Characterization of salivary proteins of schizophrenic and bipolar disorder patients by top-down proteomics

Journal of Proteomics

Volumn 103, Issue , 2014, Pages 15-22

  Iavarone, Federica ^a   Melis, Marianna ^b   Platania, Giovanna ^b   Cabras, Tiziana ^c   Manconi, Barbara ^c   Petruzzelli, Raffaele ^d   Cordaro, Massimo ^a   Siracusano, Alberto ^b   Faa, Gavino ^e   Messana, Irene ^c   Zanasi, Marco ^b   Castagnola, Massimo ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c Dip di Scienze della Vita e dell'Ambiente Sezione di Biochimica e Biologia Molecolare Università di Cagliari   (Italy)

^d UNIVERSITY OF CHIETI   (Italy)

^e UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Alpha defensins; Bipolar disorder; Cystatins; S100 A12; Schizophrenia; Whole saliva

Indexed keywords

ALPHA DEFENSIN; ALPHA DEFENSIN 1; ALPHA DEFENSIN 2; ALPHA DEFENSIN 3; ALPHA DEFENSIN 4; CYSTATIN B; CYSTATIN B CYSTEINYL; CYSTATIN B GLUTATHIONYL; PROTEIN S 100; S100A12 PROTEIN; SALIVA PROTEIN; STEFIN A; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CYSTATIN; S100A12 PROTEIN, HUMAN;

ADULT; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEOMICS; SCHIZOPHRENIA; SMOKING; CHEMISTRY; INNATE IMMUNITY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALPHA-DEFENSINS; BIOLOGICAL MARKERS; BIPOLAR DISORDER; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYSTATINS; HUMANS; IMMUNITY, INNATE; PROTEOMICS; S100 PROTEINS; SALIVARY PROTEINS AND PEPTIDES; SCHIZOPHRENIA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84898842298     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2014.03.020     Document Type: Article

References (29)

1. Holmes E., Tsang T.M., Huang J.T., Leweke F.M., Koethe D., Gerth C.W., et al. Metabolic profiling of CSF: evidence that early intervention may impact on disease progression and outcome in schizophrenia. PLoS Med 2006, 3:1420-1428.
2. Hope S., Ueland T., Steen N.E., Dieset I., Lorentzen S., Berg A.O., et al. Interleukin 1 receptor antagonist and soluble tumor necrosis factor receptor 1 are associated with general severity and psychotic symptoms in schizophrenia and bipolar disorder. Schizophr Res 2013, 145:36-42.
3. Dickerson F., Stallings C., Origoni A., Vaughan C., Khushalani S., Yang S., et al. C-reactive protein is elevated in schizophrenia. Schizophr Res 2013, 143:198-202.
4. Dickerson F., Stallings C., Origoni A., Vaughan C., Khushalani S., Yolken R. Elevated C-reactive protein and cognitive deficits in individuals with bipolar disorder. J Affect Disord 2013, 150:456-459.
5. Martins-de-Souza D., Guest P.C., Rahmoune H., Bahn S. Proteomic approaches to unravel the complexity of schizophrenia. Expert Rev Proteomics 2012, 9:97-108.
6. Craddock R.M., Huang J.T., Jackson E., Harris N., Torrey E.F., Herberth M., et al. Increased alpha-defensins as a blood marker for schizophrenia susceptibility. Mol Cell Proteomics 2008, 7:1204-1213.
7. Tabak L.A. Point-of-care diagnostics enter the mouth. Ann N Y Acad Sci 2007, 1098:7-14.
8. Castagnola M., Inzitari R., Fanali C., Iavarone F., Vitali A., Desiderio C., et al. The surprising composition of the salivary proteome of preterm human newborn. Mol Cell Proteomics 2011, 10. [M110.003467].
9. Castagnola M., Cabras T., Iavarone F., Vincenzoni F., Vitali A., Pisano E., et al. Top-down platform for deciphering the human salivary proteome. J Matern Fetal Neonatal Med 2012, 25:27-43.
10. Messana I., Cabras T., Iavarone F., Vincenzoni F., Urbani A., Castagnola M. Unraveling the different proteomic platforms. J Sep Sci 2013, 36:128-139.
11. Whitelegge J.P., Zabrouskov V., Halgand F., Souda P., Bassilian S., Yan W., et al. Protein-sequence polymorphisms and post-translational modifications in proteins from human saliva using top-down Fourier-transform ion cyclotron resonance mass spectrometry. Int J Mass Spectrom 2007, 268:190-197.
12. Halgand F., Zabrouskov V., Bassilian S., Souda P., Wong D.T., Loo J.A., et al. Micro-heterogeneity of human saliva Peptide P-C characterized by high-resolution top-down Fourier-transform mass spectrometry. J Am Soc Mass Spectrom 2010, 21:868-877.
13. Halgand F., Zabrouskov V., Bassilian S., Souda P., Loo J.A., Faull K.F., et al. Defining intact protein primary structures from saliva: a step toward the human proteome project. Anal Chem 2012, 84:4383-4395.
14. Peng Y., Chen X., Sato T., Rankin S.A., Tsuji R.F., Ge Y. Purification and high-resolution top-down mass spectrometric characterization of human salivary α-amylase. Anal Chem 2012, 84:3339-3346.
15. Cabras T., Manconi B., Iavarone F., Fanali C., Nemolato S., Fiorita A., et al. RP-HPLC-ESI-MS evidenced that salivary cystatin B is detectable in adult human whole saliva mostly as S-modified derivatives: S-glutathionyl, S-cysteinyl and S-S 2-mer. J Proteomics 2012, 75:908-913.
16. Zhang Z., Marshall A.G. A universal algorithm for fast and automated charge state deconvolution of electrospray mass-to-charge ratio spectra. J Am Soc Mass Spectrom 1998, 9:225-233.
17. Levin Y., Schwarz E., Wang L., Leweke F.M., Bahn S. Label-free LC-MS/MS quantitative proteomics for large-scale biomarker discovery in complex samples. J Sep Sci 2007, 30:2198-2203.
18. Pisano E., Cabras T., Montaldo C., Piras V., Inzitari R., Olmi C., et al. Peptides of human gingival crevicular fluid determined by HPLC-ESI-MS. Eur J Oral Sci 2005, 113:462-468.
19. Castagnola M., Cabras T., Iavarone F., Fanali C., Messana I. Detection of Ca2+-binding S100 proteins in human saliva by HPLC-ESI-MS. Methods Mol Biol 2013, 963:357-371.
20. Lehrer R.I., Lu W. α-Defensins in human innate immunity. Immunol Rev 2012, 245:84-112.
21. Agerberth B., Charo J., Werr J., Olsson B., Idali F., Lindbom L., et al. The human antimicrobial and chemotactic peptides LL-37 and apha-defensins are expressed by specific lymphocyte and monocyte populations. Blood 2000, 96:3086-3093.
22. Chalifour A., Jeannin P., Gauchat J.F., Blaecke A., Malissard M., N'Guyen T., et al. Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production. Blood 2004, 104:1778-1783.
23. Grigat J., Soruri A., Forssmann U., Riggert J., Zwirner J. Chemoattraction of macrophages, T lymphocytes, and mast cells is evolutionarily conserved within the human alpha-defensin family. J Immunol 2007, 179:3958-3965.
24. Harwig S.S., Park A.S., Lehrer R.I. Characterization of defensin precursors in mature human neutrophils. Blood 1992, 79:1532-1537.
25. Foell D., Wittkowski H., Vogl T., Roth J. S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol 2007, 81:28-37.
26. Tang Y., Xu H., Du X., Lit L., Walker W., Lu A., et al. Gene expression in blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. J Cereb Blood Flow Metab 2006, 26:1089-1102.
27. Pietzsch J., Hoppmann S. Human S100A12: a novel key player in inflammation?. Amino Acids 2009, 36:381-389.
28. Turk V., Stoka V., Turk D. Cystatins: biochemical and structural properties, and medical relevance. Front Biosci 2008, 13:5406-5420.
29. Magister S., Kos J. Cystatins in immune system. J Cancer 2013, 4:45-56.