Design, synthesis, ADME characterization and antileishmanial evaluation of novel substituted quinoline analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 9, 2014, Pages 2046-2052

  Gopinath, Vadiraj S ^a   Rao, Mukkavilli ^a   Shivahare, Rahul ^b   Vishwakarma, Preeti ^b   Ghose, Sweta ^a   Pradhan, Ashok ^a   Hindupur, Ramamohan ^a   Sarma, Koushik Das ^a   Gupta, Suman ^b   Puri, Sunil K ^b   Launay, Delphine ^c   Martin, Denis ^c  

^a Advinus Therapeutics Private Limited Bangalore   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

^c Drugs for Neglected Diseases Initiative   (Switzerland)

Author keywords

ADME assays; In vitro activity; Leishmania donovani; Substituted quinoline chalcones

Indexed keywords

ALPHA NAPHTHOFLAVONE; ANTILEISHMANIAL AGENT; CYTOCHROME P450 1A2; CYTOCHROME P450 2C19; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; KETOCONAZOLE; N 3 BENZYLNIRVANOL; QUINIDINE; QUINOLINE DERIVATIVE; SULFAPHENAZOLE; UNCLASSIFIED DRUG; ANTITRYPANOSOMAL AGENT; CYTOCHROME P450;

ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; ARTICLE; COMPARATIVE STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LEISHMANIA DONOVANI; LEISHMANIASIS; LIVER MICROSOME; NONHUMAN; PHLEBOTOMUS ARGENTIPES; SUZUKI REACTION; VISCERAL LEISHMANIASIS; ANIMAL; CHEMISTRY; DRUG EFFECTS; DRUG SENSITIVITY; HAMSTER; LEISHMANIASIS, VISCERAL; METABOLISM; MOUSE;

CRICETINAE; LEISHMANIA DONOVANI;

ANIMALS; CRICETINAE; CYTOCHROME P-450 ENZYME SYSTEM; DRUG DESIGN; HUMANS; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; MICE; MICROSOMES, LIVER; PARASITIC SENSITIVITY TESTS; QUINOLINES; TRYPANOCIDAL AGENTS;

EID: 84899068534     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.065     Document Type: Article

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