Effects of ulinastatin on cerebral oxygen metabolism and CRP levels in patients with severe traumatic brain injury

Experimental and Therapeutic Medicine

Volumn 7, Issue 6, 2014, Pages 1683-1686

  Hui, Lei ^a   Shen, Fazheng ^a   Chang, Haigang ^a   Li, Xiangsheng ^a   Gao, Guojun ^a   Ma, Jiwei ^a  

^a THE FIRST AFFILIATED HOSPITAL OF XINXIANG MEDICAL UNIVERSITY   (China)

Author keywords

Brain injury; C reactive protein; Cerebral oxygen metabolism; Ulinastatin

Indexed keywords

C REACTIVE PROTEIN; HEMOGLOBIN; LACTIC ACID; PLACEBO; ULINASTATIN;

ADULT; ARTERIOVENOUS OXYGEN CONTENT; ARTICLE; BLOOD GAS ANALYSIS; BLOOD OXYGEN TENSION; BRAIN METABOLISM; CEREBRAL METABOLIC RATE OF OXYGEN; CONTROLLED STUDY; DEHYDRATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GASTROINTESTINAL HEMORRHAGE; HUMAN; INTRACRANIAL PRESSURE; JUGULAR VEIN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OXYGEN SATURATION; OXYGEN THERAPY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; TRAUMATIC BRAIN INJURY; VENTILATOR ASSISTED THERAPY;

EID: 84898424802     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1666     Document Type: Article

References (17)

1. Rockswold SB, Rockswold GL, Zaun DA and Liu J: A prospective, randomized Phase II clinical trial to evaluate the effect of combined hyperbaric and normobaric hyperoxia on cerebral metabolism, intracranial pressure, oxygen toxicity, and clinical outcome in severe traumatic brain injury. J Neurosurg 118: 1317-1328, 2013.
2. Lee KS, Shim JJ, Yoon SM and Bae HG: Prognostic value of the C-reactive protein levels in the head injury. J Kor Eurotraumatol Soc 1: 57-60, 2005.
3. Gullo Jda S, Bertotti MM, Silva CC, et al: Hospital mortality of patients with severe traumatic brain injury is associated with serum PTX3 levels. Neurocrit Care 14: 194-199, 2011.
4. Cao LJ, Wang J, Hao PP, Sun CL and Chen YG: Effects of ulinastatin, a urinary trypsin inhibitor, on synaptic plasticity and spatial memory in a rat model of cerebral ischemia/reperfusion injury. Chin J Physiol 54: 435-442, 2011.
5. Wang X, Xue Q, Yan F, et al: Ulinastatin as a neuroprotective and anti-inflammatory agent in infant piglets model undergoing surgery on hypothermic low-flow cardiopulmonary bypass. Paediatr Anaesth 23: 209-216, 2013.
6. Stewart TC, Alharfi IM and Fraser DD: The role of serious concomitant injuries in the treatment and outcome of pediatric severe traumatic brain injury. J Trauma Acute Care Surg 75: 836-842, 2013.
7. Schmidt AT, Hanten G, Li X, et al: Emotional prosody and diffusion tensor imaging in children after traumatic brain injury. Brain Inj 27: 1528-1535, 2013.
8. Lord LD, Expert P, Huckins JF and Turkheimer FE: Cerebral energy metabolism and the brain's functional network architecture: an integrative review. J Cereb Blood Flow Metab 33: 1347-1354, 2013.
9. McCarthy MC, Moncrief H, Sands JM, et al: Neurologic outcomes with cerebral oxygen monitoring in traumatic brain injury. Surgery 146: 585-591, 2009.
10. Mayer CL, Huber BR and Peskind E: Traumatic brain injury, neuroinflammation, and post-traumatic headaches. Headache 53: 1523-1530, 2013.
11. Wang XH, Wei RL, Fan H and Hu JH: The protective effects of edaravone combined with ulinastatin on the treatment of brain iniury in rats with severe acute pancreatitis. Zhonghua Gan Dan Wai Ke Za Zhi 19: 544-549, 2013.(In Chinese).
12. Bouzat P, Millet A, Boue Y, et al: Changes in brain tissue oxygenation after treatment of diffuse traumatic brain injury by erythropoietin. Crit Care Med 41: 1316-1324, 2013.
13. Kamenskaia OV, Loginova IIu, Karpenko AA, Karas'kov AM and Kuzhuget RA: Oxygen supply to the brain in chronic disturbances of cerebral circulation in patients with pathology of brachiocephalic arteries. Kardiologiia 53: 49-53, 2013.(In Russian).
14. Faraco G, Moraga A, Moore J, et al: Circulating endothelin-1 alters critical mechanisms regulating cerebral microcirculation. Hypertension 62: 759-766, 2013.
15. Tu Y, Diao YF, Yang XP, Sun HT and Zhang S: Effect of ulinastatin in traumatic brain injury with multiple injuries. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 24: 677-679, 2012.(In Chinese).
16. Xu CE, Zou CW, Zhang MY and Guo L: Effects of high-dose ulinastatin on inflammatory response and pulmonary function in patients with type-A aortic dissection after cardiopulmonary bypass under deep hypothermic circulatory arrest. J Cardiothorac Vasc Anesth 27: 479-484, 2013.
17. Cao BP, Zhang L, Su N, Wang K, Bian H, Fei Z and Li B: Protective effects of ulinastatin on mice with traumatic brain injury. Zhonghua Shen Jing Wai Ke Ji Bing Yan Jiu Za Zhi 12: 244-246, 2013.(In Chinese).