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Volumn 6, Issue 1, 2014, Pages 4-15

Maintenance treatment after induction therapy in non-small cell lung cancer: Latest evidence and clinical implications

Author keywords

cost benefit analysis; decision making; disease management; maintenance chemotherapy; metastatic; non small cell lung cancer; quality of life

Indexed keywords

ANALGESIC AGENT; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CARBOPLATIN; CETUXIMAB; CISPLATIN; DOCETAXEL; ERLOTINIB; GEMCITABINE; NAVELBINE; PACLITAXEL; PEMETREXED; PLACEBO;

EID: 84899093486     PISSN: 17588340     EISSN: 17588359     Source Type: Journal    
DOI: 10.1177/1758834013510589     Document Type: Review
Times cited : (18)

References (42)
  • 1
    • 84857506268 scopus 로고    scopus 로고
    • AVAPERL (MO22089): final efficacy outcomes for patients (pts) with advanced non-squamous non-small cell lung cancer (NSNSCLC) randomised to continuation maintenance (MTC) with bevacizumab (Bev) or Bev + pemetrexed (Pem) after first-line (1L) Bev-cisplatin (Cis)-Pem treatment (TX)
    • Barlesi F. de Castro J. Dvornichenko V. Kim J. Pazzola A. Rittmeyer A. et al. (2011) AVAPERL (MO22089): final efficacy outcomes for patients (pts) with advanced non-squamous non-small cell lung cancer (NSNSCLC) randomised to continuation maintenance (MTC) with bevacizumab (Bev) or Bev + pemetrexed (Pem) after first-line (1L) Bev-cisplatin (Cis)-Pem treatment (TX). Eur J Cancer (Oxford) 47: 16.
    • (2011) Eur J Cancer (Oxford) , vol.47 , pp. 16
    • Barlesi, F.1    de Castro, J.2    Dvornichenko, V.3    Kim, J.4    Pazzola, A.5    Rittmeyer, A.6
  • 2
    • 84886385462 scopus 로고    scopus 로고
    • Randomized phase III trial of maintenance bevacizumab with or without pemetrexed after first-line induction with bevacizumab, cisplatin, and pemetrexed in advanced nonsquamous non-small-cell lung cancer: AVAPERL (MO22089)
    • in press.
    • Barlesi F. Scherpereel A. Rittmeyer A. Pazzola A. Ferrer Tur N. Kim J. et al. (2013) Randomized phase III trial of maintenance bevacizumab with or without pemetrexed after first-line induction with bevacizumab, cisplatin, and pemetrexed in advanced nonsquamous non-small-cell lung cancer: AVAPERL (MO22089). J Clin Oncol, in press.
    • (2013) J Clin Oncol
    • Barlesi, F.1    Scherpereel, A.2    Rittmeyer, A.3    Pazzola, A.4    Ferrer Tur, N.5    Kim, J.6
  • 3
    • 84862781680 scopus 로고    scopus 로고
    • Quality of life in patients with advanced non-small-cell lung cancer given maintenance treatment with pemetrexed versus placebo (H3E-MC-JMEN): results from a randomised, double-blind, phase 3 study
    • Belani C. Brodowicz T. Ciuleanu T. Krzakowski M. Yang S. Franke F. et al. (2012) Quality of life in patients with advanced non-small-cell lung cancer given maintenance treatment with pemetrexed versus placebo (H3E-MC-JMEN): results from a randomised, double-blind, phase 3 study. Lancet Oncol 13: 292–299.
    • (2012) Lancet Oncol , vol.13 , pp. 292-299
    • Belani, C.1    Brodowicz, T.2    Ciuleanu, T.3    Krzakowski, M.4    Yang, S.5    Franke, F.6
  • 4
    • 78049401119 scopus 로고    scopus 로고
    • Phase III study of maintenance gemcitabine (G) and best supportive care (BSC) versus BSC, following standard combination therapy with gemcitabine-carboplatin (G-Cb) for patients with advanced non-small cell lung cancer (NSCLC)
    • Belani C. Waterhouse D. Ghazal H. Ramalingam S. Bordoni R. Greenberg R. et al. (2010) Phase III study of maintenance gemcitabine (G) and best supportive care (BSC) versus BSC, following standard combination therapy with gemcitabine-carboplatin (G-Cb) for patients with advanced non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 28: 7506.
    • (2010) ASCO Meeting Abstracts , vol.28 , pp. 7506
    • Belani, C.1    Waterhouse, D.2    Ghazal, H.3    Ramalingam, S.4    Bordoni, R.5    Greenberg, R.6
  • 5
    • 33646485007 scopus 로고    scopus 로고
    • Cisplatin and gemcitabine first-line chemotherapy followed by maintenance gemcitabine or best supportive care in advanced non-small cell lung cancer: a phase III trial
    • Brodowicz T. Krzakowski M. Zwitter M. Tzekova V. Ramlau R. Ghilezan N. et al. (2006) Cisplatin and gemcitabine first-line chemotherapy followed by maintenance gemcitabine or best supportive care in advanced non-small cell lung cancer: a phase III trial. Lung Cancer 52: 155–163.
    • (2006) Lung Cancer , vol.52 , pp. 155-163
    • Brodowicz, T.1    Krzakowski, M.2    Zwitter, M.3    Tzekova, V.4    Ramlau, R.5    Ghilezan, N.6
  • 6
    • 77953541527 scopus 로고    scopus 로고
    • Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study
    • Cappuzzo F. Ciuleanu T. Stelmakh L. Cicenas S. Szczesna A. Juhasz E. et al. (2010) Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 11: 521–529.
    • (2010) Lancet Oncol , vol.11 , pp. 521-529
    • Cappuzzo, F.1    Ciuleanu, T.2    Stelmakh, L.3    Cicenas, S.4    Szczesna, A.5    Juhasz, E.6
  • 7
    • 70350225538 scopus 로고    scopus 로고
    • Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study
    • Ciuleanu T. Brodowicz T. Zielinski C. Kim J. Krzakowski M. Laack E. et al. (2009) Maintenance pemetrexed plus best supportive care versus placebo plus best supportive care for non-small-cell lung cancer: a randomised, double-blind, phase 3 study. Lancet 374: 1432–1440.
    • (2009) Lancet , vol.374 , pp. 1432-1440
    • Ciuleanu, T.1    Brodowicz, T.2    Zielinski, C.3    Kim, J.4    Krzakowski, M.5    Laack, E.6
  • 8
    • 84857501696 scopus 로고    scopus 로고
    • Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): a randomised multicentre, open-label, phase 3 study
    • Ciuleanu T. Stelmakh L. Cicenas S. Miliauskas S. Grigorescu A. Hillenbach C. et al. (2012) Efficacy and safety of erlotinib versus chemotherapy in second-line treatment of patients with advanced, non-small-cell lung cancer with poor prognosis (TITAN): a randomised multicentre, open-label, phase 3 study. Lancet Oncol 13: 300–308.
    • (2012) Lancet Oncol , vol.13 , pp. 300-308
    • Ciuleanu, T.1    Stelmakh, L.2    Cicenas, S.3    Miliauskas, S.4    Grigorescu, A.5    Hillenbach, C.6
  • 9
    • 0032887573 scopus 로고    scopus 로고
    • Mitomycin, ifosfamide, and cisplatin in unresectable non-small-cell lung cancer: effects on survival and quality of life
    • Cullen M. Billingham L. Woodroffe C. Chetiyawardana A. Gower N. Joshi R. et al. (1999) Mitomycin, ifosfamide, and cisplatin in unresectable non-small-cell lung cancer: effects on survival and quality of life. J Clin Oncol 17: 3188–3194.
    • (1999) J Clin Oncol , vol.17 , pp. 3188-3194
    • Cullen, M.1    Billingham, L.2    Woodroffe, C.3    Chetiyawardana, A.4    Gower, N.5    Joshi, R.6
  • 11
    • 59149092945 scopus 로고    scopus 로고
    • Phase III study of immediate compared with delayed docetaxel after front-line therapy with gemcitabine plus carboplatin in advanced non-small-cell lung cancer
    • Fidias P. Dakhil S. Lyss A. Loesch D. Waterhouse D. Bromund J. et al. (2009) Phase III study of immediate compared with delayed docetaxel after front-line therapy with gemcitabine plus carboplatin in advanced non-small-cell lung cancer. J Clin Oncol 27: 591–598.
    • (2009) J Clin Oncol , vol.27 , pp. 591-598
    • Fidias, P.1    Dakhil, S.2    Lyss, A.3    Loesch, D.4    Waterhouse, D.5    Bromund, J.6
  • 12
    • 84866927445 scopus 로고    scopus 로고
    • TAILOR: a phase III trial comparing erlotinib with docetaxel as the second-line treatment of NSCLC patients with wild-type (WT) EGFR
    • Garassino M. Martelli O. Bettini A. Floriani I. Copreni E. Lauricella C. et al. (2012) TAILOR: a phase III trial comparing erlotinib with docetaxel as the second-line treatment of NSCLC patients with wild-type (WT) EGFR. ASCO Meeting Abstracts 30: LBA7501.
    • (2012) ASCO Meeting Abstracts , vol.30 , pp. LBA7501
    • Garassino, M.1    Martelli, O.2    Bettini, A.3    Floriani, I.4    Copreni, E.5    Lauricella, C.6
  • 13
    • 84871600705 scopus 로고    scopus 로고
    • Maintenance chemotherapy for advanced non-small-cell lung cancer: new life for an old idea
    • Gerber D. Schiller J. (2013) Maintenance chemotherapy for advanced non-small-cell lung cancer: new life for an old idea. J Clin Oncol 31: 1009–1020.
    • (2013) J Clin Oncol , vol.31 , pp. 1009-1020
    • Gerber, D.1    Schiller, J.2
  • 14
    • 0018569942 scopus 로고
    • A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate
    • Goldie J. Coldman A. (1979) A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate. Cancer Treat Rep 63: 1727–1733.
    • (1979) Cancer Treat Rep , vol.63 , pp. 1727-1733
    • Goldie, J.1    Coldman, A.2
  • 15
    • 84865154870 scopus 로고    scopus 로고
    • First-line erlotinib followed by second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: the TORCH randomized trial
    • Gridelli C. Ciardiello F. Gallo C. Feld R. Butts C. Gebbia V. et al. (2012 a) First-line erlotinib followed by second-line cisplatin-gemcitabine chemotherapy in advanced non-small-cell lung cancer: the TORCH randomized trial. J Clin Oncol 30: 3002–3011.
    • (2012) J Clin Oncol , vol.30 , pp. 3002-3011
    • Gridelli, C.1    Ciardiello, F.2    Gallo, C.3    Feld, R.4    Butts, C.5    Gebbia, V.6
  • 16
    • 84867894352 scopus 로고    scopus 로고
    • Safety, resource use, and quality of life in paramount: a phase III study of maintenance pemetrexed versus placebo after induction pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer
    • Gridelli C. de Marinis F. Pujol J. Reck M. Ramlau R. Parente B. et al. (2012 b) Safety, resource use, and quality of life in paramount: a phase III study of maintenance pemetrexed versus placebo after induction pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer. J Thorac Oncol 7: 1713–1721.
    • (2012) J Thorac Oncol , vol.7 , pp. 1713-1721
    • Gridelli, C.1    de Marinis, F.2    Pujol, J.3    Reck, M.4    Ramlau, R.5    Parente, B.6
  • 17
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • Hanna N. Shepherd F. Fossella F. Pereira J. de Marinis F. von Pawel J. et al. (2004) Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 22: 1589–1597.
    • (2004) J Clin Oncol , vol.22 , pp. 1589-1597
    • Hanna, N.1    Shepherd, F.2    Fossella, F.3    Pereira, J.4    de Marinis, F.5    von Pawel, J.6
  • 18
    • 0028267598 scopus 로고
    • Measurement of quality of life in patients with lung cancer in multicenter trials of new therapies. psychometric assessment of the lung cancer symptom scale
    • Hollen P. Gralla R. Kris M. Cox C. Belani C. Grunberg S. et al. (1994) Measurement of quality of life in patients with lung cancer in multicenter trials of new therapies. psychometric assessment of the lung cancer symptom scale. Cancer 73: 2087–2098.
    • (1994) Cancer , vol.73 , pp. 2087-2098
    • Hollen, P.1    Gralla, R.2    Kris, M.3    Cox, C.4    Belani, C.5    Grunberg, S.6
  • 19
    • 84875706413 scopus 로고    scopus 로고
    • Effects of erlotinib first-line maintenance therapy versus placebo on the health-related quality of life of patients with metastatic non-small-cell lung cancer
    • Juhasz E. Kim J. Klingelschmitt G. Walzer S. (2013) Effects of erlotinib first-line maintenance therapy versus placebo on the health-related quality of life of patients with metastatic non-small-cell lung cancer. Eur J Cancer 49: 1205–1215.
    • (2013) Eur J Cancer , vol.49 , pp. 1205-1215
    • Juhasz, E.1    Kim, J.2    Klingelschmitt, G.3    Walzer, S.4
  • 20
    • 78449274913 scopus 로고    scopus 로고
    • and the Atlas Investigators
    • Overall survival (OS) in Atlas, a phase IIIb trial comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy (Chemo) with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • Kabbinavar F. Miller V. Johnson B. O'Connor P. Soh C. and the Atlas Investigators (2010) Overall survival (OS) in Atlas, a phase IIIb trial comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy (Chemo) with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 28: 7526.
    • (2010) ASCO Meeting Abstracts , vol.28 , pp. 7526
    • Kabbinavar, F.1    Miller, V.2    Johnson, B.3    O'Connor, P.4    Soh, C.5
  • 21
    • 56249109644 scopus 로고    scopus 로고
    • Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial
    • Kim E. Hirsh V. Mok T. Socinski M. Gervais R. Wu Y. et al. (2008) Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial. Lancet 372: 1809–1818.
    • (2008) Lancet , vol.372 , pp. 1809-1818
    • Kim, E.1    Hirsh, V.2    Mok, T.3    Socinski, M.4    Gervais, R.5    Wu, Y.6
  • 22
    • 77955097091 scopus 로고    scopus 로고
    • Cost-effectiveness of pemetrexed as first-line maintenance therapy for advanced nonsquamous non-small cell lung cancer
    • Klein R. Wielage R. Muehlenbein C. Liepa A. Babineaux S. Lawson A. et al. (2010) Cost-effectiveness of pemetrexed as first-line maintenance therapy for advanced nonsquamous non-small cell lung cancer. J Thorac Oncol 5: 1263–1272.
    • (2010) J Thorac Oncol , vol.5 , pp. 1263-1272
    • Klein, R.1    Wielage, R.2    Muehlenbein, C.3    Liepa, A.4    Babineaux, S.5    Lawson, A.6
  • 23
    • 77955118508 scopus 로고    scopus 로고
    • PEM and the cost of multicycle maintenance
    • Learn P. Bach P. (2010) PEM and the cost of multicycle maintenance. J Thorac Oncol 5: 1111–1112.
    • (2010) J Thorac Oncol , vol.5 , pp. 1111-1112
    • Learn, P.1    Bach, P.2
  • 24
    • 58849090571 scopus 로고    scopus 로고
    • An empiric estimate of the value of life: updating the renal dialysis cost-effectiveness standard
    • Lee C. Chertow G. Zenios S. (2009) An empiric estimate of the value of life: updating the renal dialysis cost-effectiveness standard. Value Health 12: 80–87.
    • (2009) Value Health , vol.12 , pp. 80-87
    • Lee, C.1    Chertow, G.2    Zenios, S.3
  • 25
    • 84856013080 scopus 로고    scopus 로고
    • Cost-effectiveness of maintenance pemetrexed in patients with advanced nonsquamous-cell lung cancer from the perspective of the Swiss health care system
    • Matter-Walstra K. Joerger M. Kuhnel U. Szucs T. Pestalozzi B. Schwenkglenks M. (2012) Cost-effectiveness of maintenance pemetrexed in patients with advanced nonsquamous-cell lung cancer from the perspective of the Swiss health care system. Value Health 15: 65–71.
    • (2012) Value Health , vol.15 , pp. 65-71
    • Matter-Walstra, K.1    Joerger, M.2    Kuhnel, U.3    Szucs, T.4    Pestalozzi, B.5    Schwenkglenks, M.6
  • 26
    • 70349477817 scopus 로고    scopus 로고
    • for the Atlas Investigators
    • A randomized, double-blind, placebo-controlled, phase IIIb trial (Atlas) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC)
    • Miller V. O'Connor P. Soh C. Kabbinavar F. for the Atlas Investigators (2009) A randomized, double-blind, placebo-controlled, phase IIIb trial (Atlas) comparing bevacizumab (B) therapy with or without erlotinib (E) after completion of chemotherapy with B for first-line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 27: LBA8002.
    • (2009) ASCO Meeting Abstracts , vol.27 , pp. LBA8002
    • Miller, V.1    O'Connor, P.2    Soh, C.3    Kabbinavar, F.4
  • 27
    • 84971581087 scopus 로고
    • Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials
    • Non-Small Cell Lung Cancer Collaborative Group
    • Non-Small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. BMJ 311: 899–909.
    • (1995) BMJ , vol.311 , pp. 899-909
  • 28
    • 84887107225 scopus 로고    scopus 로고
    • Exploratory analyses of efficacy and safety of pemetrexed (Pem) plus bevacizumab (Bev) and Bev alone as maintenance therapy (MT) in patients (Pts) with stage IIIb or IV nonsquamous non-small cell lung cancer (NS-NSCLC)
    • Patel J. Garon E. Govindan R. Reynolds C. Spigel D. Olsen M. et al. (2013) Exploratory analyses of efficacy and safety of pemetrexed (Pem) plus bevacizumab (Bev) and Bev alone as maintenance therapy (MT) in patients (Pts) with stage IIIb or IV nonsquamous non-small cell lung cancer (NS-NSCLC). ASCO Meeting Abstracts 31: 8012.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. 8012
    • Patel, J.1    Garon, E.2    Govindan, R.3    Reynolds, C.4    Spigel, D.5    Olsen, M.6
  • 29
    • 70249116447 scopus 로고    scopus 로고
    • Phase II study of pemetrexed and carboplatin plus bevacizumab with maintenance pemetrexed and bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer
    • Patel J. Hensing T. Rademaker A. Hart E. Blum M. Milton D. et al. (2009) Phase II study of pemetrexed and carboplatin plus bevacizumab with maintenance pemetrexed and bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer. J Clin Oncol 27: 3284–3289.
    • (2009) J Clin Oncol , vol.27 , pp. 3284-3289
    • Patel, J.1    Hensing, T.2    Rademaker, A.3    Hart, E.4    Blum, M.5    Milton, D.6
  • 30
    • 84874936166 scopus 로고    scopus 로고
    • A randomized, open-label, phase 3, superiority study of pemetrexed (Pem)+carboplatin (Cb)+bevacizumab (B) followed by maintenance Pem+B versus paclitaxel (Pac)+Cb+B followed by maintenance B in patients (Pts) with stage IIIb or IV non-squamous non-small cell lung cancer (NS-NSCLC)
    • Abstract LBPL331.
    • Patel J. Socinski M. Garon E. Reynolds C. Spigel D. Hermann R. et al. (2012) A randomized, open-label, phase 3, superiority study of pemetrexed (Pem)+carboplatin (Cb)+bevacizumab (B) followed by maintenance Pem+B versus paclitaxel (Pac)+Cb+B followed by maintenance B in patients (Pts) with stage IIIb or IV non-squamous non-small cell lung cancer (NS-NSCLC). J Thoracic Oncol 7: S336, Abstract LBPL331.
    • (2012) J Thoracic Oncol , vol.7 , pp. S336
    • Patel, J.1    Socinski, M.2    Garon, E.3    Reynolds, C.4    Spigel, D.5    Hermann, R.6
  • 31
    • 84885924300 scopus 로고    scopus 로고
    • PARAMOUNT: final overall survival results of the phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer
    • in press.
    • Paz-Ares L. de Marinis F. Dediu M. Thomas M. Pujol J. Bidoli P. et al. (2013) PARAMOUNT: final overall survival results of the phase III study of maintenance pemetrexed versus placebo immediately after induction treatment with pemetrexed plus cisplatin for advanced nonsquamous non-small-cell lung cancer. J Clin Oncol, in press.
    • (2013) J Clin Oncol
    • Paz-Ares, L.1    de Marinis, F.2    Dediu, M.3    Thomas, M.4    Pujol, J.5    Bidoli, P.6
  • 32
    • 84867059528 scopus 로고    scopus 로고
    • Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine induction chemotherapy in advanced non-small-cell lung cancer
    • Perol M. Chouaid C. Perol D. Barlesi F. Gervais R. Westeel V. et al. (2012) Randomized, phase III study of gemcitabine or erlotinib maintenance therapy versus observation, with predefined second-line treatment, after cisplatin-gemcitabine induction chemotherapy in advanced non-small-cell lung cancer. J Clin Oncol 30: 3516–3524.
    • (2012) J Clin Oncol , vol.30 , pp. 3516-3524
    • Perol, M.1    Chouaid, C.2    Perol, D.3    Barlesi, F.4    Gervais, R.5    Westeel, V.6
  • 33
    • 80053646484 scopus 로고    scopus 로고
    • Erlotinib as maintenance therapy in patients with advanced non-small cell lung cancer: a pooled analysis of three randomized trials
    • Petrelli F. Borgonovo K. Cabiddu M. Barni S. (2011) Erlotinib as maintenance therapy in patients with advanced non-small cell lung cancer: a pooled analysis of three randomized trials. Anticancer Drugs 22: 1010–1019.
    • (2011) Anticancer Drugs , vol.22 , pp. 1010-1019
    • Petrelli, F.1    Borgonovo, K.2    Cabiddu, M.3    Barni, S.4
  • 34
    • 65349116059 scopus 로고    scopus 로고
    • Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial
    • Pirker R. Pereira J. Szczesna A. von Pawel J. Krzakowski M. Ramlau R. et al. (2009) Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 373: 1525–1531.
    • (2009) Lancet , vol.373 , pp. 1525-1531
    • Pirker, R.1    Pereira, J.2    Szczesna, A.3    von Pawel, J.4    Krzakowski, M.5    Ramlau, R.6
  • 35
    • 84890800973 scopus 로고    scopus 로고
    • Effect of maintenance bevacizumab (Bev) plus pemetrexed (Pem) after first-line cisplatin/Pem/Bev in advanced nonsquamous non-small cell lung cancer (NSNSCLC) on overall survival (Os) of patients (Pts) on the AVAPERL (MO22089) phase III randomized trial
    • Rittmeyer A. Scherpereel A. Gorbunova V. Gervais R. Vikstrom A. Chouaid C. et al. (2013) Effect of maintenance bevacizumab (Bev) plus pemetrexed (Pem) after first-line cisplatin/Pem/Bev in advanced nonsquamous non-small cell lung cancer (NSNSCLC) on overall survival (Os) of patients (Pts) on the AVAPERL (MO22089) phase III randomized trial. ASCO Meeting Abstracts 31: 8014.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. 8014
    • Rittmeyer, A.1    Scherpereel, A.2    Gorbunova, V.3    Gervais, R.4    Vikstrom, A.5    Chouaid, C.6
  • 36
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel–carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler A. Gray R. Perry M. Brahmer J. Schiller J. Dowlati A. et al. (2006) Paclitaxel–carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 355: 2542–2550.
    • (2006) N Engl J Med , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.3    Brahmer, J.4    Schiller, J.5    Dowlati, A.6
  • 37
    • 49049089802 scopus 로고    scopus 로고
    • Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
    • Scagliotti G. Parikh P. von Pawel J. Biesma B. Vansteenkiste J. Manegold C. et al. (2008) Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 26: 3543–3551.
    • (2008) J Clin Oncol , vol.26 , pp. 3543-3551
    • Scagliotti, G.1    Parikh, P.2    von Pawel, J.3    Biesma, B.4    Vansteenkiste, J.5    Manegold, C.6
  • 38
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • Schiller J. Harrington D. Belani C. Langer C. Sandler A. Krook J. et al. (2002) Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346: 92–98.
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.1    Harrington, D.2    Belani, C.3    Langer, C.4    Sandler, A.5    Krook, J.6
  • 40
    • 6344254442 scopus 로고    scopus 로고
    • Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life
    • Spiro S. Rudd R. Souhami R. Brown J. Fairlamb D. Gower N. et al. (2004) Chemotherapy versus supportive care in advanced non-small cell lung cancer: improved survival without detriment to quality of life. Thorax 59: 828–836.
    • (2004) Thorax , vol.59 , pp. 828-836
    • Spiro, S.1    Rudd, R.2    Souhami, R.3    Brown, J.4    Fairlamb, D.5    Gower, N.6
  • 41
    • 84872390640 scopus 로고    scopus 로고
    • Cost-effectiveness of continuation maintenance pemetrexed after cisplatin and pemetrexed chemotherapy for advanced nonsquamous non-small-cell lung cancer: estimates from the perspective of the Chinese health care system
    • Zeng X. Peng L. Li J. Chen G. Tan C. Wang S. et al. (2013) Cost-effectiveness of continuation maintenance pemetrexed after cisplatin and pemetrexed chemotherapy for advanced nonsquamous non-small-cell lung cancer: estimates from the perspective of the Chinese health care system. Clin Ther 35: 54–65.
    • (2013) Clin Ther , vol.35 , pp. 54-65
    • Zeng, X.1    Peng, L.2    Li, J.3    Chen, G.4    Tan, C.5    Wang, S.6
  • 42
    • 84891858787 scopus 로고    scopus 로고
    • Randomized, open-label, phase III study of pemetrexed plus carboplatin (PEMC) followed by maintenance pemetrexed versus paclitaxel/carboplatin/bevacizumab (PCB) Followed by maintenance bevacizumab in patients with advanced nonsquamous (NS) non-small cell lung cancer (NSCLC)
    • Zinner R. Ross H. Weaver R. Govindan R. Holden V. Chowhan N. et al. (2013) Randomized, open-label, phase III study of pemetrexed plus carboplatin (PEMC) followed by maintenance pemetrexed versus paclitaxel/carboplatin/bevacizumab (PCB) Followed by maintenance bevacizumab in patients with advanced nonsquamous (NS) non-small cell lung cancer (NSCLC). ASCO Meeting Abstracts 31: LBA8003.
    • (2013) ASCO Meeting Abstracts , vol.31 , pp. LBA8003
    • Zinner, R.1    Ross, H.2    Weaver, R.3    Govindan, R.4    Holden, V.5    Chowhan, N.6


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