MicroRNA-100 regulates SW620 colorectal cancer cell proliferation and invasion by targeting RAP1B

Oncology Reports

Volumn 31, Issue 5, 2014, Pages 2055-2062

  Peng, Hui ^a   Luo, Jun ^a   Hao, Hu ^a   Hu, Jun ^a   Xie, Shang Kui ^a   Ren, Donglin ^a   Rao, Benqiang ^b  

^a THE SIXTH AFFILIATED HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

^b NANCHANG UNIVERSITY   (China)

Author keywords

Cell growth; Cell invasion; Colorectal cancer; MiR 100; RAP1B

Indexed keywords

MICRORNA 100; RAP1 PROTEIN; RAP1B PROTEIN; UNCLASSIFIED DRUG; MESSENGER RNA; MICRORNA; MIRN100 MICRORNA, HUMAN; RAP PROTEIN; RAP1B PROTEIN, HUMAN; TUMOR MARKER;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CARCINOGENESIS; CELL INVASION; CELL PROLIFERATION; CLINICAL ARTICLE; COLONY FORMATION; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE TARGETING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAP1B GENE; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; REPORTER GENE; TUMOR GROWTH; UPREGULATION; ANIMAL; BIOSYNTHESIS; CELL TRANSFORMATION; COLORECTAL TUMOR; GENETICS; METASTASIS; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; MICE; MICE, NUDE; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RAP GTP-BINDING PROTEINS; RNA, MESSENGER; TUMOR MARKERS, BIOLOGICAL;

EID: 84898655889     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3075     Document Type: Article

References (24)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin 57: 43-66, 2007
2. Cunningham D, Atkin W, Lenz HJ, et al: Colorectal cancer. Lancet 375: 1030-1047, 2010
3. Cho KR and Vogelstein B: Genetic alterations in the adenoma - carcinoma sequence. Cancer 70 (Suppl 6): 1727-1731, 1992
4. Fearon ER and Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61: 759-767, 1990
5. Zhang J, Guo H, Zhang H, et al: Putative tumor suppressor miR-145 inhibits colon cancer cell growth by targeting oncogene Friend leukemia virus integration 1 gene. Cancer 117: 86-95, 2011
6. Lin Y, Wu J, Chen H, et al: Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells. FEBS Lett 586: 442-447, 2012
7. Hutvagner G and Zamore PD: A microRNA in a multiple-turnover RNAi enzyme complex. Science 297: 2056-2060, 2002
8. Ma Y, Zhang P, Yang J, Liu Z, Yang Z and Qin H: Candidate microRNA biomarkers in human colorectal cancer: Systematic review profiling studies and experimental validation. Int J Cancer 130: 2077-2087, 2012
9. Liu J, Lu KH, Liu ZL, Sun M, De W and Wang ZX: MicroRNA-100 is a potential molecular marker of non-small cell lung cancer and functions as a tumor suppressor by targeting polo-like kinasee 1. BMC Cancer 12: 519, 2012
10. Li XJ, Luo XQ, Han BW, Duan FT, Wei PP and Chen YQ: MicroRNA-100/99a, deregulated in acute lymphoblastic leukaemia, suppress proliferation and promote apoptosis by regulating the FKBP51 and IGF1R/mTOR signalling pathways. Br J Cancer 109: 2189-2198, 2013
11. Sun J, Chen Z, Tan X, et al: MicroRNA-99a/100 promotes apoptosis by targeting mTOR in human esophageal squamous cell carcinoma. Med Oncol 30: 411, 2013
12. Xu C, Zeng Q, Xu W, et al: MiRNA-100 inhibits human bladder urothelial carcinogenesis by directly targeting mTOR. Mol Cancer Ther 12: 207-219, 2013
13. Chen P, Zhao X and Ma L: Downregulation of microRNA-100 correlates with tumor progression and poor prognosis in hepatocellular carcinoma. Mol Cell Biochem 383: 49-58, 2013
14. Gebeshuber CA and Martinez J: MiR-100 suppresses IGF2 and inhibits breast tumorigenesis by interfering with proliferation and survival signaling. Oncogene 32: 3306-3310, 2013
15. Wang G, Chen L, Meng J, Chen M, Zhuang L and Zhang L: Overexpression of microRNA-100 predicts an unfavorable prognosis in renal cell carcinoma. Int Urol Nephrol 45: 373-379, 2013
16. Bernardi B, Guidetti GF, Campus F, et al: The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3. Blood 107: 2728-2735, 2006
17. Carmona G, Gottig S, Orlandi A, et al: Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis. Blood 113: 488-497, 2009
18. Matsuse M, Mitsutake N, Rogounovitch T, et al: Mutation analysis of RAP1 gene in papillary thyroid carcinomas. Endocr J 56: 161-164, 2009
19. Edreira MM, Li S, Hochbaum D, et al: Phosphorylation-induced conformational changes in Rap1b: Allosteric effects on switch domains and effector loop. J Biol Chem 284: 27480-27486, 2009
20. Wittchen ES, Aghajanian A and Burridge K: Isoform-specific differences between Rap1A and Rap1B GTPases in the formation of endothelial cell junctions. Small GTPases 2: 65-76, 2011
21. Zhang M, Zhou S, Zhang L, et al: MiR-518b is down-regulated, and involved in cell proliferation and invasion by targeting Rap1b in esophageal squamous cell carcinoma. FEBS Lett 586: 3508-3521, 2012
22. Guo H, Hu X, Ge S, Qian G and Zhang J: Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation. Int J Biochem Cell Biol 44: 1465-1472, 2012
23. Hobert O: MiRNAs play a tune. Cell 131: 22-24, 2007
24. Peter ME: Targeting of mRNAs by multiple miRNAs: The next step. Oncogene 29: 2161-2164, 2010