Nrf1 to the rescue: When the level of proteasomal activity in a cell drops off, a transcription factor called Nrf1 travels to the nucleus to activate the genes that code for proteasomes

eLife

Volumn 2014, Issue 3, 2014, Pages

  Ye, Jin ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEASOME; PROTEASOME INHIBITOR; PROTEIN P97; TRANSCRIPTION FACTOR NRF1; ADENOSINE TRIPHOSPHATASE; CELL CYCLE PROTEIN; NUCLEAR RESPIRATORY FACTOR 1;

ARTICLE; BASIC LEUCINE ZIPPER MOTIF; CARBOXY TERMINAL SEQUENCE; CELL PROLIFERATION; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENZYME ACTIVITY; GENE ACTIVATION; INTRACELLULAR SIGNALING; MULTIPLE MYELOMA; PROTEIN DEGRADATION; PROTEIN TARGETING; RETROTRANSLOCATION; TRANSCRIPTION REGULATION; ANIMAL; DRUG EFFECTS; ENDOPLASMIC RETICULUM; HUMAN; METABOLISM;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CELL CYCLE PROTEINS; ENDOPLASMIC RETICULUM; HUMANS; NUCLEAR RESPIRATORY FACTOR 1; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS;

EID: 84898735488     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.02062     Document Type: Article

References (5)

1. Halawani D, Latterich M. 2006. p97: the cell's molecular purgatory? Molecular Cell 22:713-717. doi: 10.1016/j.molcel.2006.06.003.
2. Lehman NL. 2009. The ubiquitin proteasome system in neuropathology. Acta Neuropathology 118:329-347. doi: 10.1007/s00401-009-0560-x.
3. Mahindra A, Laubach J, Raje N, Munshi N, Richardson PG, Anderson K. 2012. Latest advances and current challenges in the treatment of multiple myeloma. Nature Reviews Clinical Oncology 9: 135-143. doi: 10.1038/nrclinonc.2012.15.
4. Radhakrishnan SK, den Besten W, Deshaeis RJ. 2014. p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. eLife 3:e01856. doi: 10.7554/ eLife.01856.
5. Vembar S, Brodsky JL. 2008. One step at a time: endoplasmic reticulum-associated degradation. Nature Reviews Molecular Cell Biology 9:944-957. doi: 10.1038/nrm2546.