Correlation of missed doses of enoxaparin with increased incidence of deep vein thrombosis in trauma and general surgery patients

JAMA Surgery

Volumn 149, Issue 4, 2014, Pages 365-370

  Louis, Scott G ^a   Sato, Misa ^a   Geraci, Travis ^a   Anderson, Ross ^a   Cho, S David ^a   Van, Philbert Y ^a   Barton, Jeffrey S ^a   Riha, Gordon M ^a   Underwood, Samantha ^a   Differding, Jerome ^a   Watters, Jennifer M ^a   Schreiber, Martin A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENOXAPARIN; FIBRINOGEN;

ADULT; ARTICLE; ARTIFICIAL VENTILATION; BIVARIATE ANALYSIS; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATIONAL STUDY; DEEP VEIN THROMBOSIS; ECHOGRAPHY; FEMALE; GENERAL SURGERY; HUMAN; INCIDENCE; INTERNATIONAL NORMALIZED RATIO; MALE; PARTIAL THROMBOPLASTIN TIME; PATIENT SELECTION; POPULATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; THROMBOCYTE COUNT; TRAUMATIC BRAIN INJURY; UNIVARIATE ANALYSIS;

ANTICOAGULANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENOXAPARIN; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MALE; MIDDLE AGED; OREGON; PROSPECTIVE STUDIES; RISK FACTORS; SURGICAL PROCEDURES, OPERATIVE; TRAUMA CENTERS; TREATMENT OUTCOME; VENOUS THROMBOSIS; WOUNDS AND INJURIES;

EID: 84898792986     PISSN: 21686254     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamasurg.2013.3963     Document Type: Article

References (19)

1. Guyatt GH, Akl EA, Crowther M, Schünemann HJ, Gutterman DD, Zelman Lewis S; American College of Chest Physicians. Introduction to the ninth edition: antithrombotic therapy and prevention of thrombosis: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2012;141(2) (suppl):48S-52S.
2. Cook DJ, Crowther MA, Meade MO, Douketis J; VTE in the ICUWorkshop Participants. Prevalence, incidence, and risk factors for venous thromboembolism in medical-surgical intensive care unit patients. J Crit Care. 2005;20(4):309-313.
3. Shorr AF, Ramage AS. Enoxaparin for thromboprophylaxis after major trauma: potential cost implications. Crit Care Med. 2001;29(9):1659- 1665.
4. O'Malley KF, Ross SE. Pulmonary embolism in major trauma patients. J Trauma. 1990;30(6):748-750.
5. Geerts WH, Bergqvist D, Pineo GF, et al American College of Chest Physicians. Prevention of venous thromboembolism: American College of Chest Physicians evidence-based clinical practice guidelines (8th Edition). Chest. 2008;133(6)(suppl): 381S-453S.
6. Geerts WH, Code KI, Jay RM, Chen E, Szalai JP. A prospective study of venous thromboembolism after major trauma. N Engl J Med. 1994;331(24):1601-1606.
7. O'Brien JA, Caro JJ. Direct medical cost of managing deep vein thrombosis according to the occurrence of complications. Pharmacoeconomics. 2002;20(9):603-615.
8. Rasmussen MS, Jørgensen LN, Wille-Jørgensen P. Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery. Cochrane Database Syst Rev. 2009;(1):CD004318.
9. Gould MK, Garcia DA,Wren SM, et al American College of Chest Physicians. Prevention of VTE in nonorthopedic surgical patients: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines [published correction appears in Chest. 2012;141(5):1369]. Chest. 2012;141(2)(suppl):e227Se277S. doi:10.1378/chest.11-2297.
10. Kanaan AO, SilvaMA, Donovan JL, Roy T, Al-Homsi AS.Meta-analysis of venous thromboembolism prophylaxis in medically ill patients. Clin Ther. 2007;29(11):2395-2405.
11. Salottolo K, Offner P, Levy AS, Mains CW, Slone DS, Bar-Or D. Interrupted pharmacologic thromboprophylaxis increases venous thromboembolism in traumatic brain injury. J Trauma. 2011;70(1):19-24.
12. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65(4):748-754.
13. Schols SE, Lancé MD, FeijgeMA, et al. Impaired thrombin generation and fibrin clot formation in patients with dilutional coagulopathy during major surgery. Thromb Haemost. 2010;103(2):318-328.
14. Lustenberger T, Relja B, Puttkammer B, et al. Activated thrombin-activatable fibrinolysis inhibitor (TAFIa) levels are decreased in patients with trauma-induced coagulopathy. Thromb Res. 2013;131(1):e26-e30. doi:10.1016/j.thromres.2012.11.005.
15. Knudson MM, Morabito D, Paiement GD, Shackleford S. Use of low molecular weight heparin in preventing thromboembolism in trauma patients. J Trauma. 1996;41(3):446-459.
16. Goldhaber SZ, Bounameaux H. Pulmonary embolism and deep vein thrombosis. Lancet. 2012;379(9828):1835-1846.
17. Reitsma PH, Versteeg HH, Middeldorp S. Mechanistic view of risk factors for venous thromboembolism. Arterioscler Thromb Vasc Biol. 2012;32(3):563-568.
18. Allman-Farinelli MA. Obesity and venous thrombosis: a review. Semin Thromb Hemost. 2011;37(8):903-907.
19. Haut ER, Chang DC, Pierce CA, et al. Predictors of posttraumatic deep vein thrombosis (DVT): hospital practice versus patient factors: an analysis of the National Trauma Data Bank (NTDB). J Trauma. 2009;66(4):994-1001.