Mice lacking selenoprotein P and selenocysteine lyase exhibit severe neurological dysfunction, neurodegeneration, and audiogenic seizures

Journal of Biological Chemistry

Volumn 289, Issue 14, 2014, Pages 9662-9674

  Byrns, China N ^a   Pitts, Matthew W ^a   Gilman, Christy A ^a   Hashimoto, Ann C ^a   Berry, Marla J ^a  

^a UNIVERSITY OF HAWAII   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; NEUROLOGY; NUTRITION; PLANTS (BOTANY); SELENIUM;

ANTIOXIDANT DEFENSE; MAMMALIAN BRAIN; MOTOR CO-ORDINATION; NEURODEGENERATION; NEUROLOGICAL DEFICIT; SELENIUM METABOLISM; SELENIUM SUPPLEMENTATION; SELENIUM TRANSPORT;

MAMMALS;

GLUTAMATE DECARBOXYLASE 67; GLUTATHIONE PEROXIDASE; LIPOPROTEIN RECEPTOR; LYASE; PARVALBUMIN; PROTEIN C FOS; SELENOCYSTEINE LYASE; SELENOPROTEIN P; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUDIOGENIC SEIZURE; BRAIN STEM; CONTROLLED STUDY; COORDINATION DISORDER; FEMALE; HIPPOCAMPUS; INFERIOR COLLICULUS; MALE; MOTOR DYSFUNCTION; MOUSE; NERVE DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EPILEPSY; INFERIOR COLLICULUS; NEURODEGENERATION; OXIDATIVE STRESS; PARVALBUMIN INTERNEURONS; SELENOCYSTEINE; SELENOCYSTEINE LYASE; SELENOPROTEIN; SELENOPROTEIN P;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; LYASES; MICE; MICE, KNOCKOUT; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; SEIZURES; SELENOCYSTEINE; SELENOPROTEIN P;

EID: 84898073119     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.540682     Document Type: Article

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