Analysis of circulating cholesterol levels as a mediator of an association between ABO blood group and coronary heart disease

Circulation: Cardiovascular Genetics

Volumn 7, Issue 1, 2014, Pages 43-48

  Chen, Yequn ^a   Chen, Chang ^a,b   Ke, Xiayi ^c   Xiong, Longgen ^d   Shi, Yongying ^d   Li, Jiafu ^e   Tan, Xuerui ^a   Ye, Shu ^a,f,g  

^a THE FIRST AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d GUANGZHOU MEDICAL UNIVERSITY   (China)

^e SOUTHWEST MEDICAL UNIVERSITY   (China)

^f SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^g QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

ABO blood group system; Cholesterol; Cholesterol LDL; Coronary disease; Myocardial infarction

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD GROUP A; BLOOD GROUP AB; BLOOD GROUP ABO SYSTEM; BLOOD GROUP B; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY DISEASE; CORONARY ARTERY OBSTRUCTION; DISEASE PREDISPOSITION; FEMALE; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; LIPID ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

ABO BLOOD-GROUP SYSTEM; CHOLESTEROL; CHOLESTEROL, LDL; CORONARY DISEASE; MYOCARDIAL INFARCTION;

ABO BLOOD-GROUP SYSTEM; AGED; CHOLESTEROL; CHOLESTEROL, LDL; CORONARY ANGIOGRAPHY; CORONARY DISEASE; CORONARY STENOSIS; DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; ODDS RATIO; PREVALENCE; RISK FACTORS; TRIGLYCERIDES;

EID: 84898731130     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.113.000299     Document Type: Article

References (25)

1. Wu O, Bayoumi N, Vickers MA, Clark P. ABO(H) blood groups and vascular disease: A systematic review and meta-analysis. J Thromb Haemost. 2008;6:62-69
2. Reilly MP, Li M, He J, Ferguson JF, Stylianou IM, Mehta NN, et al Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: Two genome-wide association studies. Lancet. 2011;377:383-392
3. He M, Wolpin B, Rexrode K, Manson JE, Rimm E, Hu FB, et al. ABO blood group and risk of coronary heart disease in two prospective cohort studies. Arterioscler Thromb Vasc Biol. 2012;32:2314-2320
4. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999;340:115-126
5. Langman MJ, Elwood PC, Foote J, Ryrie DR. ABO and Lewis blood- groups and serum-cholesterol. Lancet. 1969;2:607-609
6. Oliver MF, Geizerova H, Cumming RA, Heady JA. Serum-cholesterol and ABO and rhesus blood-groups. Lancet. 1969;2:605-606
7. Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, et al. Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 2010;466:707-713
8. Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, et al; Cardiogenics; CARDIoGRAM Consortium. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 2011;43:333-338
9. Wu Y, Waite LL, Jackson AU, Sheu WH, Buyske S, Absher D, et al. Trans- ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained. PLoS Genet. 2013;9:e1003379
10. Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, et al. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013;45:25-33
11. Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, et al. Discovery and refinement of loci associated with lipid levels. Nat Genet. 2013;45:1274-1283
12. Silbernagel G, Chapman MJ, Genser B, Kleber ME, Fauler G, Scharnagl H, et al. High intestinal cholesterol absorption is associated with cardiovascular disease and risk alleles in ABCG8 and ABO: evidence from the LURIC and YFS cohorts and from a meta-analysis. J Am Coll Cardiol. 2013;62:291-299
13. Teupser D, Baber R, Ceglarek U, Scholz M, Illig T, Gieger C, et al. Genetic regulation of serum phytosterol levels and risk of coronary artery disease. Circ Cardiovasc Genet. 2010;3:331-339
14. Strandberg TE, Tilvis RS, Pitkala KH, Miettinen TA. Cholesterol and glucose metabolism and recurrent cardiovascular events among the elderly: A prospective study. J Am Coll Cardiol. 2006;48:708-714
15. Imai K, Kees L, Tingley D, Yamamoto T. Causal mediation analysis using R. In: Vinod HD, ed. Advances in Social Science Research Using R. New York: Springer; 2010:129-154
16. Liu J, Sempos CT, Donahue RP, Dorn J, Trevisan M, Grundy SM. Non- high-density lipoprotein and very-low-density lipoprotein cholesterol and their risk predictive values in coronary heart disease. Am J Cardiol. 2006;98:1363-1368
17. Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51:1173-1182
18. Huang B, Sivaganesan S, Succop P, Goodman E. Statistical assessment of mediational effects for logistic mediational models. Stat Med. 2004;23:2713-2728
19. Li Y, Schneider JA, Bennett DA. Estimation of the mediation effect with a binary mediator. Stat Med. 2007;26:3398-3414
20. Albert JM. Mediation analysis via potential outcomes models. Stat Med. 2008;27:1282-1304
21. Stoltenberg SF, Twitchell GR, Hanna GL, Cook EH, Fitzgerald HE, Zucker RA, et al. Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism. Am J Med Genet. 2002;114:230-234
22. VanderWeele TJ, Asomaning K, Tchetgen Tchetgen EJ, Han Y, Spitz MR, Shete S, et al. Genetic variants on 15q25.1, smoking, and lung cancer: An assessment of mediation and interaction. Am J Epidemiol. 2012;175:1013-1020
23. Machiela MJ, Lindström S, Allen NE, Haiman CA, Albanes D, Barricarte A, et al. Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium. Am J Epidemiol. 2012;176:1121-1129
24. Siedlinski M, Tingley D, Lipman PJ, Cho MH, Litonjua AA, Sparrow D, et al COPDGene and ECLIPSE Investigators. Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet. 2013;132:431-441
25. Zhu F, Tao S, Xu X, Ying Y, Hong X, Zhu H, et al. Distribution of ABO blood group allele and identification of three novel alleles in the Chinese Han population. Vox Sang. 2010;98:554-559