ADMA/SDMA in elderly subjects with asymptomatic carotid atherosclerosis: Values and site-specific association

International Journal of Molecular Sciences

Volumn 15, Issue 4, 2014, Pages 6391-6398

  Riccioni, Graziano ^a   Scotti, Luca ^b   D'Orazio, Nicolantonio ^b   Gallina, Sabina ^b   Speziale, Giuseppe ^c   Speranza, Lorenza ^b   Bucciarelli, Tonino ^b  

^a Cardiology Unit   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c Anthea Hospital   (Italy)

Author keywords

ADMA; Atherosclerosis; Carotid arteries; Carotid intima media thickness; Elderly; Endothelium; Plaque

Indexed keywords

6 N, N' DIMETHYLARGININE; C REACTIVE PROTEIN; CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; N (G), N (G) DIMETHYLARGININE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ARGININE; N,N'-DIMETHYLARGININE; N,N-DIMETHYLARGININE;

AGED; ARTERIAL WALL THICKNESS; ARTICLE; CAROTID ATHEROSCLEROSIS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; ANALOGS AND DERIVATIVES; BLOOD; CAROTID ARTERY; CAROTID ARTERY DISEASE; ECHOGRAPHY; MIDDLE AGED; PATHOLOGY; VERY ELDERLY;

AGED; AGED, 80 AND OVER; ARGININE; C-REACTIVE PROTEIN; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CHOLESTEROL; CHOLESTEROL, LDL; FEMALE; HUMANS; MALE; MIDDLE AGED; TRIGLYCERIDES;

EID: 84898617924     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15046391     Document Type: Article

References (25)

1. Franceschelli, S.; Ferrone, A.; Pesce, M.; Riccioni, G.; Speranza, L. Biological functional relevance of asymmetric dimethylarginine (ADMA) in cardiovascular disease. Int. J. Mol. Sci. 2013, 14, 24412-24421.
2. Böger, R.H. Asymmetric dimethylarginine (ADMA): A novel risk marker in cardiovascular medicine and beyond. Ann. Med. 2006, 38, 126-136.
3. Zoccali, C. Traditional and emerging cardiovascular and renal risk factors: An epidemiological perspective. Kidney Int. 2006, 70, 26-33.
4. Krempl, T.K.; Kähler, J.; Maas, R.; Silberhorn, L.; Meinertz, T.; Böger, R.H. Elevation of asymmetric dimethylarginine (ADMA) in patients with unstable angina and recurrent cardiovascular events. Eur. Heart J. 2005, 26, 1846-1851.
5. Lu, T.M.; Ding, Y.A.; Lin, S.J.; Lee, W.S.; Tai, H.C. Plasma levels of asymmetrical dimethylarginine and adverse cardiovascular events after percutaneous coronary intervention. Eur. Heart J. 2003, 24, 1912-1919.
6. Mittermayer, F.; Krzyzanowska, K.; Exner, M.; Mlekusch, W.; Amighi, J.; Sabeti, S.; Minar, E.; Müller, M.; Wolzt, M.; Schillinger, M. Asymmetric dimethylarginine predicts major adverse cardiovascular events in patients with advanced peripheral artery disease. Arterioscler. Thromb. Vasc. Biol. 2006, 26, 2536-2540.
7. Chen, S.; Li, N.; Deb-Chatterji, M.; Dong, Q.; Kielstein, J.T.; Weissenborn, K.; Worthmann, H. Asymmetric dimethyarginine as marker and mediator in ischemic stroke. Int. J. Mol. Sci. 2012, 13, 15983-16004.
8. Dimitroulas, T.; Sandoo, A.; Kitas, G.D. Asymmetric dimethylarginine as a surrogate marker of endothelial dysfunction and cardiovascular risk in patients with systemic rheumatic diseases. Int. J. Mol. Sci. 2012, 13, 12315-12335.
9. Doneen, A.L.; Bale, B.F. Carotid intima-media thickness testing as an asymptomatic cardiovascular disease identifier and method for making therapeutic decisions. Postgrad. Med. 2013, 125, 108-123.
10. Honda, O.; Sugiyama, S.; Kugiyama, K.; Fukushima, H.; Nakamura, S.; Koide, S.; Kojima, S.; Hirai, N.; Kawano, H.; Soejima, H. et al. Echolucent carotid plaques predict future coronary events in patients with coronary artery disease. J. Am. Coll. Cardiol. 2004, 43, 1177-1784.
11. Davis, P.H.; Dawson, J.D.; Riley, W.A.; Lauer, R.M. Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: The Muscatine study. Circulation 2001, 104, 2815-2859.
12. Furuki, K.; Adachi, H.; Matsuoka, H.; Enomoto, M.; Satoh, A.; Hino, A.; Hirai, Y.; Imaizumi, T. Plasma levels of asymmetric dimethylarginine (ADMA) are related to intima-media thickness of the carotid artery: An epidemiological study. Atherosclerosis 2007, 191, 206-210.
13. Furuki, K.; Adachi, H.; Enomoto, M.; Otsuka, M.; Fukami, A.; Kumagae, S.; Matsuoka, H.; Nanjo, Y.; Kakuma, T.; Imaizumi, T. Plasma level of asymmetric dimethylarginine (ADMA) as a predictor of carotid intima-media thickness progression: Six-year prospective study using carotid ultrasonography. Hypertens. Res. 2008, 31, 1185-1189
14. Chirinos, J.A.; David, R.; Bralley, J.A.; Zea-Díaz, H.; Muñoz-Atahualpa, E.; Corrales-Medina, F.; Cuba-Bustinza, C.; Chirinos-Pacheco, J.; Medina-Lezama, J. Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease: The PREVENCION Study. Hypertension 2008, 52, 1051-1059.
15. Nanayakkara, P.W.; Teerlink, T.; Stehouwer, C.D.; Allajar, D.; Spijkerman, A.; Schalkwijk, C.; Ter Wee, P.M.; van Guldener, C. Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure. Kidney Int. 2005, 68, 2230-2236.
16. Zoccali, C.; Benedetto, F.A.; Maas, R.; Mallamaci, F.; Tripepi, G.; Malatino, L.S.; Böger, R.; CREED Investigators. Asymmetric dimethylarginine, C-reactive protein, and carotid intima-media thickness in end-stage renal disease. J. Am. Soc. Nephrol. 2002, 13, 490-496.
17. Schott, L.L.; Wildman, R.P.; Brockwell, S.; Simkin-Silverman, L.R.; Kuller, L.H.; Sutton-Tyrrell, K. Segment-specific effects of cardiovascular risk factors on carotid artery intima-medial thickness in women at midlife. Arterioscler. Thromb. Vasc. Biol. 2004, 24, 1951-1956.
18. Santilli, F.; Bucciarelli, L.; Noto, D.; Cefalù, A.B.; Davì, V.; Ferrante, E.; Pettinella, C.; Averna, M.R.; Ciabattoni, G.; Davì, G. Decreased plasma soluble RAGE in patients with hypercholesterolemia: Effects of statins. Free. Radic. Biol. Med. 2007, 43, 1255-1262.
19. Wolf, A.; Zalpour, C.; Theilmeier, G. Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. J. Am. Coll. Cardiol. 1997, 29, 479-485.
20. Sibal, L.; Agarwal, S.C.; Home, P.D.; Boger, R.H. The Role of asymmetric dimethylarginine (ADMA) in endothelial dysfunction and cardiovascular disease. Curr. Cardiol. Rev. 2010, 6, 82-90.
21. Srinidi Mohan, S.; Fung, H.L. Mechanism of cellular oxidation stress induced by asymmetric dimethylarginine. Int. J. Mol. Sci. 2012, 13, 7521-7531.
22. Xia, W.; Shao, W.; Wang, Y.; Wang, X.; Chi, Y. Asymmetric dimethylarginine and carotid atherosclerosis in Type 2 diabetes mellitus. J. Endocrinol. Investig. 2012, 35, 824-827.
23. Riccioni, G.; Bucciarelli, V.; Scotti, L.; Aceto, A.; D'Orazio, N.; di Ilio, E.; Bucciarelli, T. Relationship between asymetric dimethyargine and asymptomatic carotid atherosclerosis. J. Biol. Regul. Homeost. Agents 2010, 24, 351-358.
24. Sandoo, A.; Dimitroulas, T.; Veldhuijzen van Zanten, J.J.; Smith, J.P.; Metsios, G.S.; Nightingale, P.; Stravroupoulos-Kalinglou, A.; Kitas, G.D. Lack odf association between asymmetric dimethylarginine and in viso microvascular and macroascular endothelial function in patients with rheumatoid arthritis. Clin. Exp. Rhemumatol. 2012, 30, 388-396.
25. De Jong, S.; Teerlink, T. Analysis of asymmetric dimethylarginine in plasma by HPLC using a monolithic column. Anal. Biochem. 2006, 353, 287-289.