Serotonin (5-HT3) receptor antagonists for the reduction of symptoms of low anterior resection syndrome

Clinical and Experimental Gastroenterology

Volumn 7, Issue 1, 2014, Pages 47-52

  Itagaki, Ryohei ^a   Koda, Keiji ^a   Yamazaki, Masato ^a   Shuto, Kiyohiko ^a   Kosugi, Chihiro ^a   Hirano, Atsushi ^a   Arimitsu, Hidehito ^a   Shiragami, Risa ^a   Yoshimura, Yukino ^a   Suzuki, Masato ^a  

^a TEIKYO UNIVERSITY CHIBA MEDICAL CENTER   (Japan)

Author keywords

Defecatory malfunction; ISR; Low anterior resection syndrome; Serotonin receptor antagonist

Indexed keywords

RAMOSETRON;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONSTIPATION; CONTROLLED STUDY; DEFECATION HABIT; DEFECATION URGENCY; DISEASE SEVERITY; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; FECES INCONTINENCE; HUMAN; INTESTINE FUNCTION DISORDER; LOW ANTERIOR RESECTION SYNDROME; MALE; OUTCOME ASSESSMENT; POSTOPERATIVE CARE; SYMPTOM ASSESSMENT; TREATMENT DURATION;

EID: 84897898246     PISSN: None     EISSN: 11787023     Source Type: Journal    
DOI: 10.2147/CEG.S55410     Document Type: Article

References (18)

1. Pachler J, Wille-Jørgensen P. Quality of life after rectal resection for cancer, with or without permanent colostomy [review]. Cochrane Database Syst Rev. 2012;12:CD004323.
2. Martin ST, Heneghan HM, Winter DC. Systemic review of outcomes after intersphincteric resection for low rectal cancer. Br J Surg. 2012;99(5):603-612.
3. Lewis WG, Martin IG, Williamson ME, et al. Why do some patients experience poor function results after anterior resection of the rectum for carcinoma? Dis Colon Rectum. 1995;38(3):259-263.
4. Denost Q, Laurent C, Capdepont M, Zerbib F, Rullier E. Risk factors for fecal incontinence after intersphincteric resection for rectal cancer. Dis Colon Rectum. 2011;54(8):963-968.
5. Hirano A, Koda K, Kosugi C, Yamazaki M, Yasuda H. Damage to anal sphincter/levator ani muscles caused by operative procedure in anal sphincter-preserving operation for rectal cancer. Am J Surg. 2011;201(4): 508-513.
6. Jorge JM, Wexner SD. Etiology and management of fecal incontinence. Dis Colon Rectum. 1993;36(1):77-97.
7. Bryant CLC, Lunniss PJ, Knowles CH, Thaha MA, Chan CLH. Anterior resection syndrome. Lancet Oncology. 2012;13(9):e403-e408.
8. Fürst A, Burghofer K, Hutzel L, Jauch KW. Neorectal reservoir is not the functional principle of the colonic J-pouch: the volume of a short colonic J-pouch does not differ from a straight coloanal anastomosis. Dis Colon Rectum. 2002;45(5):660-667.
9. Iizuka I, Koda K, Seike K, et al. Defecatory malfunction caused by motility disorder of the neorectum after anterior resection for rectal cancer. Am J Surg. 2004;188(2):176-180.
10. Koda K, Saito N, Seike K, Shimizu K, Kosugi C, Miyazaki M. Denervation of the neorectum as a potential cause of defecatory disorder following low anterior resection for rectal cancer. Dis Colon Rectum. 2005;48(2):210-217.
11. Shimizu K, Koda K, Kase Y, et al. Induction and recovery of colonic motility/defecatory disorders following extrinsic denervation of the colon and rectum in rats. Surgery. 2006;139(3):395-406.
12. Lee WY, Takahashi T, Pappas T, Mantyh CR, Ludwig KA. Surgical autonomic denervation results in altered colonic motility: an explanation for low anterior resection syndrome? Surgery. 2008;143(6):778-783.
13. Spiller RC. Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome. Curr Opin Pharmacol. 2011;11(1):68-74.
14. Eshraghian A, Eshraghian H. Intestinal cells of Cajal: a novel hypothesis for the pathophysiology of irritable bowel syndrome. Can J Gastroenterol. 2011;25(5):277-279.
15. Cremonini F, Delgado-Aros S, Camilleri M. Efficacy of alosetoron in irritable bowel syndrome: a meta-analysis of randomized controlled trials. Neurogastroenterol Motil. 2003;15(1):79-86.
16. Ito M, Saito N, Sugito M, Kobayashi A, Nishizawa Y, Tsunoda Y. Analysis of clinical factors associated with anal function after intersphincteric resection for very low rectal cancer. Dis Colon Rectum. 2009;52(1):64-70.
17. Liu HN, Ohya S, Nishizawa Y, et al. Serotonin augments gut pacemaker activity via 5-HT3 receptors. PLoS One. 2011;6(9):e24928.
18. Tabe Y, Mochiki E, Ando H, et al. Correlation between colonic motility and defecatory disorders after anterior resection of the rectum in canine models. Neurogastroenterol Motil. 2008;20(10):1174-1184.