Anemia at the initiation of tuberculosis therapy is associated with delayed sputum conversion among pulmonary tuberculosis patients in dar-es-salaam, Tanzania

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Nagu, Tumaini J ^a,b   Spiegelman, Donna ^c   Hertzmark, Ellen ^c   Aboud, Said ^a   Makani, Julie ^a   Matee, Mecky I ^a   Fawzi, Wafaie ^c   Mugusi, Ferdinand ^a  

^a MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^b KAROLINSKA INSTITUTE   (Sweden)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; ISONIAZID; RIFAMPICIN; TUBERCULOSTATIC AGENT;

ACID FAST BACTERIUM; ADOLESCENT; ADULT; ANEMIA; ARTICLE; BLOOD CELL COUNT; BLOOD CHEMISTRY; CLINICAL ASSESSMENT; CLINICAL EVALUATION; DIRECTLY OBSERVED THERAPY; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG EFFECT; FEMALE; FOLLOW UP; HEMOGLOBIN BLOOD LEVEL; HUMAN; LUNG TUBERCULOSIS; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PHYSICAL EXAMINATION; RISK ASSESSMENT; SPUTUM CYTODIAGNOSIS; SPUTUM SMEAR; TANZANIA; TREATMENT DURATION; CLINICAL TRIAL; COMPLICATION; DRUG EFFECTS; MICROBIOLOGY; MULTICENTER STUDY; MYCOBACTERIUM TUBERCULOSIS; PHYSIOLOGY; PROSPECTIVE STUDY; RISK; SEVERITY OF ILLNESS INDEX; SPUTUM; TREATMENT OUTCOME; TUBERCULOSIS, PULMONARY;

ADOLESCENT; ADULT; ANEMIA; ANTITUBERCULAR AGENTS; FEMALE; HUMANS; MALE; MIDDLE AGED; MYCOBACTERIUM TUBERCULOSIS; PROSPECTIVE STUDIES; RISK; SEVERITY OF ILLNESS INDEX; SPUTUM; TANZANIA; TREATMENT OUTCOME; TUBERCULOSIS, PULMONARY;

EID: 84898644225     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0091229     Document Type: Article

References (46)

1. World Health Organisation (1993) Tuberculosis: a global emergency. World Health Forum 14:438.
2. World health Organization, 2012, Global Tuberculosis Report. Geneva, Switzerland, 8-13.
3. Shaw JB, Wynn-Williams N (1954) Infectivity of pulmonary tuberculosis in relation to sputum status. Am Rev Tuberc 69(5):724-32.
4. Rouillon A, Perdrizet S, Parrot R (1976) Transmission of tubercle bacilli: The effects of chemotherapy. Tubercle 57(4):275-99.
5. Jindani A, Doré CJ, Mitchison DA (2003) Bactericidal and sterilizing activit (Pubitemid 36609718)
6. Fitzwater SP, Caviedes L, Gilman RH, Coronel J, LaChira D, et al. (2010) Prolonged infectiousness of tuberculosis patients in a directly observed therapy short-course program with standardized therapy. CID 51(4):371-78.
7. Fortún J, Martin-Davila P, Molina A, Navas E, Hermida JM, et al. (2007) Sputum conversion among patients with pulmonary tuberculosis: are there implications for removal of respiratory isolation? The J Antimicrob Chemother 59(4):794-98. (Pubitemid 47073422)
8. Long R, Bochar K, Chomyc S, Talbot J, Barrie J, et al. (2003) Relative Versus Absolute Noncontagiousness of Respiratory Tuberculosis on Treatment. Infect Control Hosp Epidemiol 24(11):831-38. (Pubitemid 37516813)
9. Parikh R, Nataraj G, Kanade S, Khatri V, Mehta P (2012) Time to sputum conversion in smear positive pulmonary TB patients on category I DOTS and factors delaying it. J Assoc Physicians India 60:22-26.
10. Chien JY, Chen YT, Shu CC, Lee JJ, Wang JY, et al. (2013) Outcome Correlation of Smear-Positivity for Acid-Fast Bacilli at the Fifth Month of Treatment in Non-Multidrug-Resistant TB. Chest 143(6):1725-32.
11. Tiwari S, Kumar A, Kapoor SK (2012) Relationship between sputum smear grading and smear conversion rate and treatment outcome in the patients of pulmonary tuberculosis undergoing dots-a prospective cohort study. Indian J Tuberc 59(3):135-40.
12. Güler M, Unsal E, Dursun B, Aydln O, Capan N (2007) Factors influencing sputum smear and culture conversion time among patients with new case pulmonary tuberculosis. Int J Clin Pract 61(2):231-35.
13. Senkoro M, Mfinanga SG, Morkve O (2010) Smear microscopy and culture conversion rates among smear positive pulmonary tuberculosis patients by HIV status in Dar es Salaam, Tanzania. BMC infectious diseases 10: 210.
14. Vos T, Flamax AD, Naghavi M, Lozano R, Michaud C, et al. (2012) Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2163-96.
15. McLean E, Cogswell M, Egli I, Wojdyla D, de Benoist B (2009) Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993-2005. Public Health Nutrition, 12: 444-54.
16. Lee SW, Kang YA, Yoon YS, Um SW, Lee SM, et al. (2006). The Prevalence and Evolution of Anemia Associated with Tuberculosis. J Korean Med Sci 21:1028-32.
17. Isanaka S Mugusi FM, Urassa W, Willett WC, Bosch RJ, et al. (2012) Iron Deficiency and Anemia Predict Mortality in Patients with Tuberculosis. J Nutr 142(2):350-57.
18. Saathoff E, Villamor E, Mugusi F, Bosch RJ, Urassa W, et al (2011) Anemia in adults with tuberculosis is associated with HIV and anthropometric status in Dar es Salaam, Tanzania. Int J Tuberc Lung Dis 15(7):925-32.
19. Hussain SF, Irfan M, Abbasi M, Anwer SS, Davidson S, et al (2004) Clinical characteristics of 110 miliary tuberculosis patients from a low HIV prevalence country. Int J Tuberc Lung Dis 8(4):493-99. (Pubitemid 38624859)
20. Olaniyi JA, Aken'Ova YA (2003) Haematological profile of patients with pulmonary tuberculosis in Ibadan, Nigeria. Afr J Med Med Sci 32(3): 239-42.
21. Karyadi E, Schultink W, Nelwan RHH, Gross R, Amin Z, et al. (2000) Poor Micronutrient Status of Active Pulmonary Tuberculosis Patients in Indonesia. J Nutr 130:2953-58. (Pubitemid 32005324)
22. Morris CD, Bird AR, Nell H (1989) The haematological and biochemical changes in severe pulmonary tuberculosis. Q J Med 73(272):1151-59. (Pubitemid 20019609)
23. Kourbatova EV, Borodulin BE, Borodulina EA, del Rio C, Blumberg HM, et al (2006) Risk factors for mortality among adult patients with newly diagnosed tuberculosis in Samara, Russia. Int J Tuberc Lung Dis 10(11):1224-30. (Pubitemid 44713475)
24. United Republic of Tanzania (2013) Population and Housing census: Population Distribution by Administrative Areas. Dar es Salaam, Tanzania.
25. United Republic of Tanzania (2011) Ministry of Health and Social welfare: National Tuberculosis and Leprosy programme annual report. Dar es Salaam, Tanzania.
26. United Republic of Tanzania (2006) Ministry of Health and Social welfare, the manual of the National Tuberculosis and Leprosy programme in Tanzania 5th edition. Dar es Salaam, Tanzania.
27. Spiegelman D, Hertzmark E (2005) Easy SAS calculations for risk or prevalence ratios and differences. Am J Epidemiol 162:199.
28. Govindarajulu US, Malloy EJ, Ganguli B, Spiegelman D, Eisen EA (2009). The comparison of alternative smoothing methods for fitting non-linear exposureresponse relationships with Cox models in a simulation study. Int J Biostat 5(1): 2.
29. Maldonado G, Greenland S (1993) Simulation study of confounder-selection strategies. Am J Epidemiol138 (11):923-36. (Pubitemid 24002359)
30. World Health Organisation (2011) Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. Geneva, Switzerland.
31. Durrleman S, Simon R (1989) Flexible regression models with cubic splines. Stat Med 8(5):551-61. (Pubitemid 19116001)
32. Govindarajulu U, Spiegelman D, Thurston S, Eisen E (2007) Comparing smoothing techniques for modeling exposure-response curves in Cox models. Stat Med 26:3735-52. (Pubitemid 47307746)
33. Karzakova LM, Mokhireva LV, Elenkina ZhB, Suslikov VL (2005) The clinical and immunological manifestations of infiltrative pulmonary tuberculosis under natural zinc deficiency. Probl Tuberk Bolezn Legk 6:36-39.
34. Isanaka S, Mugusi F, Bosch RJ, Willett WC, Spiegelman D, et al (2012) Iron status predicts treatment failure and mortality in tuberculosis patients: a prospective cohort study from Dar es Salaam, Tanzania. PLoS One 7(5):e37350.
35. Weiss G (2009) Iron metabolism in the anemia of chronic disease. Biochimica et Biophysica Acta 1790(7): 682-93.
36. Weiss G (2002). Iron and immunity: a double-edged sword. Eur J Clin Invest 32(S1):70-78. (Pubitemid 41704991)
37. Slama K, Chiang CY, Enarson DA, Hassmiller K, Fanning A, et al (2012)Tobacco and tuberculosis: a qualitative systematic review and metaanalysis. Int J Tuberc Lung Dis 11(10):1049-61. (Pubitemid 47605393)
38. Visser ME, Sted MC, Walzl G, Warren Rob, Schomaker M, et al (2012) Baseline Predictors of Sputum Culture Conversion in Pulmonary Tuberculosis: Importance of Cavities, Smoking, Time to Detection and W-Beijing Genotype. PloS one 7(1):e29588.
39. Bagaitkar J, Demuth DR, Scott DA (2008) Tobacco use increases susceptibility to bacterial infection. Tob Induc Dis 4(12).
40. Mugusi FM, Mehta S, Villamor E, Urassa W, Saathoff E, et al (2009) Factors associated with mortality in HIV-infected and uninfected patients with pulmonary tuberculosis. BMC Public Health 9:409.
41. Guglielmetti L, Cazzadori A, Conti M, Boccafoglio F, Vella A, et al (2013) Lymphocyte subpopulations in active tuberculosis: association with disease severity and the QFT-GIT assay. Int J Tuberc Lung Dis 17(6):825-28.
42. Kwange SO, Budambula NL (2007) Effectiveness of anti-tuberculosis treatment among patients receiving highly active antiretroviral therapy at Vihiga district hospital in 2007. Indian J Med Microbiol 28: 221-25.
43. Orofino Rde L, Brasil PE, Trajman A, Schmaltz CA, Dalcolmo M, et al (2012) Predictors of tuberculosis treatment outcomes. J Bras Pneumol 38(1):88-97.
44. Hermans SM, Castelnuovo B, Katabira C, Mbidde P, Lange JM, et al (2012) Integration of HIV and TB services results in improved TB treatment outcomes and earlier prioritized ART initiation in a large urban HIV clinic in Uganda. J Acquir Immune Defic Syndr 60(2):e29-35.
45. United republic of Tanzania (2012) National Guidelines for the management of HIV and AIDS. Dar es Salaam, Tanzania.
46. Mkopi A, Range N, Lwilla F, Egwaga S, Schulze A, et al (2012) Adherence to tuberculosis therapy among patients receiving home-based directly observed treatment: evidence from the United Republic of Tanzania. PloS one 7(12):e51828.