Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes 2014;63:1605-1611

Diabetes

Volumn 63, Issue 5, 2014, Pages

  Cedernaes, Jonathan ^a   Benedict, Christian ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

PPARGC1A PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

ANIMAL; ANIMAL EXPERIMENT; DNA METHYLATION; FEMALE; METABOLISM; NOTE; OBESITY; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE;

ANIMALS; DNA METHYLATION; FEMALE; OBESITY; PHYSICAL CONDITIONING, ANIMAL; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; TRANSCRIPTION FACTORS;

EID: 84899128626     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0086     Document Type: Letter

References (4)

1. Laker RC, Lillard TS, Okutsu M, et al. Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring. Diabetes 2014;63:1605-1611
2. Houten SM, Auwerx J. PGC-1α: turbocharging mitochondria. Cell 2004;119:5-7
3. Barrès R, Yan J, Egan B, et al. Acute exercise remodels promoter methylation in human skeletal muscle. Cell Metab 2012;15:405-411
4. Ng SF, Lin RC, Laybutt DR, Barrès R, Owens JA, Morris MJ. Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring. Nature 2010;467:963-966