Is a GnRH Antagonist Protocol Better in PCOS Patients? A Meta-Analysis of RCTs

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Lin, Haiyan ^a   Li, Yu ^a   Li, Lin ^a   Wang, Wenjun ^a   Yang, Dongzi ^a   Zhang, Qingxue ^a  

^a SUN YAT SEN MEMORIAL HOSPITAL OF SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BUSERELIN; BUSERELIN ACETATE; CETRORELIX; GANIRELIX; GONADORELIN ANTAGONIST; GONADOTROPIN; LEUPRORELIN; TRIPTORELIN; GONADORELIN; HORMONE ANTAGONIST; LUTEOLYTIC AGENT;

AGE; ARTICLE; BODY MASS; CLINICAL EFFECTIVENESS; CLINICAL EVALUATION; CLINICAL PROTOCOL; COMPARATIVE EFFECTIVENESS; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG DOSE REDUCTION; DRUG EFFICACY; HUMAN; META ANALYSIS; OOCYTE RETRIEVAL; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; PREGNANCY RATE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; SINGLE DRUG DOSE; SYSTEMATIC REVIEW; TREATMENT OUTCOME; WOMEN'S HEALTH; AGONISTS; ANTAGONISTS AND INHIBITORS; CYTOLOGY; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; INFERTILITY, FEMALE; INTRACYTOPLASMIC SPERM INJECTION; METABOLISM; OOCYTE; OVARIAN HYPERSTIMULATION SYNDROME; OVULATION INDUCTION; PATHOLOGY; PHYSIOLOGY; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PROCEDURES;

EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; GONADOTROPIN-RELEASING HORMONE; HORMONE ANTAGONISTS; HUMANS; INFERTILITY, FEMALE; LUTEOLYTIC AGENTS; OOCYTES; OVARIAN HYPERSTIMULATION SYNDROME; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; PREGNANCY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SPERM INJECTIONS, INTRACYTOPLASMIC; TRIPTORELIN PAMOATE;

EID: 84898645099     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091796     Document Type: Article

References (25)

1. Smitz J, Ron-El R, Tarlatzis BC (1992) The use of gonadotrophin releasing hormone agonists for in vitro fertilization and other assisted procreation techniques: Experience from three centres. Hum Reprod 7 (suppl 1): 49-66.
2. Al-Inany H, Aboulghar M (2002) GnRH antagonist in assisted reproduction: a Cochrane review. Human Reproduction 17(4): 874-885. (Pubitemid 34411116)
3. Orvieto R, Meltcer S, Liberty G, Rabinson J, Anteby EY, et al. (2012) Does day- 3 LH/FSH ratio influence in vitro fertilization outcome in PCOS patients undergoing controlled ovarian hyperstimulation with different GnRH-analogue? Gynecol Endocrinol 28(6):422-4.
4. Haydardedeoglu B, Kilicdag EB, Parlakgumus AH, Zeyneloglu HB (2012) IVF/ ICSI outcomes of the OCP plus GnRH agonist protocol versus the OCP plus GnRH antagonist fixed protocol in women with PCOS: a randomized trial. Arch Gynecol Obstet 286(3):763-9.
5. Kim CH, Moon JW, Kang HJ, Ahn JW, Kim SH, et al. (2012) Effectiveness of GnRH antagonist multiple dose protocol applied during early and late follicular phase compared with GnRH agonist long protocol in non-obese and obese patients with polycystic ovary syndrome undergoing IVF/ICSI. Clin Exp Reprod Med 39(1):22-7.
6. Hosseini MA, Aleyasin A, Saeedi H, Mahdavi A (2010) Comparison of gonadotropin-releasing hormone agonists and antagonists in assisted reproduction cycles of polycystic ovarian syndrome patients. J Obstet Gynaecol Res 36(3):605-10.
7. Tehraninejad ES, Nasiri R, Rashidi B, Haghollahi F, Ataie M (2010) Comparison of GnRH antagonist with long GnRH agonist protocol after OCP pretreatment in PCOs patients. Arch Gynecol Obstet 282(3):319-25.
8. Lainas TG, Sfontouris IA, Zorzovilis IZ, Petsas GK, Lainas GT, et al. (2010) Flexible GnRH antagonist protocol versus GnRH agonist long protocol in patients with polycystic ovary syndrome treated for IVF: a prospective randomized controlled trial (RCT). Hum Reprod 25(3):683-9.
9. Vrtacnik-Bokal E, Virant Klun I, Verdenik I (2009) Follicular oestradiol and VEGF after GnRH antagonists or GnRH agonists in women with PCOS. Reprod Biomed Online 18(1):21-8.
10. Kurzawa R, Ciepiela P, Baczkowski T, Safranow K, Brelik P (2008) Comparison of embryological and clinical outcome in GnRH antagonist vs. GnRH agonist protocols for in vitro fertilization in PCOS non-obese patients. A prospective randomized study. J Assist Reprod Genet 25(8):365-74.
11. Orvieto R, Meltcer S, Homburg R, Nahum R, Rabinson J, et al. (2009) What is the preferred GnRH analogue for polycystic ovary syndrome patients undergoing controlled ovarian hyperstimulation for in vitro fertilization? Fertil Steril 91(4 Suppl):1466-8.
12. Lainas TG, Petsas GK, Zorzovilis IZ, Iliadis GS, Lainas GT, et al. (2007) Initiation of GnRH antagonist on Day 1 of stimulation as compared to the long agonist protocol in PCOS patients. A randomized controlled trial: effect on hormonal levels and follicular development. Hum Reprod 22(6):1540-6. (Pubitemid 47055140)
13. Bahceci M, Ulug U, Ben-Shlomo I, Erden HF, Akman MA (2005) Use of a GnRH antagonist in controlled ovarian hyperstimulation for assisted conception in women with polycystic ovary disease: a randomized, prospective, pilot study. J Reprod Med 50(2):84-90. (Pubitemid 40204875)
14. Hwang JL, Seow KM, Lin YH, Huang LW, Hsieh BC, et al. (2004) Ovarian stimulation by concomitant administration of cetrorelix acetate and HMG following Diane-35 pre-treatment for patients with polycystic ovary syndrome: a prospective randomized study. Hum Reprod 19(9):1993-2000.
15. Ragni G, Vegetti W, Riccaboni A, Engl B, Brigante C, et al. (2005) Comparison of GnRH agonists and antagonists in assisted reproduction cycles of patients at high risk of ovarian hyperstimulation syndrome. Hum. Reprod 20 (9): 2421-2425. (Pubitemid 41222487)
16. Tesarik J, Hazout A, Mendoza-Tesarik R, Mendoza N, Mendoza C (2006) Beneficial effect of luteal-phase GnRH agonist administration on embryo implantation after ICSI in both GnRH agonist-and antagonist-treated ovarian stimulation cycles.Hum. Reprod 21 (10): 2572-2579. (Pubitemid 44548853)
17. Ashrafi M, Moini A, Mohammadzadeh A, Ezabadi Z, Zafarani F, et al. (2005) A comparative study of GnRH antagonist and GnRH agonist in PCO patients undergoing IVF/ICSI cycles. Iranian Journal of Reproductive Medicine 3(1): 14-18.
18. Garcia-Velasco JA, Bermejo A, Ruiz F, Martinez-Salazar J, Requena A, et al. (2011) Cycle cheduling with oral contraceptive pills in the GnRH antagonist protocol vs the long protocol: a randomized, controlled trial. Fertil Steril 96:590-3.
19. Kaur H, Krishna D, Shetty N, Krishnan S, Srinivas MS, et al. (2012) A prospective study of GnRH long agonist versus flexible GnRH antagonist protocol in PCOS: Indian experience. J Hum Reprod Sci 5:181-6.
20. Olivennes F, Cunha-Filho JS, Fanchin R, Bouchard P, Frydman R (2002) The use of GnRH antagonists in ovarian stimulation. Human reproductive update 8(3):279-290. (Pubitemid 34618945)
21. Pundir J, Sunkara SK, El-Toukhy T, Khalaf Y (2012) Meta-analysis of GnRH antagonist protocols: do they reduce the risk of OHSS in PCOS? Reproductive BioMedicine Online 24: 6-22.
22. Kolibianakis EM, Zikopoulos K, Schiettecatte J, Smitz J, Tournaye H, et al. (2004) Profound LH suppression after GnRH antagonist administration is associated with a significantly higher ongoing pregnancy rate in IVF. Human Reproduction 19(11): 2490-2496. (Pubitemid 39481272)
23. Huirne JA, van Loenen AC, Schats R, McDonnell J, Hompes PG, et al. (2005) Dose-finding study of daily GnRH antagonist for the prevention of premature LH surges in IVF/ICSI patients: optimal changes in LH and progesterone for clinical pregnancy. Human Reproduction 20:359-367. (Pubitemid 40277602)
24. Mancini F, Tur R, Martinez F, Coroleu B, Rodriguez I, et al. (2011) Gonadotrophin-releasing hormone-antagonists vs long agonist in in-vitro fertilization patients with polycystic ovary syndrome: a meta-analysis. Gynecological Endocrinology 27(3): 150-155.
25. Xiao J, Chen S, Zhang C, Chang S (2013) Effectiveness of GnRH antagonist in the treatment of patients with polycystic ovary syndrome undergoing IVF: a systematic review and meta analysis. Gynecological Endocrinology 29(3): 187-191.