Thalidomide influences atherogenesis in aortas of ApoE-/-/ LDLR-/- double knockout mice: A nano-CT study

International Journal of Cardiovascular Imaging

Volumn 30, Issue 4, 2014, Pages 795-802

  Kampschulte, Marian ^a   Gunkel, Irina ^a   Stieger, Philipp ^a,b   Sedding, Daniel G ^a,c   Brinkmann, Anne ^a   Ritman, Erik L ^d   Krombach, Gabriele A ^a   Langheinrich, Alexander C ^e  

^a UNIVERSITY HOSPITAL GIESSEN   (Germany)

^b UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d MAYO GRADUATE SCHOOL   (United States)

^e BG Unfallklinik Frankfurt Am Main   (Germany)

Author keywords

Angiogenesis; Atherosclerosis; Nano CT; Thalidomide; Vasa vasorum

Indexed keywords

APOENZYME; THALIDOMIDE; ANGIOGENESIS INHIBITOR; APOLIPOPROTEIN E; LOW DENSITY LIPOPROTEIN RECEPTOR;

ANIMAL EXPERIMENT; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC PLAQUE; CELL MIGRATION ASSAY; CELL PROLIFERATION; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; DESCENDING AORTA; DIET; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN CORONARY ARTERY ENDOTHELIAL CELL; IMAGE ANALYSIS; KNOCKOUT MOUSE; MALE; MOUSE; NANOFOCUSED COMPUTED TOMOGRAPHY; NANOIMAGING; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; VASA VASORUM; ANIMAL; AORTA; AORTA DISEASE; AORTOGRAPHY; ATHEROSCLEROSIS; CELL CULTURE; CELL MOTION; COMPUTER ASSISTED TOMOGRAPHY; DEFICIENCY; DISEASE COURSE; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; NANOTECHNOLOGY; PATHOLOGY; PROCEDURES; RADIOGRAPHY; TIME;

ANGIOGENESIS INHIBITORS; ANIMALS; AORTA; AORTIC DISEASES; AORTOGRAPHY; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; ENDOTHELIAL CELLS; HUMANS; MALE; MICE; MICE, KNOCKOUT; NANOTECHNOLOGY; NEOVASCULARIZATION, PATHOLOGIC; PLAQUE, ATHEROSCLEROTIC; RECEPTORS, LDL; THALIDOMIDE; TIME FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84898786946     PISSN: 15695794     EISSN: 15730743     Source Type: Journal    
DOI: 10.1007/s10554-014-0380-5     Document Type: Article

References (20)

1. Mulligan-Kehoe MJ (2010) The vasa vasorum in diseased and nondiseased arteries. Am J Physiol Heart Circ Physiol 298(2):H295-H305
2. Kolodgie FD, Gold HK, Burke AP, Fowler DR, Kruth HS, Weber DK, Farb A, Guerrero LJ, Hayase M, Kutys R, Narula J, Finn AV, Virmani R (2003) Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med 349(24):2316-2325 (Pubitemid 37509739)
3. Moreno PR, Purushothaman KR, Fuster V, Echeverri D, Truszczynska H, Sharma SK, Badimon JJ, O'Connor WN (2004) Plaque neovascularization is increased in ruptured atherosclerotic lesions of human aorta: implications for plaque vulnerability. Circulation 110(14):2032-2038 (Pubitemid 39331918)
4. Kampschulte M, Brinkmann A, Stieger P, Sedding DG, Dierkes C, Bohle RM, Krombach G, Ritman EL, Langheinrich AC (2010) Quantitative CT imaging of the spatio-temporal distribution patterns of vasa vasorum in aortas of apoE-/-/LDL-/- double knockout mice. Atherosclerosis 212(2):444-450
5. D'Amato RJ, Loughnan MS, Flynn E, Folkman J (1994) Thalidomide is an inhibitor of angiogenesis. Proc Natl Acad Sci USA 91(9):4082-4085 (Pubitemid 24139577)
6. Witzig TE, Laumann KM, Lacy MQ, Hayman SR, Dispenzieri A, Kumar S, Reeder CB, Roy V, Lust JA, Gertz MA, Greipp PR, Hassoun H, Mandrekar SJ, Rajkumar SV (2013) A phase III randomized trial of thalidomide plus zoledronic acid versus zoledronic acid alone in patients with asymptomatic multiple myeloma. Leukemia 27(1):220-225
7. Chen M, Doherty SD, Hsu S (2010) Innovative uses of thalidomide. Dermatol Clin 28(3):577-586
8. Chew M, Zhou J, Daugherty A, Eriksson T, Ellermann-Eriksen S, Hansen PR, Falk E (2003) Thalidomide inhibits early atherogenesis in apoE-deficient mice. APMIS Suppl 109:113-116 (Pubitemid 36723742)
9. Gossl M, Herrmann J, Tang H, Versari D, Galili O, Mannheim D, Rajkumar SV, Lerman LO, Lerman A (2009) Prevention of vasa vasorum neovascularization attenuates early neointima formation in experimental hypercholesterolemia. Basic Res Cardiol 104(6):695-706
10. Moreira AL, Wang J, Sarno EN, Kaplan G (1997) Thalidomide protects mice against LPS-induced shock. Braz J Med Biol Res 30(10):1199-1207
11. Ito T, Ando H, Suzuki T, Ogura T, Hotta K, Imamura Y, Yamaguchi Y, Handa H (2010) Identification of a primary target of thalidomide teratogenicity. Science 327(5971):1345-1350
12. Ishikawa M, Kanno S, Takayanagi M, Takayanagi Y, Sasaki K (1998) Thalidomide promotes the release of tumor necrosis factor-alpha (TNF-alpha) and lethality by lipopolysaccharide in mice. Biol Pharm Bull 21(6):638-640 (Pubitemid 28317325)
13. Kawai T, Watanabe N, Yokoyama M, Arai K, Oana S, Harayama S, Yasui K, Oh-Ishi T, Onodera M (2013) Thalidomide attenuates excessive inflammation without interrupting lipopolysaccharide-driven inflammatory cytokine production in chronic granulomatous disease. Clin Immunol 147(2):122-128
14. Yasui K, Yashiro M, Tsuge M, Manki A, Takemoto K, Yamamoto M, Morishima T (2010) Thalidomide dramatically improves the symptoms of early-onset sarcoidosis/Blau syndrome: its possible action and mechanism. Arthritis Rheum 62(1):250-257
15. Bauer SM, Bauer RJ, Velazquez OC (2005) Angiogenesis, vasculogenesis, and induction of healing in chronic wounds. Vasc Endovascular Surg 39(4):293-306 (Pubitemid 41061696)
16. Marks MG, Shi J, Fry MO, Xiao Z, Trzyna M, Pokala V, Ihnat MA, Li PK (2002) Effects of putative hydroxylated thalidomide metabolites on blood vessel density in the chorioallantoic membrane (CAM) assay and on tumor and endothelial cell proliferation. Biol Pharm Bull 25(5):597-604 (Pubitemid 39663255)
17. Kumar S, Witzig TE, Dispenzieri A, Lacy MQ, Wellik LE, Fonseca R, Lust JA, Gertz MA, Kyle RA, Greipp PR, Rajkumar SV (2004) Effect of thalidomide therapy on bone marrow angiogenesis in multiple myeloma. Leukemia 18(3):624-627 (Pubitemid 38425879)
18. Langheinrich AC, Sedding DG, Kampschulte M, Moritz R, Wilhelm J, Haberbosch WG, Ritman EL, Bohle RM (2009) 3-Deazaadenosine inhibits vasa vasorum neovascularization in aortas of ApoE(-/-)/LDL(-/-) double knockout mice. Atherosclerosis 202(1):103-110
19. Moulton KS, Vakili K, Zurakowski D, Soliman M, Butterfield C, Sylvin E, Lo KM, Gillies S, Javaherian K, Folkman J (2003) Inhibition of plaque neovascularization reduces macrophage accumulation and progression of advanced atherosclerosis. Proc Natl Acad Sci USA 100(8):4736-4741 (Pubitemid 36457799)
20. Langheinrich AC, Michniewicz A, Sedding DG, Walker G, Beighley PE, Rau WS, Bohle RM, Ritman EL (2006) Correlation of vasa vasorum neovascularization and plaque progression in aortas of apolipoprotein E(-/-)/low-density lipoprotein(-/-) double knockout mice. Arterioscler Thromb Vasc Biol 26(2):347-352 (Pubitemid 43732198)