Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration.

International journal of pharmaceutics

Volumn 456, Issue 1, 2013, Pages 235-242

  Abu Lila, Amr S ^a   Nawata, Kosuke ^b   Shimizu, Taro ^b   Ishida, Tatsuhiro ^b   Kiwada, Hiroshi ^b  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,2-DISTEAROYLPHOSPHATIDYLETHANOLAMINE; ANTINEOPLASTIC AGENT; DOXORUBICIN; DRUG ADMINISTRATION; GLYCEROL; IMMUNOGLOBULIN M; LIPOSOME; MACROGOL DERIVATIVE; PHARMACOKINETICS; PHOSPHATIDYLETHANOLAMINE; POLYGLYCEROL; POLYMER;

ANIMAL; BLOOD; C57BL MOUSE; CARCINOMA, LEWIS LUNG; CHEMISTRY; DRUG EFFECTS; DRUG THERAPY; MALE; MOUSE; PATHOLOGY; RAT; TUMOR CELL LINE; TUMOR VOLUME; WISTAR RAT;

ADMINISTRATION AND DOSAGE; ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD; CARCINOMA, LEWIS LUNG; CELL LINE, TUMOR; CHEMISTRY; DOXORUBICIN; DRUG EFFECTS; DRUG THERAPY; GLYCEROL; IMMUNOGLOBULIN M; LIPOSOMES; MALE; MICE; MICE, INBRED C57BL; PATHOLOGY; PHARMACOKINETICS; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, WISTAR; TUMOR BURDEN;

EID: 84899040898     PISSN: None     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.07.059     Document Type: Article

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