Improved minicircle DNA biosynthesis for gene therapy applications

Human Gene Therapy Methods

Volumn 25, Issue 2, 2014, Pages 93-105

  Gaspar, Vítor M ^a   Maia, Cláudio J ^a   Queiroz, João A ^a   Pichon, Chantal ^b   Correia, Ilídio J ^a   Sousa, Fani ^a  

^a UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^b UNIVERSITÉ D'ORLÉANS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MINICIRCLE DNA; PLASMID DNA; CIRCULAR DNA;

ARTICLE; BIOMASS; BIOSYNTHESIS; FERMENTATION; GENE THERAPY; HUMAN; MONITORING; PLASMID; PRIORITY JOURNAL; TEMPERATURE; BATCH CELL CULTURE; ESCHERICHIA COLI; GENETICS; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; PROCEDURES;

BATCH CELL CULTURE TECHNIQUES; DNA, CIRCULAR; ESCHERICHIA COLI; GENETIC THERAPY; PLASMIDS; TEMPERATURE;

EID: 84898737624     PISSN: 19466536     EISSN: 19466544     Source Type: Journal    
DOI: 10.1089/hgtb.2013.020     Document Type: Article

References (31)

1. Bohle, K., and Ross, A. (2011). Plasmid DNA production for pharmaceutical use: Role of specific growth rate and impact on process design. Biotechnol. Bioeng. 108, 2099-2106
2. Carnes, A., Hodgson, C., and Williams, J. (2006). Inducible Escherichia coli fermentation for increased plasmid DNA production. Biotechnol. Appl. Biochem. 45, 155-166
3. Carnes, A.E., Luke, J.M., Vincent, J.M., et al. (2011). Plasmid DNA fermentation strain and process-specific effects on vector yield, quality, and transgene expression. Biotechnol. Bioeng. 108, 354-363
4. Chabot, S., Orio, J., Schmeer, M., et al. (2013). Minicircle DNA electrotransfer for efficient tissue-Targeted gene delivery. Gene Ther. 20, 62-68
5. Chen, Z., He, C., Ehrhardt, A., and Kay, M. (2003). Minicircle DNA vectors devoid of bacterial DNA result in persistent and high-level transgene expression in vivo. Mol. Ther. 8, 495-500
6. Chen, Z., He, C., Meuse, L., and Kay, M. (2004). Silencing of episomal transgene expression by plasmid bacterial DNA elements in vivo. Gene Ther. 11, 856-864
7. Chen, Z., He, C., and Kay, M. (2005). Improved production and purification of minicircle DNA vector free of plasmid bacterial sequences and capable of persistent transgene expression in vivo. Hum. Gene Ther. 16, 126-131
8. Chen, Z.Y., Riu, E., He, C.Y., et al. (2008). Silencing of episomal transgene expression in liver by plasmid bacterial backbone DNAis independent ofCpGmethylation.Mol. Ther. 16, 548-556
9. Gill, D.R., Pringle, I.A., and Hyde, S.C. (2009). Progress and prospects: The design and production of plasmid vectors. Gene Ther. 16, 165-171
10. Gonçalves, G.A., Bower, D.M., Prazeres, D.M.F., et al. (2011). Rational engineering of Escherichia coli strains for plasmid biopharmaceutical manufacturing. Biotechnol. J. 7, 251-261
11. Ismail, R., Allaudin, Z.N., and Lila, M.A. (2012). Scaling-up recombinant plasmid DNA for clinical trial: Current concern, solution and status. Vaccine 30, 5914-5920
12. Jechlinger, W., Azimpour Tabrizi, C., Lubitz, W., and Mayrhofer, P. (2004). Minicircle DNA immobilized in bacterial ghosts: In vivo production of safe non-viral DNA delivery vehicles. J. Mol. Microbiol. Biotechnol. 8, 222-231
13. Kay, M.A. (2011). State-of-The-Art gene-based therapies: The road ahead. Nat. Rev. Genet. 12, 316-328
14. Kay, A., O'Kennedy, R., Ward, J., and Keshavarz-Moore, E. (2003). Impact of plasmid size on cellular oxygen demand in Escherichia coli. Biotechnol. Appl. Biochem. 38, 1-7
15. Kay, M.A., He, C.Y., and Chen, Z.Y. (2010). A robust system for production of minicircle DNA vectors. Nat. Biotechnol. 28, 1287-1289
16. Kimelman Bleich, N., Kallai, I., Lieberman, J.R., et al. (2012). Gene therapy approaches to regenerating bone. Adv. Drug Deliv. Rev. 64, 1320-1330
17. Kobelt, D., Schleef, M., Schmeer, M., et al. (2013). Performance of high quality minicircle DNA for in vitro and in vivo gene transfer. Mol. Biotechnol. 53, 80-89
18. Kwon, M.J., An, S., Choi, S., et al. (2012). Effective healing of diabetic skin wounds by using nonviral gene therapy based on minicircle vascular endothelial growth factor DNA and a cationic dendrimer. J. Gene Med. 14, 272-278
19. Kwon, K.C., Verma, D., Singh, N.D., et al. (2013). Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells. Adv. Drug Deliv. Rev. 65, 782-799
20. Mayrhofer, P., and Iro, M. (2012). Minicircle-DNA. In Gene Vaccines. Thalhamer, J [Hrsg.] (Springer, Wien), pp. 297-310
21. Osborn, M.J., Mcelmurry, R.T., Lees, C.J., et al. (2011). Minicircle DNA-based gene therapy coupled with immune modulation permits long-Term expression of alpha-L-iduronidase in mice with mucopolysaccharidosis type I. Mol. Ther. 19, 450-460
22. Ow, D.S.W., Nissom, P.M., Philp, R., et al. (2006). Global transcriptional analysis of metabolic burden due to plasmid maintenance in Escherichia coli DH5a during batch fermentation. Enzyme Microb. Technol. 39, 391-398
23. Pfaffl, M.W. (2001). A new mathematical model for relative quantification in real-Time RT-PCR. Nucleic Acids Res. 29, e45
24. Roychoudhury, A., Basu, S., and Sengupta, D.N. (2009). Analysis of comparative efficiencies of different transformation methods of E. coli using two common plasmid vectors. Indian J. Biochem. Biophys. 46, 395-400
25. Salyers, A.A., Gupta, A., and Wang, Y. (2004). Human intestinal bacteria as reservoirs for antibiotic resistance genes. Trends Microbiol. 12, 412-416
26. Santos, J.L., Nouri, A., Fernandes, T., et al. (2012). Gene delivery using biodegradable polyelectrolyte microcapsules prepared through the layer-by-layer technique. Biotechnol. Prog. 28, 1088-1094
27. Silva, F., Passarinha, L., Sousa, F., et al. (2009). Influence of growth conditions on plasmid DNA production. J. Microbiol. Biotechnol. 19, 1408-1414
28. Silva, F., Lourenço, O., Maia, C., et al. (2011). Impact of plasmid induction strategy on overall plasmid DNA yield and E. coli physiology using flow cytometry and real-Time PCR. Process Biochem. 46, 174-181
29. Silva, F., Queiroz, J.A., and Domingues, F.C. (2012). Evaluating metabolic stress and plasmid stability in plasmid DNA production by Escherichia coli. Biotechnol. Adv. 30, 691-708
30. Wong, E.M., Muesing, M.A., and Polisky, B. (1982). Temperature-sensitive copy number mutants of CoIE1 are located in an untranslated region of the plasmid genome. Proc. Natl. Acad. Sci. USA 79, 3570-3574
31. Wong, S.P., Argyros, O., and Harbottle, R.P. (2012). Vector systems for prenatal gene therapy: Principles of non-viral vector design and production. Methods Mol. Biol. 891, 133-167