Improved expression of recombinant human factor IX by co-expression of GGCX, VKOR and furin

Protein Journal

Volumn 33, Issue 2, 2014, Pages 174-183

  Liu, Jianming ^a   Jonebring, Anna ^a   Hagström, Jonas ^a   Nyström, Ann Christin ^a   Lövgren, Ann ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

CHO cells; Co expression; Haemophilia; Purification; Recombinant factor IX; carboxylation

Indexed keywords

CARBOXYLASE; FURIN; GAMMA GLUTAMYL CARBOXYLASE; GLUTAMIC ACID; HUMAN RECOMBINANT BLOOD CLOTTING FACTOR 9; MESSENGER RNA; RECOMBINANT BLOOD CLOTTING FACTOR 9; SIGNAL PEPTIDE; UNCLASSIFIED DRUG; VITAMIN K EPOXIDE REDUCTASE;

ANIMAL CELL; ARTICLE; CARBOXYLATION; CHO CELL; CLONE; EXPRESSION VECTOR; MOLECULAR WEIGHT; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PURIFICATION;

CRICETULUS GRISEUS;

AMINO ACID SEQUENCE; ANIMALS; CARBON-CARBON LIGASES; CHO CELLS; CRICETINAE; CRICETULUS; FACTOR IX; FURIN; GENE EXPRESSION; GENETIC VECTORS; HUMANS; MOLECULAR SEQUENCE DATA; RECOMBINANT PROTEINS; VITAMIN K EPOXIDE REDUCTASES;

EID: 84898546231     PISSN: 15723887     EISSN: 18758355     Source Type: Journal    
DOI: 10.1007/s10930-014-9550-5     Document Type: Article

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