Mediators of methylphenidate effects on math performance in children with attention-deficit hyperactivity disorder

Journal of Developmental and Behavioral Pediatrics

Volumn 35, Issue 2, 2014, Pages 100-107

  Froehlich, Tanya E ^a   Antonini, Tanya N ^b   Brinkman, William B ^a   Langberg, Joshua M ^c   Simon, John O ^a   Adams, Ryan ^a   Fredstrom, Bridget ^a   Narad, Megan E ^b   Kingery, Kathleen M ^b   Altaye, Mekibib ^a   Matheson, Heather ^b   Tamm, Leanne ^a   Epstein, Jeffery N ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

ADHD; Math mathematics; Mediation; Methylphenidate; Stimulant psychostimulant

Indexed keywords

CENTRAL STIMULANT AGENT; METHYLPHENIDATE; PLACEBO;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CHILD; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; EDUCATION; HUMAN; INHIBITION (PSYCHOLOGY); MALE; MATHEMATICS; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; RANDOMIZED CONTROLLED TRIAL; REACTION TIME; TASK PERFORMANCE; TIME FACTOR; TREATMENT OUTCOME;

ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CENTRAL NERVOUS SYSTEM STIMULANTS; CHILD; DOUBLE-BLIND METHOD; EDUCATIONAL MEASUREMENT; HUMANS; INHIBITION (PSYCHOLOGY); MALE; MATHEMATICS; METHYLPHENIDATE; NEUROPSYCHOLOGICAL TESTS; PLACEBOS; REACTION TIME; TASK PERFORMANCE AND ANALYSIS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84898424054     PISSN: 0196206X     EISSN: 15367312     Source Type: Journal    
DOI: 10.1097/DBP.0000000000000025     Document Type: Article

References (35)

1. Loe IM, Feldman HM. Academic and educational outcomes of children with ADHD. J Pediatr Psychol. 2007;32: 643-654.
2. Frazier TW, Youngstrom EA, Glutting JJ, et al. ADHD and achievement: meta-analysis of the child, adolescent, and adult literatures and a concomitant study with college students. J Learn Disabil. 2007;40: 49-65.
3. Benedetto-Nasho E, Tannock R. Math computation, error patterns and stimulant effects in children with Attention Deficit Hyperactivity Disorder. J Attention Disord. 1999;3: 121-134.
4. Swanson JM, Cantwell D, Lerner M, et al. Effects of stimulant medication on learning in children with ADHD. J Learn Disabil. 1991;24: 219-230, 255.
5. Langberg JM, Becker SP. Does long-term medication use improve the academic outcomes of youth with attention-deficit hyperactivity disorder? Clin Child Fam Psychol Rev. 2012;15: 215-233.
6. Swanson JM, Wigal SB, Wigal T, et al. A comparison of once-daily extended-release methylphenidate formulations in children with attention-deficit hyperactivity disorder in the laboratory school (the Comacs Study). Pediatrics. 2004;113(3 pt 1): e206-e216.
7. Volkow ND,Wang GJ, Fowler JS, et al. Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain. Am J Psychiatry. 2004;161: 1173-1180.
8. Biederman J, Monuteaux MC, Doyle AE, et al. Impact of executive function deficits and attention-deficit hyperactivity disorder (ADHD) on academic outcomes in children. J Consult Clin Psychol. 2004;72: 757-766.
9. Stevens C, Bavelier D. The role of selective attention on academic foundations: a cognitive neuroscience perspective. Dev Cogn Neurosci. 2012;2(suppl 1): S30-S48.
10. St Clair-Thompson HL, Gathercole SE. Executive functions and achievements in school: shifting, updating, inhibition, and working memory. Q J Exp Psychol (Hove). 2006;59: 745-759.
11. Epstein JN, Brinkman WB, Froehlich T, et al. Effects of stimulant medication, incentives, and event rate on reaction time variability in children with ADHD. Neuropsychopharmacology. 2011;36: 1060-1072.
12. Epstein JN, Langberg JM, Rosen PJ, et al. Evidence for higher reaction time variability for children with ADHD on a range of cognitive tasks including reward and event rate manipulations. Neuropsychology. 2011;25: 427-441.
13. DuPaul GJ, Rapport MD. Does methylphenidate normalize the classroom performance of children with attention deficit disorder? J Am Acad Child Adolesc Psychiatry. 1993;32: 190-198.
14. Zentall SS, Smith YN, Lee YB, et al. Mathematical outcomes of attentiondeficit hyperactivity disorder. J Learn Disabil. 1994;27: 510-519.
15. Shaffer D, Fisher P, Lucas CP, et al. NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry. 2000;39: 28-38.
16. Wolraich ML, Feurer ID, Hannah JN, et al. Obtaining systematic teacher reports of disruptive behavior disorders utilizing DSM-IV. J Abnorm Child Psychol. 1998;26: 141-152.
17. Dombrowski SC, Kamphaus RW, Reynolds CR. After the demise of the discrepancy: proposed learning disabilities diagnostic criteria. Prof Psychol Res Pract. 2004;35: 364-372.
18. Wolraich ML, Lambert W, Doffing MA, et al. Psychometric properties of the Vanderbilt ADHD diagnostic parent rating scale in a referred population. J Pediatr Psychol. 2003;28: 559-567.
19. Pelham WE. Pharmacotherapy of children with attention-deficit hyperactivity disorder. Sch Psychol Rev. 1993;22: 199-227.
20. MTA. A 14-month randomized clinical trial of treatment strategies for attention-deficit hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Arch Gen Psychiatry. 1999;56: 1073-1086.
21. Simmonds DJ, Pekar JJ, Mostofsky SH. Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent. Neuropsychologia. 2008;46: 224-232.
22. Kratz O, Studer P, Malcherek S, et al. Attentional processes in children with ADHD: an event-related potential study using the attention network test. Int J Psychophysiol. 2011;81: 82-90.
23. Wright J. Curriculum-based measurement: a manual for teachers. Available at: www.interventioncentral.org/download.php. Accessed February 27, 2010.
24. Antonini TN, Narad ME, Langberg J, et al. Behavioral correlates of reaction time variability in children with and without ADHD. Neuropsychology. 2013;27: 201-209.
25. Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. J Pers Soc Psychol. 1986;51: 1173-1182.
26. MacKinnon DP, Lockwood CM, Hoffman JM, et al. A comparison of methods to test mediation and other intervening variable effects. Psychol Methods. 2002;7: 83-104.
27. Rubin DB. Multiple Imputation for Nonresponse in Surveys. New York, NY: John Wiley & Sons; 1987.
28. Schafer JL. Analysis of Incomplete Multivariate Data. London, United Kingdom: Chapman & Hall; 1997.
29. Faraone SV, Biederman J, Spencer TJ, et al. Comparing the efficacy of medications for ADHD using meta-analysis. MedGenMed. 2006;8: 4.
30. Brams M, Muniz R, Childress A, et al. A randomized, double-blind, crossover study of once-daily dexmethylphenidate in children with attention-deficit hyperactivity disorder: rapid onset of effect. CNS Drugs. 2008;22: 693-704.
31. Malkovsky E, Merrifield C, Goldberg Y, et al. Exploring the relationship between boredom and sustained attention. Exp Brain Res. 2012;221: 59-67.
32. Wang GJ, Volkow ND, Wigal T, et al. Long-term stimulant treatment affects brain dopamine transporter level in patients with attention deficit hyperactive disorder. PloS One. 2013;8: e63023.
33. Barkley RA, DuPaul GJ, McMurray MB. Attention deficit disorder with and without hyperactivity: clinical response to three dose levels of methylphenidate. Pediatrics. 1991;87: 519-531.
34. Barkley RA. Attention-Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. 3rd ed. New York, NY: The Guilford Press; 2006.
35. Hinshaw SP. Moderators and mediators of treatment outcome for youth with ADHD: understanding for whom and how interventions work. Ambul Pediatr. 2007;7(1 suppl): 91-100.