Chronic endometritis due to common bacteria is prevalent in women with recurrent miscarriage as confirmed by improved pregnancy outcome after antibiotic treatment

Reproductive Sciences

Volumn 21, Issue 5, 2014, Pages 640-647

  Cicinelli, Ettore ^a   Matteo, Maria ^b   Tinelli, Raffaele ^c   Pinto, Vincenzo ^a   Marinaccio, Marco ^a   Indraccolo, Ugo ^d   De Ziegler, Dominique ^e   Resta, Leonardo ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF FOGGIA   (Italy)

^c Department of Obstetrics and Gynecology San Bastiano Hospital   (Italy)

^d Operative Unit of Obstetric and Gynecology of Civitanova Marche   (Italy)

^e UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

antibiotic treatment; chronic endometritis; endometrial culture; hysteroscopy; repeated miscarriage

Indexed keywords

ADULT; ALPHA HEMOLYTIC STREPTOCOCCUS; ANTIBIOTIC THERAPY; ARTICLE; BACTERIUM; CANDIDA; CHLAMYDIA; CHRONIC ENDOMETRITIS; CONTROLLED STUDY; ENDOMETRITIS; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; FEMALE; HISTOLOGY; HUMAN; HYSTEROSCOPY; KLEBSIELLA PNEUMONIAE; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; MYCOPLASMA; POLYMERASE CHAIN REACTION; PREGNANCY OUTCOME; PRIORITY JOURNAL; RECURRENT MISCARRIAGE; SPONTANEOUS ABORTION; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS HAEMOLYTICUS; STREPTOCOCCUS AGALACTIAE; STREPTOCOCCUS BOVIS; STREPTOCOCCUS MILLERI; STREPTOCOCCUS MITIS; UREAPLASMA; ABORTION, HABITUAL; CHRONIC DISEASE; ISOLATION AND PURIFICATION; MICROBIOLOGY; NEISSERIA GONORRHOEAE; PREGNANCY; PREVALENCE; RETROSPECTIVE STUDY;

ANTIINFECTIVE AGENT;

ABORTION, HABITUAL; ADULT; ANTI-BACTERIAL AGENTS; CHLAMYDIA; CHRONIC DISEASE; ENDOMETRITIS; FEMALE; HUMANS; MYCOPLASMA; NEISSERIA GONORRHOEAE; PREGNANCY; PREGNANCY OUTCOME; PREVALENCE; RETROSPECTIVE STUDIES;

EID: 84899001993     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719113508817     Document Type: Article

References (35)

1. Rai R, Regan L. Recurrent miscarriage. Lancet. 2006 ; 368 (9535). 601-611
2. La Sala GB, Montanari R, Dessanti L, Cigarini C, Sartori F. The role of diagnostic hysteroscopy and endometrial biopsy in assisted reproductive technologies. Fertil Steril. 1998 ; 70 (2). 378-380
3. Oliveira FG, Abdelmassih VG, Diamond MP, Dozortsev D, Nagy ZP, Abdelmassih R. Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilization-embryo transfer who repeatedly cannot conceive. Fertil Steril. 2003 ; 80 (6). 1371-1375
4. Demirol A, Gurgan T. Effect of treatment of intrauterine pathologies with office hysteroscopy in patients with recurrent IVF failure. Reprod Biomed Online. 2004 ; 8 (5). 590-594
5. Rama Raju GA, Shashi Kumari G, Krishna KM, Prakash GJ, Madan K. Assessment of uterine cavity by hysteroscopy in assisted reproduction programme and its influence on pregnancy outcome. Arch Gynecol Obstet. 2006 ; 274 (3). 160-164
6. Bosteels J, Weyers S, Puttemans P, et al. The effectiveness of hysteroscopy in improving pregnancy rates in subfertile women without other gynaecological symptoms: a systematic review. Hum Reprod Update. 2010 ; 16 (1). 1-11
7. Fatemi HM, Kasius JC, Timmermans A, et al. Prevalence of unsuspected uterine cavity abnormalities diagnosed by office hysteroscopy prior to in vitro fertilization. Hum Reprod. 2010 ; 25 (8). 1959-1965
8. Makrakis E, Pantos K. The outcomes of hysteroscopy in women with implantation failures after in-vitro fertilization: findings and effect on subsequent pregnancy rates. Curr Opin Obstet Gynecol. 2010 ; 22 (4). 339-343
9. Greenwood SM, Moran JJ. Chronic endometritis: morphologic and clinical observations. Obstet Gynecol. 1981 ; 58 (2). 176-184
10. Resta L, Palumbo M, Rossi R, Piscitelli D, Grazia Fiore M, Cicinelli E. Histology of micro polyps in chronic endometritis. Histopathology. 2012 ; 60 (4). 670-674
11. Cicinelli E, Resta L, Nicoletti R, Zappimbulso V, Tartagni M, Saliani N. Endometrial micropolyps at fluid hysteroscopy suggest the existence of chronic endometritis. Hum Reprod. 2005 ; 20 (5). 1386-1389
12. Cicinelli E, Resta L, Nicoletti R, et al. Detection of chronic endometritis at fluid hysteroscopy. J Minim Invasive Gynecol. 2005 ; 12 (6). 514-518
13. Cicinelli E, De Ziegler D, Nicoletti R, et al. Chronic endometritis: correlation among hysteroscopic, histologic, and bacteriologic findings in a prospective trial with 2190 consecutive office hysteroscopies. Fertil Steril. 2008 ; 89 (3). 677-684
14. Matteo M, Cicinelli E, Greco P, et al. Abnormal pattern of lymphocyte subpopulations in the endometrium of infertile women with chronic endometritis. Am J Reprod Immunol. 2009 ; 61 (5). 322-329
15. Kitaya K, Yasuo T.. Aberrant expression of selectin E, CXCL1, and CXCL13 in chronic endometritis. Mod Pathol. 2010 ; 23 (8). 1136-1146
16. Johnston-MacAnanny EB, Hartnett J, Engmann LL, Nulsen JC, Sanders MM, Benadiva CA. Chronic endometritis is a frequent finding in women with recurrent implantation failure after in vitro fertilization. Fertil Steril. 2010 ; 93 (2). 437-441
17. Kasius JC, Fatemi HM, Bourgain C, et al. The impact of chronic endometritis on reproductive outcome. Fertil Steril. 2011 ; 96 (6). 1451-1456
18. Workowski KA, Berman S. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep. 2010 ; 59 (RR-12). 1-110
19. Nigro G, Mazzocco M, Mattia E, Di Renzo GC, Carta G, Anceschi MM. Role of the infections in recurrent spontaneous abortion. J Matern Fetal Neonatal Med. 2011 ; 24 (8). 983-989
20. Ness RB, Soper DE, Holley RL, et al. Effectiveness of inpatient and outpatient treatment strategies for women with pelvic inflammatory disease: results from the Pelvic Inflammatory Disease Evaluation and Clinical Health (PEACH) randomized trial. Am J Obstet Gynecol. 2002 ; 186 (5). 929-937
21. Espinoza J, Erez O, Romero R. Preconceptional antibiotic treatment to prevent preterm birth in women with a previous preterm delivery. Am J Obstet Gynecol. 2006 ; 194 (3). 630-637
22. Kamiyama S, Teruya Y, Nohara M, Kanazawa K. Impact of detection of bacterial endotoxin in menstrual effluent on the pregnancy rate in in vitro fertilization and embryo transfer. Fertil Steril. 2004 ; 82 (4). 788-792
23. Cowling P, McCoy DR, Marshall RJ, Padfield CJ, Reeves DS. Bacterial colonization of the non-pregnant uterus: a study of pre-menopausal abdominal hysterectomy specimens. Eur J Clin Microbiol Infect Dis. 1992 ; 11 (2). 204-205
24. Cicinelli E, Ballini A, Marinaccio M, et al. Microbiological findings in endometrial specimen: our experience. Arch Gynecol Obstet. 2012 ; 285 (5). 1325-1329
25. Korn AP, Bolan G, Padian N, Ohm-Smith M, Schachter J, Landers DV. Plasma cell endometritis in women with symptomatic bacterial vaginosis. Obstet Gynecol. 1995 ; 85 (3). 387-390
26. Eckert LO, Moore DE, Patton DL, Agnew KJ, Eschenbach DA. Relationship of vaginal bacteria and inflammation with conception and early pregnancy loss following in-vitro fertilization. Infect Dis Obstet Gynecol. 2003 ; 11 (1). 11-17
27. Romero R, Espinoza J, Mazor M. Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization?. Fertil Steril. 2004 ; 82 (4). 799-804
28. Romero R, Mazor M. Infection and preterm labor. Clin Obstet Gynecol. 1988 ; 31 (3). 553-584
29. Salim R, Ben-Shlomo I, Colodner R, Keness Y, Shalev E. Bacterial colonization of the uterine cervix and success rate in assisted reproduction: results of a prospective survey. Hum Reprod. 2002 ; 17 (2). 337-340
30. Haggerty CL, Totten PA, Astete SG, Ness RB. Mycoplasma genitalium among women with nongonococcal, nonchlamydial pelvic inflammatory disease. Infect Dis Obstet Gynecol. 2006 ; 2006: 30184
31. Stern RA, Svoboda-Newman SM, Frank TS. Analysis of chronic endometritis for Chlamydia trachomatis by polymerase chain reaction. Hum Pathol. 1996 ; 27 (10). 1085-1088
32. Cicinelli E, De Ziegler D, Nicoletti R, et al. Poor reliability of vaginal and endocervical cultures for evaluating microbiology of endometrial cavity in women with chronic endometritis. Gynecol Obstet Invest. 2009 ; 68 (2). 108-115
33. Valli E, Zupi E, Marconi D, et al. Hysteroscopic findings in 344 women with recurrent spontaneous abortion. J Am Assoc Gynecol Laparosc. 2001 ; 8 (3). 398-401
34. Bohlmann MK, von Wolff M, Luedders DW, et al. Hysteroscopic findings in women with two and with more than two first-trimester miscarriages are not significantly different. Reprod Biomed Online. 2010 ; 21 (2). 230-236
35. Cicinelli E, Parisi C, Galantino P, Pinto V, Barba B, Schonauer S. Reliability, feasibility, and safety of minihysteroscopy with a vaginoscopic approach: experience with 6,000 cases. Fertil Steril. 2003 ; 80 (1). 199-202