopus 로고
    • Combining proteasome with cell cycle inhibitors: a dual attack potentially applicable to multiple hematopoietic malignancies
    • Holkova B, Grant S. Combining proteasome with cell cycle inhibitors: a dual attack potentially applicable to multiple hematopoietic malignancies. Expert Rev Hematol 2011; 4: 483-6.
    • (2011) Expert Rev Hematol , vol.4 , pp. 483-486
    • Holkova, B.1    Grant, S.2
  • 170
    • 0242468166 scopus 로고    scopus 로고
    • Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process
    • Dai Y, Rahmani M, Grant S. Proteasome inhibitors potentiate leukemic cell apoptosis induced by the cyclin-dependent kinase inhibitor flavopiridol through a SAPK/JNK- and NF-kappaB-dependent process. Oncogene 2003; 22: 7108-22.
    • (2003) Oncogene , vol.22 , pp. 7108-7122
    • Dai, Y.1    Rahmani, M.2    Grant, S.3
  • 171
    • 3142554015 scopus 로고    scopus 로고
    • Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms
    • Dai Y, Rahmani M, Pei XY, Dent P, Grant S. Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. Blood 2004; 104: 509-18.
    • (2004) Blood , vol.104 , pp. 509-518
    • Dai, Y.1    Rahmani, M.2    Pei, X.Y.3    Dent, P.4    Grant, S.5
  • 172
    • 33947504730 scopus 로고    scopus 로고
    • Sunitinib: from rational design to clinical efficacy
    • Chow LQ, Eckhardt SG. Sunitinib: from rational design to clinical efficacy. J Clin Oncol 2007; 25: 884-96.
    • (2007) J Clin Oncol , vol.25 , pp. 884-896
    • Chow, L.Q.1    Eckhardt, S.G.2
  • 173
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X, et al. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 2003; 9: 327-37.
    • (2003) Clin Cancer Res , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 174
    • 77649189887 scopus 로고    scopus 로고
    • Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action
    • Miller SC, Huang R, Sakamuru S, et al. Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochem Pharmacol 2010; 79: 1272-80.
    • (2010) Biochem Pharmacol , vol.79 , pp. 1272-1280
    • Miller, S.C.1    Huang, R.2    Sakamuru, S.3
  • 175
    • 84866026922 scopus 로고    scopus 로고
    • Blockade of NF??B activity by Sunitinib increases cell death in Bortezomib-treated endometrial carcinoma cells
    • Sorolla A, Yeramian A, Valls J, et al. Blockade of NF??B activity by Sunitinib increases cell death in Bortezomib-treated endometrial carcinoma cells. Mol Oncol 2012; 6: 530-41.
    • (2012) Mol Oncol , vol.6 , pp. 530-541
    • Sorolla, A.1    Yeramian, A.2    Valls, J.3
  • 176
    • 83955161761 scopus 로고    scopus 로고
    • Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitizes melanoma cells to Bortezomib by blocking Akt pathway
    • Yeramian A, Sorolla A, Velasco A, et al. Inhibition of activated receptor tyrosine kinases by Sunitinib induces growth arrest and sensitizes melanoma cells to Bortezomib by blocking Akt pathway. Int J Cancer 2012; 130: 967-78.
    • (2012) Int J Cancer , vol.130 , pp. 967-978
    • Yeramian, A.1    Sorolla, A.2    Velasco, A.3
  • 177
    • 84857362253 scopus 로고    scopus 로고
    • Transcriptomic rationale for the synergy observed with dasatinib + bortezomib + dexamethasone in multiple myeloma
    • de Queiroz Crusoe E, Maiso P, Fernandez-Lazaro D, et al. Transcriptomic rationale for the synergy observed with dasatinib + bortezomib + dexamethasone in multiple myeloma. Ann Hematol 2012; 91: 257-69.
    • (2012) Ann Hematol , vol.91 , pp. 257-269
    • de Queiroz Crusoe, E.1    Maiso, P.2    Fernandez-Lazaro, D.3
  • 178
    • 51649116942 scopus 로고    scopus 로고
    • Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib
    • Coluccia AM, Cirulli T, Neri P, et al. Validation of PDGFRbeta and c-Src tyrosine kinases as tumor/vessel targets in patients with multiple myeloma: preclinical efficacy of the novel, orally available inhibitor dasatinib. Blood 2008; 112: 1346-56.
    • (2008) Blood , vol.112 , pp. 1346-1356
    • Coluccia, A.M.1    Cirulli, T.2    Neri, P.3
  • 179
    • 19944428353 scopus 로고    scopus 로고
    • Discovery of N-(2-chloro-6- methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2- methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS- 354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
    • Lombardo LJ, Lee FY, Chen P, et al. Discovery of N-(2-chloro-6- methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2- methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS- 354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004; 47: 6658-61.
    • (2004) J Med Chem , vol.47 , pp. 6658-6661
    • Lombardo, L.J.1    Lee, F.Y.2    Chen, P.3
  • 180
    • 31544459272 scopus 로고    scopus 로고
    • Dasatinib (BMS- 354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
    • Schittenhelm MM, Shiraga S, Schroeder A, et al. Dasatinib (BMS- 354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 2006; 66: 473-81.
    • (2006) Cancer Res , vol.66 , pp. 473-481
    • Schittenhelm, M.M.1    Shiraga, S.2    Schroeder, A.3
  • 181
    • 48749110809 scopus 로고    scopus 로고
    • Synergistic antiproliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells
    • Cascone T, Morelli MP, Morgillo F, et al. Synergistic antiproliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells. J Cell Physiol 2008; 216(3): 698-707.
    • (2008) J Cell Physiol , vol.216 , Issue.3 , pp. 698-707
    • Cascone, T.1    Morelli, M.P.2    Morgillo, F.3
  • 182
    • 33645470112 scopus 로고    scopus 로고
    • Differential cellular and molecular effects of bortezomib, a proteasome inhibitor, in human breast cancer cells
    • Erratum in: Mol Cancer Ther 2006; 5(5): 1383
    • Codony-Servat J, Tapia MA, Bosch M, et al. Differential cellular and molecular effects of bortezomib, a proteasome inhibitor, in human breast cancer cells. Mol Cancer Ther 2006; 5: 665-75. Erratum in: Mol Cancer Ther 2006; 5(5): 1383.
    • (2006) Mol Cancer Ther , vol.5 , pp. 665-675
    • Codony-Servat, J.1    Tapia, M.A.2    Bosch, M.3
  • 183
    • 33846805694 scopus 로고    scopus 로고
    • Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib
    • An J, Rettig MB. Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib. Mol Cancer Ther 2007; 6: 61-9.
    • (2007) Mol Cancer Ther , vol.6 , pp. 61-69
    • An, J.1    Rettig, M.B.2
  • 184
    • 33748159249 scopus 로고    scopus 로고
    • Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumabinduced growth inhibition in trastuzumab-resistant cells
    • Fujita T, Doihara H, Washio K, et al. Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumabinduced growth inhibition in trastuzumab-resistant cells. Anticancer Drugs 2006; 17: 455-62.
    • (2006) Anticancer Drugs , vol.17 , pp. 455-462
    • Fujita, T.1    Doihara, H.2    Washio, K.3
  • 185
    • 34548402083 scopus 로고    scopus 로고
    • Schedule-dependent interaction between the proteosome inhibitor bortezomib and the EGFR-TK inhibitor erlotinib in human non-small cell lung cancer cell lines
    • Piperdi B, Ling YH, Perez-Soler R. Schedule-dependent interaction between the proteosome inhibitor bortezomib and the EGFR-TK inhibitor erlotinib in human non-small cell lung cancer cell lines. J Thorac Oncol 2007; 2: 715-21.
    • (2007) J Thorac Oncol , vol.2 , pp. 715-721
    • Piperdi, B.1    Ling, Y.H.2    Perez-Soler, R.3
  • 186
    • 49049097294 scopus 로고    scopus 로고
    • Effect of bortezomib and cetuximab in EGF-stimulated HNSCC
    • Wagenblast J, Baghi M, Arnoldner C, et al. Effect of bortezomib and cetuximab in EGF-stimulated HNSCC. Anticancer Res 2008; 28: 2239-43.
    • (2008) Anticancer Res , vol.28 , pp. 2239-2243
    • Wagenblast, J.1    Baghi, M.2    Arnoldner, C.3
  • 187
    • 59449087428 scopus 로고    scopus 로고
    • Cetuximab enhances the efficacy of bortezomib in squamous cell carcinoma cell lines
    • Wagenblast J, Baghi M, Arnoldner C, et al. Cetuximab enhances the efficacy of bortezomib in squamous cell carcinoma cell lines. J Cancer Res Clin Oncol 2009; 135: 387-93.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 387-393
    • Wagenblast, J.1    Baghi, M.2    Arnoldner, C.3
  • 188
    • 52649173202 scopus 로고    scopus 로고
    • Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cellss
    • Sloss CM, Wang F, Liu R, et al. Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells. Clin Cancer Res 2008; 14(16): 5116-23.
    • (2008) Clin Cancer Res , vol.14 , Issue.16 , pp. 5116-5123
    • Sloss, C.M.1    Wang, F.2    Liu, R.3
  • 189
    • 84855522062 scopus 로고    scopus 로고
    • From node to pathway blockade: lessons learned from targeting mammalian target of rapamycin
    • Hidalgo M. From node to pathway blockade: lessons learned from targeting mammalian target of rapamycin. J Clin Oncol 2012; 30: 85-7.
    • (2012) J Clin Oncol , vol.30 , pp. 85-87
    • Hidalgo, M.1
  • 190
    • 84904576347 scopus 로고    scopus 로고
    • Dual proteasome and mTOR inhibition promotes apoptosis in non-Hodgkin lymphoma cell lines
    • Abstract
    • Shanks JC, Fauble V, Lobocki CA, Terebelo H. Dual proteasome and mTOR inhibition promotes apoptosis in non-Hodgkin lymphoma cell lines. Blood 2008; 112: 3696; Abstract.
    • (2008) Blood , vol.112 , pp. 3696
    • Shanks, J.C.1    Fauble, V.2    Lobocki, C.A.3    Terebelo, H.4
  • 191
    • 72949111715 scopus 로고    scopus 로고
    • The mTOR inhibitor RAD001 (Everolimus) inhibits myeloma tumor growth in vivo and enhances the anti-MM effects of bortezomib and arsenic trioxide
    • 110 Abstract
    • Campbell R, Sanchez E, Steiberg J et al. The mTOR inhibitor RAD001 (Everolimus) inhibits myeloma tumor growth in vivo and enhances the anti-MM effects of bortezomib and arsenic trioxide. Blood 2007: 110 Abstract.
    • (2007) Blood
    • Campbell, R.1    Sanchez, E.2    Steiberg, J.3
  • 192
    • 33646577479 scopus 로고    scopus 로고
    • Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells
    • Hideshima T, Catley L, Yasui H, et al. Perifosine, an oral bioactive novel alkylphospholipid, inhibits Akt and induces in vitro and in vivo cytotoxicity in human multiple myeloma cells. Blood 2006; 107(10): 4053-62.
    • (2006) Blood , vol.107 , Issue.10 , pp. 4053-4062
    • Hideshima, T.1    Catley, L.2    Yasui, H.3
  • 193
    • 34548181762 scopus 로고    scopus 로고
    • Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells
    • Hideshima T, Catley L, Raje N, et al. Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells. Br J Haematol 2007; 138: 783-91.
    • (2007) Br J Haematol , vol.138 , pp. 783-791
    • Hideshima, T.1    Catley, L.2    Raje, N.3
  • 194
    • 58149343900 scopus 로고    scopus 로고
    • Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt
    • Ayala G, Yan J, Li R, et al. Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt. Clin Cancer Res 2008; 14: 7511-8.
    • (2008) Clin Cancer Res , vol.14 , pp. 7511-7518
    • Ayala, G.1    Yan, J.2    Li, R.3
  • 195
    • 75149157969 scopus 로고    scopus 로고
    • The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan
    • Sanchez E, Li M, Steinberg JA, et al. The proteasome inhibitor CEP-18770 enhances the anti-myeloma activity of bortezomib and melphalan. Br J Haematol 2010; 148: 569-81.
    • (2010) Br J Haematol , vol.148 , pp. 569-581
    • Sanchez, E.1    Li, M.2    Steinberg, J.A.3
  • 196
    • 38949125853 scopus 로고    scopus 로고
    • Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma
    • Chauhan D, Singh A, Brahmandam M, et al. Combination of proteasome inhibitors bortezomib and NPI-0052 trigger in vivo synergistic cytotoxicity in multiple myeloma. Blood 2008; 111: 1654-64.
    • (2008) Blood , vol.111 , pp. 1654-1664
    • Chauhan, D.1    Singh, A.2    Brahmandam, M.3
  • 197
    • 78649755360 scopus 로고    scopus 로고
    • A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma
    • Chauhan D, Singh AV, Aujay M, et al. A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma. Blood 2010; 116(23): 4906-15.
    • (2010) Blood , vol.116 , Issue.23 , pp. 4906-4915
    • Chauhan, D.1    Singh, A.V.2    Aujay, M.3
  • 198
    • 0035437143 scopus 로고    scopus 로고
    • Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray
    • Hofmann WK, de Vos S, Tsukasaki K, et al. Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray. Blood 2001; 98: 787-94.
    • (2001) Blood , vol.98 , pp. 787-794
    • Hofmann, W.K.1    de Vos, S.2    Tsukasaki, K.3
  • 199
    • 0037207516 scopus 로고    scopus 로고
    • Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression
    • Khoury JD, Medeiros LJ, Rassidakis GZ, McDonnell TJ, Abruzzo LV, Lai R. Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression. J Pathol 2003; 199: 90-7.
    • (2003) J Pathol , vol.199 , pp. 90-97
    • Khoury, J.D.1    Medeiros, L.J.2    Rassidakis, G.Z.3    McDonnell, T.J.4    Abruzzo, L.V.5    Lai, R.6
  • 200
    • 0142244338 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cell
    • Pei X-Y, Dai Y, Grant S. The proteasome inhibitor bortezomib promotes mitochondrial injury and apoptosis induced by the small molecule Bcl-2 inhibitor HA14-1 in multiple myeloma cell. Leukemia 2003; 17: 2036-45.
    • (2003) Leukemia , vol.17 , pp. 2036-2045
    • Pei, X.-Y.1    Dai, Y.2    Grant, S.3
  • 201
    • 30144442233 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status
    • Perez-Galan P, Roue G, Villamor N, Montserrat E, Campo E, Colomer D. The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status. Blood 2006; 107: 257-64.
    • (2006) Blood , vol.107 , pp. 257-264
    • Perez-Galan, P.1    Roue, G.2    Villamor, N.3    Montserrat, E.4    Campo, E.5    Colomer, D.6
  • 202
    • 34248362003 scopus 로고    scopus 로고
    • The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak
    • Pérez-Galán P, Roué G, Villamor N, Campo E, Colomer D. The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak. Blood 2007; 109: 4441-9.
    • (2007) Blood , vol.109 , pp. 4441-4449
    • Pérez-Galán, P.1    Roué, G.2    Villamor, N.3    Campo, E.4    Colomer, D.5
  • 203
    • 34249982915 scopus 로고    scopus 로고
    • Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma
    • Trudel S, Li ZH, Rauw J, Tiedemann RE, Wen XY, Stewart AK. Preclinical studies of the pan-Bcl inhibitor obatoclax (GX015-070) in multiple myeloma. Blood 2007; 109: 5430-8.
    • (2007) Blood , vol.109 , pp. 5430-5438
    • Trudel, S.1    Li, Z.H.2    Rauw, J.3    Tiedemann, R.E.4    Wen, X.Y.5    Stewart, A.K.6
  • 204
    • 51649115498 scopus 로고    scopus 로고
    • BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15- 070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells
    • Pérez-Galán P, Roué G, López-Guerra M, Nguyen et al. BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15- 070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells. Leukemia 2008; 22: 1712-20.
    • (2008) Leukemia , vol.22 , pp. 1712-1720
    • Pérez-Galán, P.1    Roué, G.2    López-Guerra, M.3    Nguyen4
  • 205
    • 34147142477 scopus 로고    scopus 로고
    • A novel Bcl- 2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma
    • Chauhan D, Velankar M, Brahmandam M, et al. A novel Bcl- 2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma. Oncogene 2007; 26: 2374-80.
    • (2007) Oncogene , vol.26 , pp. 2374-2380
    • Chauhan, D.1    Velankar, M.2    Brahmandam, M.3
  • 206
    • 34347395733 scopus 로고    scopus 로고
    • Trastuzumab-mechanism of action and use in clinical practice
    • Hudis CA. Trastuzumab-mechanism of action and use in clinical practice. N Engl J Med 2007; 357: 39-51.
    • (2007) N Engl J Med , vol.357 , pp. 39-51
    • Hudis, C.A.1
  • 207
    • 33748511674 scopus 로고    scopus 로고
    • CD45neg but not CD45pos human myeloma cells are sensitive to the inhibition of IGF-1 signaling by a murine anti-IGF-1R monoclonal antibody, mAVE1642
    • Descamps G, Wuillème-Toumi S, Trichet V, et al. CD45neg but not CD45pos human myeloma cells are sensitive to the inhibition of IGF-1 signaling by a murine anti-IGF-1R monoclonal antibody, mAVE1642. J Immunol 2006; 177: 4218-23.
    • (2006) J Immunol , vol.177 , pp. 4218-4223
    • Descamps, G.1    Wuillème-Toumi, S.2    Trichet, V.3
  • 208
    • 58749086023 scopus 로고    scopus 로고
    • A humanised anti-IGF-1R monoclonal antibody (AVE1642) enhances Bortezomib-induced apoptosis in myeloma cells lacking CD45
    • Descamps G, Gomez-Bougie P, Venot C, Moreau P, Bataille R, Amiot M. A humanised anti-IGF-1R monoclonal antibody (AVE1642) enhances Bortezomib-induced apoptosis in myeloma cells lacking CD45. J Cancer 2009; 100: 366-9.
    • (2009) J Cancer , vol.100 , pp. 366-369
    • Descamps, G.1    Gomez-Bougie, P.2    Venot, C.3    Moreau, P.4    Bataille, R.5    Amiot, M.6
  • 209
    • 77953665404 scopus 로고    scopus 로고
    • Combination bortezomib and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma
    • Alinari L, White VL, Earl CT, Ryan, et al. Combination bortezomib and rituximab treatment affects multiple survival and death pathways to promote apoptosis in mantle cell lymphoma. MAbs 2009; 1: 31-40.
    • (2009) MAbs , vol.1 , pp. 31-40
    • Alinari, L.1    White, V.L.2    Earl, C.T.3    Ryan4
  • 210
    • 0026610881 scopus 로고
    • Humanization of an antip185HER2 antibody for human cancer therapy
    • Carter P, Presta L, Gorman CM, et al. Humanization of an antip185HER2 antibody for human cancer therapy. Proc Natl Acad Sci USA 1992; 89: 4285-9.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4285-4289
    • Carter, P.1    Presta, L.2    Gorman, C.M.3
  • 211
    • 33846216907 scopus 로고    scopus 로고
    • Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2- positive breast cancer cells in a synergistic manner
    • Cardoso F, Durbecq V, Laes JF, et al. Bortezomib (PS-341, Velcade) increases the efficacy of trastuzumab (Herceptin) in HER-2- positive breast cancer cells in a synergistic manner. Mol Cancer Ther 2006; 5: 3042-51.
    • (2006) Mol Cancer Ther , vol.5 , pp. 3042-3051
    • Cardoso, F.1    Durbecq, V.2    Laes, J.F.3
  • 212
    • 33748159249 scopus 로고    scopus 로고
    • Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumabinduced growth inhibition in trastuzumab-resistant cells
    • Fujita T, Doihara H, Washio K, et al. Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumabinduced growth inhibition in trastuzumab-resistant cells. Anticancer Drugs 2006; 17: 455-62.
    • (2006) Anticancer Drugs , vol.17 , pp. 455-462
    • Fujita, T.1    Doihara, H.2    Washio, K.3
  • 213
    • 34248210118 scopus 로고    scopus 로고
    • Development of the farnesyltransferase inhibitor tipifarnib for therapy of hematologic malignancies
    • Karp JE, Lancet JE. Development of the farnesyltransferase inhibitor tipifarnib for therapy of hematologic malignancies. Future Oncol 2005; 1: 719-31.
    • (2005) Future Oncol , vol.1 , pp. 719-731
    • Karp, J.E.1    Lancet, J.E.2
  • 214
    • 77955733153 scopus 로고    scopus 로고
    • Antitumor effects of combined bortezomib and tipifarnib in head and neck squamous cell carcinoma (HNSCC) cells
    • Abstract
    • Klass CM, Chen G, Zhang X, Lonial S, Khuri FR, Shin DM. Antitumor effects of combined bortezomib and tipifarnib in head and neck squamous cell carcinoma (HNSCC) cells. J Clin Oncol 2006; 24: 5581. Abstract.
    • (2006) J Clin Oncol , vol.24 , pp. 5581
    • Klass, C.M.1    Chen, G.2    Zhang, X.3    Lonial, S.4    Khuri, F.R.5    Shin, D.M.6
  • 215
    • 31544482800 scopus 로고    scopus 로고
    • Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia
    • Yanamandra N, Colaco NM, Parquet NA, et al. Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia. Clin Cancer Res 2006; 12: 591-9.
    • (2006) Clin Cancer Res , vol.12 , pp. 591-599
    • Yanamandra, N.1    Colaco, N.M.2    Parquet, N.A.3
  • 216
    • 77955738377 scopus 로고    scopus 로고
    • Enhanced levels of apoptosis by combination of farnesyl transferase inhibition (tipifarnib) and proteasome inhibition (bortezomib) in myeloma cell lines and primary myeloma cells and its mechanistic effects on Akt and caspase pathway
    • Abstract
    • Kaufman JL, David E, Torre C et al. Enhanced levels of apoptosis by combination of farnesyl transferase inhibition (tipifarnib) and proteasome inhibition (bortezomib) in myeloma cell lines and primary myeloma cells and its mechanistic effects on Akt and caspase pathway. Blood 2005; 106: 451a. Abstract.
    • (2005) Blood , vol.106
    • Kaufman, J.L.1    David, E.2    Torre, C.3
  • 217
    • 39749176985 scopus 로고    scopus 로고
    • Farnesyltransferase inhibitor R115777 inhibits cell growth and induces apoptosis in mantle cell lymphoma
    • Rolland D, Camara-Clayette V, Barbarat A, et al. Farnesyltransferase inhibitor R115777 inhibits cell growth and induces apoptosis in mantle cell lymphoma. Cancer Chemother Pharmacol 2008; 61: 855-63.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 855-863
    • Rolland, D.1    Camara-Clayette, V.2    Barbarat, A.3
  • 218
    • 78650087357 scopus 로고    scopus 로고
    • Emerging therapies for the treatment of relapsed or refractory multiple myeloma
    • Dimopoulos MA, San-Miguel JF, Anderson KC. Emerging therapies for the treatment of relapsed or refractory multiple myeloma. Eur J Haematol 2011; 86: 1-15.
    • (2011) Eur J Haematol , vol.86 , pp. 1-15
    • Dimopoulos, M.A.1    San-Miguel, J.F.2    Anderson, K.C.3
  • 219
    • 33846665934 scopus 로고    scopus 로고
    • Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells
    • Verhelle D, Corral LG, Wong K, et al. Lenalidomide and CC-4047 inhibit the proliferation of malignant B cells while expanding normal CD34+ progenitor cells. Cancer Res 2007; 67: 746-55.
    • (2007) Cancer Res , vol.67 , pp. 746-755
    • Verhelle, D.1    Corral, L.G.2    Wong, K.3
  • 220
    • 34347375499 scopus 로고    scopus 로고
    • NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells
    • Miller CP, Ban K, Dujka ME et al. NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Blood 2007; 110: 267-77.
    • (2007) Blood , vol.110 , pp. 267-277
    • Miller, C.P.1    Ban, K.2    Dujka, M.E.3
  • 221
    • 66149121016 scopus 로고    scopus 로고
    • Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells
    • Miller CP, Rudra S, Keating MJ, et al. Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells. Blood 2009; 113: 4289- 99.
    • (2009) Blood , vol.113 , pp. 4289-4299
    • Miller, C.P.1    Rudra, S.2    Keating, M.J.3
  • 222
    • 77949315484 scopus 로고    scopus 로고
    • Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma
    • Chauhan D, Singh AV, Ciccarelli B, et al. Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma. Blood 2010 28; 115: 834-45.
    • (2010) Blood , vol.28 , Issue.115 , pp. 834-845
    • Chauhan, D.1    Singh, A.V.2    Ciccarelli, B.3
  • 223
    • 80052784486 scopus 로고    scopus 로고
    • Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo
    • Dasmahapatra G, Lembersky D, Son MP, et al. Carfilzomib interacts synergistically with histone deacetylase inhibitors in mantle cell lymphoma cells in vitro and in vivo. Mol Cancer Ther 2011; 10: 1686-97.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1686-1697
    • Dasmahapatra, G.1    Lembersky, D.2    Son, M.P.3
  • 224
    • 77953937449 scopus 로고    scopus 로고
    • The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo
    • Dasmahapatra G, Lembersky D, Kramer L, et al. The pan-HDAC inhibitor vorinostat potentiates the activity of the proteasome inhibitor carfilzomib in human DLBCL cells in vitro and in vivo. Blood 2010; 115: 4478-87.
    • (2010) Blood , vol.115 , pp. 4478-4487
    • Dasmahapatra, G.1    Lembersky, D.2    Kramer, L.3
  • 225
    • 84862727403 scopus 로고    scopus 로고
    • Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo
    • Dasmahapatra G, Lembersky D, Son MP, et al. Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC-DLBCL cells in vitro and in vivo. Mol Cancer Ther 2011; 11: 1122-32.
    • (2011) Mol Cancer Ther , vol.11 , pp. 1122-1132
    • Dasmahapatra, G.1    Lembersky, D.2    Son, M.P.3
  • 226
    • 84866341173 scopus 로고    scopus 로고
    • CEP-18770 (delanzomib) in combination with dexamethasone and lenalidomide inhibits the growth of multiple myeloma
    • Aug 17
    • Sanchez E, Li M, Li J, et al. CEP-18770 (delanzomib) in combination with dexamethasone and lenalidomide inhibits the growth of multiple myeloma. Leuk Res 2012 Aug 17.
    • (2012) Leuk Res
    • Sanchez, E.1    Li, M.2    Li, J.3
  • 227
    • 80051691845 scopus 로고    scopus 로고
    • In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells
    • Chauhan D, Tian Z, Zhou B et al.In vitro and in vivo selective antitumor activity of a novel orally bioavailable proteasome inhibitor MLN9708 against multiple myeloma cells. Clin Cancer Res 2011; 17: 5311-21.
    • (2011) Clin Cancer Res , vol.17 , pp. 5311-5321
    • Chauhan, D.1    Tian, Z.2    Zhou, B.3
  • 228
    • 84859538161 scopus 로고    scopus 로고
    • Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study
    • Friday BB, Anderson SK, Buckner J, et al. Phase II trial of vorinostat in combination with bortezomib in recurrent glioblastoma: a north central cancer treatment group study. Neuro Oncol 2012 14: 215-21.
    • (2012) Neuro Oncol , vol.14 , pp. 215-221
    • Friday, B.B.1    Anderson, S.K.2    Buckner, J.3
  • 229
    • 84861570021 scopus 로고    scopus 로고
    • Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage
    • Nov 15 [Epub ahead of print]
    • Premkumar DR, Jane EP, Agostino NR, Didomenico JD, Pollack IF. Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage. Mol Carcinog 2011 Nov 15 [Epub ahead of print].
    • (2011) Mol Carcinog
    • Premkumar, D.R.1    Jane, E.P.2    Agostino, N.R.3    Didomenico, J.D.4    Pollack, I.F.5
  • 230
    • 69349097803 scopus 로고    scopus 로고
    • Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma
    • Badros A, Burger AM, Philip S, et al. Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma. Clin Cancer Res 2009; 15: 5250-7.
    • (2009) Clin Cancer Res , vol.15 , pp. 5250-5257
    • Badros, A.1    Burger, A.M.2    Philip, S.3
  • 231
    • 79957539428 scopus 로고    scopus 로고
    • Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study
    • Richardson PG, Chanan-Khan AA, Lonial S, et al. Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study. Br J Haematol 2011; 15: 729-40.
    • (2011) Br J Haematol , vol.15 , pp. 729-740
    • Richardson, P.G.1    Chanan-Khan, A.A.2    Lonial, S.3
  • 232
    • 42349084306 scopus 로고    scopus 로고
    • NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
    • Eccles SA, Massey A, Raynaud FI, et al. NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res 2008; 68: 2850- 60.
    • (2008) Cancer Res , vol.68 , pp. 2850-2860
    • Eccles, S.A.1    Massey, A.2    Raynaud, F.I.3
  • 233
    • 79956036001 scopus 로고    scopus 로고
    • Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms
    • Holkova B, Perkins EB, Ramakrishnan V, et al. Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms. Clin Cancer Res 2011; 17: 3388-97.
    • (2011) Clin Cancer Res , vol.17 , pp. 3388-3397
    • Holkova, B.1    Perkins, E.B.2    Ramakrishnan, V.3
  • 235
    • 65549125308 scopus 로고    scopus 로고
    • Phase I study of bortezomib and cetuximab in patients with solid tumours expressing epidermal growth factor receptor
    • Dudek AZ, Lesniewski-Kmak K, Shehadeh NJ, et al. Phase I study of bortezomib and cetuximab in patients with solid tumours expressing epidermal growth factor receptor. Br J Cancer 2009; 100: 1379-84.
    • (2009) Br J Cancer , vol.100 , pp. 1379-1384
    • Dudek, A.Z.1    Lesniewski-Kmak, K.2    Shehadeh, N.J.3
  • 236
    • 80052428483 scopus 로고    scopus 로고
    • Early tumor progression associated with enhanced EGFR signaling with bortezomib, cetuximab, and radiotherapy for head and neck cancer
    • Argiris A, Duffy AG, Kummar S, et al. Early tumor progression associated with enhanced EGFR signaling with bortezomib, cetuximab, and radiotherapy for head and neck cancer. Clin Cancer Res 2011; 17: 5755-64.
    • (2011) Clin Cancer Res , vol.17 , pp. 5755-5764
    • Argiris, A.1    Duffy, A.G.2    Kummar, S.3
  • 237
    • 68349122406 scopus 로고    scopus 로고
    • A randomized phase 2 study of erlotinib alone and in combination with bortezomib in previously treated advanced non-small cell lung cancer
    • Lynch TJ, Fenton D, Hirsh V, et al. A randomized phase 2 study of erlotinib alone and in combination with bortezomib in previously treated advanced non-small cell lung cancer. J Thorac Oncol 2009; 4: 1002-9.
    • (2009) J Thorac Oncol , vol.4 , pp. 1002-1009
    • Lynch, T.J.1    Fenton, D.2    Hirsh, V.3
  • 238
    • 84861332378 scopus 로고    scopus 로고
    • Phase-I/II study of bortezomib in combination with carboplatin and bevacizumab as firstline therapy in patients with advanced non-small-cell lung cancer
    • Piperdi B, Walsh WV, Bradley K, et al. Phase-I/II study of bortezomib in combination with carboplatin and bevacizumab as firstline therapy in patients with advanced non-small-cell lung cancer. J Thorac Oncol 2012; 7: 1032-40.
    • (2012) J Thorac Oncol , vol.7 , pp. 1032-1040
    • Piperdi, B.1    Walsh, W.V.2    Bradley, K.3
  • 239
    • 84904560756 scopus 로고    scopus 로고
    • Results from AMBER, a randomized phase 2 study of bevacizumab and bortezomib versus bortezomib in relapsed or refractory multiple myeloma
    • Jul 18 [Epub ahead of print]
    • White D, Kassim A, Bhaskar B, Yi J, Wamstad K, Paton VE. Results from AMBER, a randomized phase 2 study of bevacizumab and bortezomib versus bortezomib in relapsed or refractory multiple myeloma. Cancer 2012 Jul 18 [Epub ahead of print].
    • (2012) Cancer
    • White, D.1    Kassim, A.2    Bhaskar, B.3    Yi, J.4    Wamstad, K.5    Paton, V.E.6
  • 240
    • 79959923820 scopus 로고    scopus 로고
    • Bortezomib combined with rituximab and dexamethasone is an active regimen for patients with relapsed and chemotherapy-refractory mantle cell lymphoma
    • Lamm W, Kaufmann H, Raderer M, et al. Bortezomib combined with rituximab and dexamethasone is an active regimen for patients with relapsed and chemotherapy-refractory mantle cell lymphoma. Haematologica 2011; 96: 1008-14.
    • (2011) Haematologica , vol.96 , pp. 1008-1014
    • Lamm, W.1    Kaufmann, H.2    Raderer, M.3
  • 241
    • 79952263744 scopus 로고    scopus 로고
    • A phase I clinicalpharmacodynamic study of the farnesyltransferase inhibitor tipifarnib in combination with the proteasome inhibitor bortezomib in advanced acute leukemias
    • Lancet JE, Duong VH, Winton EF, et al. A phase I clinicalpharmacodynamic study of the farnesyltransferase inhibitor tipifarnib in combination with the proteasome inhibitor bortezomib in advanced acute leukemias. Clin Cancer Res 2011; 17: 1140-6.
    • (2011) Clin Cancer Res , vol.17 , pp. 1140-1146
    • Lancet, J.E.1    Duong, V.H.2    Winton, E.F.3
  • 242
    • 73349115580 scopus 로고    scopus 로고
    • Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma
    • Richardson PG, Weller E, Jagannath S, et al. Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myeloma. J Clin Oncol 2009; 27: 5713-9.
    • (2009) J Clin Oncol , vol.27 , pp. 5713-5719
    • Richardson, P.G.1    Weller, E.2    Jagannath, S.3
  • 243
    • 77954618168 scopus 로고    scopus 로고
    • Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma
    • Richardson PG, Weller E, Lonial S, et al. Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma. Blood 2010; 116: 679-86.
    • (2010) Blood , vol.116 , pp. 679-686
    • Richardson, P.G.1    Weller, E.2    Lonial, S.3
  • 244
    • 77955450608 scopus 로고    scopus 로고
    • Phase Ib Multicenter Dose Escalation Study of Carfilzomib Plus Lenalidomide and Low Dose Dexamethasone (CRd) in Relapsed and Refractory Multiple Myeloma (MM)
    • Niesvizky R, Wang L, Orlowski RZ, et al. Phase Ib Multicenter Dose Escalation Study of Carfilzomib Plus Lenalidomide and Low Dose Dexamethasone (CRd) in Relapsed and Refractory Multiple Myeloma (MM). Blood (ASH Annual Meeting Abstracts), 2009; 114: 304.
    • (2009) Blood (ASH Annual Meeting Abstracts) , vol.114 , pp. 304
    • Niesvizky, R.1    Wang, L.2    Orlowski, R.Z.3
  • 245
    • 84862688138 scopus 로고    scopus 로고
    • Interim results from PX- 171-006, a phase (Ph) II multicenter study of carfilzomib (CFZ), lenalidomide (LEN), and low-dose dexamethasone (loDEX) in relapsed and/or refractory multiple myeloma (RR/MM)
    • Abstract 8025
    • Wang M, Bensinger W, Martin T et al. Interim results from PX- 171-006, a phase (Ph) II multicenter study of carfilzomib (CFZ), lenalidomide (LEN), and low-dose dexamethasone (loDEX) in relapsed and/or refractory multiple myeloma (RR/MM). J Clin Oncol 2011; 29(suppl): Abstract 8025.
    • (2011) J Clin Oncol , vol.29 , Issue.SUPPL.
    • Wang, M.1    Bensinger, W.2    Martin, T.3
  • 246
    • 84857261392 scopus 로고    scopus 로고
    • Final Results of a Frontline Phase 1/2 Study of Carfilzomib, Lenalidomide, and Low- Dose Dexamethasone (CRd) in Multiple Myeloma (MM)
    • AJ Jakubowiak, D Dytfeld, S Jagannath, et al. Final Results of a Frontline Phase 1/2 Study of Carfilzomib, Lenalidomide, and Low- Dose Dexamethasone (CRd) in Multiple Myeloma (MM). Blood (ASH Annual Meeting Abstracts), 2011; 118: 631.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , pp. 631
    • Jakubowiak, A.J.1    Dytfeld, D.2    Jagannath, S.3
  • 247
    • 84864568291 scopus 로고    scopus 로고
    • Carfilzomib Combined with Thalidomide and Dexamethasone (CARTHADEX) As Induction Treatment Prior to High-Dose Melphalan (HDM) in Newly Diagnosed Patients with Multiple Myeloma (MM). A Trial of the European Myeloma Network EMN
    • P Sonneveld, E Hacker, S Zweegman, et al. Carfilzomib Combined with Thalidomide and Dexamethasone (CARTHADEX) As Induction Treatment Prior to High-Dose Melphalan (HDM) in Newly Diagnosed Patients with Multiple Myeloma (MM). A Trial of the European Myeloma Network EMN. Blood (ASH Annual Meeting Abstracts), 2011; 118: 633.
    • (2011) Blood (ASH Annual Meeting Abstracts) , vol.118 , pp. 633
    • Sonneveld, P.1    Hacker, E.2    Zweegman, S.3
  • 248
    • 84871407100 scopus 로고    scopus 로고
    • Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination
    • Millward M, Price T, Townsend A, et al. Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination. Invest New Drugs 2012; 30(6): 2303-17.
    • (2012) Invest New Drugs , vol.30 , Issue.6 , pp. 2303-2317
    • Millward, M.1    Price, T.2    Townsend, A.3
  • 249
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • Michael D, Oren M. The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 2003; 13: 49-58.
    • (2003) Semin Cancer Biol , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 250
    • 77449155637 scopus 로고    scopus 로고
    • The multiple levels of regulation by p53 ubiquitination
    • Lee JT, Gu W. The multiple levels of regulation by p53 ubiquitination. Cell Death Differ 2010; 17: 86-92.
    • (2010) Cell Death Differ , vol.17 , pp. 86-92
    • Lee, J.T.1    Gu, W.2
  • 251
    • 77449153351 scopus 로고    scopus 로고
    • Regulation of death receptor signaling by the ubiquitin system
    • Wertz IE, Dixit VM. Regulation of death receptor signaling by the ubiquitin system. Cell Death Differ 2010; 17: 14-24.
    • (2010) Cell Death Differ , vol.17 , pp. 14-24
    • Wertz, I.E.1    Dixit, V.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.