메뉴 건너뛰기




Volumn 34, Issue 1, 2014, Pages 36-45

Effects of metformin dose on cancer risk reduction in patients with type 2 diabetes mellitus: A 6-year follow-up study

Author keywords

Cancer; Dose effect; Metformin; Risk; Type 2 diabetes

Indexed keywords

ACARBOSE; GLITAZONE DERIVATIVE; INSULIN; METFORMIN; SULFONYLUREA DERIVATIVE;

EID: 84898048917     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1002/phar.1334     Document Type: Article
Times cited : (34)

References (45)
  • 1
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Association and the European Association for the Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32: 193-203.
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 2
    • 77952116629 scopus 로고    scopus 로고
    • Metformin in cancer therapy: A new perspective for an old antidiabetic drug?
    • Sahra IB, Le Marchand-Brustel Y, Tanti J-F, Bost F. Metformin in cancer therapy: a new perspective for an old antidiabetic drug? Mol Cancer Ther 2010;9: 1092-9.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1092-1099
    • Sahra, I.B.1    Le Marchand-Brustel, Y.2    Tanti, J.-F.3    Bost, F.4
  • 5
    • 77954986682 scopus 로고    scopus 로고
    • Risk of cancer following hospitalization for type 2 diabetes
    • Helminki K, Li X, Sundquist J, Sandquist K. Risk of cancer following hospitalization for type 2 diabetes. Oncologist 2010;15: 548-55.
    • (2010) Oncologist , vol.15 , pp. 548-555
    • Helminki, K.1    Li, X.2    Sundquist, J.3    Sandquist, K.4
  • 7
    • 84855182612 scopus 로고    scopus 로고
    • Diabetes and cancer: Is diabetes causally related to cancer?
    • Suh S, Kim KW. Diabetes and cancer: is diabetes causally related to cancer? Diabetes Metab J 2011;35: 193-8.
    • (2011) Diabetes Metab J , vol.35 , pp. 193-198
    • Suh, S.1    Kim, K.W.2
  • 9
    • 33750930105 scopus 로고    scopus 로고
    • Diabetes mellitus and risk of bladder cancer: A meta-analysis
    • Larsson SC, Orsini N, Brismar K, Wolk A. Diabetes mellitus and risk of bladder cancer: a meta-analysis. Diabetologia 2006;49: 2819-23.
    • (2006) Diabetologia , vol.49 , pp. 2819-2823
    • Larsson, S.C.1    Orsini, N.2    Brismar, K.3    Wolk, A.4
  • 10
    • 68449088664 scopus 로고    scopus 로고
    • Does diabetes therapy influence the risk of cancer?
    • Smith U, Gale EAM. Does diabetes therapy influence the risk of cancer? Diabetologia 2009;52: 1699-708.
    • (2009) Diabetologia , vol.52 , pp. 1699-1708
    • Smith, U.1    Gale, E.A.M.2
  • 11
    • 79951708837 scopus 로고    scopus 로고
    • Metformin and cancer occurrence in insulin-treated type 2 diabetic patients
    • Monami M, Colombi C, Balzi D, et al. Metformin and cancer occurrence in insulin-treated type 2 diabetic patients. Diabetes Care 2011;34: 129-31.
    • (2011) Diabetes Care , vol.34 , pp. 129-131
    • Monami, M.1    Colombi, C.2    Balzi, D.3
  • 14
    • 84862296372 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor c and colorectal cancer
    • Dai Y, Wang WH. Peroxisome proliferator-activated receptor c and colorectal cancer. World J Gastrointest Oncol 2010;2: 159-64.
    • (2010) World J Gastrointest Oncol , vol.2 , pp. 159-164
    • Dai, Y.1    Wang, W.H.2
  • 15
    • 77953537179 scopus 로고    scopus 로고
    • Glucose-lowering agents and the cancer mortality in type 2 diabetes assessing effects of time-varying exposure
    • Bowker SL, Yasui Y, Veugelers P, Johnson JA. Glucose-lowering agents and the cancer mortality in type 2 diabetes assessing effects of time-varying exposure. Diabetologia 2010;53: 1631-7.
    • (2010) Diabetologia , vol.53 , pp. 1631-1637
    • Bowker, S.L.1    Yasui, Y.2    Veugelers, P.3    Johnson, J.A.4
  • 16
    • 68449094325 scopus 로고    scopus 로고
    • The influence of glucoselowering therapies on cancer risk in type 2 diabetes
    • Currie CJ, Poole CD, Gale EAM. The influence of glucoselowering therapies on cancer risk in type 2 diabetes. Diabetologia 2009;52: 1766-77.
    • (2009) Diabetologia , vol.52 , pp. 1766-1777
    • Currie, C.J.1    Poole, C.D.2    Gale, E.A.M.3
  • 18
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signaling in neoplasia
    • Pollak M. Insulin and insulin-like growth factor signaling in neoplasia. Nat Rev Cancer 2008;8: 915-28.
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 19
    • 60749108023 scopus 로고    scopus 로고
    • The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells
    • Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells. Cell Cycle 2008;8: 88-96.
    • (2008) Cell Cycle , vol.8 , pp. 88-96
    • Vazquez-Martin, A.1    Oliveras-Ferraros, C.2    Menendez, J.A.3
  • 20
    • 58149354390 scopus 로고    scopus 로고
    • Cell cycle arrest in metformin treated breast cancer cells involves activation of AMPK, down-regulation of cyclin D1, and requires p27Kip1 or p21Cip1
    • Zhuang Y, Miskimins WK. Cell cycle arrest in metformin treated breast cancer cells involves activation of AMPK, down-regulation of cyclin D1, and requires p27Kip1 or p21Cip1. J Mol Signal 2008;3: 18-28.
    • (2008) J Mol Signal , vol.3 , pp. 18-28
    • Zhuang, Y.1    Miskimins, W.K.2
  • 21
    • 34547114031 scopus 로고    scopus 로고
    • Systemic treatment with antidiabetic drug metformin selectively impairs p53-deficient tumour cell growth
    • Buzzai M, Jones RG, Amaravadi RK, et al. Systemic treatment with antidiabetic drug metformin selectively impairs p53-deficient tumour cell growth. Cancer Res 2007;67: 6745-53.
    • (2007) Cancer Res , vol.67 , pp. 6745-6753
    • Buzzai, M.1    Jones, R.G.2    Amaravadi, R.K.3
  • 22
    • 44849099894 scopus 로고    scopus 로고
    • The antidiabetic drug metformin exerts an antitumoural effect in in-vitro and in-vivo through a decrease of cyclin D1 level
    • Ben Sahra IB, Laurent K, Loubat A, et al. The antidiabetic drug metformin exerts an antitumoural effect in in-vitro and in-vivo through a decrease of cyclin D1 level. Oncogene 2008;27: 3576-86.
    • (2008) Oncogene , vol.27 , pp. 3576-3586
    • Ben Sahra, I.B.1    Laurent, K.2    Loubat, A.3
  • 23
    • 78149321257 scopus 로고    scopus 로고
    • Diabetes mellitus and increased risk of cancer: Focus on metformin and the insulin analogs
    • McFarland MS, Cripps R. Diabetes mellitus and increased risk of cancer: focus on metformin and the insulin analogs. Pharmacotherapy 2010;30: 1159-78.
    • (2010) Pharmacotherapy , vol.30 , pp. 1159-1178
    • McFarland, M.S.1    Cripps, R.2
  • 24
    • 70350583054 scopus 로고    scopus 로고
    • Metformin use and prostate cancer in Caucasian men: Results from a population-based case-control study
    • Wright JL, Stanford JL. Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study. Cancer Causes Control 2009;20: 1617-22.
    • (2009) Cancer Causes Control , vol.20 , pp. 1617-1622
    • Wright, J.L.1    Stanford, J.L.2
  • 25
    • 67749144226 scopus 로고    scopus 로고
    • Metformin and complete pathologic response to neoadjuvant chemotherapy in diabetic patients with breast cancer
    • Jiralerspong S, Palla SL, Giordano SH, et al. Metformin and complete pathologic response to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol 2009;27: 3297-302.
    • (2009) J Clin Oncol , vol.27 , pp. 3297-3302
    • Jiralerspong, S.1    Palla, S.L.2    Giordano, S.H.3
  • 27
    • 83655161344 scopus 로고    scopus 로고
    • Cancer mortality reduction and metformin
    • Bo S, Ciccone G, Rosato R, et al. Cancer mortality reduction and metformin. Diabetes Obes Metab 2012;14: 23-9.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 23-29
    • Bo, S.1    Ciccone, G.2    Rosato, R.3
  • 28
    • 78651451726 scopus 로고    scopus 로고
    • Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: A representative population prospective cohort study of 800,000 individuals
    • doi: 10.1186/1471-2407-11
    • Lee MS, Hsu CC, Wahlqvist LM, Tsai HN, Chang YH, Huang YC. Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals. BMC Cancer 2011;11: 20. doi: 10.1186/1471-2407-11.
    • (2011) BMC Cancer , vol.11 , pp. 20
    • Lee, M.S.1    Hsu, C.C.2    Wahlqvist, L.M.3    Tsai, H.N.4    Chang, Y.H.5    Huang, Y.C.6
  • 29
    • 69549097703 scopus 로고    scopus 로고
    • New users of metformin are at low risk of incident cancer: A cohort study among people with type 2 diabetes
    • Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 2009;32: 1620-5.
    • (2009) Diabetes Care , vol.32 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3    Alessi, D.R.4    Morris, A.D.5    Evans, J.M.6
  • 30
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res 2006;66: 10269-73.
    • (2006) Cancer Res , vol.66 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3    Sonenberg, N.4    Pollak, M.5
  • 31
    • 70350236538 scopus 로고    scopus 로고
    • Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
    • Hirsch HA, Iliopoulos D, Tsichlis PN, Struhl K. Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission. Cancer Res 2009;69: 7507-11.
    • (2009) Cancer Res , vol.69 , pp. 7507-7511
    • Hirsch, H.A.1    Iliopoulos, D.2    Tsichlis, P.N.3    Struhl, K.4
  • 32
    • 77950354885 scopus 로고    scopus 로고
    • Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression
    • Fierz Y, Novosyadlyy R, Vijayakumar A, Yakar S, LeRoith D. Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression. Diabetes 2010;59: 686-93.
    • (2010) Diabetes , vol.59 , pp. 686-693
    • Fierz, Y.1    Novosyadlyy, R.2    Vijayakumar, A.3    Yakar, S.4    Leroith, D.5
  • 34
    • 77955923866 scopus 로고    scopus 로고
    • Metformin: Taking away the candy for cancer?
    • Jalving MG, Gietema JA, Lefrandt JD, et al. Metformin: taking away the candy for cancer? Eur J Cancer 2010;46: 2369-80.
    • (2010) Eur J Cancer , vol.46 , pp. 2369-2380
    • Jalving, M.G.1    Gietema, J.A.2    Lefrandt, J.D.3
  • 36
    • 79961244975 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and cancer: Challenges and opportunities
    • Youssef J, Badr M. Peroxisome proliferator-activated receptors and cancer: challenges and opportunities. Br J Pharmacol 2011;164: 68-82.
    • (2011) Br J Pharmacol , vol.164 , pp. 68-82
    • Youssef, J.1    Badr, M.2
  • 37
    • 38849100174 scopus 로고    scopus 로고
    • Cancer incidence among patients treated with antidiabetic pharmacotherapy
    • Oliveria SA, Koro CE, Yood MU, Sowell M. Cancer incidence among patients treated with antidiabetic pharmacotherapy. Diabetes Metab Syndr 2008;2: 47-57.
    • (2008) Diabetes Metab Syndr , vol.2 , pp. 47-57
    • Oliveria, S.A.1    Koro, C.E.2    Yood, M.U.3    Sowell, M.4
  • 38
    • 78649482632 scopus 로고    scopus 로고
    • Diabetes and cancer
    • Chowdhury TA. Diabetes and cancer. QJM 2010;103: 905-15.
    • (2010) QJM , vol.103 , pp. 905-915
    • Chowdhury, T.A.1
  • 39
    • 78651335893 scopus 로고    scopus 로고
    • Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs
    • Okumura T. Mechanisms by which thiazolidinediones induce anti-cancer effects in cancers in digestive organs. J Gastroenterol 2010;45: 1097-102.
    • (2010) J Gastroenterol , vol.45 , pp. 1097-1102
    • Okumura, T.1
  • 40
    • 0035191137 scopus 로고    scopus 로고
    • Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians
    • Raji A, Seely EW, Arky RA, Simonson DC. Body fat distribution and insulin resistance in healthy Asian Indians and Caucasians. J Clin Endocrinol Metab 2001;86: 5366-71.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 5366-5371
    • Raji, A.1    Seely, E.W.2    Arky, R.A.3    Simonson, D.C.4
  • 41
    • 84864222342 scopus 로고    scopus 로고
    • Type 2 diabetes in Asians: Prevalence, risk factors, and effectiveness of behavioral intervention at individual and population levels
    • Weber MB, Oza-Frank R, Staimez LR, Ali MK, Narayan KM. Type 2 diabetes in Asians: prevalence, risk factors, and effectiveness of behavioral intervention at individual and population levels. Annu Rev Nutr 2012;32: 417-39.
    • (2012) Annu Rev Nutr , vol.32 , pp. 417-439
    • Weber, M.B.1    Oza-Frank, R.2    Staimez, L.R.3    Ali, M.K.4    Narayan, K.M.5
  • 43
    • 84864110583 scopus 로고    scopus 로고
    • Use of thiazolidinedione and cancer risk in type 2 diabetes: The Hong Kong diabetes registry
    • Yang X, So WY, Ma RC, et al. Use of thiazolidinedione and cancer risk in type 2 diabetes: the Hong Kong diabetes registry. Diabetes Res Clin Pract 2012;97:e13-7.
    • (2012) Diabetes Res Clin Pract , vol.97
    • Yang, X.1    So, W.Y.2    Ma, R.C.3
  • 44
    • 78751500357 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of metformin
    • Graham GG, Punt J, Arora M, et al. Clinical pharmacokinetics of metformin. Clin Pharmacokinet 2011;50: 81-98.
    • (2011) Clin Pharmacokinet , vol.50 , pp. 81-98
    • Graham, G.G.1    Punt, J.2    Arora, M.3
  • 45
    • 19144370601 scopus 로고    scopus 로고
    • Accuracy of diabetes diagnosis in health insurance claims data in Taiwan
    • Lin CC, Lai MS, Syu CY, Chang SC, Tseng FY. Accuracy of diabetes diagnosis in health insurance claims data in Taiwan. J Formos Med Assoc 2005;104: 157-63.
    • (2005) J Formos Med Assoc , vol.104 , pp. 157-163
    • Lin, C.C.1    Lai, M.S.2    Syu, C.Y.3    Chang, S.C.4    Tseng, F.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.