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Volumn 30, Issue 5, 2014, Pages 367-371

The effects of metformin on endothelial dysfunction, lipid metabolism and oxidative stress in women with polycystic ovary syndrome

Author keywords

Metformin; Polycystic ovary syndrome; PON1 activity; Small dense LDL C

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; ARYLDIALKYLPHOSPHATASE 1; CHOLESTEROL; ENDOTHELIN 1; GLUKOFEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; MALONALDEHYDE; METFORMIN; NITRIC OXIDE; PRASTERONE SULFATE; SEX HORMONE; SEX HORMONE BINDING GLOBULIN; TESTOSTERONE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; ARYLDIALKYLPHOSPHATASE; ESTRADIOL; FOLLITROPIN; PROGESTERONE;

EID: 84898918811     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2014.887063     Document Type: Article
Times cited : (42)

References (37)
  • 2
    • 69249205728 scopus 로고    scopus 로고
    • Polycystic ovary syndrome: A major unrecognized cardiovascular risk factor in women
    • Alexander CJ, Tangchitnob EP, Lepor NE. Polycystic ovary syndrome: a major unrecognized cardiovascular risk factor in women. Rev Cardiovasc Med 2009;10:83-90
    • (2009) Rev Cardiovasc Med , vol.10 , pp. 83-90
    • Alexander, C.J.1    Tangchitnob, E.P.2    Lepor, N.E.3
  • 4
    • 33144462200 scopus 로고    scopus 로고
    • Low-density lipoprotein size and cardiovascular prevention
    • Rizzo M, Berneis K. Low-density lipoprotein size and cardiovascular prevention. Eur J Int Med 2006;17:77-80
    • (2006) Eur J Int Med , vol.17 , pp. 77-80
    • Rizzo, M.1    Berneis, K.2
  • 5
    • 0035725280 scopus 로고    scopus 로고
    • Smaller LDL particle size in women with polycystic ovary syndrome compared to controls
    • Dejager S, Pichard C, Giral P, et al. Smaller LDL particle size in women with polycystic ovary syndrome compared to controls. Clin Endocrinol 2001;54:455-62
    • (2001) Clin Endocrinol , vol.54 , pp. 455-462
    • Dejager, S.1    Pichard, C.2    Giral, P.3
  • 6
    • 30444439216 scopus 로고    scopus 로고
    • The discovery of nitric oxide and its role in vascular biology
    • Moncada S, Higgs EA. The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 2006;147:193-201
    • (2006) Br J Pharmacol , vol.147 , pp. 193-201
    • Moncada, S.1    Higgs, E.A.2
  • 7
    • 20444488435 scopus 로고    scopus 로고
    • Vascular endothelin in hypertension
    • Schiffrin EL. Vascular endothelin in hypertension. Vascul Pharmacol 2005;43:19-29
    • (2005) Vascul Pharmacol , vol.43 , pp. 19-29
    • Schiffrin, E.L.1
  • 8
    • 0037707406 scopus 로고    scopus 로고
    • Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease
    • Fenkci V, Fenkci S, Yilmazer M, Serteser M. Decreased total antioxidant status and increased oxidative stress in women with polycystic ovary syndrome may contribute to the risk of cardiovascular disease. Fertil Steril 2003;80:123-7
    • (2003) Fertil Steril , vol.80 , pp. 123-127
    • Fenkci, V.1    Fenkci, S.2    Yilmazer, M.3    Serteser, M.4
  • 9
    • 18144452679 scopus 로고    scopus 로고
    • Oxy radicals, lipid peroxidation and DNA damage
    • Marnett LJ. Oxy radicals, lipid peroxidation and DNA damage. Toxicology 2002;181-2:219-22
    • (2002) Toxicology , vol.181 , Issue.2 , pp. 219-222
    • Marnett, L.J.1
  • 10
    • 0032522985 scopus 로고    scopus 로고
    • Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase
    • Aviram M, Rosenblat M, Bisgaier CL, et al. Paraoxonase inhibits high-density lipoprotein oxidation and preserves its functions. A possible peroxidative role for paraoxonase. J Clin Invest 1998; 101:1581-90
    • (1998) J Clin Invest , vol.101 , pp. 1581-1590
    • Aviram, M.1    Rosenblat, M.2    Bisgaier, C.L.3
  • 11
    • 33847640229 scopus 로고    scopus 로고
    • Effects of medical therapy on insulin resistance and the cardiovascular system in polycystic ovary syndrome
    • Meyer C, McGrath BP, Teede HJ. Effects of medical therapy on insulin resistance and the cardiovascular system in polycystic ovary syndrome. Diabetes Care 2007;30:471-8
    • (2007) Diabetes Care , vol.30 , pp. 471-478
    • Meyer, C.1    McGrath, B.P.2    Teede, H.J.3
  • 12
    • 0346725827 scopus 로고    scopus 로고
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
    • The Rotterdam ESHRE/ ASRM - Sponsored PCOS Consensus Workshop Group
    • Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. The Rotterdam ESHRE/ ASRM - Sponsored PCOS Consensus Workshop Group. Fertil Steril 2004;81:19-25
    • (2004) Fertil Steril , vol.81 , pp. 19-25
  • 13
    • 84920244726 scopus 로고
    • Multifollicular ovaries: Clinical and endocrine features and response to pulsatile gonadotropin releasing hormone
    • Adams J, Franks S, Polson DW, et al. Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone. Lancet 1985;2:1375-9
    • (1985) Lancet , vol.2 , pp. 1375-1379
    • Adams, J.1    Franks, S.2    Polson, D.W.3
  • 14
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3
  • 15
    • 0015348189 scopus 로고
    • Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald Wi, Levy RI, Fredrickson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18: 499-505
    • (1972) Clin Chem , vol.18 , pp. 499-505
    • Friedewald, W.I.1    Levy, R.I.2    Fredrickson, D.S.3
  • 16
    • 0029033537 scopus 로고
    • Nitrite and nitrate determinations in plasma: A critical evaluation
    • Moshage H, Kok B, Huizenga JR, Jansen PL. Nitrite and nitrate determinations in plasma: a critical evaluation. Clin Chem 1995;41: 892-6
    • (1995) Clin Chem , vol.41 , pp. 892-896
    • Moshage, H.1    Kok, B.2    Huizenga, J.R.3    Jansen, P.L.4
  • 17
    • 0020534463 scopus 로고
    • The human serum paraoxonase polymorphism: Identification of phenotypes by their response to salts
    • Eckerson EW, Romson J, Wyte C, La Du BN. The human serum paraoxonase polymorphism: identification of phenotypes by their response to salts. Am J Hum Gen 1983;35:214-27
    • (1983) Am J Hum Gen , vol.35 , pp. 214-227
    • Eckerson, E.W.1    Romson, J.2    Wyte, C.3    La Du, B.N.4
  • 18
    • 0345098354 scopus 로고    scopus 로고
    • A novel and simple method for quantification of small, dense LDL
    • Hirano T, Ito Y, Saegusa H, Yoshino G. A novel and simple method for quantification of small, dense LDL. J Lipid Res 2003;44: 2193-201
    • (2003) J Lipid Res , vol.44 , pp. 2193-2201
    • Hirano, T.1    Ito, Y.2    Saegusa, H.3    Yoshino, G.4
  • 19
    • 19744365285 scopus 로고    scopus 로고
    • Metformin administration improves endothelial function in women with polycystic ovary syndrome
    • Diamanti-Kandarakis E, Alexandraki K, Protogerou A, et al. Metformin administration improves endothelial function in women with polycystic ovary syndrome. Eur J Endocrinol 2005;152: 749-56
    • (2005) Eur J Endocrinol , vol.152 , pp. 749-756
    • Diamanti-Kandarakis, E.1    Alexandraki, K.2    Protogerou, A.3
  • 20
    • 27744599917 scopus 로고    scopus 로고
    • Improvement in endothelial structure and function after metformin treatment in young normalweight women with polycystic ovary syndrome: Results of a 6-month study
    • Orio Jr F, Palomba S, Cascella T, et al. Improvement in endothelial structure and function after metformin treatment in young normalweight women with polycystic ovary syndrome: results of a 6-month study. J Clin Endocrinol Metab 2005;90:6072-6
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6072-6076
    • Orio Jr., F.1    Palomba, S.2    Cascella, T.3
  • 21
    • 75149149178 scopus 로고    scopus 로고
    • Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome
    • Palomba S, Falbo A, Giallauria F, et al. Effects of metformin with or without supplementation with folate on homocysteine levels and vascular endothelium of women with polycystic ovary syndrome. Diabetes Care 2010;33:246-51
    • (2010) Diabetes Care , vol.33 , pp. 246-251
    • Palomba, S.1    Falbo, A.2    Giallauria, F.3
  • 22
    • 4544265733 scopus 로고    scopus 로고
    • Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome
    • Orio Jr F, Palomba S, Cascella T, et al. Early impairment of endothelial structure and function in young normal-weight women with polycystic ovary syndrome. J Clin Endocrinol Metab 2004;89: 4588-93
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4588-4593
    • Orio Jr., F.1    Palomba, S.2    Cascella, T.3
  • 23
    • 0022467232 scopus 로고
    • Estradiol-17 affects estrogen receptor distribution and elevates progesterone receptor content in baboon aorta
    • Lin AL, Gonzalezn Jr R, Carey KD, Shain SA. Estradiol-17 affects estrogen receptor distribution and elevates progesterone receptor content in baboon aorta. Arteriosclerosis 1986;6:495-504
    • (1986) Arteriosclerosis , vol.6 , pp. 495-504
    • Lin, A.L.1    Gonzalezn Jr., R.2    Carey, K.D.3    Shain, S.A.4
  • 24
    • 21244456905 scopus 로고    scopus 로고
    • Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: Role of ETB receptor, NADPH oxidase and caveolin-1
    • Dong F, Zhang X, Wold LE, et al. Endothelin-1 enhances oxidative stress, cell proliferation and reduces apoptosis in human umbilical vein endothelial cells: role of ETB receptor, NADPH oxidase and caveolin-1. Br J Pharmacol 2005;145:323-33
    • (2005) Br J Pharmacol , vol.145 , pp. 323-333
    • Dong, F.1    Zhang, X.2    Wold, L.E.3
  • 25
    • 0036845966 scopus 로고    scopus 로고
    • Oxidants, antioxidants and carcinogenesis
    • Ray G, Husain SA. Oxidants, antioxidants and carcinogenesis. Indian J Exp Biol 2002;40:1213-32
    • (2002) Indian J Exp Biol , vol.40 , pp. 1213-1232
    • Ray, G.1    Husain, S.A.2
  • 26
    • 0038410183 scopus 로고    scopus 로고
    • An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress
    • Bonnefont-Rousselot D, Raji B, Walrand S, et al. An intracellular modulation of free radical production could contribute to the beneficial effects of metformin towards oxidative stress. Metabolism 2003;52:586-9
    • (2003) Metabolism , vol.52 , pp. 586-589
    • Bonnefont-Rousselot, D.1    Raji, B.2    Walrand, S.3
  • 27
    • 0034527379 scopus 로고    scopus 로고
    • Effect of four-week metformin treatment on plasma and erythrocyte antioxidative defense enzymes in newly diagnosed obese patients with type 2 diabetes
    • Pavlovic D, Kocic R, Kocic G, et al. Effect of four-week metformin treatment on plasma and erythrocyte antioxidative defense enzymes in newly diagnosed obese patients with type 2 diabetes. Diabetes Obes Metab 2000;2:251-6
    • (2000) Diabetes Obes Metab , vol.2 , pp. 251-256
    • Pavlovic, D.1    Kocic, R.2    Kocic, G.3
  • 28
    • 28544441286 scopus 로고    scopus 로고
    • The effects of rosiglitazone and metformin on oxidative stres and homocysteine levels in lean patients with polycystic ovary syndrome
    • Yilmaz M, Bukan N, Ayvaz G. The effects of rosiglitazone and metformin on oxidative stres and homocysteine levels in lean patients with polycystic ovary syndrome. Hum Reprod 2005;20: 3333-40
    • (2005) Hum Reprod , vol.20 , pp. 3333-3340
    • Yilmaz, M.1    Bukan, N.2    Ayvaz, G.3
  • 29
    • 0030838509 scopus 로고    scopus 로고
    • Plasma malondialdehyde as biomarker for oxidative stress: Reference interval and effects of life-style factors
    • Nielsen F, Mikkelsen BB, Nielsen JB, et al. Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clin Chem 1997;43:1209-14
    • (1997) Clin Chem , vol.43 , pp. 1209-1214
    • Nielsen, F.1    Mikkelsen, B.B.2    Nielsen, J.B.3
  • 30
    • 29144485802 scopus 로고    scopus 로고
    • Decreased serum paraoxonase 1 (PON1) activity: An additional risk factor for atherosclerotic heart disease in patients with PCOS?
    • Dursun P, Demirtas E, Bayrak A, Yarali H. Decreased serum paraoxonase 1 (PON1) activity: an additional risk factor for atherosclerotic heart disease in patients with PCOS? Hum Reprod 2006;21:104-8
    • (2006) Hum Reprod , vol.21 , pp. 104-108
    • Dursun, P.1    Demirtas, E.2    Bayrak, A.3    Yarali, H.4
  • 31
    • 38449101187 scopus 로고    scopus 로고
    • Paraoxonase levels in women with polycystic ovary syndrome
    • Fenkci IV, Serteser M, Fenkci S, Kose S. Paraoxonase levels in women with polycystic ovary syndrome. J Reprod Med 2007;52: 879-83
    • (2007) J Reprod Med , vol.52 , pp. 879-883
    • Fenkci, I.V.1    Serteser, M.2    Fenkci, S.3    Kose, S.4
  • 32
    • 0037375932 scopus 로고    scopus 로고
    • Expression of major HDL-associated antioxidant
    • Bin Ali A, Zhang Q, Lim YK, et al. Expression of major HDL-associated antioxidant. Free Radic Biol Med 2003;34:824-9
    • (2003) Free Radic Biol Med , vol.34 , pp. 824-829
    • Bin Ali, A.1    Zhang, Q.2    Lim, Y.K.3
  • 33
    • 0025947444 scopus 로고
    • Atherogenic effects of anabolic steroids on serum lipid levels. A literature review
    • Glazer G. Atherogenic effects of anabolic steroids on serum lipid levels. A literature review. Arch Int Med 1991;151:1925-33
    • (1991) Arch Int Med , vol.151 , pp. 1925-1933
    • Glazer, G.1
  • 34
    • 34548400893 scopus 로고    scopus 로고
    • Effect of metformin on serum lipoprotein lipase mass levels and LDL particle size in type 2 diabetes mellitus patients
    • Ohira M, Miyashita Y, Ebisuno M. Effect of metformin on serum lipoprotein lipase mass levels and LDL particle size in type 2 diabetes mellitus patients. Diabetes Res Clin Pract 2007;78: 34-41
    • (2007) Diabetes Res Clin Pract , vol.78 , pp. 34-41
    • Ohira, M.1    Miyashita, Y.2    Ebisuno, M.3
  • 35
    • 33745183175 scopus 로고    scopus 로고
    • Cardiovascular risk in women with polycystic ovary syndrome
    • Orio F, Palomba S, Colao A. Cardiovascular risk in women with polycystic ovary syndrome. Fertil Steril 2006;86:S20-1
    • (2006) Fertil Steril , vol.86
    • Orio, F.1    Palomba, S.2    Colao, A.3
  • 36
    • 19944426044 scopus 로고    scopus 로고
    • The increase of leukocytes as a new putative marker of low-grade chronic inflammation and early cardiovascular risk in polycystic ovary syndrome
    • Orio Jr F, Palomba S, Cascella T, et al. The increase of leukocytes as a new putative marker of low-grade chronic inflammation and early cardiovascular risk in polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:2-5
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2-5
    • Orio Jr., F.1    Palomba, S.2    Cascella, T.3
  • 37
    • 34547406316 scopus 로고    scopus 로고
    • Metformin administration improves leukocyte count in women with polycystic ovary syndrome: A 6-month prospective study
    • Orio F, Manguso F, Di Biase S, et al. Metformin administration improves leukocyte count in women with polycystic ovary syndrome: a 6-month prospective study. Eur J Endocrinol 2007;157: 69-73.
    • (2007) Eur J Endocrinol , vol.157 , pp. 69-73
    • Orio, F.1    Manguso, F.2    Di Biase, S.3


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