Endosomal H2O2 production leads to localized cysteine sulfenic acid formation on proteins during lysophosphatidic acid-mediated cell signaling

Free Radical Biology and Medicine

Volumn 71, Issue , 2014, Pages 49-60

  Klomsiri, Chananat ^a   Rogers, Leann C ^a   Soito, Laura ^a,c   McCauley, Anita K ^b   King, S Bruce ^b   Nelson, Kimberly J ^a   Poole, Leslie B ^a   Daniel, Larry W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b WAKE FOREST UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cysteine modifications; Lipid mediators; LPA signaling; Proliferative signaling; Protein oxidation

Indexed keywords

CYSTEINE; CYSTEINE SULFENIC ACID; HYDROGEN PEROXIDE; LYSOPHOSPHATIDIC ACID; PROTEIN; PROTEIN KINASE B; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; 3-(2,6-DIMETHYL-4-CARBAMOYLPHENYL)PROPANOIC ACID; AKT2 PROTEIN, HUMAN; BENZAMIDE DERIVATIVE; CYSTEINESULFENIC ACID; EARLY ENDOSOME ANTIGEN 1; LYSOPHOSPHATIDIC ACID RECEPTOR; LYSOPHOSPHOLIPID; PHENYLPROPIONIC ACID DERIVATIVE; PROTEIN TYROSINE PHOSPHATASE 1B; PTPN1 PROTEIN, HUMAN; SULFENIC ACID DERIVATIVE; VESICULAR TRANSPORT PROTEIN;

ARTICLE; CELL SIGNALING ASSAY; ENDOSOME; HUMAN; HUMAN CELL; INTERNALIZATION; OXIDATION; PRIORITY JOURNAL; ANALOGS AND DERIVATIVES; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

BENZAMIDES; CELL LINE, TUMOR; CYSTEINE; ENDOSOMES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; LYSOPHOSPHOLIPIDS; MALE; NADPH OXIDASE; OXIDATION-REDUCTION; PHENYLPROPIONATES; PROTEIN TRANSPORT; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, LYSOPHOSPHATIDIC ACID; SIGNAL TRANSDUCTION; SULFENIC ACIDS; VESICULAR TRANSPORT PROTEINS;

EID: 84898402832     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.03.017     Document Type: Article

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