Critical roles for PU.1, GATA1, and GATA2 in the expression of human FcεRI on mast cells: PU.1 and GATA1 transactivate FCER1A, and GATA2 transactivates FCER1A and MS4A2

Journal of Immunology

Volumn 192, Issue 8, 2014, Pages 3936-3946

  Inage, Eisuke ^a,b   Kasakura, Kazumi ^a,c   Yashiro, Takuya ^a,c   Suzuki, Ryuyo ^b   Baba, Yosuke ^a,b   Nakano, Nobuhiro ^a   Hara, Mutsuko ^a   Tanabe, Atsushi ^a   Oboki, Keisuke ^d,e   Matsumoto, Kenji ^d   Saito, Hirohisa ^d   Niyonsaba, François ^a   Ohtsuka, Yoshikazu ^b   Ogawa, Hideoki ^a   Okumura, Ko ^a   Shimizu, Toshiaki ^b   Nishiyama, Chiharu ^a,c  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

^d NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^e TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELL LINE; CELL MEMBRANE; CHROMATIN IMMUNOPRECIPITATION; GATA1 TRANSCRIPTION FACTOR; GATA2 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; HUMANS; MAST CELLS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-KIT; RECEPTORS, IGE; RNA INTERFERENCE; RNA, MESSENGER; TRANS-ACTIVATORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84898638725     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1302366     Document Type: Article

References (34)

1. Yamaguchi, M., C. S. Lantz, H. C. Oettgen, I. M. Katona, T. Fleming, I. Miyajima, J. P. Kinet, and S. J. Galli. 1997. IgE enhances mouse mast cell Fc (epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J. Exp. Med. 185: 663-672.
2. Asai, K., J. Kitaura, Y. Kawakami, N. Yamagata, M. Tsai, D. P. Carbone, F. T. Liu, S. J. Galli, and T. Kawakami. 2001. Regulation of mast cell survival by IgE. Immunity 14: 791-800.
3. Kalesnikoff, J., M. Huber, V. Lam, J. E. Damen, J. Zhang, R. P. Siraganian, and G. Krystal. 2001. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity 14: 801-811.
4. Nishiyama, C., T. Yokota, K. Okumura, and C. Ra. 1999. The transcription factors Elf-1 and GATA-1 bind to cell-specific enhancer elements of human high-affinity IgE receptor alpha-chain gene. J. Immunol. 163: 623-630.
5. Nishiyama, C., M. Hasegawa, M. Nishiyama, K. Takahashi, Y. Akizawa, T. Yokota, K. Okumura, H. Ogawa, and C. Ra. 2002. Regulation of human Fc epsilon RI alpha-chain gene expression by multiple transcription factors. J. Immunol. 168: 4546-4552.
6. Akizawa, Y., C. Nishiyama, M. Hasegawa, K. Maeda, T. Nakahata, K. Okumura, C. Ra, and H. Ogawa. 2003. Regulation of human FcepsilonRI beta chain gene expression by Oct-1. Int. Immunol. 15: 549-556.
7. Maeda, K., C. Nishiyama, T. Tokura, H. Nakano, S. Kanada, M. Nishiyama, K. Okumura, and H. Ogawa. 2006. FOG-1 represses GATA-1-dependent FcepsilonRI beta-chain transcription: transcriptional mechanism of mast-cell-specific gene expression in mice. Blood 108: 262-269.
8. Takahashi, K., C. Nishiyama, M. Hasegawa, Y. Akizawa, and C. Ra. 2003. Regulation of the human high affinity IgE receptor beta-chain gene expression via an intronic element. J. Immunol. 171: 2478-2484.
9. Wang, Q. H., C. Nishiyama, N. Nakano, N. Shimokawa, M. Hara, S. Kanada, H. Ogawa, and K. Okumura. 2008. Suppressive effect of Elf-1 on FcepsilonRI alpha-chain expression in primary mast cells. Immunogenetics 60: 557-563.
10. Masuda, A., K. Hashimoto, T. Yokoi, T. Doi, T. Kodama, H. Kume, K. Ohno, and T. Matsuguchi. 2007. Essential role of GATA transcriptional factors in the activation of mast cells. J. Immunol. 178: 360-368.
11. Ishijima, Y., S. Ohmori, A. Uenishi, and K. Ohneda. 2012. GATA transcription factors are involved in IgE-dependent mast cell degranulation by enhancing the expression of phospholipase C-g1. Genes Cells 17: 285-301.
12. Kirshenbaum, A. S., C. Akin, Y. Wu, M. Rottem, J. P. Goff, M. A. Beaven, V. K. Rao, and D. D. Metcalfe. 2003. Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. Leuk. Res. 27: 677-682.
13. Saito, H., A. Kato, K. Matsumoto, and Y. Okayama. 2006. Culture of human mast cells from peripheral blood progenitors. Nat. Protoc. 1: 2178-2183.
14. Baba, Y., K. Maeda, T. Yashiro, E. Inage, K. Kasakura, R. Suzuki, F. Niyonsaba, M. Hara, A. Tanabe, H. Ogawa, et al. 2012. GATA2 is a critical transactivator for the human IL1RL1/ST2 promoter in mast cells/basophils: opposing roles for GATA2 and GATA1 in human IL1RL1/ST2 gene expression. J. Biol. Chem. 287: 32689-32696.
15. Kitamura, N., H. Yokoyama, T. Yashiro, N. Nakano, M. Nishiyama, S. Kanada, T. Fukai, M. Hara, S. Ikeda, H. Ogawa, et al. 2012. Role of PU.1 in MHC class II expression through transcriptional regulation of class II transactivator pI in dendritic cells. J. Allergy Clin. Immunol. 129: 814-824.e6.
16. Nakano, N., C. Nishiyama, S. Kanada, Y. Niwa, N. Shimokawa, H. Ushio, M. Nishiyama, K. Okumura, and H. Ogawa. 2007. Involvement of mast cells in IL-12/23 p40 production is essential for survival from polymicrobial infections. Blood 109: 4846-4855.
17. Kanada, S., C. Nishiyama, N. Nakano, R. Suzuki, K. Maeda, M. Hara, N. Kitamura, H. Ogawa, and K. Okumura. 2011. Critical role of transcription factor PU.1 in the expression of CD80 and CD86 on dendritic cells. Blood 117: 2211-2222.
18. Maeda, K., C. Nishiyama, H. Ogawa, and K. Okumura. 2010. GATA2 and Sp1 positively regulate the c-kit promoter in mast cells. J. Immunol. 185: 4252-4260.
19. Maeda, K., C. Nishiyama, T. Tokura, Y. Akizawa, M. Nishiyama, H. Ogawa, K. Okumura, and C. Ra. 2003. Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter. J. Immunol. 170: 334-340.
20. Walsh, J. C., R. P. DeKoter, H. J. Lee, E. D. Smith, D. W. Lancki, M. F. Gurish, D. S. Friend, R. L. Stevens, J. Anastasi, and H. Singh. 2002. Cooperative and antagonistic interplay between PU.1 and GATA-2 in the specification of myeloid cell fates. Immunity 17: 665-676.
21. Rekhtman, N., F. Radparvar, T. Evans, and A. I. Skoultchi. 1999. Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells. Genes Dev. 13: 1398-1411.
22. Nerlov, C., E. Querfurth, H. Kulessa, and T. Graf. 2000. GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription. Blood 95: 2543-2551.
23. Zhang, P., G. Behre, J. Pan, A. Iwama, N. Wara-Aswapati, H. S. Radomska, P. E. Auron, D. G. Tenen, and Z. Sun. 1999. Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1. Proc. Natl. Acad. Sci. USA 96: 8705-8710.
24. Matsumura, I., A. Kawasaki, H. Tanaka, J. Sonoyama, S. Ezoe, N. Minegishi, K. Nakajima, M. Yamamoto, and Y. Kanakura. 2000. Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines. Blood 96: 2440-2450.
25. Stopka, T., D. F. Amanatullah, M. Papetti, and A. I. Skoultchi. 2005. PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure. EMBO J. 24: 3712-3723.
26. Hong, W., A. Y. Kim, S. Ky, C. Rakowski, S. B. Seo, D. Chakravarti, M. Atchison, and G. A. Blobel. 2002. Inhibition of CBP-mediated protein acetylation by the Ets family oncoprotein PU.1. Mol. Cell. Biol. 22: 3729-3743.
27. Rekhtman, N., K. S. Choe, I. Matushansky, S. Murray, T. Stopka, and A. I. Skoultchi. 2003. PU.1 and pRB interact and cooperate to repress GATA-1 and block erythroid differentiation. Mol. Cell. Biol. 23: 7460-7474.
28. Chou, S. T., E. Khandros, L. C. Bailey, K. E. Nichols, C. R. Vakoc, Y. Yao, Z. Huang, J. D. Crispino, R. C. Hardison, G. A. Blobel, and M. J. Weiss. 2009. Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood 114: 983-994.
29. Henkel, G., and M. A. Brown. 1994. PU.1 and GATA: components of a mast cell-specific interleukin 4 intronic enhancer. Proc. Natl. Acad. Sci. USA 91: 7737-7741.
30. Takemoto, C. M., S. Brandal, A. G. Jegga, Y. N. Lee, A. Shahlaee, Y. Ying, R. Dekoter, and M. A. McDevitt. 2010. PU.1 positively regulates GATA-1 expression in mast cells. J. Immunol. 184: 4349-4361.
31. Nishiyama, C., T. Ito, M. Nishiyama, S. Masaki, K. Maeda, N. Nakano, W. Ng, K. Fukuyama, M. Yamamoto, K. Okumura, and H. Ogawa. 2005. GATA-1 is required for expression of FcepsilonRI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow. Int. Immunol. 17: 847-856.
32. Migliaccio, A. R., R. A. Rana, M. Sanchez, R. Lorenzini, L. Centurione, L. Bianchi, A. M. Vannucchi, G. Migliaccio, and S. H. Orkin. 2003. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J. Exp. Med. 197: 281-296.
33. Hasegawa, M., C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Mitsuishi, T. Ito, H. Kawada, S. Furukawa, C. Ra, K. Okumura, and H. Ogawa. 2003. A novel-66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases. J. Immunol. 171: 1927-1933.
34. Kanada, S., N. Nakano, D. P. Potaczek, K. Maeda, N. Shimokawa, Y. Niwa, T. Fukai, M. Sanak, A. Szczeklik, H. Yagita, et al. 2008. Two different transcription factors discriminate the-315C.T polymorphism of the Fc epsilon RI alpha gene: binding of Sp1 to-315C and of a high mobility group-related molecule to-315T. J. Immunol. 180: 8204-8210.