The multi-targeted kinase inhibitor sorafenib inhibits enterovirus 71 replication by regulating IRES-dependent translation of viral proteins

Antiviral Research

Volumn 106, Issue 1, 2014, Pages 80-85

  Gao, Meng ^a   Duan, Hao ^a   Liu, Jing ^a   Zhang, Hao ^a   Wang, Xin ^a   Zhu, Meng ^a   Guo, Jitao ^a   Zhao, Zhenlong ^a   Meng, Lirong ^b   Peng, Yihong ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b MACAO POLYTECHNIC INSTITUTE   (Macao)

Author keywords

Antiviral therapy; EV71; IRES; Sorafenib

Indexed keywords

CYCLOOXYGENASE 2; GENOMIC RNA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; PROTEIN VP1; SORAFENIB; PROTEIN SERINE THREONINE KINASE INHIBITOR; VIRUS ENVELOPE PROTEIN; ANTIVIRUS AGENT; CARBANILAMIDE DERIVATIVE; NICOTINAMIDE; PROTEIN KINASE INHIBITOR; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENTEROVIRUS 71; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HAND FOOT AND MOUTH DISEASE; INTERNAL RIBOSOME ENTRY SITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHABDOMYOSARCOMA; UPREGULATION; VERO CELL; VIRUS REPLICATION; WESTERN BLOTTING; CONCENTRATION (PARAMETERS); ENTEROVIRUS; GENE TRANSLOCATION; HUMAN; HUMAN CELL; PICORNAVIRUS; PROGENY; REPORTER GENE; RHABDOMYOSARCOMA CELL LINE; VIRUS STRAIN; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CELL LINE; CYTOPATHOGENIC EFFECT; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; PHYSIOLOGY; PROTEIN SYNTHESIS;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CYTOPATHOGENIC EFFECT, VIRAL; ENTEROVIRUS A, HUMAN; HUMANS; NIACINAMIDE; PHENYLUREA COMPOUNDS; PROTEIN BIOSYNTHESIS; PROTEIN KINASE INHIBITORS; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84898807292     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.03.009     Document Type: Article

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