메뉴 건너뛰기




Volumn 9, Issue 3, 2014, Pages 224-234

Autoreactivity in HIV-1 broadly neutralizing antibodies: Implications for their function and induction by vaccination

Author keywords

Autoreactivity; broadly neutralizing antibodies; immune tolerance; polyreactivity; somatic hypermutation

Indexed keywords

EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS 1 BROADLY NEUTRALIZING ANTIBODY; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

EID: 84898463606     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0000000000000049     Document Type: Review
Times cited : (51)

References (108)
  • 1
    • 77954357410 scopus 로고    scopus 로고
    • Correlates of protection induced by vaccination
    • Plotkin S. Correlates of protection induced by vaccination. Clin Vaccine Immunol 2010; 17:1055-1065.
    • (2010) Clin Vaccine Immunol , vol.17 , pp. 1055-1065
    • Plotkin, S.1
  • 2
    • 0037456827 scopus 로고    scopus 로고
    • Antibody neutralization and escape by HIV
    • Wei X, Decker JM, Wang S, et al. Antibody neutralization and escape by HIV. Nature 2003; 422:307-312.
    • (2003) Nature , vol.422 , pp. 307-312
    • Wei, X.1    Decker, J.M.2    Wang, S.3
  • 3
    • 68349160853 scopus 로고    scopus 로고
    • Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques
    • Hessell AJ, Poignard P, Hunter M, et al. Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques. Nat Med 2009; 15:951-954.
    • (2009) Nat Med , vol.15 , pp. 951-954
    • Hessell, A.J.1    Poignard, P.2    Hunter, M.3
  • 4
    • 67249131966 scopus 로고    scopus 로고
    • Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers
    • Hessell AJ, Rakasz EG, Poignard P, et al. Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers. PLoS Path 2009; 5:e1000433.
    • (2009) PLoS Path , vol.5
    • Hessell, A.J.1    Rakasz, E.G.2    Poignard, P.3
  • 5
    • 84855466746 scopus 로고    scopus 로고
    • Antibody-based protection against HIV infection by vectored immunoprophylaxis
    • Balazs AB, Chen J, Hong CM, et al. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature 2012; 481:81-84.
    • (2012) Nature , vol.481 , pp. 81-84
    • Balazs, A.B.1    Chen, J.2    Hong, C.M.3
  • 6
    • 67650453747 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 elite neutralizers: Individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm
    • Simek MD, Rida W, Priddy FH, et al. Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm. J Virol 2009; 83:7337-7348.
    • (2009) J Virol , vol.83 , pp. 7337-7348
    • Simek, M.D.1    Rida, W.2    Priddy, F.H.3
  • 7
    • 79955389756 scopus 로고    scopus 로고
    • The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection
    • Gray ES, Madiga MC, Hermanus T, et al. The neutralization breadth of HIV-1 develops incrementally over four years and is associated with CD4+ T cell decline and high viral load during acute infection. J Virol 2011; 85:4828-4840.
    • (2011) J Virol , vol.85 , pp. 4828-4840
    • Gray, E.S.1    Madiga, M.C.2    Hermanus, T.3
  • 8
    • 80055104586 scopus 로고    scopus 로고
    • Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals
    • Tomaras GD, Binley JM, Gray ES, et al. Polyclonal B cell responses to conserved neutralization epitopes in a subset of HIV-1-infected individuals. J Virol 2011; 85:11502-11519.
    • (2011) J Virol , vol.85 , pp. 11502-11519
    • Tomaras, G.D.1    Binley, J.M.2    Gray, E.S.3
  • 9
    • 79551518897 scopus 로고    scopus 로고
    • Characteristics of the earliest cross-neutralizing antibody response to HIV-1
    • Mikell I, Sather DN, Kalams SA, et al. Characteristics of the earliest cross-neutralizing antibody response to HIV-1. PLoS Pathog 2011; 7:e1001251.
    • (2011) PLoS Pathog , vol.7
    • Mikell, I.1    Sather, D.N.2    Kalams, S.A.3
  • 10
    • 63749100579 scopus 로고    scopus 로고
    • A method for identification of HIV gp140 binding memory B cells in human blood
    • Schied JF, Mouquet H, Feldhahn N, et al. A method for identification of HIV gp140 binding memory B cells in human blood. J Immunol Methods 2009; 343:65-67.
    • (2009) J Immunol Methods , vol.343 , pp. 65-67
    • Schied, J.F.1    Mouquet, H.2    Feldhahn, N.3
  • 11
    • 80053584837 scopus 로고    scopus 로고
    • Isolation of a human HIV gp41 membrane proximal region neutralizing antibody by antigen-specific B cell sorting
    • Morris L, Chen X, Alam M, et al. Isolation of a human HIV gp41 membrane proximal region neutralizing antibody by antigen-specific B cell sorting. PLoS One 2011; 6:e23532.
    • (2011) PLoS One , vol.6
    • Morris, L.1    Chen, X.2    Alam, M.3
  • 12
    • 70349887757 scopus 로고    scopus 로고
    • Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target
    • Walker LM, Phogat SK, Chan-Hui PY, et al. Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target. Science 2009; 326:285-289.
    • (2009) Science , vol.326 , pp. 285-289
    • Walker, L.M.1    Phogat, S.K.2    Chan-Hui, P.Y.3
  • 13
    • 80052938385 scopus 로고    scopus 로고
    • Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors
    • Bonsignori M, Hwang KK, Chen X, et al. Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors. J Virol 2011; 85:9998-10009.
    • (2011) J Virol , vol.85 , pp. 9998-10009
    • Bonsignori, M.1    Hwang, K.K.2    Chen, X.3
  • 14
    • 0041689676 scopus 로고    scopus 로고
    • Predominant autoantibody production by early human B cell precursors
    • Wardemann H, Yurasov S, Schaefer A, et al. Predominant autoantibody production by early human B cell precursors. Science 2003; 301:1374-1377.
    • (2003) Science , vol.301 , pp. 1374-1377
    • Wardemann, H.1    Yurasov, S.2    Schaefer, A.3
  • 15
    • 64949164763 scopus 로고    scopus 로고
    • High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies
    • Liao HX, Levesque MC, Nagel A, et al. High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J Virol Methods 2009; 158:171-179.
    • (2009) J Virol Methods , vol.158 , pp. 171-179
    • Liao, H.X.1    Levesque, M.C.2    Nagel, A.3
  • 16
    • 84879302728 scopus 로고    scopus 로고
    • HIV-1 neutralizing antibodies: Understanding nature's pathways
    • Mascola JR, Haynes BF. HIV-1 neutralizing antibodies: understanding nature's pathways. Immunol Rev 2013; 254:225-244.
    • (2013) Immunol Rev , vol.254 , pp. 225-244
    • Mascola, J.R.1    Haynes, B.F.2
  • 17
    • 80052925616 scopus 로고    scopus 로고
    • Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding
    • Scheid JF, Mouquet H, Ueberheide B, et al. Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 2011; 333:1633-1637.
    • (2011) Science , vol.333 , pp. 1633-1637
    • Scheid, J.F.1    Mouquet, H.2    Ueberheide, B.3
  • 18
    • 77958115264 scopus 로고    scopus 로고
    • A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals
    • Walker LM, Simek MD, Priddy F, et al. A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals. PLoS Path 2010; 6:e1001028.
    • (2010) PLoS Path , vol.6
    • Walker, L.M.1    Simek, M.D.2    Priddy, F.3
  • 19
    • 84860723906 scopus 로고    scopus 로고
    • Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: Implications for vaccine design
    • Bonsignori M, Montefiori DC, Wu X, et al. Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design. J Virol 2012; 86:4688-4692.
    • (2012) J Virol , vol.86 , pp. 4688-4692
    • Bonsignori, M.1    Montefiori, D.C.2    Wu, X.3
  • 20
    • 84863269120 scopus 로고    scopus 로고
    • HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes
    • Doria-Rose NA, Louder MK, Yang Z, et al. HIV-1 neutralization coverage is improved by combining monoclonal antibodies that target independent epitopes. J Virol 2012; 86:3393-3397.
    • (2012) J Virol , vol.86 , pp. 3393-3397
    • Doria-Rose, N.A.1    Louder, M.K.2    Yang, Z.3
  • 21
    • 84876797103 scopus 로고    scopus 로고
    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus
    • Liao H-X, Lynch R, Zhou Z, et al. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature 2013; 496:469-476.
    • (2013) Nature , vol.496 , pp. 469-476
    • Liao, H.-X.1    Lynch, R.2    Zhou, Z.3
  • 22
    • 0032543555 scopus 로고    scopus 로고
    • The antigenic structure of the HIV gp120 envelope glycoprotein
    • Wyatt R, Kwong PD, Desjardins E, et al. The antigenic structure of the HIV gp120 envelope glycoprotein. Nature 1998; 393:705-711.
    • (1998) Nature , vol.393 , pp. 705-711
    • Wyatt, R.1    Kwong, P.D.2    Desjardins, E.3
  • 23
    • 0037069682 scopus 로고    scopus 로고
    • HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites
    • Kwong PD, Doyle ML, Casper DJ, et al. HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites. Nature 2002; 420:678-682.
    • (2002) Nature , vol.420 , pp. 678-682
    • Kwong, P.D.1    Doyle, M.L.2    Casper, D.J.3
  • 24
  • 25
    • 69149083668 scopus 로고    scopus 로고
    • Neutralizing antibodies generated during natural HIV-1 infection: Good news for an HIV-1 vaccine?
    • Stamatatos L, Morris L, Burton DR, et al. Neutralizing antibodies generated during natural HIV-1 infection: good news for an HIV-1 vaccine? Nature Med 2009; 15:866-870.
    • (2009) Nature Med , vol.15 , pp. 866-870
    • Stamatatos, L.1    Morris, L.2    Burton, D.R.3
  • 26
    • 57349127300 scopus 로고    scopus 로고
    • Initial B-cell responses to transmitted human immunodeficiency virus type 1: Virion-binding immunoglobulin M (IgM) and IgG antibodies followed by Plasma Antigp41 antibodies with ineffective control of initial viremia
    • Tomaras GD, Yates NL, Liu P, et al. Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by Plasma Antigp41 antibodies with ineffective control of initial viremia. J Virol 2008; 82:12449-12463.
    • (2008) J Virol , vol.82 , pp. 12449-12463
    • Tomaras, G.D.1    Yates, N.L.2    Liu, P.3
  • 27
    • 80055118908 scopus 로고    scopus 로고
    • Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated
    • Liao HX, Chen X, Munshaw S, et al. Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. J Exp Med 2011; 208:2237-2249.
    • (2011) J Exp Med , vol.208 , pp. 2237-2249
    • Liao, H.X.1    Chen, X.2    Munshaw, S.3
  • 28
    • 84863774072 scopus 로고    scopus 로고
    • Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses
    • Burton DR, Poignard P, Stanfield RL, et al. Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses. Science 2012; 337:183-186.
    • (2012) Science , vol.337 , pp. 183-186
    • Burton, D.R.1    Poignard, P.2    Stanfield, R.L.3
  • 29
    • 84866495323 scopus 로고    scopus 로고
    • Human antibodies that neutralize HIV-1: Identification, structures, and B cell ontogenies
    • Kwong PD, Mascola JR. Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies. Immunity 2012; 37:412-425.
    • (2012) Immunity , vol.37 , pp. 412-425
    • Kwong, P.D.1    Mascola, J.R.2
  • 30
    • 84874561170 scopus 로고    scopus 로고
    • Neutralizing antibodies to HIV-1 induced by immunization
    • McCoy LE, Weiss RA. Neutralizing antibodies to HIV-1 induced by immunization. J Exp Med 2013; 210:209-223.
    • (2013) J Exp Med , vol.210 , pp. 209-223
    • McCoy, L.E.1    Weiss, R.A.2
  • 31
    • 84880184277 scopus 로고    scopus 로고
    • Development of prophylactic vaccines against HIV-1
    • Schiffner T, Sattentau QJ, Dorrell L. Development of prophylactic vaccines against HIV-1. Retrovirology 2013; 10:72-88.
    • (2013) Retrovirology , vol.10 , pp. 72-88
    • Schiffner, T.1    Sattentau, Q.J.2    Dorrell, L.3
  • 32
    • 84866513274 scopus 로고    scopus 로고
    • Antigenicity and immunogenicity in HIV-1 antibody-based vaccine design
    • Kong L, Sattentau QJ. Antigenicity and immunogenicity in HIV-1 antibody-based vaccine design. J AIDS Clin Res 2012; S8:3.
    • (2012) J AIDS Clin Res , vol.S8 , pp. 3
    • Kong, L.1    Sattentau, Q.J.2
  • 33
    • 84879284427 scopus 로고    scopus 로고
    • Insights into B cells and HIV-specific B-cell responses in HIV-infected individuals
    • Moir S, Fauci AS. Insights into B cells and HIV-specific B-cell responses in HIV-infected individuals. Immunol Rev 2013; 254:207-224.
    • (2013) Immunol Rev , vol.254 , pp. 207-224
    • Moir, S.1    Fauci, A.S.2
  • 34
    • 21344434534 scopus 로고    scopus 로고
    • Cardiolipin polyspecific auto-reactivity in two broadly neutralizing HIV-1 antibodies
    • Haynes BF, Fleming J, St Clair EW, et al. Cardiolipin polyspecific auto-reactivity in two broadly neutralizing HIV-1 antibodies. Science 2005; 308:1906-1908.
    • (2005) Science , vol.308 , pp. 1906-1908
    • Haynes, B.F.1    Fleming, J.2    St Clair, E.W.3
  • 35
    • 79957726572 scopus 로고    scopus 로고
    • Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies
    • Verkoczy L, Kelsoe G, Moody MA, et al. Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies. Curr Opin Immunol 2011; 23:383-390.
    • (2011) Curr Opin Immunol , vol.23 , pp. 383-390
    • Verkoczy, L.1    Kelsoe, G.2    Moody, M.A.3
  • 36
    • 33646780263 scopus 로고    scopus 로고
    • Antibody polyspecificity and neutralization of HIV-1: A hypothesis
    • Haynes BF, Moody MA, Verkoczy L, et al. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Hum Antibodies 2005; 14:59-67.
    • (2005) Hum Antibodies , vol.14 , pp. 59-67
    • Haynes, B.F.1    Ma, M.2    Verkoczy, L.3
  • 37
    • 0024410488 scopus 로고
    • Rheumatologic manifestations of infection with human immunodeficiency virus (HIV)
    • Kaye BR. Rheumatologic manifestations of infection with human immunodeficiency virus (HIV). Ann Intern Med 1989; 111:158-167.
    • (1989) Ann Intern Med , vol.111 , pp. 158-167
    • Kaye, B.R.1
  • 38
    • 0027166292 scopus 로고
    • False-positive human immunodeficiency virus testing in patients with lupus erythematosus
    • Barthel HR, Wallace DJ. False-positive human immunodeficiency virus testing in patients with lupus erythematosus. Semin Arthritis Rheum 1993; 23:1-7.
    • (1993) Semin Arthritis Rheum , vol.23 , pp. 1-7
    • Barthel, H.R.1    Wallace, D.J.2
  • 39
    • 0034726377 scopus 로고    scopus 로고
    • Report of a false-positive HIV test result and the potential use of additional tests in establishing HIV serostatus
    • Mylonakis E, Paliou M, Greenbough TC, et al. Report of a false-positive HIV test result and the potential use of additional tests in establishing HIV serostatus. Arch Intern Med 2000; 160:2386-2388.
    • (2000) Arch Intern Med , vol.160 , pp. 2386-2388
    • Mylonakis, E.1    Paliou, M.2    Greenbough, T.C.3
  • 40
    • 0036179274 scopus 로고    scopus 로고
    • Human immunodeficiency virus infection and systemic lupus erythematosus. An unusual case and a review of the literature
    • Palacios R, Santos J, Valdivielso P, et al. Human immunodeficiency virus infection and systemic lupus erythematosus. An unusual case and a review of the literature. Lupus 2002; 11:60-63.
    • (2002) Lupus , vol.11 , pp. 60-63
    • Palacios, R.1    Santos, J.2    Valdivielso, P.3
  • 41
    • 0038813708 scopus 로고    scopus 로고
    • Systemic and discoid lupus erythe-matosus in HIV-infected patients treated with highly active antiretroviral therapy
    • Calza L, Manfredi R, Colangeli V, et al. Systemic and discoid lupus erythe-matosus in HIV-infected patients treated with highly active antiretroviral therapy. Int J STD AIDS 2003; 14:356-359.
    • (2003) Int J STD AIDS , vol.14 , pp. 356-359
    • Calza, L.1    Manfredi, R.2    Colangeli, V.3
  • 42
    • 76249083814 scopus 로고    scopus 로고
    • Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance
    • Verkoczy L, Diaz M, Holl TM, et al. Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. Proc Natl Acad Sci USA 2010; 107:181-186.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 181-186
    • Verkoczy, L.1    Diaz, M.2    Holl, T.M.3
  • 44
    • 84880667257 scopus 로고    scopus 로고
    • Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10
    • Chen Y, Zhang J, Hwang KK, et al. Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. J Immunol 2013; 191: 1260-1275.
    • (2013) J Immunol , vol.191 , pp. 1260-1275
    • Chen, Y.1    Zhang, J.2    Hwang, K.K.3
  • 45
    • 84884215837 scopus 로고    scopus 로고
    • Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV anti body 4E10
    • Doyle-Cooper C, Hudson KE, Cooper AB, et al. Immune tolerance negatively regulates B cells in knock-in mice expressing broadly neutralizing HIV anti body 4E10. J Immunol 2013; 191:3186-3191.
    • (2013) J Immunol , vol.191 , pp. 3186-3191
    • Doyle-Cooper, C.1    Hudson, K.E.2    Cooper, A.B.3
  • 46
    • 84884698156 scopus 로고    scopus 로고
    • Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10
    • Finton KA, Larimore K, Larman HB, et al. Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10. PLoS Pathog 2013; 9:e1003639.
    • (2013) PLoS Pathog , vol.9
    • Finton, K.A.1    Larimore, K.2    Larman, H.B.3
  • 47
    • 0024529870 scopus 로고
    • Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class i antibody genes
    • Nemazee DA, Burki K. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 1989; 337:562-566.
    • (1989) Nature , vol.337 , pp. 562-566
    • Nemazee, D.A.1    Burki, K.2
  • 48
    • 0025948793 scopus 로고
    • Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
    • Hartley SB, Crosbie J, Brink R, et al. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 1991; 353:765-769.
    • (1991) Nature , vol.353 , pp. 765-769
    • Hartley, S.B.1    Crosbie, J.2    Brink, R.3
  • 49
    • 0028850944 scopus 로고
    • The site and stage of anti-DNA B-cell deletion
    • Chen C, Nagy Z, Radic MZ, et al. The site and stage of anti-DNA B-cell deletion. Nature 1995; 373:252-255.
    • (1995) Nature , vol.373 , pp. 252-255
    • Chen, C.1    Nagy, Z.2    Radic, M.Z.3
  • 50
    • 0026762942 scopus 로고
    • Transgenic mice and analysis of B-cell tolerance
    • Goodnow CC. Transgenic mice and analysis of B-cell tolerance. Ann Rev Immunol 1992; 10:489-518.
    • (1992) Ann Rev Immunol , vol.10 , pp. 489-518
    • Goodnow, C.C.1
  • 51
    • 84874562109 scopus 로고    scopus 로고
    • Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies
    • Yang G, Holl TM, Liu Y, et al. Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. J Exp Med 2013; 210:241-256.
    • (2013) J Exp Med , vol.210 , pp. 241-256
    • Yang, G.1    Holl, T.M.2    Liu, Y.3
  • 52
    • 37849035658 scopus 로고    scopus 로고
    • Sites and stages of autoreactive B cell activation and regulation
    • Shlomchik MJ. Sites and stages of autoreactive B cell activation and regulation. Immunity 2008; 28:18-28.
    • (2008) Immunity , vol.28 , pp. 18-28
    • Shlomchik, M.J.1
  • 53
    • 0029807629 scopus 로고    scopus 로고
    • B-cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane bound antigen
    • Lang J, Jackson M, Teyton L, et al. B-cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane bound antigen. J Exp Med 1996; 184:1685-1697.
    • (1996) J Exp Med , vol.184 , pp. 1685-1697
    • Lang, J.1    Jackson, M.2    Teyton, L.3
  • 54
    • 84868597004 scopus 로고    scopus 로고
    • Anti-HIV B cell lines as candidate vaccine biosensors
    • Ota T, Doyle-Cooper C, Cooper AB, et al. Anti-HIV B cell lines as candidate vaccine biosensors. J Immunol 2012; 189:4816-4824.
    • (2012) J Immunol , vol.189 , pp. 4816-4824
    • Ota, T.1    Doyle-Cooper, C.2    Cooper, A.B.3
  • 55
    • 84867902637 scopus 로고    scopus 로고
    • HIV-1 antibodies from infection and vaccination: Insights for guiding vaccine design
    • Bonsignori M, Alam SM, Liao HX, Verkoczy L, et al. HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design. Trends Microbiol 2013; 20:532-539.
    • (2013) Trends Microbiol , vol.20 , pp. 532-539
    • Bonsignori, M.1    Alam, S.M.2    Liao, H.X.3    Verkoczy, L.4
  • 56
    • 84860759632 scopus 로고    scopus 로고
    • B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study
    • Haynes BF, Kelsoe G, Harrison SC, et al. B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study. Nat Biotech 2012; 30:423-433.
    • (2012) Nat Biotech , vol.30 , pp. 423-433
    • Haynes, B.F.1    Kelsoe, G.2    Harrison, S.C.3
  • 57
    • 84866493348 scopus 로고    scopus 로고
    • Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
    • Huang J, Ofek G, Laub L, et al. Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. Nature 2012; 491:406-412.
    • (2012) Nature , vol.491 , pp. 406-412
    • Huang, J.1    Ofek, G.2    Laub, L.3
  • 58
    • 0027434805 scopus 로고
    • Somatic hypermutation in B cells: An optimal control treatment
    • Kepler TB, Perelson AS. Somatic hypermutation in B cells: an optimal control treatment. J Theor Biol 1993; 164:37-64.
    • (1993) J Theor Biol , vol.164 , pp. 37-64
    • Kepler, T.B.1    Perelson, A.S.2
  • 59
    • 77955483636 scopus 로고    scopus 로고
    • Optimality of mutation and selection in germinal centers
    • Zhang J, Shakhnovich EI. Optimality of mutation and selection in germinal centers. PLoS Comput Biol 2010; 6:e1000800.
    • (2010) PLoS Comput Biol , vol.6
    • Zhang, J.1    Shakhnovich, E.I.2
  • 60
    • 0025017688 scopus 로고
    • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
    • Shlomchik M, Mascelli M, Shan H, et al. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med 1990; 171:265-292.
    • (1990) J Exp Med , vol.171 , pp. 265-292
    • Shlomchik, M.1    Mascelli, M.2    Shan, H.3
  • 61
    • 33847278450 scopus 로고    scopus 로고
    • Autoreactivity in human IgG+ memory B cells
    • Tiller T, Tsuiji M, Yurasov S, et al. Autoreactivity in human IgG+ memory B cells. Immunity 2007; 26:205-213.
    • (2007) Immunity , vol.26 , pp. 205-213
    • Tiller, T.1    Tsuiji, M.2    Yurasov, S.3
  • 62
    • 47749123498 scopus 로고    scopus 로고
    • Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors
    • Mietzner B, Tsuiji M, Scheid J, et al. Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors. Proc Natl Acad Sci USA 2008; 105:9727-9732.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 9727-9732
    • Mietzner, B.1    Tsuiji, M.2    Scheid, J.3
  • 63
    • 84869155712 scopus 로고    scopus 로고
    • Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape
    • Moore PL, Gray ES, Wibmer CK, et al. Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape. Nat Med 2012; 18:1688-1692.
    • (2012) Nat Med , vol.18 , pp. 1688-1692
    • Moore, P.L.1    Gray, E.S.2    Wibmer, C.K.3
  • 64
    • 84875061923 scopus 로고    scopus 로고
    • Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bnAbs
    • Hoot S, McGuire AT, Cohen KW, et al. Recombinant HIV envelope proteins fail to engage germline versions of anti-CD4bs bnAbs. PLoS Path 2013; 9:e1003106.
    • (2013) PLoS Path , vol.9
    • Hoot, S.1    McGuire, A.T.2    Cohen, K.W.3
  • 65
    • 84875759341 scopus 로고    scopus 로고
    • Somatic mutations of the immunoglobulin framework are generally required for broad and potent neutralization
    • Klein F, Diskin R, Scheid JF, et al. Somatic mutations of the immunoglobulin framework are generally required for broad and potent neutralization. Cell 2013; 153:126-138.
    • (2013) Cell , vol.153 , pp. 126-138
    • Klein, F.1    Diskin, R.2    Scheid, J.F.3
  • 66
    • 77957355961 scopus 로고    scopus 로고
    • Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation
    • Mouquet H, Scheid JF, Zoller MJ, et al. Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation. Nature 2010; 467:591-595.
    • (2010) Nature , vol.467 , pp. 591-595
    • Mouquet, H.1    Scheid, J.F.2    Zoller, M.J.3
  • 67
    • 84883348588 scopus 로고    scopus 로고
    • Induction of HIV-1 broad neutralizing antibodies in 2F5 knockin mice: Selection against MPER-associated auto-reactivity limits T-dependent responses
    • Verkoczy L, Chen Y, Zhang J, et al. Induction of HIV-1 broad neutralizing antibodies in 2F5 knockin mice: selection against MPER-associated auto-reactivity limits T-dependent responses. J Immunol 2013; 191:2538-2550.
    • (2013) J Immunol , vol.191 , pp. 2538-2550
    • Verkoczy, L.1    Chen, Y.2    Zhang, J.3
  • 68
    • 0033843089 scopus 로고    scopus 로고
    • Relative roles of somatic and Darwinian evolution in shaping the antibody response
    • Diaz M, Klinman N. Relative roles of somatic and Darwinian evolution in shaping the antibody response. Immunol Res 2000; 21:89-102.
    • (2000) Immunol Res , vol.21 , pp. 89-102
    • Diaz, M.1    Klinman, N.2
  • 70
    • 33747761954 scopus 로고    scopus 로고
    • B-1 B cell development
    • Hardy RR. B-1 B cell development. J Immunol 2006; 177:2749-2754.
    • (2006) J Immunol , vol.177 , pp. 2749-2754
    • Hardy, R.R.1
  • 71
    • 84872856582 scopus 로고    scopus 로고
    • Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies
    • Pujanauski LM, Janoff EN, McCarter MD, et al. Mouse marginal zone B cells harbor specificities similar to human broadly neutralizing HIV antibodies. Proc Natl Acad Sci USA 2013; 110:1422-1427.
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 1422-1427
    • Pujanauski, L.M.1    Janoff, E.N.2    McCarter, M.D.3
  • 72
    • 84891680667 scopus 로고    scopus 로고
    • Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41
    • Chen J, Frey G, Peng H, et al. Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41. J Virol 2014; 88:1249-1258.
    • (2014) J Virol , vol.88 , pp. 1249-1258
    • Chen, J.1    Frey, G.2    Peng, H.3
  • 73
    • 84884262472 scopus 로고    scopus 로고
    • B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates
    • Ota T, Doyle-Cooper C, Cooper AB, et al. B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates. J Immunol 2013; 191: 3179-3185.
    • (2013) J Immunol , vol.191 , pp. 3179-3185
    • Ota, T.1    Doyle-Cooper, C.2    Cooper, A.B.3
  • 74
    • 5044252860 scopus 로고    scopus 로고
    • Auto-reactive B cells against peripheral antigen, desmoglein 3, escapefrom tolerance mechanism
    • Ota T, Aoki-Ota M, Tsunoda K, et al. Auto-reactive B cells against peripheral antigen, desmoglein 3, escapefrom tolerance mechanism. Int Immunol 2004; 16:1487-1495.
    • (2004) Int Immunol , vol.16 , pp. 1487-1495
    • Ota, T.1    Aoki-Ota, M.2    Tsunoda, K.3
  • 75
    • 0344585465 scopus 로고    scopus 로고
    • Tolerance through indifference: Autoreactive B cells to the nuclear antigen la show no evidence of tolerance in a transgenic model
    • Aplin BD, Keech CL, de Kauwe AL, et al. Tolerance through indifference: autoreactive B cells to the nuclear antigen La show no evidence of tolerance in a transgenic model. J Immunol 2003; 171:5890-5900.
    • (2003) J Immunol , vol.171 , pp. 5890-5900
    • Aplin, B.D.1    Keech, C.L.2    De Kauwe, A.L.3
  • 76
    • 0027215522 scopus 로고
    • RAG-2-deficient blastocyst complementation: An assay of gene function in lymphocyte development
    • Chen J, Lansford R, Stewart V, et al. RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Natl Acad Sci USA 1993; 90:4528-4532.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 4528-4532
    • Chen, J.1    Lansford, R.2    Stewart, V.3
  • 77
    • 84897492743 scopus 로고    scopus 로고
    • An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1
    • In press
    • Bonsignori M, Wiehe K, Grimm SK, et al. An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1. J Clin Invest 2014; In press.
    • (2014) J Clin Invest
    • Bonsignori, M.1    Wiehe, K.2    Grimm, S.K.3
  • 78
    • 33745203490 scopus 로고    scopus 로고
    • Distribution and three-dimensional structure of AIDS virus envelope spikes
    • Zhu P, Liu J, Bess J Jr, et al. Distribution and three-dimensional structure of AIDS virus envelope spikes. Nature 2006; 441:847-852.
    • (2006) Nature , vol.441 , pp. 847-852
    • Zhu, P.1    Liu, J.2    Bess Jr., J.3
  • 79
    • 51349162563 scopus 로고    scopus 로고
    • Molecular architecture of native HIV-1 gp120 trimers
    • Liu J, Bartesaghi A, Borgnia MJ, et al. Molecular architecture of native HIV-1 gp120 trimers. Nature 2008; 455:109-113.
    • (2008) Nature , vol.455 , pp. 109-113
    • Liu, J.1    Bartesaghi, A.2    Borgnia, M.J.3
  • 80
    • 84864363185 scopus 로고    scopus 로고
    • Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120
    • West AP Jr, Diskin R, Nussenzweig MC, et al. Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120. Proc Natl Acad Sci USA 2012; 109:E2083-2090.
    • (2012) Proc Natl Acad Sci USA , vol.109
    • West Jr., A.P.1    Diskin, R.2    Nussenzweig, M.C.3
  • 81
    • 73949133588 scopus 로고    scopus 로고
    • Role of HIV membrane in neutralization by two broadly neutralizing antibodies
    • Alam SM, Morelli M, Dennison SM, et al. Role of HIV membrane in neutralization by two broadly neutralizing antibodies. Proc Natl Acad Sci USA 2009; 106:20234-20239.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20234-20239
    • Alam, S.M.1    Morelli, M.2    Dennison, S.M.3
  • 82
    • 37849000389 scopus 로고    scopus 로고
    • HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane
    • Sun ZY, Oh KJ, Kim M, et al. HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane. Immunity 2008; 28:52-63.
    • (2008) Immunity , vol.28 , pp. 52-63
    • Sun, Z.Y.1    Oh, K.J.2    Kim, M.3
  • 83
    • 77950537428 scopus 로고    scopus 로고
    • Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution
    • Shen X, Dennison SM, Liu P, et al. Prolonged exposure of the HIV-1 gp41 membrane proximal region with L669S substitution. Proc Natl Acad Sci USA 2010; 107:5972-5977.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 5972-5977
    • Shen, X.1    Dennison, S.M.2    Liu, P.3
  • 84
    • 84896737636 scopus 로고    scopus 로고
    • Structural Basis for HIV-1 neutralization by 2F5-like Antibodies m66 and m66.6
    • Ofek G, Zirkle B, Yang Y, et al. Structural Basis for HIV-1 neutralization by 2F5-like Antibodies m66 and m66.6. J Virol 2014; 88:2426-2441.
    • (2014) J Virol , vol.88 , pp. 2426-2441
    • Ofek, G.1    Zirkle, B.2    Yang, Y.3
  • 85
    • 33947635198 scopus 로고    scopus 로고
    • The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes
    • Alam SM, McAdams M, Boren D, et al. The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes. J Immunol 2007; 178:4424-4435.
    • (2007) J Immunol , vol.178 , pp. 4424-4435
    • Alam, S.M.1    McAdams, M.2    Boren, D.3
  • 86
    • 70349272203 scopus 로고    scopus 로고
    • Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions
    • Dennison SM, Stewart SM, Stempel KC, et al. Stable docking of neutralizing human immunodeficiency virus type 1 gp41 membrane-proximal external region monoclonal antibodies 2F5 and 4E10 is dependent on the membrane immersion depth of their epitope regions. J Virol 2009; 83: 10211-10223.
    • (2009) J Virol , vol.83 , pp. 10211-10223
    • Dennison, S.M.1    Stewart, S.M.2    Stempel, K.C.3
  • 87
    • 82355171239 scopus 로고    scopus 로고
    • Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41
    • Dennison SM, Sutherland LL, Jaeger FH, et al. Induction of antibodies in rhesus macaques that recognize a fusion-intermediate conformation of HIV-1 gp41. PLoS One 2011; 6:e27824.
    • (2011) PLoS One , vol.6
    • Dennison, S.M.1    Sutherland, L.L.2    Jaeger, F.H.3
  • 88
    • 84887027667 scopus 로고    scopus 로고
    • Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry
    • Kim M, Song L, Moon J, et al. Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry. J Biol Chem 2014; 288:31888-31901.
    • (2014) J Biol Chem , vol.288 , pp. 31888-31901
    • Kim, M.1    Song, L.2    Moon, J.3
  • 89
    • 84898473080 scopus 로고    scopus 로고
    • Lipid components in MPER-based immunization regimens are critical for inducing broadly neutralizing antibody responses in 2F5 and 4E10 knockin mice
    • Chen Y, Zhang J, Bouton-Verville H, et al. Lipid components in MPER-based immunization regimens are critical for inducing broadly neutralizing antibody responses in 2F5 and 4E10 knockin mice. AIDS Res Human Retr 2013; 29:A20-A120.
    • (2013) AIDS Res Human Retr , vol.29
    • Chen, Y.1    Zhang, J.2    Bouton-Verville, H.3
  • 90
    • 64049092486 scopus 로고    scopus 로고
    • In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth
    • Shen X, Parks RJ, Montefiori DC, et al. In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth. J Virol 2009; 83:3617-3625.
    • (2009) J Virol , vol.83 , pp. 3617-3625
    • Shen, X.1    Parks, R.J.2    Montefiori, D.C.3
  • 91
    • 20944446452 scopus 로고    scopus 로고
    • Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies
    • Trkola A, Kuster H, Rusert P, et al. Delay of HIV-1 rebound after cessation of antiretroviral therapy through passive transfer of human neutralizing antibodies. Nat Med 2005; 11:615-622.
    • (2005) Nat Med , vol.11 , pp. 615-622
    • Trkola, A.1    Kuster, H.2    Rusert, P.3
  • 92
    • 37349086800 scopus 로고    scopus 로고
    • Reassessment of autoreactivity of the broadly neutralizing HIV antibodies 4E10 and 2F5 and retrospective analysis of clinical safety data
    • Vcelar B, Stiegler G, Wolf HM, et al. Reassessment of autoreactivity of the broadly neutralizing HIV antibodies 4E10 and 2F5 and retrospective analysis of clinical safety data. AIDS 2007; 21:2161-2170.
    • (2007) AIDS , vol.21 , pp. 2161-2170
    • Vcelar, B.1    Stiegler, G.2    Wolf, H.M.3
  • 93
    • 35148864699 scopus 로고    scopus 로고
    • Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection
    • Mehandru S, Vcelar B, Wrin T, et al. Adjunctive passive immunotherapy in human immunodeficiency virus type 1-infected individuals treated with antiviral therapy during acute and early infection. J Virol 2007; 81:11016-11031.
    • (2007) J Virol , vol.81 , pp. 11016-11031
    • Mehandru, S.1    Vcelar, B.2    Wrin, T.3
  • 94
    • 80052287270 scopus 로고    scopus 로고
    • Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01
    • Li Y, O'Dell S, Walker LM, et al. Mechanism of neutralization by the broadly neutralizing HIV-1 monoclonal antibody VRC01. J Virol 2011; 85:8954-8967.
    • (2011) J Virol , vol.85 , pp. 8954-8967
    • Li, Y.1    O'Dell, S.2    Walker, L.M.3
  • 95
    • 77649132440 scopus 로고    scopus 로고
    • Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region
    • Ofek G, McKee K, Yang Y, et al. Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region. J Virol 2010; 84:2955-2962.
    • (2010) J Virol , vol.84 , pp. 2955-2962
    • Ofek, G.1    McKee, K.2    Yang, Y.3
  • 96
    • 76549125090 scopus 로고    scopus 로고
    • Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions
    • Scherer EM, Leaman DP, Zwick MB, et al. Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions. Proc Natl Acad Sci USA 2010; 107:1529-1534.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 1529-1534
    • Scherer, E.M.1    Leaman, D.P.2    Zwick, M.B.3
  • 97
    • 77954912140 scopus 로고    scopus 로고
    • Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1
    • Pejchal R, Walker LM, Stanfield RL, et al. Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1. Proc Natl Acad Sci USA 2010; 107:11483-11488.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 11483-11488
    • Pejchal, R.1    Walker, L.M.2    Stanfield, R.L.3
  • 98
    • 84860706280 scopus 로고    scopus 로고
    • Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes
    • Briney BS, Willis JR, Crowe JE Jr. Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes. PLoS One 2012; 7:e36750.
    • (2012) PLoS One , vol.7
    • Briney, B.S.1    Willis, J.R.2    Crowe Jr., J.E.3
  • 99
    • 84893352067 scopus 로고    scopus 로고
    • Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline
    • Georgiev IS, Rudicell RS, Saunders KO, et al. Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline. J Immunol 2014; 192:1100-1106.
    • (2014) J Immunol , vol.192 , pp. 1100-1106
    • Georgiev, I.S.1    Rudicell, R.S.2    Saunders, K.O.3
  • 100
    • 84898453773 scopus 로고    scopus 로고
    • Identifying the minimal mutations in VRC01 required for neutralization potency and breadth to inform vaccine design
    • Jardine JG, Sok D, Kalyuzhniy O, et al. Identifying the minimal mutations in VRC01 required for neutralization potency and breadth to inform vaccine design. AIDS Res Human Retr 2013; 29:A14-A114.
    • (2013) AIDS Res Human Retr , vol.29
    • Jardine, J.G.1    Sok, D.2    Kalyuzhniy, O.3
  • 101
    • 84888009485 scopus 로고    scopus 로고
    • The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-p1 production and FcRL4 expression
    • Jelicic K, Cimbro R, Nawaz F, et al. The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-p1 production and FcRL4 expression. Nat Immunol 2013; 14:1256-1265.
    • (2013) Nat Immunol , vol.14 , pp. 1256-1265
    • Jelicic, K.1    Cimbro, R.2    Nawaz, F.3
  • 102
    • 68049135892 scopus 로고    scopus 로고
    • Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection
    • Levesque MC, Moody MA, Hwang KK, et al. Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. PLoS Med 2009; 6:e1000107.
    • (2009) PLoS Med , vol.6
    • Levesque, M.C.1    Ma, M.2    Hwang, K.K.3
  • 103
    • 84875551472 scopus 로고    scopus 로고
    • Broadly neutralizing antiviral antibodies
    • Corti D, Lanzavecchia A. Broadly neutralizing antiviral antibodies. Annu Rev Immunol 2013; 31:705-742.
    • (2013) Annu Rev Immunol , vol.31 , pp. 705-742
    • Corti, D.1    Lanzavecchia, A.2
  • 104
    • 84862108532 scopus 로고    scopus 로고
    • Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase z activity
    • Daly J, Bebenek K, Watt DL, et al. Altered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase z activity. J Immunol 2012; 188:5528-5537.
    • (2012) J Immunol , vol.188 , pp. 5528-5537
    • Daly, J.1    Bebenek, K.2    Watt, D.L.3
  • 105
    • 84877609579 scopus 로고    scopus 로고
    • Rational HIV immunogen design to target specific germline B cell receptors
    • Jardine J, Julien J-P, Menis S, et al. Rational HIV immunogen design to target specific germline B cell receptors. Science 2013; 340:711-716.
    • (2013) Science , vol.340 , pp. 711-716
    • Jardine, J.1    Julien, J.-P.2    Menis, S.3
  • 106
    • 84878626061 scopus 로고    scopus 로고
    • Engineering HIV envelope protein to & activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies
    • McGuire AT, Hoot S, Dreyer AM, et al. Engineering HIV envelope protein to & activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies. J Exp Med 2013; 210:655-663.
    • (2013) J Exp Med , vol.210 , pp. 655-663
    • McGuire, A.T.1    Hoot, S.2    Dreyer, A.M.3
  • 107
    • 80655143478 scopus 로고    scopus 로고
    • Differential reactivity germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation
    • Alam SM, Liao HX, Dennison SM, et al. Differential reactivity germ line allelic variants of a broadly neutralizing HIV-1 antibody to a gp41 fusion intermediate conformation. J Virol 2011; 85:11725-11731.
    • (2011) J Virol , vol.85 , pp. 11725-11731
    • Alam, S.M.1    Liao, H.X.2    Dennison, S.M.3
  • 108
    • 84896703681 scopus 로고    scopus 로고
    • H epitope overlapping those of MPER broad neutralizing antibodies
    • H epitope overlapping those of MPER broad neutralizing antibodies. J Immunol 2014; 192:1693-1706.
    • (2014) J Immunol , vol.192 , pp. 1693-1706
    • Zhang, J.1    Alam, S.M.2    Bouton-Verville, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.