The epidemiology of infectious mononucleosis in Northern Scotland: A decreasing incidence and winter peak

BMC Infectious Diseases

Volumn 14, Issue 1, 2014, Pages

  Visser, Elizabeth ^a   Milne, Denis ^b   Collacott, Ian ^b   McLernon, David ^a   Counsell, Carl ^a   Vickers, Mark ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

^b ABERDEEN ROYAL INFIRMARY   (United Kingdom)

Author keywords

Epidemiology; Epstein Barr virus (EBV); Infectious Mononucleosis (IM); Seasonality

Indexed keywords

ADOLESCENT; ADULT; AGE DISTRIBUTION; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; GEOGRAPHIC DISTRIBUTION; HUMAN; INCIDENCE; INFECTION RATE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MONONUCLEOSIS; MONONUCLEOSIS TEST; SEASONAL VARIATION; SEX RATIO; SUMMER; TREND STUDY; UNITED KINGDOM; WINTER;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; INCIDENCE; INFANT; INFECTIOUS MONONUCLEOSIS; LATEX FIXATION TESTS; MALE; MIDDLE AGED; SCOTLAND; SEASONS; YOUNG ADULT;

EID: 84899114537     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/1471-2334-14-151     Document Type: Article

References (46)

1. Luzuriaga K, Sullivan JL. Infectious mononucleosis. N Engl J Med 2010, 362:1993-2000. 10.1056/NEJMcp1001116, 20505178.
2. Haque T, Iliadou P, Hossain A, Crawford DH. Seroepidemiological study of Epstein-Barr virus infection in Bangladesh. J Med Virol 1996, 48:17-21. 10.1002/(SICI)1096-9071(199601)48:1<17::AID-JMV3>3.0.CO;2-O, 8825705.
3. Crowcroft NS, Vyse A, Brown DW, Strachan DP. Epidemiology of Epstein-Barr virus infection in pre-adolescent children: application of a new salivary method in Edinburgh, Scotland. J Epidemiol Community Health 1998, 52:101-104. 10.1136/jech.52.2.101, 1756670, 9578856.
4. Higgins CD, Swerdlow AJ, Macsween KF, Harrison N, Williams H, McAulay R, Thomas R, Reid S, Conacher M, Britton K, Crawford DH. A study of risk factors for acquisition of Epstein-Barr virus and its subtypes. J Infect Dis 2007, 195:474-482. 10.1086/510854, 17230406.
5. Crawford DH, Macsween KF, Higgins CD, Thomas R, McAulay K, Harrison N, Reid S, Conacher M, Douglas J, Swerdlow AJ. A cohort study among University students: Identification of risk factors for Epstein-Barr virus seroconversion and infectious mononucleosis. Clin Infect Dis 2006, 43:276-282. 10.1086/505400, 16804839.
6. Hislop AD, Taylor GS, Sauce D, Rickinson AB. Cellular responses to viral infection in humans: lessons from Epstein-Barr virus. Ann Rev Immunol 2007, 25:587-617.
7. Hadinoto V, Shapiro M, Greenough TC, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood 2008, 111:1420-1427. 2214734, 17991806.
8. Rezk SA, Weiss LM. Epstein-Barr virus-associated lymphoproliferative disorders. Hum Pathol 2007, 38:1293-1304. 10.1016/j.humpath.2007.05.020, 17707260.
9. Natelson BH, Ye N, Moul DE, Jenkins FJ, Oren DA, Tapp WN, Cheng Y. High titers of anti-Epstein-Barr virus DNA polymerase are found in patients with severe fatiguing illness. J Med Virol 1994, 42:42-46. 10.1002/jmv.1890420109, 8308519.
10. Ascherio A, Munger KL. Environmental risk factors for multiple sclerosis. Part I: the role of infection. Ann Neurol 2007, 61:288-299. 10.1002/ana.21117, 17444504.
11. Almohmeed YH, Avenell A, Aucott L, Vickers MA. Systematic review and meta-analysis of the sero-epidemiological association between Epstein Barr virus and Multiple Sclerosis. PLoS One 2013, 8(4):e61110. doi:10.1371/journal.pone.0061110, 10.1371/journal.pone.0061110, 3621759, 23585874.
12. Hanlon P, Avenell A, Aucott L, Vickers MA. Systematic review and meta-analysis of the sero-epidemiological association between Epstein Barr virus and Systemic Lupus Erythematosus. Arthritis Res Ther 2014, 16:R3. 10.1186/ar4429, 24387619.
13. McAulay KA, Higgins CD, Macsween KF, Lake A, Jarrett RF, Robertson FL, Crawford DH. HLA class I polymorphisms are associated with development of infectious mononucleosis upon primary EBV infection. J Clin Invest 2007, 117:3042-3048. 10.1172/JCI32377, 1994627, 17909631.
14. Welsh RM, Che JW, Brehm MA, Selin LK. Heterologous immunity between viruses. Immunol Rev 2010, 235:244-266. 2917921, 20536568.
15. Huynh GT, Adler FR. Mathematical modelling the age dependence of Epstein-Barr virus associated infectious mononucleosis. Math Med Biol 2012, 29:245-261. 10.1093/imammb/dqr007, 21700566.
16. Asher M, Montefort S, Bjorksten B, Lai CKW, Strachan DP, Weiland SK, Williams H, The ISAAC Phase Three Study Group Worldwide time trends in the prevalence of symptoms of asthma, allergic rhino-conjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multi-country cross-sectional surveys. Lancet 2006, 368:733-743. 10.1016/S0140-6736(06)69283-0, 16935684, The ISAAC Phase Three Study Group.
17. Jacobson LD, Gange SJ, Rose NR, Graham NMH. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol 1997, 84:223-243. 10.1006/clin.1997.4412, 9281381.
18. Fisman DN. Seasonality of infectious diseases. Annu Rev Public Health 2007, 28:127-143. 10.1146/annurev.publhealth.28.021406.144128, 17222079.
19. Staples J, Ponsonby A, Lim L. Low maternal exposure to ultraviolet in pregnancy, month of birth and risk of multiple sclerosis in offspring: longitudinal analysis. BMJ 2010, 340:c1640. 2862149, 21030361.
20. Disanto G, Chaplin G, Morahan JM, Giovannoni G, Hypponen E, Ebers GC, Ramagopalan SV. Month of birth, vitamin D and risk of autoimmune mediated disease: a case control study. BMC Med 2012, 10:69. 10.1186/1741-7015-10-69, 3395583, 22764877.
21. Albert PL, Proal AD, Marshall TG. Vitamin D: the alternative hypothesis. Autoimmun Rev 2009, 8:639-644. 10.1016/j.autrev.2009.02.011, 19393200.
22. Ureta G, Osorio F, Morales J, Rosemblatt M, Bono MR, Fierro JA. Generation of Dendritic cells with regulatory properties. Transplant Proc 2007, 39:633-637. 10.1016/j.transproceed.2006.12.032, 17445563.
23. Cannell JJ, Vieth R, Umhau JC, Holick MF, Grant WB, Madronich S, Garland CF, Giovannucci E. Epidemic influenza and vitamin D. Epidemiol Infect 2006, 134:1129-1140. 10.1017/S0950268806007175, 2870528, 16959053.
24. Holmoy T. Vitamin D status modulates the immune response to Epstein Barr virus: Synergistic effect of risk factors in multiple sclerosis. Med Hypotheses 2008, 70:66-69. 10.1016/j.mehy.2007.04.030, 17574770.
25. Davidson RJL. A Survey of infectious mononucleosis in the North-East Regional Hospital Board area of Scotland 1960-9. J Hyg 1970, 68:393-400. 10.1017/S0022172400042297, 2130813, 5272344.
26. Tilton RC, Dias F, Ryan RW. Comparative evaluation of three commercial tests for detection of heterophile antibody in patients with infectious mononucleosis. J Clin Microbiol 1988, 26:275-278. 266266, 2830311.
27. Information Services Division Scotland. http://www.isdscotlandarchive.scot.nhs.uk/isd/3793.html.
28. Scotland's Census Results On Line. http://www.scotlandscensus.gov.uk/documents/censusresults/release2a/StatsBulletin2A.pdf.
29. General register Office for Scotland. http://www.gro-scotland.gov.uk/statistics/theme/population/estimates/mid-year/.
30. Roger JH. A significance test for cyclic trends in incidence data. Biometrika 1977, 64:152-155.
31. Edwards JH. The recognition of cyclic trends. Ann Hum Genet 1961, 25:83-85. 10.1111/j.1469-1809.1961.tb01501.x, 13725808.
32. Morris MC, Edmunds WJ. The changing epidemiology of infectious mononucleosis?. J Infect 2002, 45:107-109. 10.1053/jinf.2002.1022, 12217713.
33. Tattevin P, Le Tulso Y, Minjolle S, Person A, Chapplain JM, Arvieux C, Thomas R, Michelet C. Increasing incidence of severe Epstein-Barr virus-related infectious mononucleosis: Surveillance study. J Clin Microbiol 2006, 44:1873-1874. 10.1128/JCM.44.5.1873-1874.2006, 1479173, 16672427.
34. Cheng C, Chang L, Shao P, Lee P, Chen J, Lu C, Lee C, Huang L. Clinical manifestations and quantitative analysis of virus load in Taiwanese children with Epstein-Barr virus-associated Infectious mononucleosis. J Microbiol Immunol Infect 2007, 40:216-221.
35. Wan K, Yu Y, Wu W. Primary Epstein-Barr virus infection in 2 year old children: report of 3 cases. Turk J Pediatr 2010, 52:655-658.
36. Hope-Simpson RE. The transmission of epidemic Influenza. J Hygiene 1981, 86:35-47.
37. Newell KW. The reported incidence of glandular fever. An analysis of a report of the Public Health Laboratory service. J Clin Pathol 1957, 10:20-22. 10.1136/jcp.10.1.20, 1023988, 13406067.
38. Henke CE, Kurland LT, Elveback LR. Infectious mononucleosis in Rochester, Minnesota, 1950 through 1969. Am J Epidemiol 1973, 98:483-490.
39. Brodsky AL, Heath CW. Infectious mononucleosis: epidemiologic patterns at United States colleges and universities. Am J Epidemiol 1972, 96:87-93.
40. Heath CW, Brodsky AL, Potolsky AI. Infectious mononucleosis in a general population. Am J Epidemiol 1972, 95:46-52.
41. Leard SE. Seasonal incidence of infectious mononucleosis. J AM Coll Health Assoc 1972, 21:169.
42. Chang RS, Rosen L, Kapikian AZ. Epstein-Barr virus infections in a nursery. Am J Epidemiol 1981, 113:22-29.
43. Grotto I, Mimouni D, Huerta M, Mimouni M, Cohen D, Robin G, Pitlik S, Green MS. Clinical and laboratory presentation of EBV positive infectious mononucleosis in young adults. Epidemiol Infect 2003, 131:683-689. 10.1017/S0950268803008550, 2870009, 12948368.
44. Crawford DH, Swerdlow AJ, Higgins CD, McAulay R, Harrison N, Williams H, Britton K, Macsween KF. Sexual history and Epstein - Barr virus infection. J Infect Dis 2002, 186:731-736. 10.1086/342596, 12198605.
45. General Household survey. http://www.ons.gov.uk/ons/rel/ghs/general-household-survey/2002-edition/index.html.
46. Andiman WA, Miller G. Antibody Responses to Epstein-Barr Virus. Man Clin Imm 1980, 628-633. Washington, DC: American Society for Microbiology, Rose NR, Friedman H, 2.