Thrombelastography detects the anticoagulant effect of rivaroxaban in patients with stroke

Stroke

Volumn 45, Issue 3, 2014, Pages 880-883

  Bowry, Ritvij ^a   Fraser, Stuart ^a   Archeval Lao, Joancy M ^a   Parker, Stephanie A ^a   Cai, Chunyan ^b   Rahbar, Mohammad H ^b   Grotta, James C ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF TEXAS   (United States)

Author keywords

Factor Xa; Rivaroxaban; Stroke; Thrombolytic therapy

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR; RIVAROXABAN; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 11; MORPHOLINE DERIVATIVE; THIOPHENE DERIVATIVE;

ACTION POTENTIAL; ADULT; AGED; ANTICOAGULATION; ARTICLE; BLOOD CLOT LYSIS; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CLINICAL ARTICLE; CONTROLLED STUDY; EMERGENCY CARE; FEMALE; HEART ATRIUM FIBRILLATION; HEMATOLOGY ANALYZER; HUMAN; MALE; MIDDLE AGED; PRIORITY JOURNAL; SINGLE DRUG DOSE; STROKE PATIENT; THROMBOELASTOGRAPHY; BLOOD; BLOOD CLOTTING; DRUG ANTAGONISM; DRUG EFFECT; FIBRINOLYTIC THERAPY; METHODOLOGY; STATISTICS;

FACTOR XA; RIVAROXABAN; STROKE; THROMBOLYTIC THERAPY;

AGED; ANTICOAGULANTS; BLOOD COAGULATION; FACTOR XI; FEMALE; HUMANS; MALE; MIDDLE AGED; MORPHOLINES; STROKE; THIOPHENES; THROMBELASTOGRAPHY; THROMBOLYTIC THERAPY;

EID: 84899131115     PISSN: 00392499     EISSN: 15244628     Source Type: Journal    
DOI: 10.1161/STROKEAHA.113.004016     Document Type: Article

References (6)

1. Samama MM, Martinoli JL, LeFlem L, Guinet C, Plu-Bureau G, Depasse F, et al. Assessment of laboratory assays to measure rivaroxaban- An oral, direct factor Xa inhibitor. Thromb Haemost. 2010;103:815-825.
2. Haas S. Facts and artefacts of coagulation assays for factor Xa inhibitors. Thromb Haemost. 2010;103:686-688.
3. Mallett SV, Cox DJ. Thrombelastography. Br J Anaesth. 1992;69:307-313.
4. Casutt M, Konrad C, Schuepfer G. Effect of rivaroxaban on blood coagulation using the viscoelastic coagulation test ROTEM™. Anaesthesist. 2012;61:948-953.
5. Elliott A, Wetzel J, Roper T, Pivalizza E, McCarthy J, Wallace C, et al. Thromboelastography in patients with acute ischemic stroke. Inl J Stroke. September 27, 2012. http://onlinelibrary.wiley.eom/doi/10.l111/j.1747-4949.2012. 00919.x/abstract. Accessed October 25, 2013.
6. Kubitza D, Becka M, Voith B, Zuehlsdorf M, Wensing G. Safety, pharmacodynamics, and pharmacokinetics of single doses of BAY 59- 7939, an oral, direct factor Xa inhibitor. Clin Pharmacol Ther. 2005; 78:412-421.