Effects of clonidine in women with fecal incontinence

Clinical Gastroenterology and Hepatology

Volumn 12, Issue 5, 2014, Pages

  Bharucha, Adil E ^a   Fletcher, Joel G ^a   Camilleri, Michael ^a   Edge, Jessica ^a   Carlson, Paula ^a   Zinsmeister, Alan R ^a  

^a MAYO CLINIC   (United States)

Author keywords

FICA; IBS; MRI; Randomized Controlled Trial; Stool Consistency

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR; CLONIDINE; LOPERAMIDE; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; PLACEBO;

ADULT; ANORECTAL PRESSURE; ANORECTAL SENSATION; ANUS INJURY; ANUS SPHINCTER; ARTICLE; BAROSTAT; BRISTOL STOOL FORM SCORE; CLINICAL ARTICLE; CONSTIPATION ASSESSMENT SYMPTOM SEVERITY SCORE; CONTROLLED STUDY; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DROWSINESS; FATIGUE; FECES INCONTINENCE; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HUMAN; INTESTINE FUNCTION; IRRITABLE COLON; LOOSE FECES; MANOMETRY; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NUCLEAR MAGNETIC RESONANCE IMAGING; OUTCOME ASSESSMENT; PATIENT SATISFACTION; PERCEPTIVE THRESHOLD; PROSPECTIVE STUDY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RECTAL COMPLIANCE; ROCKWOOD SYMPTOM SEVERITY SCORE; SCORING SYSTEM; SENSORIMOTOR FUNCTION; VISUAL ANALOG SCALE; XEROSTOMIA; ADOLESCENT; AGED; ANAL CANAL; FECAL INCONTINENCE; MIDDLE AGED; ORAL DRUG ADMINISTRATION; PHYSIOLOGY; TREATMENT OUTCOME; YOUNG ADULT;

ADMINISTRATION, ORAL; ADOLESCENT; ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; AGED; ANAL CANAL; CLONIDINE; FECAL INCONTINENCE; FEMALE; HUMANS; MANOMETRY; MIDDLE AGED; PLACEBOS; PROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84898771108     PISSN: 15423565     EISSN: 15427714     Source Type: Journal    
DOI: 10.1016/j.cgh.2013.06.035     Document Type: Article

References (30)

1. Whitehead W.E., Bharucha A.E. Diagnosis and treatment of pelvic floor disorders: what's new and what to do. Gastroenterology 2010, 138:1231-1235. 1235.e1-e4.
2. Bharucha A.E., Zinsmeister A.R., Locke G.R., et al. Prevalence and burden of fecal incontinence: a population based study in women. Gastroenterology 2005, 129:42-49.
3. Bharucha A.E., Zinsmeister A.R., Schleck C.D., et al. Bowel disturbances are the most important risk factors for late onset fecal incontinence: a population-based case-control study in women. Gastroenterology 2010, 139:1559-1566.
4. Bharucha A.E., Wald A.M. Anorectal disorders. Am J Gastroenterol 2010, 105:786-794.
5. Cheetham M.J., Brazzelli M., Norton C.C., et al. Drug treatment for faecal incontinence in adults. Cochrane Database Syst Rev 2003, 3:CD002116.
6. Bharucha A.E., Fletcher J.G., Harper C.M., et al. Relationship between symptoms and disordered continence mechanisms in women with idiopathic fecal incontinence. Gut 2005, 54:546-555.
7. Andrews C., Bharucha A.E., Camilleri M., et al. Rectal sensorimotor dysfunction in women with fecal incontinence. Am J Physiol Gastrointest Liver Physiol 2007, 292:G282-G289.
8. Unnerstall J.R., Kopajtic T.A., Kuhar M.J. Distribution of alpha 2 agonist binding sites in the rat and human central nervous system: analysis of some functional, anatomic correlates of the pharmacologic effects of clonidine and related adrenergic agents. Brain Res 1984, 319:69-101.
9. Bharucha A.E., Camilleri M., Zinsmeister A.R., et al. Adrenergic modulation of human colonic motor and sensory function. Am J Physiol 1997, 273:G997-G1006.
10. Malcolm A., Camilleri M., Kost L., et al. Towards identifying optimal doses for alpha-2 adrenergic modulation of colonic and rectal motor and sensory function. Aliment Pharmacol Ther 2000, 14:783-793.
11. Bharucha A.E., Seide B.M., Zinsmeister A.R. The effects of clonidine on symptoms and anorectal sensorimotor function in women with faecal incontinence. Aliment Pharmacol Ther 2010, 32:681-688.
12. Camilleri M., Kim D.-Y., McKinzie S., et al. Arandomized, controlled exploratory study of clonidine in diarrhea-predominant irritable bowel syndrome. Clin Gastroenterol Hepatol 2003, 1:111-121.
13. Kim H.J., Camilleri M., Carlson P.J., et al. Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut 2004, 53:829-837.
14. Grudell A.B.M., Camilleri M., Carlson P., et al. An exploratory study of the association of adrenergic and serotonergic genotype and gastrointestinal motor functions. Neurogastroenterol Motil 2008, 20:213-219.
15. Camilleri M., Busciglio I., Carlson P., et al. Pharmacogenetics of low dose clonidine in irritable bowel syndrome. Neurogastroenterol Motil 2009, 21:399-410.
16. Bharucha A.E., Locke G.R., Seide B., et al. Anew questionnaire for constipation and fecal incontinence. Aliment Pharmacol Ther 2004, 20:355-364.
17. Bharucha A.E., Zinsmeister A.R., Locke G.R., et al. Symptoms and quality of life in community women with fecal incontinence. Clin Gastroenterol Hepatol 2006, 4:1004-1009.
18. Heaton K.W., O'Donnell L.J. An office guide to whole-gut transit time. Patients' recollection of their stool form. JClin Gastroenterol 1994, 19:28-30.
19. Rockwood T.H., Church J.M., Fleshman J.W., et al. Patient and surgeon ranking of the severity of symptoms associated with fecal incontinence: the fecal incontinence severity index. Dis Colon Rectum 1999, 42:1525-1532.
20. Rockwood T.H., Church J.M., Fleshman J.W., et al. Fecal incontinence quality of life scale: quality of life instrument for patients with fecal incontinence. Dis Colon Rectum 2000, 43:9-16. discussion 16-17.
21. Law N.M., Bharucha A.E., Undale A.S., et al. Cholinergic stimulation enhances colonic motor activity, transit, and sensation in humans. Am J Physiol Gastrointest Liver Physiol 2001, 281:G1228-G1237.
22. Fletcher J.G., Busse R.F., Riederer S.J., et al. Magnetic resonance imaging of anatomic and dynamic defects of the pelvic floorindefecatory disorders. Am J Gastroenterol 2003, 98:399-411.
23. Bharucha A.E., Fletcher J.G., Melton L.J., et al. Obstetric trauma, pelvic floor injury and fecal incontinence: a population-based case-control study. Am J Gastroenterol 2012, 107:902-911.
24. Ford A.C., Moayyedi P. Meta-analysis: factors affecting placebo response rate in the irritable bowel syndrome. Aliment Pharmacol Ther 2010, 32:144-158.
25. Graf W., Mellgren A., Matzel K.E., et al. Efficacy of dextranomer instabilised hyaluronic acid for treatment of faecal incontinence: a randomised, sham-controlled trial. Lancet 2011, 377:997-1003.
26. Mellgren A., Wexner S.D., Coller J.A., et al. Long-term efficacy and safety of sacral nerve stimulation for fecal incontinence. Dis Colon Rectum 2011, 54:1065-1075.
27. Norton C., Chelvanayagam S., Wilson-Barnett J., et al. Randomized controlled trial of biofeedback for fecal incontinence. Gastroenterology 2003, 125:1320-1329.
28. Bharucha A.E., Seide B., Zinsmeister A.R., et al. Relation of bowel habits to fecal incontinence in women. Am J Gastroenterol 2008, 103:1470-1475.
29. Schiller L.R., Santa Ana C.A., Morawski S.G., et al. Studies of the antidiarrheal action of clonidine. Effects on motility and intestinal absorption. Gastroenterology 1985, 89:982-988.
30. Viramontes B.E., Malcolm A., Camilleri M., et al. Effects of an alpha(2)-adrenergic agonist on gastrointestinal transit, colonic motility, and sensation in humans. Am J Physiol Gastrointest Liver Physiol 2001, 281:G1468-G1476.