The Hsp90 inhibitor SNX-2112 induces apoptosis of human hepatocellular carcinoma cells: The role of ER stress

Biochemical and Biophysical Research Communications

Volumn 446, Issue 1, 2014, Pages 160-166

  Wang, Xiao ^a,b   Wang, Shaoxiang ^b   Liu, Yuting ^b   Ding, Weichao ^b   Zheng, Kai ^b   Xiang, Yangfei ^b   Liu, Kaisheng ^b   Wang, Dongmei ^a   Zeng, Yaoying ^b   Xia, Min ^c   Yang, Depo ^a   Wang, Yifei ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b JINAN UNIVERSITY   (China)

^c Guangzhou Tongde Pharmaceutical Co Ltd   (China)

Author keywords

Apoptosis; ER stress; HCC; Hsp90; SNX 2112

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CALNEXIN; CASPASE; CHOLECYSTOKININ OCTAPEPTIDE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; IMMUNOGLOBULIN BINDING FACTOR; PHOSPHOTRANSFERASE; PKR LIKE ER KINASE; PROTEIN IRE1; SNX 2112; TUNICAMYCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CANCER MODEL; CELL STRAIN HEPG2; CELL VIABILITY; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR XENOGRAFT; WESTERN BLOTTING;

APOPTOSIS; ER STRESS; HCC; HSP90; SNX-2112;

ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASES; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; HEP G2 CELLS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HETEROGRAFTS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE;

EID: 84897971576     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.02.081     Document Type: Article

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