Non-culture neisseria gonorrhoeae molecular penicillinase production surveillance demonstrates the long-term success of empirical dual therapy and informs gonorrhoea management guidelines in a highly endemic setting

Journal of Antimicrobial Chemotherapy

Volumn 69, Issue 5, 2014, Pages 1243-1247

  Speers, David J ^a,b   Fisk, Rachel E ^a   Goire, Namraj ^a   Mak, Donna B ^c  

^a PATHWEST LABORATORY MEDICINE   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c Communicable Disease Control Directorate Grace Vaughan House WA Health Department ^*  (Australia)

Author keywords

Antimicrobial resistance surveillance; Plasmids; Public health

Indexed keywords

AMOXICILLIN; AZITHROMYCIN; BACTERIAL DNA; BETA LACTAMASE TEM 1; PENICILLINASE; PROBENECID;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL RESISTANCE SURVEILLANCE; ARTICLE; AUSTRALIA; BACTERIAL STRAIN; BACTERIUM DETECTION; BACTERIUM ISOLATE; BIOSURVEILLANCE; CONTROLLED STUDY; DRUG EFFICACY; ENZYME SYNTHESIS; EVIDENCE BASED PRACTICE; GONORRHEA; HUMAN; MAJOR CLINICAL STUDY; MOLECULAR DIAGNOSIS; NEISSERIA GONORRHOEAE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRACTICE GUIDELINE; REAL TIME POLYMERASE CHAIN REACTION; RURAL AREA; DRUG COMBINATION; ENZYMOLOGY; EPIDEMIOLOGICAL MONITORING; GENETICS; ISOLATION AND PURIFICATION; MICROBIOLOGY; ORAL DRUG ADMINISTRATION; PROCEDURES;

ADMINISTRATION, ORAL; AMOXICILLIN; AZITHROMYCIN; DRUG THERAPY, COMBINATION; EPIDEMIOLOGICAL MONITORING; GONORRHEA; HUMANS; NEISSERIA GONORRHOEAE; PENICILLINASE; PLASMIDS; PROBENECID; WESTERN AUSTRALIA;

EID: 84898464075     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkt501     Document Type: Article

References (19)

1. Ohnishi M, Golparian D, Shimuta K et al. Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone. Antimicrob Agents Chemother 2011; 55: 3538-45.
2. Unemo M, Golparian D, Nicholas R et al. High-level cefixime-and ceftriaxone-resistant Neisseria gonorrhoeae in Europe (France): novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother 2012; 56: 1273-80.
3. Cámara J, Serra J, Ayats J et al. Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain. J Antimicrob Chemother 2012; 67: 1858-60.
4. CDC. Sexually transmitted diseases treatment guidelines, 2010. MMWR Recomm Rep 2010; 59: 1-110.
5. Bignell C, Fitzgerald M. UK national guideline for the management of gonorrhoea in adults, 2011. Int J STD AIDS 2011; 22: 541-7.
6. Whiley DM, Goire N, Lahra MM et al. The ticking time bomb: escalating antibiotic resistance in Neisseria gonorrhoeae is a public health disaster in waiting. J Antimicrob Chemother 2012; 67: 2059-61.
7. Goire N, Freeman K, Tapsall JW et al. Enhancing gonococcal antimicrobial resistance surveillance: a real-time PCR assay for detection of penicillinase-producing Neisseria gonorrhoeae by use of noncultured clinical samples. J Clin Microbiol 2011; 49: 513-8.
8. Government ofWestern Australia Public Health. Guidelines for Managing Sexually Transmitted Infections-WA. http://silverbook.health.wa.gov.au/ (26 September 2013, date last accessed).
9. Lahra M. Annual report of the Australian Gonococcal Surveillance Programme, 2011. Commun Dis Intell 2012; 36: 166-73.
10. Disease Watch-The Western Australian Communicable Diseases Bulletin. http://www.public.health.wa.gov.au/3/533/2/disease_watch.pm (26 November 2013, date last accessed).
11. Ison CA, Alexander S. Antimicrobial resistance in Neisseria gonorrhoeae in the UK: surveillance and management. Expert Anti Infect Ther Rev 2010; 9: 867-76.
12. Whiley DM, Tapsall JW, Sloots TP. Nucleic acid amplification testing for Neisseria gonorrhoeae: an ongoing challenge. J Mol Diagn 2006; 8: 3-15.
13. Smith JC, Mailman T, MacDonald NE. How to get and get rid of gonorrhea. Adv Exp Med Biol 2013; 764: 219-39.
14. Kwan K, Mak D, Minas B. The Epidemiology of Notifiable Sexually Transmitted Infections and Blood-Borne Viruses in Western Australia 2010. Department of Health, Western Australia, Perth. http://www.public. health.wa.gov.au/cproot/4221/2/2010_Annual_STI_BBV_Report.pdf (26 November 2013, date last accessed).
15. Goire N, Freeman K, Lambert SB et al. The influence of target population on nonculture-based detection of markers of Neisseria gonorrhoeae antimicrobial resistance. Sex Health 2012; 9: 422-9.
16. National Pathology Accreditation Advisory Council. Requirements for the Development and Use of In-House In Vitro Diagnostic Devices 2007. http://www.health.gov.au/internet/main/publishing.nsf/Content/healthnpaac-dhaivd.htm (21 December 2013, date last accessed).
17. Quarterly Surveillance Report. Notifiable Sexually Transmissible Infections and Blood-Borne Viruses in Western Australia. Period ending 30 June 2013, Vol. 10(3). Government of Western Australia Public Health and Clinical Services. http://www.public.health.wa.gov.au/3/480/2/ sexually_transmitted_infections_and_bloodborne_vir.pm (26 November 2013, date last accessed).
18. Dillon JA. Sustainable antimicrobial surveillance programs essential for controlling Neisseria gonorrhoeae superbug. Sex Transm Dis 2011; 38: 899-901.
19. WHO. Guidelines for the Management of Sexually Transmitted Infections. 2004. http://www.who.int/hiv/pub/sti/pub6/en/ (26 November 2013, date last accessed).