Donor-matched mesenchymal stem cells from knee infrapatellar and subcutaneous adipose tissue of osteoarthritic donors display differential chondrogenic and osteogenic commitment

European Cells and Materials

Volumn 27, Issue , 2014, Pages 298-311

  Lopa, S ^a   Colombini, A ^a   Stanco, D ^a   de Girolamo, L ^a   Sansone, V ^a,b   Moretti, M ^a  

^a IRCCS ISTITUTO ORTOPEDICO GALEAZZI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Adipose tissue; Bone; Cartilage; Cell based therapy; Infrapatellar fat pad; Mesenchymal stem cell; Osteoarthritis

Indexed keywords

5' NUCLEOTIDASE; ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALKALINE PHOSPHATASE; BETA1 INTEGRIN; CD31 ANTIGEN; CD45 ANTIGEN; CELL SURFACE MARKER; ENDOGLIN; GLYCOSAMINOGLYCAN; HERMES ANTIGEN; MICROSOMAL AMINOPEPTIDASE; THY 1 ANTIGEN; TRANSCRIPTION FACTOR SOX9;

ADIPOSE DERIVED STEM CELL; ADIPOSE TISSUE; ADULT; AGED; ARTICLE; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL THERAPY; CHONDROGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DONOR; DONOR SITE; ENZYME RELEASE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOPHENOTYPING; INFRAPATELLAR FAT PAD; LIPID STORAGE; MALE; MESENCHYMAL STEM CELL; OSTEOARTHRITIS; PATELLA; PROTEIN EXPRESSION; SUBCUTANEOUS FAT; TOTAL KNEE REPLACEMENT;

ADIPOGENESIS; ADIPOSE TISSUE; AGED; AGED, 80 AND OVER; AGGRECANS; ALKALINE PHOSPHATASE; ANTIGENS, CD; CALCIUM; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CELLS, CULTURED; CHONDROGENESIS; COLLAGEN TYPE I; COLLAGEN TYPE X; FEMALE; GLYCOSAMINOGLYCANS; HUMANS; LEPTIN; MALE; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; OSTEOARTHRITIS; OSTEOGENESIS; PATELLA; SOX9 TRANSCRIPTION FACTOR; TISSUE DONORS;

EID: 84899148742     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Chuckpaiwong B, Charles HC, Kraus VB, Guilak F, Nunley JA (2010) Age-associated increases in the size of the infrapatellar fat pad in knee osteoarthritis as measured by 3T MRI. J Orthop Res 28: 1149-1154.
2. Felimban R, Ye K, Traianedes K, Di Bella C, Crook J, Wallace GG, Quigley AF, Choong PF, Myers D (2014) Differentiation of stem cells from human infrapatellar fat pad: Characterization of cells undergoing chondrogenesis. Tissue Eng Part A, in press.
3. He F, Pei M (2013) Extracellular matrix enhances differentiation of adipose stem cells from infrapatellar fat pad toward chondrogenesis. J Tissue Eng Regen Med 7: 73-84.
4. Koh YG, Choi YJ (2012) Infrapatellar fat pad-derived mesenchymal stem cell therapy for knee osteoarthritis. Knee 19: 902-907.
5. Koh YG, Jo SB, Kwon OR, Suh DS, Lee SW, Park SH, Choi YJ (2013) Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. Arthroscopy 29: 748-755.