Maximal cardiac output determines 6 minutes walking distance in pulmonary hypertension

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Deboeck, Gaël ^a   Taboada, Dolores ^b   Hagan, Guy ^b   Treacy, Carmen ^b   Page, Kathy ^b   Sheares, Karen ^b   Naeije, Robert ^c   Pepke Zaba, Joanna ^b  

^a ERASME HOSPITAL   (Belgium)

^b PAPWORTH HOSPITAL   (United Kingdom)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE;

6 MINUTES WALK TEST; ADULT; ARTICLE; CARDIOPULMONARY EXERCISE TEST; CLINICAL ARTICLE; CONTROLLED STUDY; EXERCISE; FEMALE; FUNCTION TEST; HEART OUTPUT; HEART RATE; HEART RIGHT VENTRICLE FAILURE; HEART STROKE VOLUME; HUMAN; MALE; PULMONARY HYPERTENSION; WALKING;

ADULT; CARDIAC OUTPUT; EXERCISE TEST; FEMALE; HUMANS; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED; WALKING;

EID: 84898604596     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0092324     Document Type: Article

References (30)

1. Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, et al. (2013) Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol 62: D42-50.
2. Stringer W, Hansen J, Wasserman K (1997) Cardiac Output estimated noninvsively from oxygen uptake (VO2) during exercise. J Appl Physiol 1997;82:908-912. (Pubitemid 27123273)
3. Naeije R (2010) The 6-min walk distance in pulmonary arterial hypertension: "Je t'aime, moi non plus". Chest;137:1258-60
4. Mainguy V, Malenfant S, Neyron AS, Bonnet S, Maltais F, et al. (2013) Repeatability and responsiveness of exercise tests in pulmonary arterial hypertension. Eur Resp J;42:425-434
5. Sitbon O, Humbert M, Nunes H, Parent F, Garcia G, et al. (2002) Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. J Am Coll Cardiol.;40:780-788. (Pubitemid 34925627)
6. Groepenhoff H, Vonk-Noordegraaf A, Boonstra, Spreeuwenberg MD, Postmus PE, et al. (2008) Exercise testing to estimate survival in pulmonary hypertension. Med Sci Sports Exerc.;40:1725-32.
7. Deboeck G, Scoditi C, Huez S, Vachiéry JL, Lamotte M, et al. (2012) Exercise testing to predict outcome in idiopathic versus associated pulmonary arterial hypertension. Eur Respir J.;40:1410-9
8. Deboeck G, Niset G, Vachiery JL, Moraine JJ, Naeije R (2005) Physiological response to the six-minute walk test in pulmonary arterial hypertension. Eur Respir J;26: 667-672. (Pubitemid 41448666)
9. McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M, et al. (2012) ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure Eur Heart J. 2012 Jul;33(14):1787-847. doi: 10.1093/eurheartj/ehs104. Epub 2012 May 19.
10. Agostoni P, Cattadori G, Apostolo A, Contini M, Palermo P, et al. (2005) Noninvasive measurement of cardiac output during exercise by inert gas rebreathing technique: a new tool for heart failure evaluation. J Am Coll Cardiol 46:1779e81
11. Lang CC, Karlin P, Haythe J, Tsao L, Mancini DM (2007) Ease of noninvasive measurement of cardiac output coupled with peak VO2 determination at rest and during exercise in patients with heart failure. Am J Cardiol;99:404e5.
12. Farina S, Teruzzi G, Cattadori G, Ferrari C, De Martini S, et al. (2014) Noninvasive cardiac output measurement by inert gas rebreathing in suspected pulmonary hypertension. Am J Cardiol. Feb 1;113(3):546-51
13. Lee WT, Brown A, Peacock AJ, Johnson MK (2011) Use of non-invasive haemodynamic measurements to detect treatment response in precapillary pulmonary hypertension. Thorax. Sep;66(9):810-4.
14. Sun XG, Hansen JE, Oudiz RJ, Wasserman K (2002) Gas exchange detection of exercise-induced right-to-left shunt in patients with primary pulmonary hypertension. Circulation; 105:54-60. (Pubitemid 34049142)
15. American Thoracic Society (2002) ATS Statement: Guidelines for the six-minute walk test. Am J Respir Crit Care Med.;166:111-117.
16. Palange P, Ward SA, Carlsen KH, Casaburi R, Gallagher CG, et al. (2007) ERS Task Force, Recommendations on the use of exercise testing in clinical practice. Eur Respir J;29: 185-209. (Pubitemid 46092015)
17. Champion HC, Michelakis ED, Hassoun PM (2009) Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications. Circulation;120: 992-1007
18. Lipkin DP, Scriven AJ, Crake T, Poole-Wilson PA (1986) Six minute walking test for assessing exercise capacity in chronic heart failure. Br Med J (Clin Res Ed) 8;292:653-5.
19. Frost AE, Langleben D, Oudiz R, Hill N, Horn E, et al. (2005) The 6-min walk test (6MW) as an efficacy endpoint in pulmonary arterial hypertension clinical trials: demonstration of a ceiling effect. Vascul Pharmacol 43:36-9. (Pubitemid 40828831)
20. Deboeck G, Van Muylem A, Vachiéry JL, Naeije R (2013) Physiological response to the 6 minute walk test in chronic heart failure patients versus normal subjects. Eur J Prev Cardiol Mar 19 [Epub ahead of print]
21. Fijalkowska A, Kurzyna M, Torbicki A, Szewczyk G, Florczyk M, et al. (2006) Serum N-terminal brain natriuretic peptide as a prognostic parameter in patients with pulmonary hypertension. Chest 129: 1313-1321.
22. Frantz RP, McDevitt S, Walker S (2012) Baseline NT-proBNP correlates with change in 6-minute walk distance in patients with pulmonary arterial hypertension in the pivotal inhaled treprostinil study TRIUMPH-1. J Heart Lung Transplant 31:811-6.
23. Nootens M, Wolfkiel CJ, Chomka EV, Rich S (1995) Understanding right and left ventricular systolic function and interactions at rest and with exercise in primary pulmonary hypertension. Am J Cardiol 75: 374-377.
24. Laskey WK, Ferrari VA, Palevsky HI, Kussmaul WG (1993) Pulmonary artery hemodynamics in primary pulmonary hypertension. J Am Coll Cardiol 21: 406-412. (Pubitemid 23047924)
25. Deboeck G, Niset G, Lamotte M, Vachiéry JL, Naeije R (2004) Cardiopulmonary exercise testing in pulmonary arterial hypertension and in congestive heart failure. Eur Respir J 23:747-751. (Pubitemid 38618147)
26. Provencher S, Chemla D, Herve P, Sitbon O, Humbert M, et al. (2006) Heart rate responses during the 6 min walk test in pulmonary arterial hypertension. Eur Respir J 27:114-120. (Pubitemid 43092674)
27. Wensel R, Opitz CF, Anker SD, Winkler J, Höffken G, et al. (2002) Assessment of survival in patients with primary pulmonary hypertension. Importance of cardiopulmonary exercise testing. Circulation 106: 319-324. (Pubitemid 34778955)
28. Wensel R, Francis DP, Meyer FJ, Opitz CF, Bruch L, et al. (2013) Incremental prognostic value of cardiopulmonary exercise testing and resting haemodynamics in pulmonary arterial hypertension. Int J Cardiol 167: 1193-8
29. Guyton AC, Hall JE (2011) Textbook of Medical Physiology (12th ed.). Philadelphia, Pa.: Saunders/Elsevier.
30. Vella CA, Robergs RA (2005) A review of the stroke volume repsonse to upright exercise in healthy subjects. Br J Sports Med 39:190-195. (Pubitemid 40478201)