Lactam and oxazolidinone derived potent 5-hydroxytryptamine 6 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 9, 2014, Pages 2094-2097

  Hostetler, Greg ^a   Dunn, Derek ^a   McKenna, Beth Ann ^a   Kopec, Karla ^a   Chatterjee, Sankar ^a  

^a CEPHALON INC   (United States)

Author keywords

5 Hydroxytryptamine; Antagonist; CNS; Lactam; Oxazolidinone

Indexed keywords

CYCLIC AMP; LACTAM DERIVATIVE; OXAZOLIDINONE DERIVATIVE; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; LACTAM; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ARTICLE; BINDING ASSAY; BLOOD BRAIN BARRIER; CHIRALITY; DRUG BINDING; DRUG PENETRATION; DRUG SYNTHESIS; ENANTIOMER; IC 50; NONHUMAN; ANIMAL EXPERIMENT; BINDING AFFINITY; BRAIN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; IC50; RAT; ANIMAL; CHEMISTRY; HUMAN; METABOLISM;

RATTUS;

ANIMALS; BRAIN; HUMANS; LACTAMS; OXAZOLIDINONES; RATS; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 84899124226     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.049     Document Type: Article

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