Structural basis of substrate specificity of human oligosaccharyl transferase subunit N33/Tusc3 and its role in regulating protein N-glycosylation

Structure

Volumn 22, Issue 4, 2014, Pages 590-601

  Mohorko, Elisabeth ^a,c   Owen, Robin L ^b   Malojčić, Goran ^a,e   Brozzo, Maurice S ^a,d   Aebi, Markus ^a   Glockshuber, Rudi ^a  

^a ETH ZURICH   (Switzerland)

^b DIAMOND LIGHT SOURCE LTD   (United Kingdom)

^c MAX PLANCK INSTITUTE FOR TERRESTRIAL MICROBIOLOGY   (Germany)

^d ABBOTT LABORATORIES   (United States)

^e HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; OLIGOSACCHARIDE; OLIGOSACCHARYLTRANSFERASE SUBUNIT N33; THIOREDOXIN; TRANSFERASE; UNCLASSIFIED DRUG; GLUTATHIONE; OLIGOSACCHARYL TRANSFERASE SUBUNIT N33; OLIGOSACCHARYL TRANSFERASE SUBUNIT TUSC3; PEPTIDE FRAGMENT; DISULFIDE; MEMBRANE PROTEIN; N33 PROTEIN, HUMAN; PEPTIDE; PROTEIN BINDING; PROTEIN SUBUNIT; RECOMBINANT PROTEIN; TUMOR SUPPRESSOR PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; ENDOPLASMIC RETICULUM; ENZYME SPECIFICITY; HUMAN; HYDROPHOBICITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN GLYCOSYLATION; REGULATORY MECHANISM; STRUCTURE ANALYSIS; CATALYSIS; CONTROLLED STUDY; CRYSTALLIZATION; DISULFIDE BOND; ENZYME SUBSTRATE; EQUILIBRIUM CONSTANT; OXIDATION REDUCTION POTENTIAL; OXIDATION REDUCTION STATE; PH; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROCESSING; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT; THERMOSTABILITY; AMINO ACID SEQUENCE; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; GENE EXPRESSION; GENETICS; GLYCOSYLATION; MOLECULAR GENETICS; PROTEIN MULTIMERIZATION; PROTEIN SUBUNIT; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

EUKARYOTA;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DISULFIDES; GENE EXPRESSION; GLYCOSYLATION; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TUMOR SUPPRESSOR PROTEINS;

EID: 84898469110     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2014.02.013     Document Type: Article

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