High-dose cholecalciferol supplementation significantly increases peripheral CD4+ Tregs in healthy adults without negatively affecting the frequency of other immune cells

European Journal of Nutrition

Volumn 53, Issue 3, 2014, Pages 751-759

  Prietl, Barbara ^a   Treiber, Gerlies ^a   Mader, Julia K ^a   Hoeller, Evelyne ^a   Wolf, Michael ^a   Pilz, Stefan ^a   Graninger, Winfried B ^a   Obermayer Pietsch, Barbara M ^a   Pieber, Thomas R ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Immune regulation; Immunotherapy; Regulatory T cells; Tolerance; Vitamin D

Indexed keywords

CD4 ANTIGEN; COLECALCIFEROL; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 7 RECEPTOR; PLACEBO; TRANSCRIPTION FACTOR FOXP3; CALCIFEDIOL; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN; IMMUNOLOGICAL ADJUVANT;

ADULT; APOPTOSIS ASSAY; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; COCULTURE; CONTROLLED STUDY; DENDRITIC CELL; DOUBLE BLIND PROCEDURE; DRUG SAFETY; EX VIVO STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNOCOMPETENT CELL; IN VITRO STUDY; MALE; MONOCYTE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; RANDOMIZED CONTROLLED TRIAL; T LYMPHOCYTE; VITAMIN SUPPLEMENTATION; APOPTOSIS; AUSTRIA; BLOOD; BLOOD CELL COUNT; CELL CULTURE; CYTOLOGY; DIET SUPPLEMENTATION; DIET THERAPY; IMMUNOLOGY; LEUKOPOIESIS; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; REGULATORY T LYMPHOCYTE; VITAMIN D DEFICIENCY; YOUNG ADULT;

ANIMALIA;

ADJUVANTS, IMMUNOLOGIC; ADULT; ANTIGENS, CD4; APOPTOSIS; AUSTRIA; BLOOD CELL COUNT; CALCIFEDIOL; CELLS, CULTURED; CHOLECALCIFEROL; COCULTURE TECHNIQUES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEUKOCYTES, MONONUCLEAR; LEUKOPOIESIS; MALE; T-LYMPHOCYTES, REGULATORY; VITAMIN D DEFICIENCY; YOUNG ADULT;

EID: 84898806391     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-013-0579-6     Document Type: Article

References (40)

1. Adams JS, Hewison M (2010) Update in vitamin D. J Clin Endocrinol Metab 95:471-478. doi: 10.1210/jc.2009-1773
2. Hewison M, Gacad MA, Lemire J, Adams JS (2001) Vitamin D as a cytokine and hematopoetic factor. Rev Endocr Metab Disord 2:217-227
3. Holick MF (2007) Vitamin D deficiency. N Engl J Med 357:266-281
4. Smolders J, Thewissen M, Peelen E et al (2009) Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. PLoS ONE 4:e6635. doi: 10.1371/journal.pone.0006635
5. Takiishi T, Gysemans C, Bouillon RMC (2010) Vitamin D and diabetes. Endocrinol Metab Clin North Am 39:419-446. doi: 10.1016/j.jsbmb.2010.03.042
6. Hyppönen E (2010) Vitamin D and increasing incidence of type 1 diabetes-evidence for an association? Diabetes Obes Metab 12:737-743. doi: 10.1111/j.1463-1326.2010.01211.x
7. Littorin B, Blom P, Schölin A et al (2006) Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS). Diabetologia 49:2847-2852. doi: 10.1007/s00125-006-0426-x
8. Brusko TM, Wasserfall CH, Clare-Salzler MJ et al (2005) Functional defects and the influence of age on the frequency of CD4 + CD25 + T-cells in type 1 diabetes. Diabetes 54:1407-1414
9. Kukreja A, Cost G, Marker J et al (2002) Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest 109:131-140. doi: 10.1172/JCI13605
10. Lindley S, Dayan CM, Bishop A et al (2005) Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54:92-99
11. Marwaha AK, Crome SQ, Panagiotopoulos C et al (2010) Cutting edge: increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol 185:3814-3818. doi: 10.4049/jimmunol.1001860
12. Putnam AL, Vendrame F, Dotta F, Gottlieb PA (2005) CD4 + CD25 high regulatory T cells in human autoimmune diabetes. J Autoimmun 24:55-62. doi: 10.1016/j.jaut.2004.11.004
13. Brusko TM, Putnam AL, Bluestone JA (2008) Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol Rev 223:371-390. doi: 10.1111/j.1600-065X.2008.00637.x
14. Monti P, Scirpoli M, Maffi P et al (2008) Rapamycin monotherapy in patients with Type 1 diabetes modifies CD4 + CD25 + FOXP3 + regulatory T-cells. Diabetes 57:2341-2347. doi: 10.2337/db08-0138.E.B
15. Notley CA, McCann FE, Inglis JJ, Williams RO (2010) ANTI-CD3 therapy expands the numbers of CD4 + and CD8 + Treg cells and induces sustained amelioration of collagen-induced arthritis. Arthritis Rheum 62:171-178. doi: 10.1002/art.25058
16. Webster KE, Walters S, Kohler RE et al (2009) In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med 206:751-760. doi: 10.1084/jem.20082824
17. Adorini L, Penna G (2009) Dendritic cell tolerogenicity: a key mechanism in immunomodulation by vitamin D receptor agonists. Hum Immunol 70:345-352. doi: 10.1016/j.humimm.2009.01.016
18. Jeffery LE, Burke F, Mura M et al (2009) 1,25-Dihydroxyvitamin D3 and IL-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP3. J Immunol 183:5458-5467. doi: 10.4049/jimmunol.0803217
19. Morales-Tirado V, Wichlan DG, Leimig TE et al (2010) 1α,25- dihydroxyvitamin D3 (vitamin D3) catalyzes suppressive activity on human natural regulatory T cells, uniquely modulates cell cycle progression, and augments FOXP3. Clin Immunol 138:212-221. doi: 10.1016/j.clim.2010.11.003
20. Smolders J, Peelen E, Thewissen M et al (2010) Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis. PLoS ONE 5:e15235. doi: 10.1371/journal.pone.0015235
21. Gabbay MAL, Sato MN, Finazzo C et al (2012) Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and decline of residual β-cell function in new-onset type 1 diabetes mellitus. Arch Pediatr Adolesc Med 166:601-607. doi: 10.1001/archpediatrics.2012.164
22. Khoo A-L, Koenen HJPM, Chai LYA et al (2012) Seasonal variation in vitamin D3 levels is paralleled by changes in the peripheral blood human T cell compartment. PLoS ONE 7:e29250. doi: 10.1371/journal.pone.0029250
23. Prietl B, Pilz S, Wolf M et al (2010) Vitamin D supplementation and regulatory T cells in apparently healthy subjects: vitamin D treatment for autoimmune diseases? Isr Med Assoc J 12:136-139
24. Konradsen S, Ag H, Lindberg F et al (2008) Serum 1, 25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr 47:87-91. doi: 10.1007/s00394-008-0700-4
25. Roederer M (2002) Compensation in flow cytometry. Curr Protoc Cytom 1.14.1-1.14.20. doi: 10.1002/0471142956.cy0114s22
26. Toss G, Magnusson P (2012) Is a daily supplementation with 40 microgram vitamin D3 sufficient? A randomised controlled trial. Eur J Nutr 51:939-945. doi: 10.1007/s00394-011-0271-7
27. Khoo A-L, Joosten I, Michels M et al (2011) 1,25-dihydroxyvitamin D3 inhibits proliferation but not the suppressive function of regulatory T cells in the absence of antigen-presenting cells. Immunology 134:459-468. doi: 10.1111/j.1365-2567.2011.03507.x
28. Gregori S, Giarratana N, Smiroldo S et al (2002) A 1,25-dihydroxyvitamin D3 analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes 51:1367-1374. doi: 10.2337/diabetes.51.5.1367
29. Gorman S, Judge MA, Burchell JT et al (2010) 1,25-dihydroxyvitamin D3 enhances the ability of transferred CD4 + CD25 + cells to modulate T helper type 2-driven asthmatic responses. Immunology 130:181-192. doi: 10.1111/j.1365-2567. 2009.03222.x
30. Gorman S, Kuritzky LA, Judge MA et al (2007) Topically applied 1,25-dihydroxyvitamin D3 enhances the suppressive activity of CD4 + CD25 + cells in the draining lymph nodes. J Immunol 179:6273-6283
31. Adorini L, Penna G (2008) Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 4:404-412. doi: 10.1038/ncprheum0855
32. Mohr SB, Garland CF, Gorham ED, Garland FC (2008) The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia 51:1391-1398. doi: 10.1007/s00125-008-1061-5
33. Munger KL, Zhang SM, O'Reilly E et al (2004) Vitamin D intake and incidence of multiple sclerosis. Neurology 62:60-65
34. Merlino LA, Curtis J, Mikuls TR et al (2004) Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study. Arthritis Rheum 50:72-77. doi: 10.1002/art.11434
35. Tran TA, Goër De, de Herve M-G, Hendel-Chavez H et al (2008) Resting regulatory CD4 T cells: a site of HIV persistence in patients on long-term effective antiretroviral therapy. PLoS ONE 3:e3305. doi: 10.1371/journal.pone. 0003305
36. Hewison M (2010) Vitamin D and the intracrinology of innate immunity. Mol Cell Endocrinol 321:103-111. doi: 10.1016/j.mce.2010.02.013
37. Smolders J, Menheere P, Thewissen M et al (2010) Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis. J Steroid Biochem Mol Biol 121:243-246. doi: 10.1016/j.jsbmb.2010.03.001
38. Xystrakis E, Kusumakar S, Boswell S et al (2006) Reversing the defective induction of IL-10 - secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest 116:146-155. doi: 10.1172/JCI21759.146
39. Buckner JH (2010) Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol 10:849-859. doi: 10.1038/nri2889
40. Leslie M (2011) Regulatory T cells get their chance to shine. Science 332:1020-1021