Mutations in PIK3CD can cause hyper IgM syndrome (HIGM) associated with increased cancer susceptibility

Journal of Clinical Immunology

Volumn 34, Issue 3, 2014, Pages 272-276

  Crank, M C ^a   Grossman, J K ^b   Moir, S ^a   Pittaluga, S ^c   Buckner, C M ^a   Kardava, L ^a   Agharahimi, A ^a   Meuwissen, H ^d   Stoddard, J ^e   Niemela, J ^e   Kuehn, H ^e   Rosenzweig, S D ^a,e  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b ALBERTA HEALTH SERVICES   (Canada)

^c NATIONAL CANCER INSTITUTE   (United States)

^d ALBANY MEDICAL CENTER   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

cancer susceptibility; epstein barr virus; hyper IgM; Immunodeficiency; lymphoma; PI3K

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INFLUENZA VACCINE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE, CATALYTIC SUBUNIT DELTA; PNEUMOCOCCUS VACCINE; POLYSACCHARIDE VACCINE; PREDNISONE; RITUXIMAB; UNCLASSIFIED DRUG; VINCRISTINE; PIK3CD PROTEIN, HUMAN;

ADULT; ARTICLE; B LYMPHOCYTE; BASAL CELL CARCINOMA; CANCER COMBINATION CHEMOTHERAPY; CANCER STAGING; CANCER SUSCEPTIBILITY; CASE REPORT; CD4 LYMPHOCYTE COUNT; CELLULITIS; CHOLELITHIASIS; DISEASE ASSOCIATION; ECZEMA; EPSTEIN BARR VIRUS; FEMALE; HODGKIN DISEASE; HUMAN; HYPER IGM SYNDROME; HYPERTROPHY; IMMUNE DEFICIENCY; IMMUNOGLOBULIN BLOOD LEVEL; IN VITRO STUDY; INTESTINE OBSTRUCTION; LARGE CELL LYMPHOMA; LUNG INFECTION; LYMPHADENITIS; LYMPHADENOPATHY; LYMPHOID HYPERPLASIA; LYMPHOPROLIFERATIVE DISEASE; MALE; MARGINAL ZONE LYMPHOMA; MUTATION; NONHODGKIN LYMPHOMA; OSTEOPOROSIS; PNEUMOCOCCAL INFECTION; PRIORITY JOURNAL; RECTUM DISEASE; SEXUAL MATURATION; SUPERINFECTION; THROMBOCYTOPENIA; TREATMENT RESPONSE; VERRUCA VULGARIS; YOUNG ADULT; BIOPSY; CHILD; COMPLICATION; GENETIC PREDISPOSITION; GENETICS; HETEROZYGOTE; HYPER-IGM IMMUNODEFICIENCY SYNDROME; LYMPH NODE; NEOPLASMS; PATHOLOGY; PEDIGREE;

ADULT; BIOPSY; CHILD; CLASS I PHOSPHATIDYLINOSITOL 3-KINASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HETEROZYGOTE; HUMANS; HYPER-IGM IMMUNODEFICIENCY SYNDROME; LYMPH NODES; MALE; MUTATION; NEOPLASMS; PEDIGREE; YOUNG ADULT;

EID: 84898058993     PISSN: 02719142     EISSN: 15732592     Source Type: Journal    
DOI: 10.1007/s10875-014-0012-9     Document Type: Article

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