Lactic acidosis induced by metformin in a chronic hemodialysis patient with diabetes mellitus type 2

Hemodialysis International

Volumn 18, Issue 2, 2014, Pages 529-531

  Altun, Eda ^a   Kaya, Bülent ^a   Paydaş, Saime ^a   Sariakçali, Bariş ^a   Karayaylali, Ibrahim ^a  

^a CUKUROVA UNIVERSITY   (Turkey)

Author keywords

Hemodialysis; Lactic acidosis; Metformin; Type 2 diabetes mellitus

Indexed keywords

BUFFER; CREATININE; GLUCOSE; INSULIN GLARGINE; LACTIC ACID; METFORMIN; POTASSIUM; SODIUM; ANTIDIABETIC AGENT;

ABDOMINAL PAIN; AGED; ANOREXIA; ARTICLE; BLOOD GAS ANALYSIS; BLOOD PH; CARBON DIOXIDE TENSION; CASE REPORT; CHRONIC KIDNEY FAILURE; CREATININE BLOOD LEVEL; DIARRHEA; DRUG WITHDRAWAL; GLUCOSE BLOOD LEVEL; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; HYPERTENSION; LACTATE BLOOD LEVEL; LACTIC ACIDOSIS; MALE; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; POTASSIUM BLOOD LEVEL; RISK FACTOR; SINGLE DRUG DOSE; SODIUM BLOOD LEVEL; TREATMENT DURATION; UREA NITROGEN BLOOD LEVEL; VOMITING; CHEMICALLY INDUCED; CHRONIC DISEASE; DIABETES MELLITUS, TYPE 2; INCIDENCE; KIDNEY FAILURE, CHRONIC; METABOLISM; PROCEDURES; RENAL REPLACEMENT THERAPY;

ACIDOSIS, LACTIC; AGED; CHRONIC DISEASE; DIABETES MELLITUS, TYPE 2; HUMANS; HYPOGLYCEMIC AGENTS; INCIDENCE; KIDNEY FAILURE, CHRONIC; MALE; METFORMIN; RENAL DIALYSIS; RISK FACTORS;

EID: 84898601956     PISSN: 14927535     EISSN: 15424758     Source Type: Journal    
DOI: 10.1111/hdi.12109     Document Type: Article

References (10)

1. Prod Info Glucophage. Available from: http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Glucophage_30/WC500011044.pdf (accessed date: November 22, 2013).
2. Lalau JD, Andrejak M, Moriniere P, etal. Hemodialysis in the treatment of lactic acidosis in diabetics treated by metformin: A study of metformin elimination. Int J Clin Pharmacol Ther Toxicol. 1989; 27:285-288.
3. Spiller HA. Management of antidiabetic medications in overdose. Drug Saf. 1998; 19:411-424.
4. Stang M, Wysowski DK, Butler-Jones D. Incidence of lactic acidosis in metformin users. Diabetes Care. 1999; 22:925-927.
5. Spiller HA, Sawyer TS. Toxicology of oral antidiabetic medications. Am J Health Syst Pharm. 2006; 63:929-938.
6. Scheen AJ. Clinical pharmacokinetics of metformin. Clin Pharmacokinet. 1996; 30:359-371.
7. Bailey CJ, Turner RC. Metformin. N Engl J Med. 1996; 334:574.
8. Yeung CW, Chung HY, Fong BMW, etal. Metformin-associated lactic acidosis in Chinese patients with type II diabetes. Pharmacology. 2011; 88:260-265.
9. Lalau JD, Race JM. Lactic acidosis in metformin-treated patients. Prognostic value of arterial lactate levels and plasma metformin concentrations. Drug Saf. 1999; 20:377-384.
10. Dell'Aglio DM, Perino LJ, Kazzi Z, Abramson J, Schwartz MD, Morgan BW. Acute metformin overdose: examining serum pH, lactate level, and metformin concentrations in survivors versus nonsurvivors: A systematic review of the literature. Ann Emerg Med. 2009; 54:818-823.