Lipid-Lowering and Antioxidant Functions of Bottle Gourd (Lagenaria siceraria) Extract in Human Dyslipidemia

Journal of Evidence-Based Complementary and Alternative Medicine

Volumn 19, Issue 2, 2014, Pages 112-118

  Katare, Charu ^a   Saxena, Sonali ^b   Agrawal, Supriya ^a   Joseph, Anish Zacharia ^b   Subramani, Senthil Kumar ^b   Yadav, Dhananjay ^b   Singh, Nita ^b   Bisen, Prakash Singh ^b   Prasad, G B K S ^b  

^a Vijaya Raje Govt Girls PG College   (India)

^b JIWAJI UNIVERSITY   (India)

Author keywords

atherosclerosis; dyslipidemia; hyperglycemia; Lagenaria siceraria; oxidative stress

Indexed keywords

ANTILIPEMIC AGENT; ANTIOXIDANT; LIPID; PLANT EXTRACT;

ADULT; ARTICLE; ATHEROSCLEROSIS; BLOOD; BLOOD PRESSURE; BODY WEIGHT; CASE CONTROL STUDY; CHEMISTRY; CUCURBITACEAE; DRUG EFFECT; DYSLIPIDEMIA; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; LAGENARIA SICERARIA; LIPID METABOLISM; MIDDLE AGED; OXIDATIVE STRESS; PLANT SEED;

ATHEROSCLEROSIS; DYSLIPIDEMIA; HYPERGLYCEMIA; LAGENARIA SICERARIA; OXIDATIVE STRESS;

ADULT; ANTIOXIDANTS; BLOOD GLUCOSE; BLOOD PRESSURE; BODY WEIGHT; CASE-CONTROL STUDIES; CUCURBITACEAE; DYSLIPIDEMIAS; HUMANS; HYPOLIPIDEMIC AGENTS; LIPID METABOLISM; LIPIDS; MIDDLE AGED; OXIDATIVE STRESS; PLANT EXTRACTS; SEEDS;

EID: 84898920324     PISSN: 21565872     EISSN: None     Source Type: Journal    
DOI: 10.1177/2156587214524229     Document Type: Article

References (35)

1. Durrington P.Dyslipidemia.Lancet. 2003;362:717-731.
2. Hunt JV,Smith CC,Wolff SP.Autoxidation glycosylation and possible involvement of peroxides and free radicals in LDL modification by glucose.Diabetes. 1990;39:1420-1424.
3. Henry N,Ginsberg MD.Effects of statins on triglyceride metabolism.Am J Cardiol. 1998;81 (4): 32B-35B.
4. Brunzell JDThe Metabolic and Molecular Bases of Inherited Disease. 7th ed. New York: PMcGraw-Hill; 1995:1913-1932.Scriver CRBeaudet ALSly WSValle D, ed. New York: PMcGraw-Hill; 1995:1913-1932.
5. Kolovou GD,Kostakou PM,Anagnostopoulou KK,Cokkinos DV.Therapeutic effects of fibrates in postprandial lipemia.Am J Cardiovasc Drugs. 2008;8:243-255.
6. Deshpande JR,Choudhari AA,Mishra MR,Meghre VS,Wadodkar SG,Dorale AL.Beneficial effect of Lagenariasiceraria (Mol.) Standly fruit epicarp in animal models.Indian J Exp Biol. 2008;46:234-242.
7. Sivarajan SS,Balchandra AAyurvedic Drugs and Their Plant Source. New Delhi, India: IBH Publication Company; 1994:176-177.
8. Shirwaikar A,Sreenivasan KK.Chemical investigation and antihepatotoxic activity of the fruit of Lagenaria siceraria.Indian J Pharm Sci. 1996;58:197.
9. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report.Circulation. 2002;106:3143-3421.
10. Sharma SK,Puri R,Jain A, et al.Assessment of effects on health due to consumption of bitter bottle gourd (Lagenaria siceraria) juice.Indian J Med Res. 2012;135:49-55.
11. Raobdo E,Terkildsen TC.On the enzymatic determination of blood glucose.Scand J Clin Lab Invest. 1960;12:402-407.
12. Fossati P,Prencipe L.Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide.Clin Chem. 1982;28:2077-2080.
13. Stockbrige H,Glueck J.Public cholesterol screening: motivation for participation, follow-up outcome, self-knowledge and coronary heart disease risk factor intervention.J Lab Clin Med. 1989;114:142-151.
14. Lopes-Virella MF,Stone P,Ellis S,Colwell JA.Cholesterol determination in high-density lipoproteins separated by three different methods.Clin Chem. 1977;23:882-883.
15. Friedewald WT,Levy RI,Friedrickson DS.Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.Clin Chem. 1972;18:499-502.
16. Brehm A,Pfeiler G,Pacini G,Vierhapper H,Roden M.Relationship between serum lipoprotein ratios and insulin resistance in obesity.Clin Chem. 2004;50:2316-2322.
17. Frohlich J,Dobiásová M.Fractional esterification rate of cholesterol and ratio of triglycerides to HDL-cholesterol are powerful predictors of positive findings on coronary angiography.Clin Chem. 2003;49:1873-1880.
18. Winterbourn CC,Hawkins RE,Brian M,Carrell RW.Estimation of red cell superoxide dismutase activity.J Lab Clin Med. 1975;85:337-341.
19. Sinha AK.Colorimetric assay of catalase.Anal Biochem. 1972;47:389-394.
20. Ellman GL.Tissue sulfhydryl groups.Arch Biochem. 1959;82:70-77.
21. Ohkawa H,Ohishi N,Yagi K.Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.Anal Biochem. 1979;95:351-358.
22. Harbone JBPhytochemical Methods: A Guide to Modern Techniques of Plant Analysis. London, England: Chapman & Hall; 1998:.
23. Laboratory Guide for the Analysis of Ayurveda and Siddha Formulations. New Delhi, India: Department of AYUSH, Ministry of Health and Family Welfare, Government of India; 1997:81-87.
24. Prajapati RP,Kalariya M,Parmar SK,Sheth NR.Phytochemical and pharmacological review of Lagenaria sicereria.J Ayurveda Integr Med. 2010;1:266-272.
25. Fukushima M,Matsuda T,Yamagishi K,Nakano M.Comparative hypocholesterolemic effects of six dietary oils in cholesterol-fed rats after long-term feeding.Lipids. 1997;32:1069-1074.
26. Sharma DK.Hypolipidemic effect of different extracts of Clerodendron colebrookianum Walp in normal and high-fat diet fed rats.J Ethnopharmacol. 2004;90:63-68.
27. Milind P,Kaur S.Is bottle gourd a natural guard?.Int Res J Pharm. 2011;2 (6): 13-17.
28. Usoro IN,Nsonwu AC.Lipid profile of postmenopausal women in Calabar, Nigeria.Pak J Nutr. 2006;5:79-82.
29. Erasto P,Mbwambo ZH.Antioxidant activity and HPTLC profile of Lagenaria siceraria fruits.Tanzania J Health Res. 2009;11 (2): 79-83.
30. Steinberg D,Gotto AM.Preventing coronary artery disease by lowering cholesterol levels: fifty years from bench to bedside.JAMA. 1999;282:2043-2050.
31. Mantena SK,King AL,Andringa KK,Eccleston HB,Bailey SM.Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol and obesity-induced fatty liver diseases.Free Radic Biol Med. 2008;44:1259-1272.
32. Pier GP.Flavonoids as antioxidants.J Nat Prod. 2000;63:1035-1042.
33. Joy PP,Thomas J,Mathew S,Skaria BPMedicinal Plants: Tropical Horticulture. Calcutta, India: Naya ProKash; 2001:449-632.
34. Ghule BV,Ghante MH,Yeole PG,Saoji AN.Diuretic activity of Lagenaria siceraria fruit extract in rats.Indian J Pharm Sci. 2007;69:817-819.
35. Mali VR,Bodhankar SL.Effect of Lagenaria siceraria (LS) powder on dexamethasone induced hypertension in rats.Int J Adv Pharm Sci. 2010;1:50-53.