Lack of any association of the CTLA-4 +49 G/A polymorphism with breast cancer risk in a north Indian population

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 5, 2014, Pages 2035-2038

  Minhas, Sachin ^a   Bhalla, Sunita ^a   Shokeen, Yogender ^a   Jauhri, Mayank ^a   Saxena, Renu ^a   Verma, Ishwar Chandra ^a   Aggarwal, Shyam ^a  

^a SIR GANGA RAM HOSPITAL   (India)

Author keywords

Breast cancer; CTLA 4; Ethnic groups; Immunology; North Indians; Single nucleotide polymorphisms

Indexed keywords

CYTOTOXIC T LYMPHOCYTE ANTIGEN 4;

ASIAN CONTINENTAL ANCESTRY GROUP; BREAST TUMOR; CASE CONTROL STUDY; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HUMAN; RISK; SINGLE NUCLEOTIDE POLYMORPHISM;

ASIAN CONTINENTAL ANCESTRY GROUP; BREAST NEOPLASMS; CASE-CONTROL STUDIES; CTLA-4 ANTIGEN; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK;

EID: 84899052866     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.5.2035     Document Type: Article

References (25)

1. Blank CU (2014). The perspective of immunotherapy: new molecules and new mechanisms of action in immune modulation. Curr Opin Oncol, 26, 204-14
2. Chistiakov DA, Savost'anov KV, Turakulov RI, et al (2006).Genetic analysis and functional evaluation of the C/T (-318) and A/G(-1661) polymorphisms of the CTLA-4 gene inpatients affected with Graves' disease. Clin Immunol, 118, 233-42.
3. Dilmec F, Ozgonul A, Uzunkoy A, et al (2008). Investigation of CTLA-4 and CD28 gene polymorphisms in a group of Turkish patients with colorectal cancer. Int J Immunogenet, 35, 317-21.
4. Feng M, Zhang FB, Deng HR. et al (2013). The CTLA4 +49A/G polymorphism is associated with an increased risk of Hashimoto's thyroiditis in Asian but not Caucasian populations: an updated meta-analysis. Endocrine, 44, 350-8.
5. Geng R, Song F, Yang X, et al (2013). Association between cytotoxic T lymphocyte antigen-4 +49A/G, -1722T/C, and -1661A/G polymorphisms and cancer risk: a meta-analysis. Tumour Biol. [Epub ahead of print]
6. Ghaderi A. (2011). CTLA4 gene variants in autoimmunity and cancer: a comparative review. Iran J Immunol, 8, 127-49.
7. Ghaderi A, Yeganeh F, Kalantari T, et al (2004). Cytotoxic T lymphocyte antigen-4 gene in breast cancer. Breast Cancer Res Treat, 86, 1-7.
8. Hou R, Cao B, Chen Z, et al (2010). Association of cytotoxic T lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer. Mol Biol Rep, 37, 515-20.
9. Ligers A, Teleshova N, Masterman T, et al (2001). CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms. Genes Immun, 2, 145-52.
10. Mandal RK, Mittal T, Kapoor R, et al (2010). NER and BER repair gene polymorphisms in a healthy north Indian cohort and comparison with different ethnic groups worldwide. Asian Pac J Cancer Prev, 11, 1601-4.
11. Maurer M, Loserth S, Kolb-Maurer A, et al (2002). A polymorphism in the human cytotoxic T-lymphocyte antigen 4 (CTLA4) gene (exon 1 +49) alters T-cell activation. Immunogenetics, 54, 1-8.
12. Monne M, Piras G, Palmas A, Arru L, et al (2004). Cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene polymorphism and susceptibility to non-Hodgkin's lymphoma. Am J Hematol, 76, 14-8.
13. Qi P, Ruan CP, Wang H, et al (2010). CTLA-4 +49A≥G polymorphism is associated with the risk but not with the progression of colorectal cancer in Chinese. Int J Colorectal Dis, 25, 39-45.
14. Reiman JM, Kmieciak M, Manjili MH, et al (2007). Tumor immunoediting and immunosculpting pathways to cancer progression. Semin Cancer Biol, 17, 275-87.
15. Rodriguez S, Gaunt T R and Day I. N. M. (2009) Hardy- Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol, 169, 505-14.
16. Shaukat U, Ismail M, Mehmood N (2013). Epidemiology, major risk factors and genetic predisposition for breast cancer in the Pakistani population. Asian Pac J Cancer Prev, 14, 5625-9.
17. Solerio E, Tappero G, Iannace L, et al (2005). CTLA4 gene polymorphism in Italian patients with colorectal adenoma and cancer. Dig Liver Dis, 37, 170-5.
18. Song B, Liu Y, Liu J, et al (2011). CTLA-4 +49A≥G polymorphism is associated with advanced non-small cell lung cancer prognosis. Respiration, 82, 439-44.
19. Sun T, Zhou Y, Yang M, et al (2008). Functional genetic variations in cytotoxic T-lymphocyte antigen 4 and susceptibility to multiple types of cancer. Cancer Res, 68, 7025-34.
20. Taheri NS, Bakhshandehnosrat S, Tabiei MN, et al (2012). Epidemiological pattern of breast cancer in Iranian women: is there an ethnic disparity?. Asian Pac J Cancer Prev, 13, 4517-20.
21. Takiar R, Nadayil D, Nandakumar A (2010). Projections of number of cancer cases in India (2010-2020) by cancer groups. Asian Pac J Cancer Prev, 11, 1045-9.
22. Sun T, Hu S, Shen H, et al (2009). Genetic polymorphisms in cytotoxic T-lymphocyte antigen 4 and cancer: the dialectical nature of subtle human immune dysregulation. Cancer Res, 69, 6011-4.
23. Ueda H, Howson JM, Esposito L, et al (2003). Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature, 423, 506-11
24. Wang L, Li D, Fu Z, et al (2007). Association of CTLA-4 gene polymorphisms with sporadic breast cancer in Chinese Han population. BMC Cancer, 7, 173.
25. Zhang B, Beeghly-Fadiel A, Long J, et al (2011). Genetic variants associated with breast-cancer risk: comprehensive research synopsis, meta-analysis, and epidemiological evidence. Lancet Oncol, 12, 477-88.