The risk of venous thromboembolism in patients with multiple sclerosis: The Clinical Practice Research Datalink

Journal of Thrombosis and Haemostasis

Volumn 12, Issue 4, 2014, Pages 444-451

  Peeters, P J H L ^a   Bazelier, M T ^a   Uitdehaag, B M J ^b   Leufkens, H G M ^a   De Bruin, M L ^a   de Vries, F ^a,c,d,e  

^a UTRECHT UNIVERSITY   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^d MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^e MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Autoimmune disease; Immobilization; Multiple sclerosis; Risk factors; Venous thromboembolism

Indexed keywords

ANTIDEPRESSANT AGENT; GLUCOCORTICOID; LOW MOLECULAR WEIGHT HEPARIN; WARFARIN;

ADULT; ARTICLE; BODY MASS; CARDIOVASCULAR RISK; CHRONIC OBSTRUCTIVE LUNG DISEASE; DEEP VEIN THROMBOSIS; DISABILITY; DISEASE DURATION; DRUG USE; FEMALE; HEART FAILURE; HORMONE SUBSTITUTION; HUMAN; IMMOBILITY; INJURY; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MULTIPLE SCLEROSIS; NEOPLASM; OBESITY; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SMOKING; SPASTICITY; VARICOSIS; VENOUS THROMBOEMBOLISM; ADOLESCENT; AGED; AUTOIMMUNE DISEASE; COHORT ANALYSIS; COMPLICATION; DISABLED PERSON; FACTUAL DATABASE; INFLAMMATION; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; TREATMENT OUTCOME; UNITED KINGDOM; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AUTOIMMUNE DISEASES; COHORT STUDIES; DATABASES, FACTUAL; DISABLED PERSONS; FEMALE; GLUCOCORTICOIDS; GREAT BRITAIN; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; SMOKING; TREATMENT OUTCOME; VENOUS THROMBOEMBOLISM; YOUNG ADULT;

EID: 84898031209     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12523     Document Type: Article

References (35)

1. Myhr KM, Riise T, Vedeler C, Nortvedt MW, Gronning R, Midgard R, Nyland HI. Disability and prognosis in multiple sclerosis: demographic and clinical variables important for the ability to walk and awarding of disability pension. Mult Scler 2001; 7: 59-65.
2. Zoller B, Li X, Sundquist J, Sundquist K. Risk of pulmonary embolism in patients with autoimmune disorders: a nationwide follow-up study from sweden. Lancet 2012; 379: 244-9.
3. Ramagopalan SV, Wotton CJ, Handel AE, Yeates D, Goldacre MJ. Risk of venous thromboembolism in people admitted to hospital with selected immune-mediated diseases: record-linkage study. BMC Med 2011; 9: 1.
4. Minagar A, Alexander JS. Blood-brain barrier disruption in multiple sclerosis. Mult Scler 2003; 9: 540-9.
5. Minagar A, Jy W, Jimenez JJ, Sheremata WA, Mauro LM, Mao WW, Horstman LL, Ahn YS. Elevated plasma endothelial microparticles in multiple sclerosis. Neurology 2001; 56: 1319-24.
6. Reitsma PH, Versteeg HH, Middeldorp S. Mechanistic view of risk factors for venous thromboembolism. Arterioscler Thromb Vasc Biol 2012; 32: 563-8.
7. Bovill EG, van der Vliet A. Venous valvular stasis-associated hypoxia and thrombosis: what is the link? Annu Rev Physiol 2011; 73: 527-45.
8. Kaufman J, Khatri BO, Riendl P. Are patients with multiple sclerosis protected from thrombophlebitis and pulmonary embolism? Chest 1988; 94: 998-1001.
9. Rizzo MA, Hadjimichael OC, Preiningerova J, Vollmer TL. Prevalence and treatment of spasticity reported by multiple sclerosis patients. Mult Scler 2004; 10: 589-95.
10. Oreja-Guevara C, Gonzalez-Segura D, Vila C. Spasticity in multiple sclerosis: results of a patient survey. Int J Neurosci 2013; 123: 400-8.
11. Christensen S, Farkas DK, Pedersen L, Miret M, Christiansen CF, Sorensen HT. Multiple sclerosis and risk of venous thromboembolism: a population-based cohort study. Neuroepidemiology 2012; 38: 76-83.
12. Arpaia G, Bavera PM, Caputo D, Mendozzi L, Cavarretta R, Agus GB, Milani M, Ippolito E, Cimminiello C. Risk of deep venous thrombosis (DVT) in bedridden or wheelchair-bound multiple sclerosis patients: a prospective study. Thromb Res 2010; 125: 315-7.
13. Parkinson J, Davis S, van Staa TP. The general practice research (GPRD) database: now and the future [online text]. In: Mann RD, Andrews EB, editors. Pharmacovigilance. 2nd ed. ed. Hoboken, NJ: John Wiley & Sons, 2007: 341-8.
14. Herrett E, Thomas SL, Schoonen WM, Smeeth L, Hall AJ. Validation and validity of diagnoses in the general practice research database: a systematic review. Br J Clin Pharmacol 2010; 69: 4-14.
15. Bazelier MT, van Staa T, Uitdehaag BM, Cooper C, Leufkens HG, Vestergaard P, Bentzen J, de Vries F. The risk of fracture in patients with multiple sclerosis: the UK general practice research database. J Bone Miner Res 2011; 26: 2271-9.
16. Lawrenson R, Todd JC, Leydon GM, Williams TJ, Farmer RD. Validation of the diagnosis of venous thromboembolism in general practice database studies. Br J Clin Pharmacol 2000; 49: 591-6.
17. Huerta C, Johansson S, Wallander MA, Garcia Rodriguez LA. Risk factors and short-term mortality of venous thromboembolism diagnosed in the primary care setting in the United Kingdom. Arch Intern Med 2007; 167: 935-43.
18. Severinsen MT, Kristensen SR, Johnsen SP, Dethlefsen C, Tjonneland A, Overvad K. Smoking and venous thromboembolism: a danish follow-up study. J Thromb Haemost 2009; 7: 1297-303.
19. Iorio A, Kearon C, Filippucci E, Marcucci M, Macura A, Pengo V, Siragusa S, Palareti G. Risk of recurrence after a first episode of symptomatic venous thromboembolism provoked by a transient risk factor: a systematic review. Arch Intern Med 2010; 170: 1710-6.
20. Grainge MJ, West J, Card TR. Venous thromboembolism during active disease and remission in inflammatory bowel disease: a cohort study. Lancet 2010; 375: 657-63.
21. Rizkallah J, Man SF, Sin DD. Prevalence of pulmonary embolism in acute exacerbations of COPD: a systematic review and metaanalysis. Chest 2009; 135: 786-93.
22. Matta F, Singala R, Yaekoub AY, Najjar R, Stein PD. Risk of venous thromboembolism with rheumatoid arthritis. Thromb Haemost 2009; 101: 134-8.
23. Sweetland S, Green J, Liu B, Berrington de Gonzalez A, Canonico M, Reeves G, Beral V, Million Women Study collaborators. Duration and magnitude of the postoperative risk of venous thromboembolism in middle aged women: prospective cohort study. BMJ 2009; 339: b4583.
24. Sultan AA, West J, Tata LJ, Fleming KM, Nelson-Piercy C, Grainge MJ. Risk of first venous thromboembolism in and around pregnancy: a population-based cohort study. Br J Haematol 2012; 156: 366-73.
25. Schmidt M, Christiansen CF, Horvath-Puho E, Glynn RJ, Rothman KJ, Sorensen HT. Non-steroidal anti-inflammatory drug use and risk of venous thromboembolism. J Thromb Haemost 2011; 9: 1326-33.
26. Clayton TC, Gaskin M, Meade TW. Recent respiratory infection and risk of venous thromboembolism: case-control study through a general practice database. Int J Epidemiol 2011; 40: 819-27.
27. Devine S, West S, Andrews E, Tennis P, Hammad TA, Eaton S, Thorp J, Olshan A. The identification of pregnancies within the general practice research database. Pharmacoepidemiol Drug Saf 2010; 19: 45-50.
28. Byatt N, Rothschild AJ, Riskind P, Ionete C, Hunt AT. Relationships between multiple sclerosis and depression. J Neuropsychiatry Clin Neurosci 2011; 23: 198-200.
29. Aksungar FB, Topkaya AE, Yildiz Z, Sahin S, Turk U. Coagulation status and biochemical and inflammatory markers in multiple sclerosis. J Clin Neurosci 2008; 15: 393-7.
30. Johannesdottir SA, Horvath-Puho E, Dekkers OM, Cannegieter SC, Jorgensen JO, Ehrenstein V, Vandenbroucke JP, Pedersen L, Sorensen HT. Use of glucocorticoids and risk of venous thromboembolism: a nationwide population-based case-control study. JAMA Intern Med 2013; 173: 743-52.
31. van Zaane B, Nur E, Squizzato A, Gerdes VE, Buller HR, Dekkers OM, Brandjes DP. Systematic review on the effect of glucocorticoid use on procoagulant, anti-coagulant and fibrinolytic factors. J Thromb Haemost 2010; 8: 2483-93.
32. Pollmann W, Feneberg W. Current management of pain associated with multiple sclerosis. CNS Drugs 2008; 22: 291-324.
33. Bazelier MT, Bentzen J, Vestergaard P, Stenager E, Leufkens HG, van Staa TP, de Vries F. The risk of fracture in incident multiple sclerosis patients: the danish national health registers. Mult Scler 2012; 18: 1609-16.
34. Bazelier MT, van Staa TP, Uitdehaag BM, Cooper C, Leufkens HG, Vestergaard P, Herings RM, de Vries F. Risk of fractures in patients with multiple sclerosis: a population-based cohort study. Neurology 2012; 78: 1967-73.
35. Bermel RA, Rae-Grant AD, Fox RJ. Diagnosing multiple sclerosis at a later age: more than just progressive myelopathy. Mult Scler 2010; 16: 1335-40.