Polymyxin B agonist capture therapy for intrauterine inflammation: Proof-of-principle in a fetal ovine model

Reproductive Sciences

Volumn 21, Issue 5, 2014, Pages 623-631

  Saito, Masatoshi ^a,b   Payne, Matthew S ^a   Miura, Yuichiro ^a   Ireland, Demelza J ^a   Stock, Sarah ^a   Kallapur, Suhas G ^a,c   Kannan, Paranthaman S ^c   Newnham, John P ^a   Kramer, Boris W ^a,d   Jobe, Alan H ^a,c   Keelan, Jeffrey A ^a   Kemp, Matthew W ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

agonist; fetus; infection; inflammation; preterm birth; sheep

Indexed keywords

CD3 ANTIGEN; ENDOTOXIN; HEMOGLOBIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 2; POLYMYXIN B; TUMOR NECROSIS FACTOR ALPHA; LIPOPOLYSACCHARIDE;

AMNION FLUID; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL OXYGEN TENSION; ARTERIAL PH; ARTICLE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; FETUS; FETUS LUNG; FETUS WEIGHT; HEMOGLOBIN BLOOD LEVEL; HISTOLOGY; IN VITRO STUDY; IN VIVO STUDY; INTRA-AMNIOTIC DRUG ADMINISTRATION; KERATINOCYTE; METRITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEEP; UMBILICAL CORD BLOOD; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; FETAL DISEASES; INFLAMMATION; PATHOLOGY; PREGNANCY; RANDOMIZATION; UTERUS;

ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FETAL DISEASES; INFLAMMATION; LIPOPOLYSACCHARIDES; POLYMYXIN B; PREGNANCY; RANDOM ALLOCATION; SHEEP; UTERUS;

EID: 84899000512     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719113508820     Document Type: Article

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