Effects of Hg(II) Exposure on MAPK Phosphorylation and Antioxidant System in D. melanogaster

Environmental Toxicology

Volumn 29, Issue 6, 2014, Pages 621-630

  Paula, M T ^a   Zemolin, A P ^b   Vargas, A P ^a   Golombieski, R M ^a   Loreto, E L S ^a   Saidelles, A P ^b   Picoloto, R S ^a   Flores, E M M ^a   Pereira, A B ^b   Rocha, J B T ^a   Merritt, T J S ^c   Franco, J L ^b   Posser, T ^b  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b UNIVERSIDADE FEDERAL DO PAMPA   (Brazil)

^c LAURENTIAN UNIVERSITY   (Canada)

Author keywords

Antioxidant defenses; Drosophila melanogaster; MAPKs; Mercury; PARP

Indexed keywords

ANIMALS; ANTIOXIDANTS; CELL DEATH; ENZYMES; GENE EXPRESSION; HEAVY METALS; OXYGEN; PHOSPHORYLATION; TOXICITY;

ANTIOXIDANT DEFENSE; BIOCHEMICAL PARAMETERS; DROSOPHILA MELANOGASTER; GLUTATHIONE-S-TRANSFERASE; MAPKS; PARP; SUPEROXIDE DISMUTASE ACTIVITIES; TRANSCRIPTIONAL FACTORS;

MERCURY (METAL);

ACETYLCHOLINESTERASE; ANTIOXIDANT; CATALASE; GLUTATHIONE TRANSFERASE; MERCURY CHLORIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2;

ANTIOXIDANT; APOPTOSIS; BIOCHEMISTRY; ECOTOXICOLOGY; ENZYME ACTIVITY; FLY; INHIBITION; LOCOMOTION; MERCURY (ELEMENT); MORTALITY; POLLUTION EFFECT; POLLUTION EXPOSURE; SURVIVAL; TAXIS;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; LOCOMOTION; MOLECULAR MECHANICS; MORTALITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SURVIVAL; TREATMENT RESPONSE; UPREGULATION;

DROSOPHILA MELANOGASTER; INVERTEBRATA; VERTEBRATA;

ANTIOXIDANT DEFENSES; DROSOPHILA MELANOGASTER; MAPKS; MERCURY; PARP;

ACETYLCHOLINESTERASE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; DROSOPHILA MELANOGASTER; GLUTATHIONE TRANSFERASE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPID PEROXIDATION; LOCOMOTION; MAP KINASE SIGNALING SYSTEM; MERCURIC CHLORIDE; MERCURY; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; SUPEROXIDE DISMUTASE;

EID: 84898838457     PISSN: 15204081     EISSN: 15227278     Source Type: Journal    
DOI: 10.1002/tox.21788     Document Type: Article

References (49)

1. Aebi H. 1984. Catalase in Vitro. Methods Enzymol. 105:121-126.
2. Ahamed M, Posgai R, Gorey TJ, Nielsen M, Hussain SM, Rowe JJ. 2010. Silver nanoparticles induced heat shock protein 70, oxidative stress and apoptosis in Drosophila melanogaster. Toxicol Appl Pharmacol 242:263-269.
3. Alattia JR, Kuraishi T, Dimitrov M, Chang I, Lemaitre B, Fraering PC. 2011. Mercury is a direct and potent-secretase inhibitor affecting Notch processing and development in Drosophila. FASEB J 25:2287-2295.
4. Balamurugan K, Hua H, Georgiev O, Schaffner W. 2009. Mercury and cadmium trigger expression of the copper importer Ctr1B, which enables Drosophila to thrive on heavy metal-loaded food. Biol Chem 390:109-113.
5. Bonilla-Ramirez L, Jimenez-Del-Rio M, Velez-Pardo C. 2011. Acute and chronic metal exposure impairs locomotion activity in Drosophila melanogaster: A model to study Parkinsonism. Biometals 24:1045-1057.
6. Bradford MM. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 7:248-254.
7. Carmona ER, Kossatz E, Creus A, Marcos R. 2008. Genotoxic evaluation of two mercury compounds in the Drosophila wing spot test. Chemosphere 70:1910-1914.
8. Ceccatelli S, Daré E, Moors M. 2010. Methylmercury-induced neurotoxicity and apoptosis. Chem Biol Interact 188:301-308.
9. Coulom H, Birman S. 2004. Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster. J Neurosci 24:10993-10998.
10. Ellman GL, Courtney KD, Andres VJr, Featherstone RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88-95.
11. Franco JL, Braga HC, Stringari J, Missau FC, Posser T, Mendes BG, Leal RB, Santos AR, Dafre AL, Pizzolatti MG, Farina M. 2007. Mercurial-induced hydrogen peroxide generation in mouse brain mitochondria: Protective effects of quercetin. Chem Res Toxicol 20:1919-1926.
12. Franco JL, Posser T, Dunkley PR, Dickson PW, Mattos JJ, Martins R, Bainy AC, Marques MR, Dafre AL, Farina M. 2009. Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase. Free Radic Biol Med 47:449-457.
13. Frasco MF, Colletier JP, Weik M, Carvalho F, Guilhermino L, Stojan J, Fournier D. 2007. Mechanisms of cholinesterase inhibition by inorganic mercury. FEBS J 274:1849-1861.
14. Haase H, Engelhardt G, Hebel S, Rink L. 2011. Mercuric ions inhibit mitogen-activated protein kinase dephosphorylation by inducing reactive oxygen species. Toxicol Appl Pharmacol 250:78-86.
15. Hao C, Hao W, Wei X, Xing L, Jiang J, Shang L. 2009. The role of MAPK in the biphasic dose-response phenomenon induced by cadmium and mercury in HEK293 cells. Toxicol Vitro 23:660-666.
16. Harper SJ, LoGrasso P. 2001. Signaling for survival and death in neurons: The role of stress-activated kinases, JNK and p38. Cell Signal 13:299-310.
17. Hirsch HVB, Mercer J, Sambaziotis H, Huber M, Stark DT, Torno-Morley T, Hollocher K, Ghiradella H, Ruden DM. 2003. Behavioral effects of chronic exposure to low levels of lead in Drosophila melanogaster. Neurotoxicol 24:435-442.
18. Ho Y, Logue E, Callaway CW, DeFranco DB. 2007. Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion. Neuroscience 145:248-255.
19. Jakoby WB, Habig WH. 1981. Glutathione S-transferases (rat and human). Methods Enzymol 77:218-231.
20. Jan A, Ali A, Haq Q. 2011. Glutathione as an antioxidant in inorganic mercury induced nephrotoxicity. J Postgrad Med 57:72-77.
21. Jarup L. 2003. Hazards of heavy metal contamination. Br Med Bull 68:167-182.
22. Johnson GL, Lapadat R. 2002. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912.
23. Kaercher LE, Goldschmidt F, Paniz JNG, Flores EMM, Dressler VL. 2005. Determination of inorganic and total mercury by vapor generation atomic absorption spectrometry using different temperatures of the measurement cell. Spectrochim Acta Part B 60:705-710.
24. Kaminska B. 2005. MAPK signaling pathways as molecular targets for anti-inflammatory therapy from molecular mechanisms to therapeutic benefits. Biochim Biophys Acta Protein Proteomics 1754:253-262.
25. Kostyuk VA, Potapovich AI. 1989. Superoxide-driven oxidation of quercetin and a simple sensitive assay for determination of superoxide dismutase. Biochem Int 19:1117-1124.
26. Leal RB, Ribeiro SJ, Posser T, Cordova FM, Rigon AP, Zaniboni Filho E, Bainy AC. 2006. Modulation of ERK1/2 and p38(MAPK) by lead in the cerebellum of Brazilian catfish Rhamdia quelen. Aquat Toxicol 77:98-104.
27. Leonard SS, Harris GK, Shi X. 2004. Metal-induced oxidative stress and signal transduction. Free Radic Biol Med 37:1921-1942.
28. Livak KJ, Schmittgen TD. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408.
29. Lu TH, Hsieh SY, Yen CC, Wu HC, Chen KL, Hung DZ, Chen CH, Wu CC, Su YC, Chen YW, Liu SH, Huang CF. 2011. Involvement of oxidative stress-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic signals in methylmercury-induced neuronal cell injury. Toxicol Lett 204:71-80.
30. Matsuoka M, Igisu H. 2002. Effects of heavy metals on mitogen-activated protein kinase pathways. Environ Health Prev Med 6:210-217.
31. Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358.
32. Osburn WO, Kensler TW. 2008. Nrf2 signaling: An adaptive response pathway for protection against environmental toxic insults. Mutat Res 659:31-39.
33. Pandey UB, Nichols CD. 2011. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev 63:411-436.
34. Pereira AM, Tudor C, Kanger JS, Subramaniam V, Enrique Martin-Blanco, E. 2011. Integrin-dependent activation of the JNK signaling pathway by mechanical stress. PLoS ONE 6(12):e26182. doi:10.1371/journal.pone.0026182.
35. Perez-Severiano F, Rodriguez-Perez M, Pedraza-Chaverri J, Maldonado PD, Medina-Campos ON, Ortiz-Plata A, Sanchez-Garcia A, Villeda-Hernandez J, Galvan-Arzate S, Aguilera P, Santamaria A. 2004. S-Allylcysteine, a garlic-derived antioxidant, ameliorates quinolinic acid-induced neurotoxicity and oxidative damage in rats. Neurochem Int 45:1175-1183.
36. Posgai Ryan, Cipolla-McCulloch CB, Murphy KR, Hussain SM, Rowe JJ, Nielsen MG. 2011. Differential toxicity of silver and titanium dioxide nanoparticles on Drosophila melanogaster development, reproductive effort, and viability: Size, coatings and antioxidants matter. Chemosphere 85:34-42.
37. Posser T, de Aguiar CB, Garcez RC, Rossi FM, Oliveira CS, Trentin AG, Neto VM, Leal RB. 2007. Exposure of C6 glioma cells to Pb(II) increases the phosphorylation of p38(MAPK) and JNK1/2 but not of ERK1/2. Arch Toxicol 81:407-414.
38. Posser T, Dunkley PR, Dickson PW, Franco JL. 2010. Human neuroblastoma cells transfected with tyrosine hydroxylase gain increased resistance to methylmercury-induced cell death. Toxicology in vitro: An international journal published in association with BIBRA 24:1498-1503.
39. Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR. 2009. Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells. J Neurochem 110:848-856.
40. Rand MD, Dao JC, Clason TA. 2009. Methylmercury disruption of embryonic neural development in Drosophila. Neurotoxicology 30:794-802.
41. MAPK. Neurotoxicology 29:727-734.
42. Sackton KL, Buehner NA, Wolfner MF. 2007. Modulation of MAPK activities during egg activation in Drosophila. 1:222-227.
43. Stronach BE, Perrimon N. 1999. Stress signaling in Drosophila. Oncogene 18:6172-6182.
44. Tibbles LA, Woodgett JR. 1999. The stress-activated protein kinase pathways. Cell Mol Life Sci 55:1230-1254.
45. Turney KD, Parrish AR, Orozco J, Gandolfi AJ. 1999. Selective activation in the MAPK pathway by Hg(II) in precision-cut rabbit renal cortical slices. Toxicol Appl Pharmacol 160:262-270.
46. Van der Straten A, Rommel C. 1997. The heat shock protein 83 (Hsp83) is required for Raf-mediated signaling in Drosophila. EMBO J 16:1961-1969.
47. Walters CR, Somerset VS, Leaner JJ, Nel JM. 2011. A review of mercury pollution in South Africa: Current status. J Environ Sci Health Part A 46:1129-1137.
48. Wang X, Wu Y, Zhou B. 2009. Dietary zinc absorption is mediated by ZnT1 in Drosophila melanogaster. FASEB J 23:2650-2661.
49. Zahir F, Rizwi SJ, Haqb SK, Khanb RH. 2005. Low dose mercury toxicity and human health. Environ Toxicol Pharmacol 20:351-360.