Facile synthesis of benzonitrile/nicotinonitrile based s-triazines as new potential antimycobacterial agents

European Journal of Medicinal Chemistry

Volumn 79, Issue , 2014, Pages 57-65

  Patel, Amit B ^a   Chikhalia, Kishor H ^b   Kumari, Premlata ^a  

^a SARDAR VALLABHBHAI NATIONAL INSTITUTE OF TECHNOLOGY   (India)

^b GUJARAT UNIVERSITY   (India)

Author keywords

Antimycobacterial activity; Palladium catalyzed; s Triazine; Thiazolidin 4 one

Indexed keywords

2,4 DICHLORO 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZINE; 4 (4 (4 (2 (4 BROMOPHENYL) 4 OXOTHIAZOLIDIN 3 YL)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 (2 (4 CHLOROPHENYL) 4 OXOTHIAZOLIDIN 3 YL)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 (2 (4 FLUOROPHENYL) 4 OXOTHIAZOLIDIN 4 ONEOLIDIN 3YL)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 (2 (4 HYDROXYPHENYL) 4 OXOTHIAZOLIDIN 4 ONEOLIDIN 3YL)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 (4 BROMOBENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 (4 CHLOROBENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 (4 FLUOROBENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 (4 HYDROXYBENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 (4 METHOXYBENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 (BENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 AMINOPHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 METHYLPIPERAZIN 1 YL) 6 (4 (2 (4 NITROPHENYL) 4 OXOTHIAZOLIDIN 4 ONEOLIDIN 3 YL)PHENYL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 METHYLPIPERAZIN 1 YL) 6 (4 (4 NITROBENZYLIDENEAMINO)PHENYL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 (4 METHYLPIPERAZIN 1 YL) 6 (4 (4 OXO 2 PHENYLTHIAZOLIDIN 3 YL)PHENYL 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 4 (4 CHLORO 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)BENZONITRILE; 6 (4 (4 (4 BROMOBENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)NICOTINONITRILE; 6 (4 (4 (4 CHLOROBENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)NICOTINONITRILE; 6 (4 (4 (4 FLUOROBENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)NICOTINONITRILE; 6 (4 (4 (4 HYDROXYBENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)NICOTINONITRILE; 6 (4 (4 (4 METHOXYBENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)NICOTINONITRILE; 6 (4 (4 (BENZYLIDENEAMINO)PHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)NICOTINONITRILE; 6 (4 (4 AMINOPHENYL) 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)NICOTINONITRILE; 6 (4 (4 METHYLPIPERAZIN 1 YL) 6 (4 (4 NITROBENZYLIDENEAMINO)PHENYL) 1,3,5 TRIAZIN 2 YLOXY)NICOTINONITRILE; 6 (4 CHLORO 6 (4 METHYLPIPERAZIN 1 YL) 1,3,5 TRIAZIN 2 YLOXY)NICOTINONITRILE; ANTIMYCOBACTERIAL AGENT; BENZENE DERIVATIVE; NITRILE; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ANTIINFECTIVE AGENT; BENZONITRILE; NICOTINIC ACID DERIVATIVE;

ANIMAL CELL; ANTIBACTERIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SYNTHESIS; IN VITRO STUDY; MAMMAL CELL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; VERO CELL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; MYCOBACTERIUM TUBERCULOSIS; NICOTINIC ACIDS; NITRILES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZINES;

EID: 84898419257     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.085     Document Type: Article

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