Trans-oral brush biopsies and quantitative PCR for EBV DNA detection and screening of nasopharyngeal carcinoma

Otolaryngology - Head and Neck Surgery (United States)

Volumn 150, Issue 4, 2014, Pages 602-609

  Ng, Raymond H W ^a   Ngan, Roger ^b   Wei, William Ignace ^c   Gullane, Patrick J ^d   Phillips, John ^e  

^a Rouge Valley Health System   (Canada)

^b QUEEN ELIZABETH HOSPITAL   (Hong Kong)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

disease risk; Epstein Barr virus; nasopharyngeal cancer; trans oral brush biopsies

Indexed keywords

VIRUS DNA;

ADULT; ADVERSE OUTCOME; AGED; ARTICLE; CANCER DIAGNOSIS; CHINESE; CONTROLLED STUDY; CORRELATION ANALYSIS; DIAGNOSTIC TEST ACCURACY STUDY; ENDOSCOPY; EPITHELIUM CELL; EPSTEIN BARR VIRUS; FEMALE; HONG KONG; HUMAN; LABORATORY DEVICE; MAJOR CLINICAL STUDY; MALE; MEDICAL PRACTICE; NASOPHARYNX CARCINOMA; ORAL BIOPSY; PREDICTIVE VALUE; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; TRANSORAL BRUSH BIOPSY; VIRUS DETECTION;

DISEASE RISK; EPSTEIN-BARR VIRUS; NASOPHARYNGEAL CANCER; TRANS-ORAL BRUSH BIOPSIES;

AMBULATORY CARE; BIOPSY; COHORT STUDIES; DNA, VIRAL; EARLY DETECTION OF CANCER; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; LARYNGOSCOPY; MALE; MICROSCOPY, ELECTRON; MOUTH MUCOSA; NASOPHARYNGEAL NEOPLASMS; REAL-TIME POLYMERASE CHAIN REACTION; RETROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; VIRAL LOAD;

EID: 84899085940     PISSN: 01945998     EISSN: 10976817     Source Type: Journal    
DOI: 10.1177/0194599813520136     Document Type: Article

References (35)

1. Wei WI, Sham JS. Nasopharyngeal carcinoma. Lancet. 2005 ; 365: 2041-2054 (Pubitemid 40812341)
2. Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010 ; 127: 2893-2917
3. Jia WH, Huang QH, Liao J, et al. Trends in incidence and mortality of nasopharyngeal carcinoma over a 20-25 year period (1978/1983-2002) in Sihui and Cangwu counties in southern China. BMC Cancer. 2006 ; 6: 178
4. Cao SM, Simons MJ, Qian CN. The prevalence and prevention of nasopharyngeal carcinoma in China. Chin J Cancer. 2011 ; 30: 114-119
5. Skinner DW, Van HC. Nasopharyngeal carcinoma: methods of presentation. Ear Nose Throat J. 1990 ; 69: 237-240 (Pubitemid 20192719)
6. Pathmanathan R, Prasad U, Sadler R, et al. Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma. N Engl J Med. 1995 ; 333: 693-698
7. Ho S, Teo P, Kwan WH, et al. Staging and IgA VCA titre in patients with nasopharyngeal carcinoma: changes over a 12-year period. Oral Oncol. 1998 ; 34: 491-495 (Pubitemid 28546863)
8. Mao YP, Li WF, Chen L, et al. A clinical verification of the Chinese 2008 staging system for nasopharyngeal carcinoma. Ai Zheng. 2009 ; 28: 1022-1028
9. Raab-Traub N, Flynn K, Pearson G, et al. The differentiated form of nasopharyngeal carcinoma contains Epstein-Barr virus DNA. Int J Cancer. 1987 ; 39: 25-29 (Pubitemid 17233823)
10. Teresa M, Yu G, Hu K, Li J. Plasma Epstein-Barr virus immunoglobulin A and DNA for nasopharyngeal carcinoma screening in the United States. Otolaryngol Head Neck Surg. 2007 ; 136: 992-997 (Pubitemid 46844851)
11. Lo YMD, Chan LY, Chan AT, et al. Quantitative and temporal correlation between circulating cell-free Epstein- Barr virus DNA and tumor recurrence in nasopharyngeal carcinoma. Cancer Res. 1999 ; 59: 5452-5455 (Pubitemid 29526455)
12. Lo YMD, Chan LYS, Lo KW, et al. Quantitative analysis of cell-free Epstein-Barr virus DNA in plasma of patients with nasopharyngeal carcinoma. Cancer Res. 1999 ; 59: 1188-1199
13. Lo YMD, Leung S, Chan LY, et al. Kinetics of plasma Epstein-Barr virus DNA during radiation therapy for nasopharyngeal carcinoma. Cancer Res. 2000 ; 60: 2351-2355 (Pubitemid 30262420)
14. Feinmesser R, Miyazaki I, Cheung R, et al. Diagnosis of nasopharyngeal carcinoma by DNA amplification of tissue obtained by fine-needle aspiration. N Engl J Med. 1992 ; 326: 17-21
15. Tune CE, Liavaag PG, Freeman JL, et al. Nasopharyngeal brush biopsies and detection of nasopharyngeal cancer in a high-risk population. J Natl Cancer Inst. 1999 ; 91: 796-880
16. Tong JH, Tsang RK, Lo KW, et al. Quantitative Epstein-Barr virus DNA analysis and detection of gene promoter hypermethylation in nasopharyngeal (NP) brushing samples from patients with NP carcinoma. Clin Cancer Res. 2002 ; 8: 2612-2619 (Pubitemid 34856348)
17. Adham M, Greijer AE, Verkuijlen SA, et al. Epstein-Barr virus DNA load in nasopharyngeal brushings and whole blood in nasopharyngeal carcinoma patients before and after treatment. Clin Cancer Res. 2013 ; 19: 2175-2186
18. Mutirangura A, Pornthanakasaem W, Theamboonlers A, et al. Epstein-Barr viral DNA in serum of patients with nasopharyngeal carcinoma. Clin Cancer Res. 1998 ; 4: 665-669 (Pubitemid 28193566)
19. Fournie GJ, Courtin JP, Laval F, et al. Plasma DNA as a marker of cancerous cell death. Investigations in patients suffering from lung cancer and in nude mice bearing human tumors. Cancer Lett. 1995 ; 91: 221-227
20. Low WK, Leong JL. Correlating clinical appearance of nasopharyngeal carcinoma with tumor staging. J R Coll Surg Edinb. 2000 ; 45: 146-147 (Pubitemid 30394376)
21. Sham JST, Wei WI, Kwan WH, et al. Fiberoptic endoscopic examination and biopsy in determining the extent of nasopharyngeal carcinoma. Cancer. 1989 ; 64: 1838-1842 (Pubitemid 19267801)
22. Lin JC, Wang WY, Chen KY, et al. Quantification of plasma Epstein-Barr virus DNA in patients with advanced nasopharyngeal carcinoma. N Engl J Med. 2004 ; 350: 2461-2470 (Pubitemid 38736543)
23. Lo YM, Chan AT, Chan LY, et al. Molecular prognostication of nasopharyngeal carcinoma by quantitative analysis of circulating Epstein-Barr virus DNA. Cancer Res. 2000 ; 60: 6878-6881 (Pubitemid 32059157)
24. Chan AT, Lo YM, Zee B, et al. Plasma Epstein-Barr virus DNA and residual disease after radiotherapy for undifferentiated nasopharyngeal carcinoma. J Natl Cancer Inst. 2002 ; 94: 1614-1619 (Pubitemid 35378726)
25. Leon SA, Shapiro B, Sklaroff DM, Yaros MJ. Free DNA in the serum of cancer patients and the effect of therapy. Cancer Res. 1977 ; 37: 646-650 (Pubitemid 8051621)
26. Usadel H, Brabender J, Danenberg KD, et al. Quantitative adenomatous polyposis coli promoter methylation analysis in tumor tissue, serum, and plasma DNA of patients with lung cancer. Cancer Res. 2002 ; 62: 371-375 (Pubitemid 34106406)
27. Shao ZM, Wu J, Shen ZZ, Nguyen M. P53 mutation in plasma DNA and its prognostic value in breast cancer patients. Clin Cancer Res. 2001 ; 7: 2222-2227 (Pubitemid 32751618)
28. Anker P, Mulcahy H, Stroun M. Circulating nucleic acids in plasma and serum as a noninvasive investigation for cancer: time for large-scale clinical studies?. Int J Cancer. 2003 ; 103: 149-152 (Pubitemid 35461505)
29. Jalbout M, Jrad BBH, Bouaouina N. Autoantibodies to tubulin are specifically associated with the young age of onset of the nasopharyngeal carcinoma. Int J Cancer. 2002 ; 101: 146-150 (Pubitemid 34970906)
30. Richey LM, Olshan AF, George J, et al. Incidence and survival rates for young blacks with Nasopharyngeal Carcinoma in the United States. Arch Otolaryngol Head Neck Surg. 2006 ; 132: 1035-1040 (Pubitemid 44600779)
31. Leung SF, Tam JS, Chan ATC, et al. Improved accuracy of detection of nasopharyngeal carcinoma by combined application of circulating Epstein-Barr virus DNA and anti-Epstein-Barr viral capsid antigen IgA antibody. Clin Chem. 2004 ; 50: 339-345 (Pubitemid 38156375)
32. Liu Y, Fang A, Liu L, Yang S, Zhang L. Detection of Epstein-Barr virus DNA in serum or plasma for nasopharyngeal cancer: a meta analysis. Genet Test Mol Biomarkers. 2011 ; 15: 495-502
33. Liu Y, Huang Q, Liu W, et al. Establishment of VCA and EBNA1 IgA-based combination by enzyme-linked immunosorbent assay as preferred screening method for nasopharyngeal carcinoma: a two-stage design with a preliminary performance study and a mass screening in southern China. Int J Cancer. 2012 ; 131: 406-416
34. Yang X, Goldstein AM, Chen CJ, et al. Distribution of Epstein-Barr viral load in serum of individuals from nasopharyngeal carcinoma high-risk families in Taiwan. Int J Cancer. 2006 ; 118: 780-784 (Pubitemid 43076031)
35. Bortolin MT, Pratesi C, Dolcetti R, et al. Clinical value of Epstein-Barr virus DNA levels in peripheral blood samples of Italian patients with undifferentiated carcinoma of nasopharyngeal type. Cancer Lett. 2006 ; 233: 247-254 (Pubitemid 43327380)